LOCUS       NM_001106225            2957 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tweety family member 1 (Ttyh1), mRNA.
ACCESSION   NM_001106225 XM_001070417 XM_218263
VERSION     NM_001106225.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2957)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   2  (bases 1 to 2957)
  AUTHORS   Yoon,J.C., Ng,A., Kim,B.H., Bianco,A., Xavier,R.J. and Elledge,S.J.
  TITLE     Wnt signaling regulates mitochondrial physiology and insulin
            sensitivity
  JOURNAL   Genes Dev 24 (14), 1507-1518 (2010)
   PUBMED   20634317
REFERENCE   3  (bases 1 to 2957)
  AUTHORS   Matthews,C.A., Shaw,J.E., Hooper,J.A., Young,I.G., Crouch,M.F. and
            Campbell,H.D.
  TITLE     Expression and evolution of the mammalian brain gene Ttyh1
  JOURNAL   J Neurochem 100 (3), 693-707 (2007)
   PUBMED   17116230
  REMARK    GeneRIF: These data suggest a role for Ttyh1 in process formation,
            cell adhesion and possibly as a transmembrane receptor.
REFERENCE   4  (bases 1 to 2957)
  AUTHORS   Collins,M.O., Husi,H., Yu,L., Brandon,J.M., Anderson,C.N.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Molecular characterization and comparison of the components and
            multiprotein complexes in the postsynaptic proteome
  JOURNAL   J Neurochem 97 Suppl 1, 16-23 (2006)
   PUBMED   16635246
REFERENCE   5  (bases 1 to 2957)
  AUTHORS   Suzuki,M.
  TITLE     The Drosophila tweety family: molecular candidates for
            large-conductance Ca2+-activated Cl- channels
  JOURNAL   Exp Physiol 91 (1), 141-147 (2006)
   PUBMED   16219661
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474075.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001070417.1, XM_218263.4.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC168158.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760393, SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2957
                     /gene="Ttyh1"
                     /note="tweety family member 1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
     exon            1..219
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1446
                     /gene="Ttyh1"
                     /note="tweety homolog 1; volume-regulated anion channel
                     subunit Ttyh1"
                     /codon_start=1
                     /product="protein tweety homolog 1"
                     /protein_id="NP_001099695.1"
                     /db_xref="GeneID:292597"
                     /db_xref="RGD:1310103"
                     /translation="MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQAL
                     LLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGAKSPPPGGGCVTWSCIAALLVGC
                     AGIGIGFYGNSETSDGVSQLSSALQHANHTLSTIDDLVLETVERLGEAVRTELTTLEE
                     VLSERVELVAATRGARRQAEAAAQHLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYV
                     LLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCS
                     NPDTYVLNLTQEETGISSDILNYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLER
                     EASPQFPAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGL
                     LFLMLFSLLSAGALATTLCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
                     "
     exon            220..398
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..510
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..731
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..827
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..900
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..976
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1032
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1125
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1218
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1361
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1407
