LOCUS       NM_001013886            1700 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tubulin, beta 2B class IIb (Tubb2b), mRNA.
ACCESSION   NM_001013886 XM_238004
VERSION     NM_001013886.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1700)
  AUTHORS   Stottmann,R.W., Driver,A., Gutierrez,A., Skelton,M.R.,
            Muntifering,M., Stepien,C., Knudson,L., Kofron,M., Vorhees,C.V. and
            Williams,M.T.
  TITLE     A heterozygous mutation in tubulin, beta 2B (Tubb2b) causes
            cognitive deficits and hippocampal disorganization
  JOURNAL   Genes Brain Behav 16 (2), 250-259 (2017)
   PUBMED   27594048
REFERENCE   2  (bases 1 to 1700)
  AUTHORS   Breuss,M.W., Nguyen,T., Srivatsan,A., Leca,I., Tian,G., Fritz,T.,
            Hansen,A.H., Musaev,D., McEvoy-Venneri,J., James,K.N., Rosti,R.O.,
            Scott,E., Tan,U., Kolodner,R.D., Cowan,N.J., Keays,D.A. and
            Gleeson,J.G.
  TITLE     Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting
            microtubule stability
  JOURNAL   Hum Mol Genet 26 (2), 258-269 (2017)
   PUBMED   28013290
REFERENCE   3  (bases 1 to 1700)
  AUTHORS   Laquerriere,A., Gonzales,M., Saillour,Y., Cavallin,M., Joye,N.,
            Quelin,C., Bidat,L., Dommergues,M., Plessis,G., Encha-Razavi,F.,
            Chelly,J., Bahi-Buisson,N. and Poirier,K.
  TITLE     De novo TUBB2B mutation causes fetal akinesia deformation sequence
            with microlissencephaly: An unusual presentation of tubulinopathy
  JOURNAL   Eur J Med Genet 59 (4), 249-256 (2016)
   PUBMED   26732629
REFERENCE   4  (bases 1 to 1700)
  AUTHORS   Sheldon,K.L., Gurnev,P.A., Bezrukov,S.M. and Sackett,D.L.
  TITLE     Tubulin tail sequences and post-translational modifications
            regulate closure of mitochondrial voltage-dependent anion channel
            (VDAC)
  JOURNAL   J Biol Chem 290 (44), 26784-26789 (2015)
   PUBMED   26306046
  REMARK    GeneRIF: Tubulin tail sequences and post-translational
            modifications regulate closure of mitochondrial voltage-dependent
            anion channel, VDAC.
REFERENCE   5  (bases 1 to 1700)
  AUTHORS   Cederquist,G.Y., Luchniak,A., Tischfield,M.A., Peeva,M., Song,Y.,
            Menezes,M.P., Chan,W.M., Andrews,C., Chew,S., Jamieson,R.V.,
            Gomes,L., Flaherty,M., Grant,P.E., Gupta,M.L. Jr. and Engle,E.C.
  TITLE     An inherited TUBB2B mutation alters a kinesin-binding site and
            causes polymicrogyria, CFEOM and axon dysinnervation
  JOURNAL   Hum Mol Genet 21 (26), 5484-5499 (2012)
   PUBMED   23001566
REFERENCE   6  (bases 1 to 1700)
  AUTHORS   Navarro-Lerida,I., Martinez Moreno,M., Roncal,F., Gavilanes,F.,
            Albar,J.P. and Rodriguez-Crespo,I.
  TITLE     Proteomic identification of brain proteins that interact with
            dynein light chain LC8
  JOURNAL   Proteomics 4 (2), 339-346 (2004)
   PUBMED   14760703
REFERENCE   7  (bases 1 to 1700)
  AUTHORS   Arai,K., Shibutani,M. and Matsuda,H.
  TITLE     Distribution of the class II beta-tubulin in developmental and
            adult rat tissues
  JOURNAL   Cell Motil Cytoskeleton 52 (3), 174-182 (2002)
   PUBMED   12112145
  REMARK    GeneRIF: Distribution in developmental and adult rat tissues
REFERENCE   8  (bases 1 to 1700)
  AUTHORS   Ivings,L., Pennington,S.R., Jenkins,R., Weiss,J.L. and
            Burgoyne,R.D.
  TITLE     Identification of Ca2+-dependent binding partners for the neuronal
            calcium sensor protein neurocalcin delta: interaction with actin,
            clathrin and tubulin
  JOURNAL   Biochem J 363 (Pt 3), 599-608 (2002)
   PUBMED   11964161
REFERENCE   9  (bases 1 to 1700)
  AUTHORS   Best,A., Ahmed,S., Kozma,R. and Lim,L.
  TITLE     The Ras-related GTPase Rac1 binds tubulin
  JOURNAL   J Biol Chem 271 (7), 3756-3762 (1996)
   PUBMED   8631991
REFERENCE   10 (bases 1 to 1700)
  AUTHORS   Ginzburg,I., Teichman,A., Dodemont,H.J., Behar,L. and Littauer,U.Z.
