LOCUS       NM_199094               1555 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tubulin, beta 4B class IVb (Tubb4b), mRNA.
ACCESSION   NM_199094 XM_216012
VERSION     NM_199094.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1555)
  AUTHORS   Milochau,A., Lagree,V., Benassy,M.N., Chaignepain,S., Papin,J.,
            Garcia-Arcos,I., Lajoix,A., Monterrat,C., Coudert,L.,
            Schmitter,J.M., Ochoa,B. and Lang,J.
  TITLE     Synaptotagmin 11 interacts with components of the RNA-induced
            silencing complex RISC in clonal pancreatic beta-cells
  JOURNAL   FEBS Lett 588 (14), 2217-2222 (2014)
   PUBMED   24882364
REFERENCE   2  (bases 1 to 1555)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   3  (bases 1 to 1555)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 1555)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 1555)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   6  (bases 1 to 1555)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   7  (bases 1 to 1555)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   8  (bases 1 to 1555)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   9  (bases 1 to 1555)
  AUTHORS   van Niel,G., Raposo,G., Candalh,C., Boussac,M., Hershberg,R.,
            Cerf-Bensussan,N. and Heyman,M.
  TITLE     Intestinal epithelial cells secrete exosome-like vesicles
  JOURNAL   Gastroenterology 121 (2), 337-349 (2001)
   PUBMED   11487543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 23, 2021 this sequence version replaced NM_199094.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060597.1, FQ227178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               JAXUCZ010000003.1  28438332-28438455   c
            125-233             JAXUCZ010000003.1  28437917-28438025   c
            234-344             JAXUCZ010000003.1  28437730-28437840   c
            345-1555            JAXUCZ010000003.1  28435999-28437209   c
FEATURES             Location/Qualifiers
     source          1..1555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1555
                     /gene="Tubb4b"
                     /gene_synonym="Tubb2; Tubb2c"
                     /note="tubulin, beta 4B class IVb"
                     /db_xref="GeneID:296554"
                     /db_xref="RGD:735101"
     exon            1..124
                     /gene="Tubb4b"
                     /gene_synonym="Tubb2; Tubb2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1405
                     /gene="Tubb4b"
                     /gene_synonym="Tubb2; Tubb2c"
                     /note="tubulin, beta 2C; tubulin beta-2C chain; tubulin,
                     beta, 2"
                     /codon_start=1
                     /product="tubulin beta-4B chain"
                     /protein_id="NP_954525.2"
                     /db_xref="GeneID:296554"
                     /db_xref="RGD:735101"
                     /translation="MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQL
                     ERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWA
                     KGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
                     DRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQ
                     NKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA"
     exon            125..233
                     /gene="Tubb4b"
                     /gene_synonym="Tubb2; Tubb2c"
                     /inference="alignment:Splign:2.1.0"
     exon            234..344
                     /gene="Tubb4b"
                     /gene_synonym="Tubb2; Tubb2c"
                     /inference="alignment:Splign:2.1.0"
     exon            345..1555
                     /gene="Tubb4b"
                     /gene_synonym="Tubb2; Tubb2c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcactctgt gcgcctgctc ctccctaagt gttcctcttc tacagccgct ccgcagtcgc
       61 cgccgccatg agggagatcg tgcacctgca ggctgggcag tgcggcaacc agattggcgc
      121 caagttctgg gaggtaatca gcgacgagca tggcattgat cccactggca cgtaccacgg
      181 agatagcgac ctccagctgg agcgcatcaa cgtgtactac aacgaggcca ccggtggcaa
      241 gtatgtgccc cgcgctgtgc tcgtggactt ggagcccggc accatggact cggtgcgctc
      301 agggcccttc gggcagatct tcagacctga taacttcgtt tttggtcaga gtggggctgg
      361 gaacaactgg gccaaggggc actacacaga aggtgcagag ctggttgact cggtgttgga
      421 cgttgtgagg aaggaagctg agagctgtga ctgcctgcaa ggcttccagc tgacccactc
      481 cctgggtggg gggactgggt ctgggatggg taccctcctt atcagcaaga tccgggagga
      541 gtacccagac agaatcatga acaccttcag tgtggtccct tcccccaagg tgtcggacac
      601 agtggttgag ccctacaatg ccaccctttc agtccaccag cttgttgaaa acacagatga
      661 gacctattgt attgataatg aagcactcta tgacatctgc ttcagaaccc taaagctgac
      721 cacacccact tatggtgacc tgaaccatct agtgtccgcc accatgagtg gggtaaccac
      781 ttgcctacga ttccctggcc agctaaatgc tgacctgcgg aaactggctg taaatatggt
      841 gcccttccct cgcctgcact tcttcatgcc tggctttgcc cccttgacca gccggggaag
      901 ccagcagtac cgagccctga cagttcctga gctcacccag cagatgtttg atgctaagaa
      961 catgatggct gcctgtgatc cccgccatgg gcgctacttg acagtggctg ccgtgttcag
     1021 gggccgcatg tctatgaagg aggtggacga acagatgctt aatgtccaaa acaagaacag
     1081 cagctacttt gttgagtgga tccccaacaa cgtgaaaaca gctgtctgtg acattccacc
     1141 tcggggccta aaaatgtccg ccaccttcat tggcaacagc acggctattc aggagctgtt
     1201 caaacgcatc tcagagcagt tcacagccat gttccgacgc aaggccttcc tacactggta
     1261 cacgggcgag ggcatggatg agatggagtt cactgaggct gagagcaaca tgaatgacct
     1321 ggtgtccgag taccagcagt accaggatgc tacagctgag gaggaaggag agtttgagga
     1381 ggaggctgag gaggaggtgg cttagagctg tcttagtcac tacagcatgg gagcagtgtg
     1441 aactctttat tcattcacag cttgtctgct agccatgtcc actgtgcatt tgctgtcctg
     1501 tgtcctgaca tcacttgtac agataccacc attaaagcaa ttcatagtgt ctggc
//
