LOCUS       NM_080882               2086 bp    mRNA    linear   ROD 14-OCT-2023
DEFINITION  Rattus norvegicus tubulin, beta 4A class IVa (Tubb4a), mRNA.
ACCESSION   NM_080882 XM_001059513
VERSION     NM_080882.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2086)
  AUTHORS   Duncan ID, Bugiani M, Radcliff AB, Moran JJ, Lopez-Anido C, Duong
            P, August BK, Wolf NI, van der Knaap MS and Svaren J.
  TITLE     A mutation in the Tubb4a gene leads to microtubule accumulation
            with hypomyelination and demyelination
  JOURNAL   Ann Neurol 81 (5), 690-702 (2017)
   PUBMED   28393430
  REMARK    GeneRIF: Tubb4a mutation is the genetic cause of the profound
            hypomyelination in the taiep rat model.
REFERENCE   2  (bases 1 to 2086)
  AUTHORS   Milochau A, Lagree V, Benassy MN, Chaignepain S, Papin J,
            Garcia-Arcos I, Lajoix A, Monterrat C, Coudert L, Schmitter JM,
            Ochoa B and Lang J.
  TITLE     Synaptotagmin 11 interacts with components of the RNA-induced
            silencing complex RISC in clonal pancreatic beta-cells
  JOURNAL   FEBS Lett 588 (14), 2217-2222 (2014)
   PUBMED   24882364
REFERENCE   3  (bases 1 to 2086)
  AUTHORS   Krolewski RC, Packard A, Jang W, Wildner H and Schwob JE.
  TITLE     Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal
            cells in olfactory epithelium
  JOURNAL   PLoS One 7 (12), e51737 (2012)
   PUBMED   23284756
REFERENCE   4  (bases 1 to 2086)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 2086)
  AUTHORS   Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K,
            Herrmann C, Meyer HE, Wiese S, Warscheid B, Theiss C and Erdmann R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   6  (bases 1 to 2086)
  AUTHORS   Huang T, You Y, Spoor MS, Richer EJ, Kudva VV, Paige RC, Seiler MP,
            Liebler JM, Zabner J, Plopper CG and Brody SL.
  TITLE     Foxj1 is required for apical localization of ezrin in airway
            epithelial cells
  JOURNAL   J Cell Sci 116 (Pt 24), 4935-4945 (2003)
   PUBMED   14625387
REFERENCE   7  (bases 1 to 2086)
  AUTHORS   Kultgen PL, Byrd SK, Ostrowski LE and Milgram SL.
  TITLE     Characterization of an A-kinase anchoring protein in human ciliary
            axonemes
  JOURNAL   Mol Biol Cell 13 (12), 4156-4166 (2002)
   PUBMED   12475942
REFERENCE   8  (bases 1 to 2086)
  AUTHORS   Miller LA, Wert SE and Whitsett JA.
  TITLE     Immunolocalization of sonic hedgehog (Shh) in developing mouse lung
  JOURNAL   J Histochem Cytochem 49 (12), 1593-1604 (2001)
   PUBMED   11724907
REFERENCE   9  (bases 1 to 2086)
  AUTHORS   Jimenez MA, Evangelio JA, Aranda C, Lopez-Brauet A, Andreu D, Rico
            M, Lagos R, Andreu JM and Monasterio O.
  TITLE     Helicity of alpha(404-451) and beta(394-445) tubulin C-terminal
            recombinant peptides
  JOURNAL   Protein Sci 8 (4), 788-799 (1999)
   PUBMED   10211825
REFERENCE   10 (bases 1 to 2086)
  AUTHORS   Burgoyne RD, Cambray-Deakin MA, Lewis SA, Sarkar S and Cowan NJ.
  TITLE     Differential distribution of beta-tubulin isotypes in cerebellum
  JOURNAL   EMBO J 7 (8), 2311-2319 (1988)
   PUBMED   2461292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO395990.1, DY315612.1, CO561872.1, CF978144.1, CB740167.1,
            DV728977.1 and CB774680.1.
