LOCUS       NM_022298               1617 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tubulin, alpha 1A (Tuba1a), mRNA.
ACCESSION   NM_022298 XM_217040
VERSION     NM_022298.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1617)
  AUTHORS   Renguet,E., De Loof,M., Fourny,N., Ginion,A., Bouzin,C., Pous,C.,
            Horman,S., Beauloye,C., Bultot,L. and Bertrand,L.
  TITLE     alpha-Tubulin acetylation on lysine 40 controls cardiac glucose
            uptake
  JOURNAL   Am J Physiol Heart Circ Physiol 322 (6), H1032-H1043 (2022)
   PUBMED   35486479
  REMARK    GeneRIF: alpha-Tubulin acetylation on lysine 40 controls cardiac
            glucose uptake.
REFERENCE   2  (bases 1 to 1617)
  AUTHORS   Yang,L., Zhao,L., Cui,L., Huang,Y., Ye,J., Zhang,Q., Jiang,X.,
            Zhang,D. and Huang,Y.
  TITLE     Decreased alpha-tubulin acetylation induced by an acidic
            environment impairs autophagosome formation and leads to rat
            cardiomyocyte injury
  JOURNAL   J Mol Cell Cardiol 127, 143-153 (2019)
   PUBMED   30582931
  REMARK    GeneRIF: HDAC6-mediated alpha-tubulin acetylation is an important
            mechanism of acidic pH-dependent autophagy in cardiomyocytes.
REFERENCE   3  (bases 1 to 1617)
  AUTHORS   Shin,S., Lim,S., Jeong,H., Kwan,L.T. and Kim,Y.K.
  TITLE     Visualization of TauTubulin Interaction in a Living Cell Using
            Bifluorescence Complementation Technique
  JOURNAL   Int J Mol Sci 19 (10), 2978 (2018)
   PUBMED   30274285
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1617)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1617)
  AUTHORS   Nakakura,T., Nemoto,T., Suzuki,T., Asano-Hoshino,A., Tanaka,H.,
            Arisawa,K., Nishijima,Y., Kiuchi,Y. and Hagiwara,H.
  TITLE     Adrenalectomy facilitates ATAT1 expression and alpha-tubulin
            acetylation in ACTH-producing corticotrophs
  JOURNAL   Cell Tissue Res 366 (2), 363-370 (2016)
   PUBMED   27314403
  REMARK    GeneRIF: These results agree with the hypothesis that the
            acetylation of alpha-tubulin by ATAT1 regulates the intracellular
            transport of secretory granules in corticotrophs.
REFERENCE   6  (bases 1 to 1617)
  AUTHORS   Best,A., Ahmed,S., Kozma,R. and Lim,L.
  TITLE     The Ras-related GTPase Rac1 binds tubulin
  JOURNAL   J Biol Chem 271 (7), 3756-3762 (1996)
   PUBMED   8631991
REFERENCE   7  (bases 1 to 1617)
  AUTHORS   Ginzburg,I., Teichman,A., Griffin,W.S. and Littauer,U.Z.
  TITLE     Differential expression of alpha-tubulin mRNA in rat cerebellum as
            revealed by in situ hybridization
  JOURNAL   FEBS Lett 194 (1), 161-164 (1986)
   PUBMED   3753592
REFERENCE   8  (bases 1 to 1617)
  AUTHORS   Lemischka,I. and Sharp,P.A.
  TITLE     The sequences of an expressed rat alpha-tubulin gene and a
            pseudogene with an inserted repetitive element
  JOURNAL   Nature 300 (5890), 330-335 (1982)
   PUBMED   6927856
REFERENCE   9  (bases 1 to 1617)
  AUTHORS   Lemischka,I.R., Farmer,S., Racaniello,V.R. and Sharp,P.A.
  TITLE     Nucleotide sequence and evolution of a mammalian alpha-tubulin
            messenger RNA
  JOURNAL   J Mol Biol 151 (1), 101-120 (1981)
   PUBMED   7328649
REFERENCE   10 (bases 1 to 1617)
  AUTHORS   Ginzburg,I., Behar,L., Givol,D. and Littauer,U.Z.
  TITLE     The nucleotide sequence of rat alpha-tubulin: 3'-end
            characteristics, and evolutionary conservation
  JOURNAL   Nucleic Acids Res 9 (12), 2691-2697 (1981)
   PUBMED   6269058
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from V01227.1.