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1481
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..2957
                     /gene="Ttyh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcccggga gccccgcaaa cccggctccg cccgcgcccc gcacagcacc gaggctcccg
       61 gcccggtccg ccccgctgcc cctccccggg gccatggggg cacccccggg ctaccgaccc
      121 tctgcctggg tgcatctcct ccaccagctg ccccgtgccg acttccagct ccgcccggtg
      181 cccagcggct ttgctccccg cgaccaagag taccagcagg ccctgctgct ggtggcagcc
      241 ttggctgggc tgggtttggg cctgagcctc atcttcatcg ctgtctacct catccgcttc
      301 tgctgctgca ggcctccaga accccctggg gccaagagtc ccccacccgg aggaggctgt
      361 gtcacctgga gctgcattgc tgcccttctc gtgggctgtg caggcattgg cattggtttc
      421 tatggtaaca gcgagaccag tgatggggtg tcccagctca gctcagcact gcagcatgcc
      481 aaccacacgc tcagcaccat tgatgacttg gtgctggaaa cggtagagag gctgggtgag
      541 gctgtgagga cagagctgac caccctggag gaagtgttgt cagaacgcgt ggagctggtg
      601 gctgccaccc ggggagccag aaggcaggct gaggcagcag ctcagcacct gcaaggccta
      661 gccttctggc agggagtgtc cctgagccca gtacaggtgg ctgaggatgt gactttcgtg
      721 gaggagtaca ggtggctggc ctatgtcctc ctgctgctct tggtgcttct ggtttgtctc
      781 ttcaccctcc tgggcctggc caagcagagc aagtggctgg tggttgtgat gaccgccatg
      841 agtctcctgg tgcttgtcct gagctggggt tctatgggcc tagaggctgc cacagctgtg
      901 ggtctcagtg acttctgctc caacccagac acctatgtgc tgaacttgac ccaggaggag
      961 acaggaatca gttcagacat cctcaactat tatttcctgt gcaaccaggc ggtctccaac
     1021 cccttccaac agaggctgac tctgtcccag cgtgctctag ccagcatcca ctctcagctg
     1081 caaggcctgg agcgggaagc tagccctcaa tttcctgctg cacagaagcc cttgttatcc
     1141 ttggaggaga cgctgaatgt gacagaaaga agcttccacc agttggtggc actgctgcac
     1201 tgccgcagtc tgcacaagga ctatggctca gcactccgag gcctgtgtga agatgcccta
     1261 gagggcctgc tgttcctgat gctcttttct ctcctgtctg ccggggccct agccaccact
     1321 ctttgcagcc tgccccgtgc ctgggctctc ttcccaccca gtgatgacta cgatgacaca
     1381 gacgatgacg accctttcaa ccctcaggaa tccaagcgct ttgtgcagtg gcagtcttcc
     1441 atctgagccc ccctgccagt gtggcctgcc tctcctcttt gctcctttcc ttggctgctg
     1501 gagaaggccc cactaacctg accttggctg ggctctgacc attaacactg ctggctatgg
     1561 acacctcaca taggatgaca tcctgttctg gccctaacac tcccccattc ccatttctcc
     1621 ttagcacagg tggttgctgg ggtggcacaa tagagaccag ggctgtctgg gaagggagct
     1681 gaccatacag cgtggtgttc ctcacctccg ggtaccagcc ctgtccttgg agggataaag
     1741 ctggacacag gtgcaggcat ggccatttcc tgccatatgc cagtgatctc aactgatggc
     1801 actaacttgg aagagggcgg atttgaaata aaagggaaga ctttatttta caagtaccta
     1861 ggtccttctt atcacccctg ccccaatcct ggagaaagaa gtcttgactg ggctagggga
     1921 ctcctctggt gtttgaaagg caactctcct cttgtccagg ctcagcactg ctttgcttct
     1981 gaaagtcacg tgtgaatcct gacaaggggg aagaagcaga tcccagaaga gagtaagcct
     2041 aacactaaat taaacatgcg tgcatccaca ggaagagtca accttccagt cacgtggaat
     2101 gttcaaagcc tgctgggatt aggaacggtg tggaatcgaa tcaacttgct tcctagcagc
     2161 tcatatccta cacaagaacg tcagaaaact aacgcttgtt tcaggatagg gacagaaatc
     2221 ttcagagaga agtagaatat ttgctcgtaa tgctaccacg gtgatgtaaa gggagaaggt
     2281 ttaaggaaga taatataaat ccagacagga aaagatgagg caatcatcaa gttgtcaagt
     2341 aaaaacaaac atggcagagt caaaagggaa atttattgtc tggggaacaa ttcctatgta
     2401 gttcttattt gttaaaaaaa aaaaaagtag cacacatgac aaaggaaaac attgttgtta
     2461 atagataaac ataattcaaa aagcttctat tatctaacaa aaaacagacc aactcaattt
     2521 agtaataagt aactgagatg aacgtacaag gaaacaaaat ccccaagaca aaggataaaa
     2581 ctggggattt ttggttttca ttttggtttt tggttttttg agacaggctt tctttgtaat
     2641 agacctgggt gtcctggaac tctttgtaga ccaggctggc cttgacctca cagagaacag
     2701 cctgcctctg cctccctagt actgagatta aagcatgtat caccatatca ccagctaaaa
     2761 tgttcaagtt ctaatgatta gcaaacacga tgtgctactt tcccctttct agtacctact
     2821 tgttgtggac tttaaagtgg ggtgttggct ggtgctagtc tggaggctca gggaaaaagt
     2881 tctctgaata tgctgctcag aggcggtgaa tcaccagcta tgtgaaaata ataattaaaa
     2941 caaacaaaca aaacaaa
//