            
            On Oct 14, 2007 this sequence version replaced XM_001059513.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168216.1, CB585865.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               CO395990.1         4-658
            656-1164            DY315612.1         217-725
            1165-1484           CO561872.1         307-626
            1485-1624           CF978144.1         500-639
            1625-1703           CB740167.1         360-438
            1704-1796           DV728977.1         72-164
            1797-2086           CB774680.1         103-392
FEATURES             Location/Qualifiers
     source          1..2086
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2086
                     /gene="Tubb4a"
                     /gene_synonym="Tubb4"
                     /note="tubulin, beta 4A class IVa"
                     /db_xref="GeneID:29213"
                     /db_xref="RGD:619730"
     exon            1..170
                     /gene="Tubb4a"
                     /gene_synonym="Tubb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1448
                     /gene="Tubb4a"
                     /gene_synonym="Tubb4"
                     /note="tubulin, beta 4 class IVa"
                     /codon_start=1
                     /product="tubulin beta-4A chain"
                     /protein_id="NP_543158.1"
                     /db_xref="GeneID:29213"
                     /db_xref="RGD:619730"
                     /translation="MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQL
                     ERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWA
                     KGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFP
                     DRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQ
                     SKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEGEFEEEAEEEVA"
     exon            171..279
                     /gene="Tubb4a"
                     /gene_synonym="Tubb4"
                     /inference="alignment:Splign:2.1.0"
     exon            280..390
                     /gene="Tubb4a"
                     /gene_synonym="Tubb4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..2081
                     /gene="Tubb4a"
                     /gene_synonym="Tubb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagagacgc ccgggggcgc agagacagag ctctgcagcc atctcctcca gagacggaac
       61 cacagcgacc ggttgacacc cgtccatcag ccgccaccag cagcaccccc atcatgcggg
      121 aaatcgtgca cctgcaagcc gggcaatgcg gcaaccagat cggggccaag ttctgggagg
      181 tcatcagtga tgagcatggc atcgacccca ctgggaccta tcatggggac agtgacctcc
      241 agctggagag aattaatgtc tactacaacg aggccacagg tggaaattat gttcccagag
      301 ccgtgctggt tgacctagaa cctggcacca tggactccgt ccgctctggc ccttttggcc
      361 agatcttccg gccagacaac tttgtgtttg gtcaatctgg agcaggcaac aactgggcca
      421 agggtcatta cactgagggc gcagagttag tggatgcagt cctggacgtg gtgcgcaaag
      481 aggctgaaag ctgcgactgt ctccagggct tccagctcac ccactcgctc ggaggtggca
      541 caggctcagg gatggggacc ttgctcatca gcaagatccg ggaggagttc ccagacagga
      601 tcatgaatac gttcagcgta gtgccatcgc ccaaggtgtc tgacacggtg gtggaaccct
      661 acaatgccac actgtctgtg catcaactgg tggagaacac tgatgagacc tactgtatcg
      721 acaatgaggc cttgtacgac atctgcttcc gcactctcaa gctgaccacg cccacctacg
      781 gggacctcaa ccacctagtg tcggccacca tgagtggggt gaccacctgc ctgcgctttc
      841 ccggccagct caatgcagat ctacgcaagc tggctgtgaa catggtgccg ttcccccgtc
      901 tccacttctt catgccagga ttcgcaccct tgaccagcag gggcagccag cagtaccgag
      961 ccctcaccgt tcctgagctg acccaacaga tgttcgatgc taagaacatg atggccgcgt
     1021 gcgacccgag acacggtcgc tacctgaccg tggctgctgt cttccgagga cggatgtcca
     1081 tgaaggaggt ggacgagcag atgctaagtg tgcagagcaa gaacagcagc tacttcgttg
     1141 agtggatccc caacaacgtc aagacagccg tgtgtgacat cccaccccga ggcctgaaga
     1201 tggcagccac cttcatcggc aatagcacag ccatccagga gctgttcaaa cgcatctcag
     1261 agcagttcac cgccatgttt aggcgcaagg ccttcctgca ttggtacacg ggtgaaggca
     1321 tggacgagat ggagtttacg gaagcagaga gcaatatgaa cgacctggtg tccgagtacc
     1381 agcagtatca ggatgccacg gctgaagagg gcgagttcga agaggaggcc gaagaggagg
     1441 tggcttaagt cttcagccat cgctctgccc ccggggcaca ccagcaaatc tttgaccctg
     1501 agcaccccac ctctgcaccc agctgctcgt tcccttggat tccgtgagca tcttcaccat
     1561 gacggccaag gccaaagccc aggttgcttc atctgtttca cccttaactc ctaaacccct
     1621 ctgtctctcc aaccgaggca gtttccatga gagcccccaa cagacacaca cacacacaca
     1681 cacacacaca cacacacaca cacacactcc acctccttaa atcttgaaaa gcctttcttt
     1741 catcccctat cccttcccca gcactcctga atagttctcc acctctgaca cactcagaca
     1801 tttctctaga tcttgactta accttttacc cagcctccaa gccctctcac tttgccttac
     1861 ctctgatctc ccagctcccc actgctgacc cagcaccttc actctggctc ccataggtcc
     1921 ctgtgtgttc ctgcccttgt gccttagtta gttcctacca gagaagtgct ggagaggaaa
     1981 gagaggccta ttgcctgggg tgagagagcc cctccctatg caccccaccc cgctctcccc
     2041 tgcagaccct ccatcaataa atgagtcatt gctttgttgt gaaaaa
//