            
            On Jan 12, 2005 this sequence version replaced XM_217040.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: V01227.1, BC078830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMD00132300
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1617
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1617
                     /gene="Tuba1a"
                     /gene_synonym="Tuba1"
                     /note="tubulin, alpha 1A"
                     /db_xref="GeneID:64158"
                     /db_xref="RGD:619717"
     exon            1..69
                     /gene="Tuba1a"
                     /gene_synonym="Tuba1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1422
                     /gene="Tuba1a"
                     /gene_synonym="Tuba1"
                     /note="alpha-tubulin 1; tubulin alpha-1 chain; tubulin,
                     alpha 1"
                     /codon_start=1
                     /product="tubulin alpha-1A chain"
                     /protein_id="NP_071634.1"
                     /db_xref="GeneID:64158"
                     /db_xref="RGD:619717"
                     /translation="MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANN
                     YARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
                     YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAT
                     IKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEE
                     Y"
     exon            70..292
                     /gene="Tuba1a"
                     /gene_synonym="Tuba1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..441
                     /gene="Tuba1a"
                     /gene_synonym="Tuba1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..1617
                     /gene="Tuba1a"
                     /gene_synonym="Tuba1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1617
                     /gene="Tuba1a"
                     /gene_synonym="Tuba1"
                     /note="polyA addition site"
ORIGIN      
        1 gcgctgtaag aagcaacacc tcctcctcgc ctccgccatc cacccggcag ccgcgaagca
       61 gcaaccatgc gtgagtgtat ctccatccac gtcggccagg ctggtgtcca gatcggcaat
      121 gcctgctggg agctctactg cctggaacat ggcatccagc ctgatggcca gatgccaagc
      181 gacaagacca ttgggggagg agatgactcc ttcaacacct tcttcagtga gacaggagct
      241 ggcaagcacg tgccccgggc ggtgttcgta gacctggaac ccacagttat tgatgaagtt
      301 cgcactggca cctaccgcca gctcttccac ccagagcagc tcatcacagg caaggaagat
      361 gctgccaata actatgcccg tggccactac accattggca aggagatcat tgaccttgtc
      421 ttggacagaa ttcgcaagct ggctgaccag tgcacgggtc tccagggctt cttggttttc
      481 cacagctttg gtgggggaac tggctctggg ttcacctccc tgctgatgga gaggctctct
      541 gtcgactacg gaaagaagtc caagctggag ttctccattt acccagcccc ccaggtttcc
      601 actgctgtgg ttgagcccta caattccatc ctcaccaccc acaccaccct ggagcactct
      661 gattgtgcct tcatggtaga caatgaggcc atctatgaca tctgtcgtag aaacctcgac
      721 attgagcgcc caacctacac taacttaaac aggttgatag gtcaaattgt gtcttccatc
      781 actgcttccc tcagatttga tggggccctg aatgttgatc tgacagaatt ccagaccaac
      841 ctggtgccct accctcgcat ccacttccct ctggccactt atgcccctgt catctctgct
      901 gagaaagcct accatgaaca gctttctgta gcagagatca ccaatgcctg ctttgagcca
      961 gccaaccaga tggtgaaatg tgaccctcgc catggtaaat acatggcttg ctgcctgctg
     1021 taccgtggtg atgtggtccc caaagatgtc aatgctgcca ttgccaccat caagaccaag
     1081 cgtaccatcc agtttgtgga ctggtgcccc actggcttca aggttggcat taattaccag
     1141 cctcccactg tggtccctgg tggcgacctg gccaaggtcc agagagctgt gtgtatgctg
     1201 agcaacacca cagccattgc tgaggcctgg gctcgcctgg atcacaagtt tgatctgatg
     1261 tatgccaagc gtgcctttgt gcactggtac gtgggtgagg gcatggagga gggagagttc
     1321 tctgaggccc gtgaggacat ggctgcccta gagaaggatt atgaggaggt tggtgtggat
     1381 tctgtggagg gtgagggtga ggaagaagga gaggaatact aaattaaatg tcacaaggtg
     1441 ctgctttcac agggatgttt attctggtcc aacatagaaa gttgtgggct gatcagttaa
     1501 tttgtatgtg gcaatgtgtg ctttcataca gttactgact ttaagtgtga atgatttgtc
     1561 agagacccga gccgtccact tcactgatgg gttttaaata aaatactccc tgtctta
//
