LOCUS       NM_001044270            1620 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus tubulin, alpha 1B (Tuba1b), mRNA.
ACCESSION   NM_001044270 XM_001059275
VERSION     NM_001044270.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Snelleksz,M. and Dean,B.
  TITLE     Lower levels of tubulin alpha 1b in the frontal pole in
            schizophrenia supports a role for changed cytoskeletal dynamics in
            the aetiology of the disorder
  JOURNAL   Psychiatry Res 303, 114096 (2021)
   PUBMED   34274903
  REMARK    GeneRIF: Lower levels of tubulin alpha 1b in the frontal pole in
            schizophrenia supports a role for changed cytoskeletal dynamics in
            the aetiology of the disorder.
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   Van Humbeeck,C., Cornelissen,T., Hofkens,H., Mandemakers,W.,
            Gevaert,K., De Strooper,B. and Vandenberghe,W.
  TITLE     Parkin interacts with Ambra1 to induce mitophagy
  JOURNAL   J Neurosci 31 (28), 10249-10261 (2011)
   PUBMED   21753002
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   5  (bases 1 to 1620)
  AUTHORS   Zhao,M., Ko,S.Y., Liu,J.H., Chen,D., Zhang,J., Wang,B.,
            Harris,S.E., Oyajobi,B.O. and Mundy,G.R.
  TITLE     Inhibition of microtubule assembly in osteoblasts stimulates bone
            morphogenetic protein 2 expression and bone formation through
            transcription factor Gli2
  JOURNAL   Mol Cell Biol 29 (5), 1291-1305 (2009)
   PUBMED   19103752
REFERENCE   6  (bases 1 to 1620)
  AUTHORS   Hao,G., Derakhshan,B., Shi,L., Campagne,F. and Gross,S.S.
  TITLE     SNOSID, a proteomic method for identification of cysteine
            S-nitrosylation sites in complex protein mixtures
  JOURNAL   Proc Natl Acad Sci U S A 103 (4), 1012-1017 (2006)
   PUBMED   16418269
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5242]
REFERENCE   7  (bases 1 to 1620)
  AUTHORS   Ledesma,M.D., Da Silva,J.S., Schevchenko,A., Wilm,M. and Dotti,C.G.
  TITLE     Proteomic characterisation of neuronal sphingolipid-cholesterol
            microdomains: role in plasminogen activation
  JOURNAL   Brain Res 987 (1), 107-116 (2003)
   PUBMED   14499952
REFERENCE   8  (bases 1 to 1620)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   9  (bases 1 to 1620)
  AUTHORS   Ginzburg,I., Teichman,A., Griffin,W.S. and Littauer,U.Z.
  TITLE     Differential expression of alpha-tubulin mRNA in rat cerebellum as
            revealed by in situ hybridization
  JOURNAL   FEBS Lett 194 (1), 161-164 (1986)
   PUBMED   3753592
REFERENCE   10 (bases 1 to 1620)
  AUTHORS   Ginzburg,I., Behar,L., Givol,D. and Littauer,U.Z.
