LOCUS       NM_013077               1574 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TUB bipartite transcription factor (Tub), mRNA.
ACCESSION   NM_013077
VERSION     NM_013077.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Franklin,J.M. and Carrasco,G.A.
  TITLE     Cocaine potentiates multiple 5-HT2A receptor signaling pathways and
            is associated with decreased phosphorylation of 5-HT2A receptors in
            vivo
  JOURNAL   J Mol Neurosci 55 (3), 770-777 (2015)
   PUBMED   25213649
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Loktev,A.V. and Jackson,P.K.
  TITLE     Neuropeptide Y family receptors traffic via the Bardet-Biedl
            syndrome pathway to signal in neuronal primary cilia
  JOURNAL   Cell Rep 5 (5), 1316-1329 (2013)
   PUBMED   24316073
REFERENCE   4  (bases 1 to 1574)
  AUTHORS   Sun,X., Haley,J., Bulgakov,O.V., Cai,X., McGinnis,J. and Li,T.
  TITLE     Tubby is required for trafficking G protein-coupled receptors to
            neuronal cilia
  JOURNAL   Cilia 1 (1), 21 (2012)
   PUBMED   23351594
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1574)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   6  (bases 1 to 1574)
  AUTHORS   Ikeda,A., Zheng,Q.Y., Zuberi,A.R., Johnson,K.R., Naggert,J.K. and
            Nishina,P.M.
  TITLE     Microtubule-associated protein 1A is a modifier of tubby hearing
            (moth1)
  JOURNAL   Nat Genet 30 (4), 401-405 (2002)
   PUBMED   11925566
REFERENCE   7  (bases 1 to 1574)
  AUTHORS   Koritschoner,N.P., Alvarez-Dolado,M., Kurz,S.M., Heikenwalder,M.F.,
            Hacker,C., Vogel,F., Munoz,A. and Zenke,M.
  TITLE     Thyroid hormone regulates the obesity gene tub
  JOURNAL   EMBO Rep 2 (6), 499-504 (2001)
   PUBMED   11415982
REFERENCE   8  (bases 1 to 1574)
  AUTHORS   Stubdal,H., Lynch,C.A., Moriarty,A., Fang,Q., Chickering,T.,
            Deeds,J.D., Fairchild-Huntress,V., Charlat,O., Dunmore,J.H.,
            Kleyn,P., Huszar,D. and Kapeller,R.
  TITLE     Targeted deletion of the tub mouse obesity gene reveals that tubby
            is a loss-of-function mutation
  JOURNAL   Mol Cell Biol 20 (3), 878-882 (2000)
   PUBMED   10629044
REFERENCE   9  (bases 1 to 1574)
  AUTHORS   Norman,R.A., Leibel,R.L., Chung,W.K., Power-Kehoe,L., Chua,S.C.
            Jr., Knowler,W.C., Thompson,D.B., Bogardus,C. and Ravussin,E.
  TITLE     Absence of linkage of obesity and energy metabolism to markers
            flanking homologues of rodent obesity genes in Pima Indians
  JOURNAL   Diabetes 45 (9), 1229-1232 (1996)
   PUBMED   8772727
REFERENCE   10 (bases 1 to 1574)
  AUTHORS   Kleyn,P.W., Fan,W., Kovats,S.G., Lee,J.J., Pulido,J.C., Wu,Y.,
            Berkemeier,L.R., Misumi,D.J., Holmgren,L., Charlat,O., Woolf,E.A.,
            Tayber,O., Brody,T., Shu,P., Hawkins,F., Kennedy,B., Baldini,L.,
            Ebeling,C., Alperin,G.D., Deeds,J., Lakey,N.D., Culpepper,J.,
            Chen,H., Glucksmann-Kuis,M.A., Carlson,G.A., Duyk,G.M. and
            Moore,K.J.