  TITLE     Regulation of three beta-tubulin mRNAs during rat brain development
  JOURNAL   EMBO J 4 (13B), 3667-3673 (1985)
   PUBMED   2868892
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105754.1.
            
            On Jul 14, 2006 this sequence version replaced NM_001013886.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105754.1, EV769742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1700
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1700
                     /gene="Tubb2b"
                     /gene_synonym="RGD1309427; Tubb2"
                     /note="tubulin, beta 2B class IIb"
                     /db_xref="GeneID:291081"
                     /db_xref="RGD:1309427"
     exon            1..156
                     /gene="Tubb2b"
                     /gene_synonym="RGD1309427; Tubb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1437
                     /gene="Tubb2b"
                     /gene_synonym="RGD1309427; Tubb2"
                     /note="beta-tubulin T beta15 (aa 1-445); t beta-15;
                     tubulin, beta 2"
                     /codon_start=1
                     /product="tubulin beta-2B chain"
                     /protein_id="NP_001013908.2"
                     /db_xref="GeneID:291081"
                     /db_xref="RGD:1309427"
                     /translation="MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQL
                     ERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWA
                     KGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
                     DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQ
                     NKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA"
     exon            157..265
                     /gene="Tubb2b"
                     /gene_synonym="RGD1309427; Tubb2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..376
                     /gene="Tubb2b"
                     /gene_synonym="RGD1309427; Tubb2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..1686
                     /gene="Tubb2b"
                     /gene_synonym="RGD1309427; Tubb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggagtaag ttccaggtag cccagcagtg ggtgtggaag gggaggatca tcagacccac
       61 tgacccagac ccaaggcagc aagaagctaa cgaggcacca tgcgagagat cgtgcacatt
      121 caggcgggcc agtgcggcaa ccagatcggt gccaagtttt gggaggtcat cagtgatgag
      181 catggtatcg atcccactgg aagttaccat ggagacagtg atttgcaact ggaaagaatc
      241 aatgtatact acaacgaagc aactggtaat aaatatgtgc ctcgggccat cctggtggac
      301 ctggagcctg gcaccatgga ctctgtcaga tccggaccat ttgggcagat cttcaggcca
      361 gacaacttcg tgttcggcca gagtggtgca ggaaataact gggcaaaggg ccactacaca
      421 gagggtgccg agctggtgga ctctgtcctg gacgtggtaa ggaaggagtc agaaagctgt
      481 gactgtctcc agggcttcca gctgacccac tcactggggg gaggcactgg ctcaggcatg
      541 gggaccctgc tcatcagcaa gatcagagaa gagtacccag accgcatcat gaacaccttc
      601 agcgtcatgc cctcacccaa ggtctctgac actgtggtgg agccctataa tgccaccctc
      661 tccgtgcacc agctggtaga gaacacagat gaaacctact gcatcgacaa tgaggctctg
      721 tatgacatct gcttccgcac cctgaagctg accacaccca cctatggcga tctcaaccac
      781 ctggtgtcag ccaccatgag tggagtgacc acctgcctgc gcttccctgg ccagctgaac
      841 gcagacctgc gcaagctggc tgtgaacatg gtgcctttcc cacgcctgca cttcttcatg
      901 ccaggcttcg cacctctgac cagcaggggc agccagcagt accgagccct gacagtgccc
      961 gagctcaccc agcagatgtt cgactccaag aacatgatgg ctgcctgcga cccacgccat
     1021 ggccgctacc tgaccgtagc cgccattttc cggggccgca tgtccatgaa ggaggtggat
     1081 gagcagatgc tcaacgtgca gaacaagaac agcagctact tcgtggagtg gatccccaac
     1141 aatgtgaaga cggccgtgtg tgacatccct cctcgtggcc tcaagatgtc agccaccttc
     1201 attggcaaca gcaccgccat ccaggagctg ttcaagcgca tctcggagca gttcactgcc
     1261 atgttcaggc gcaaggcttt cctgcactgg tacacgggcg agggcatgga cgagatggag
     1321 ttcaccgagg cggagagcaa catgaatgac ctggtgtctg agtaccagca gtaccaggat
     1381 gccacggctg atgagcaggg cgagttcgag gaggaggagg gcgaggatga ggcttgagtt
     1441 ccccaggcca agcaggttag ggaaagctga ggtgaaagga gggggtgggg ggtcttaatc
     1501 tgtgaaaata ccttggcagt tggaagaagg agaatggtct taggtttgtg ctgggtctct
     1561 ggtgctcttc actgttgcct gtcacttttt tctctttttg taatatcgat aacatcaatg
     1621 taacacttga gatctttctg aactcctgtt gtaatggcta aaatcacata aacctttgtg
     1681 tcctaaaaaa aaaaaaaaaa
//