  TITLE     The nucleotide sequence of rat alpha-tubulin: 3'-end
            characteristics, and evolutionary conservation
  JOURNAL   Nucleic Acids Res 9 (12), 2691-2697 (1981)
   PUBMED   6269058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 19, 2021 this sequence version replaced NM_001044270.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060572.1, FQ218850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105, SAMN12840108
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000007.1  131972486-131972587 c
            103-325             JAXUCZ010000007.1  131971197-131971419 c
            326-474             JAXUCZ010000007.1  131970917-131971065 c
            475-1620            JAXUCZ010000007.1  131969606-131970751 c
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1620
                     /gene="Tuba1b"
                     /gene_synonym="RGD1565476; Tuba1"
                     /note="tubulin, alpha 1B"
                     /db_xref="GeneID:500929"
                     /db_xref="RGD:1565476"
     exon            1..102
                     /gene="Tuba1b"
                     /gene_synonym="RGD1565476; Tuba1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1455
                     /gene="Tuba1b"
                     /gene_synonym="RGD1565476; Tuba1"
                     /note="alpha-tubulin 2; tubulin alpha-2 chain;
                     Alpha-tubulin 1; Tubulin alpha-1 chain"
                     /codon_start=1
                     /product="tubulin alpha-1B chain"
                     /protein_id="NP_001037735.1"
                     /db_xref="GeneID:500929"
                     /db_xref="RGD:1565476"
                     /translation="MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANN
                     YARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
                     YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAT
                     IKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEE
                     Y"
     exon            103..325
                     /gene="Tuba1b"
                     /gene_synonym="RGD1565476; Tuba1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..474
                     /gene="Tuba1b"
                     /gene_synonym="RGD1565476; Tuba1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..1620
                     /gene="Tuba1b"
                     /gene_synonym="RGD1565476; Tuba1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcattgc gttacttacc tcgactctta gttgtcggga acggtaaccg ggacccggtg
       61 tctgcttcta tcaccctcgc cttctaaccc gtagctatca tgcgtgagtg catctccatc
      121 cacgtcggcc aggctggtgt ccagatcggc aatgcctgct gggagctcta ctgcctggaa
      181 catggcatcc agcctgatgg ccagatgcca agcgacaaga ccattggggg aggagatgac
      241 tccttcaaca ccttcttcag tgagacagga gctggcaagc acgtgccccg ggcggtgttc
      301 gtagacctgg aacccacagt tattgatgaa gttcgcactg gcacctaccg ccagctcttc
      361 cacccagagc agctcatcac aggcaaggaa gatgctgcca ataactatgc ccgtggccac
      421 tacaccattg gcaaggagat cattgacctt gtcttggaca gaattcgcaa gctggctgac
      481 cagtgcacgg gtctccaggg cttcttggtt ttccacagct ttggtggggg aactggctct
      541 gggttcacct ccctgctgat ggagaggctc tctgtcgact acggaaagaa gtccaagctg
      601 gagttctcca tttacccagc cccccaggtt tccactgctg tggttgagcc ctacaattcc
      661 atcctcacca cccacaccac cctggagcac tctgattgtg ccttcatggt agacaatgag
      721 gccatctatg acatctgtcg tagaaacctc gacattgagc gcccaaccta cactaacctt
      781 aaccgcctta ttagccagat tgtgtcttcc atcactgctt ccctcagatt tgatggggcc
      841 ctgaatgttg atctgacaga attccagacc aacctggtgc cctaccctcg catccacttc
      901 cctctggcca cttatgcccc tgtcatctct gctgagaaag cctaccatga acagctttct
      961 gtagcagaga tcaccaatgc ctgctttgag ccagccaacc agatggtgaa atgtgaccct
     1021 cgccatggta aatacatggc ttgctgcctg ctgtaccgtg gtgatgtggt ccccaaagat
     1081 gtcaatgctg ccattgccac catcaagacc aagcgcagca tccagtttgt ggactggtgc
     1141 cccactggct tcaaggttgg cattaattac cagcctccca ctgtggtacc tggtggcgac
     1201 ctggccaagg tccagagagc tgtgtgtatg ctgagcaaca ccacagccat tgctgaggct
     1261 tgggctcgcc tggatcacaa gtttgatctg atgtatgcca agcgtgcctt tgtgcactgg
     1321 tatgtgggtg agggcatgga ggagggagag ttctctgaag cccgtgagga catggctgcc
     1381 ctagagaagg attatgagga ggttggtgtg gattctgtgg agggtgaggg tgaggaagaa
     1441 ggagaggaat actagttcat tcctgcagtc cctgtatcat gtcaaactca actccagctc
     1501 cagcactagc tgcaggcatc gatgcttcta tgctgtttcc cttctgtgat catgtcttct
     1561 ccatgtgtac ctcttaagtt tcccatgacg tctcaaagta aaagctttaa gaaaagaatt
//