  TITLE     Identification and characterization of the mouse obesity gene
            tubby: a member of a novel gene family
  JOURNAL   Cell 85 (2), 281-290 (1996)
   PUBMED   8612280
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013077.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                JAXUCZ010000001.1  172443342-172443380
            40-91               JAXUCZ010000001.1  172452084-172452135
            92-254              JAXUCZ010000001.1  172452492-172452654
            255-398             JAXUCZ010000001.1  172454759-172454902
            399-566             JAXUCZ010000001.1  172455986-172456153
            567-685             JAXUCZ010000001.1  172457065-172457183
            686-883             JAXUCZ010000001.1  172457988-172458185
            884-996             JAXUCZ010000001.1  172458403-172458515
            997-1114            JAXUCZ010000001.1  172459137-172459254
            1115-1213           JAXUCZ010000001.1  172460605-172460703
            1214-1385           JAXUCZ010000001.1  172460910-172461081
            1386-1574           JAXUCZ010000001.1  172461457-172461645
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..1574
                     /gene="Tub"
                     /note="TUB bipartite transcription factor"
                     /db_xref="GeneID:25609"
                     /db_xref="RGD:3918"
     exon            1..39
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..1519
                     /gene="Tub"
                     /note="tubby bipartite transcription factor"
                     /codon_start=1
                     /product="tubby protein homolog"
                     /protein_id="NP_037209.1"
                     /db_xref="GeneID:25609"
                     /db_xref="RGD:3918"
                     /translation="MTSKPHSDWIPYSVLDDEGSNLRQQKLDRQRALLEQKQKKKRQE
                     PLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQPGATRPP
                     APASAKKTKGAAASGGQGGAPRKEKKGKHKGTSGPATLAEDKSEAQGPVQILTVGQSD
                     HAKDAGETAAGGGAQPSGQDLRATMQRKGISSSMSFDEEEDEDENSSSSSQLNSNTRP
                     SSATSRKSTREAASAPSPAAPEPPVDIEVQDLEEFALRPAPQGITIKCRITRDKKGMD
                     RGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSN
                     LMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMN
                     MVHERVCIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQAS
                     VKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE"
     exon            40..91
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            92..254
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            255..398
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            399..566
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            567..685
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            686..883
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            884..996
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1114
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1213
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1385
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1574
                     /gene="Tub"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catgacttcc aagccgcatt ccgactggat tccctacagt gtcctagatg atgagggcag
       61 caacctgagg cagcagaagc tcgaccggca gcgggccctg ttggagcaga agcagaagaa
      121 gaagcgccaa gagccgctga tggtacaggc caatgcagat gggcggcctc ggagccggcg
      181 tgccaggcag tcagaggagc aagcccccct ggtcgagtcc tacctcagca gcagcggcag
      241 caccagctac caagttcagg aggccgactc acttgccagt gtacagccag gagccacccg
      301 cccaccagca ccagcctcag ccaagaagac caagggagca gctgcatccg ggggccaggg
      361 tggggccccc aggaaggaga agaaggggaa gcataaaggc accagcgggc cagcaactct
      421 ggcagaagac aagtctgagg cccaaggccc agtgcagatc ttgactgtgg gacagtcaga
      481 ccacgccaag gatgcagggg agacagcagc cggcgggggc gcacagccca gcgggcagga
      541 cctccgagcc acgatgcaga ggaagggcat ctccagcagc atgagctttg atgaggaaga
      601 ggatgaggat gaaaacagct ctagctcctc ccagctgaac agcaacaccc gccctagttc
      661 tgccacgagc aggaagtcca ccagggaggc agcatcagcc cccagcccag cagccccaga
      721 gccaccagtg gatattgagg tccaggatct agaggagttt gccctgaggc cagctccaca
      781 agggatcacc atcaaatgcc gaatcactcg ggacaagaag ggcatggacc ggggcatgta
      841 ccccacctac tttctgcacc tagaccgtga agatggcaag aaggtgttcc tcttggcggg
      901 caggaagaga aagaagagta aaacttccaa ttacctcatc tctgtggacc cgacagactt
      961 gtctcgggga ggcgatagct atatcgggaa attgcggtcc aacctgatgg gcactaagtt
     1021 caccgtttat gacaatggcg tcaaccctca gaaggcatca tcttctacac tggaaagtgg
     1081 aaccctgcgc caggagctgg cagccgtgtg ctatgagaca aatgtcctag gcttcaaggg
     1141 accccggaag atgagtgtga tcgtcccagg catgaacatg gttcatgaga gagtctgtat
     1201 ccggccccga aatgaacacg agacgctgtt agcacgctgg cagaacaaga acacggagag
     1261 catcattgag ctgcagaata agacgccagt ctggaatgat gacacgcagt cctatgttct
     1321 taatttccat gggcgcgtca cacaggcttc cgtgaagaac ttccagatca tccacggcaa
     1381 tgacccggac tacatcgtca tgcagtttgg ccgggtagca gaagatgtgt tcaccatgga
     1441 ttacaactac ccgctgtgtg cactgcaggc ctttgccatc gctctgtcca gctttgacag
     1501 caagctggcc tgcgagtaga ggcttccact gcctttaggg cggccccgtc tggagtggag
     1561 cctgcctgcc tgcc
//
