LOCUS       NM_012681                701 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus transthyretin (Ttr), mRNA.
ACCESSION   NM_012681
VERSION     NM_012681.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 701)
  AUTHORS   Orsat,J., Guernec,A., Le Marechal,C., Pichereau,V. and Guerrero,F.
  TITLE     Association between rat decompression sickness resistance,
            transthyretin single nucleotide polymorphism, and expression: A
            pilot study
  JOURNAL   Physiol Rep 12 (14), e16160 (2024)
   PUBMED   39039431
  REMARK    GeneRIF: Association between rat decompression sickness resistance,
            transthyretin single nucleotide polymorphism, and expression: A
            pilot study.
REFERENCE   2  (bases 1 to 701)
  AUTHORS   Wang,B., Hu,H., Zhang,H. and Zhong,D.
  TITLE     Immunohistochemical Assessment of Transthyretin Association with
            Colorectal Adenocarcinoma
  JOURNAL   Clin Lab 67 (3) (2021)
   PUBMED   33739034
REFERENCE   3  (bases 1 to 701)
  AUTHORS   Murakami,T., Yokoyama,T., Mizuguchi,M., Tone,S., Takaku,S.,
            Sango,K., Nishimura,H., Watabe,K. and Sunada,Y.
  TITLE     A low amyloidogenic E61K transthyretin mutation may cause familial
            amyloid polyneuropathy
  JOURNAL   J Neurochem 156 (6), 957-966 (2021)
   PUBMED   32852783
  REMARK    GeneRIF: A low amyloidogenic E61K transthyretin mutation may cause
            familial amyloid polyneuropathy.
REFERENCE   4  (bases 1 to 701)
  AUTHORS   Shimura,T., Shibata,M., Inoue,T., Owada-Ozaki,Y., Yamaura,T.,
            Muto,S., Hasegawa,T., Shio,Y. and Suzuki,H.
  TITLE     Prognostic impact of serum transthyretin in patients with non-small
            cell lung cancer
  JOURNAL   Mol Clin Oncol 10 (6), 597-604 (2019)
   PUBMED   31031974
REFERENCE   5  (bases 1 to 701)
  AUTHORS   Shimura,T., Shibata,M., Gonda,K., Okayama,H., Saito,M., Momma,T.,
            Ohki,S. and Kono,K.
  TITLE     Serum transthyretin level is associated with prognosis of patients
            with gastric cancer
  JOURNAL   J Surg Res 227, 145-150 (2018)
   PUBMED   29804846
REFERENCE   6  (bases 1 to 701)
  AUTHORS   Motojima,K. and Goto,S.
  TITLE     Dual promoters and tissue-specific expression of rat transthyretin
            gene
  JOURNAL   Biochem Biophys Res Commun 173 (1), 323-330 (1990)
   PUBMED   2256922
REFERENCE   7  (bases 1 to 701)
  AUTHORS   Duan,W., Cole,T. and Schreiber,G.
  TITLE     Cloning and nucleotide sequencing of transthyretin (prealbumin)
            cDNA from rat choroid plexus and liver
  JOURNAL   Nucleic Acids Res 17 (10), 3979 (1989)
   PUBMED   2734110
  REMARK    Erratum:[Nucleic Acids Res 1989 Jul 25;17(14):5882]
REFERENCE   8  (bases 1 to 701)
  AUTHORS   Fung,W.P., Thomas,T., Dickson,P.W., Aldred,A.R., Milland,J.,
            Dziadek,M., Power,B., Hudson,P. and Schreiber,G.
  TITLE     Structure and expression of the rat transthyretin (prealbumin) gene
  JOURNAL   J Biol Chem 263 (1), 480-488 (1988)
   PUBMED   2891699
REFERENCE   9  (bases 1 to 701)
  AUTHORS   Dickson,P.W., Howlett,G.J. and Schreiber,G.
  TITLE     Rat transthyretin (prealbumin). Molecular cloning, nucleotide
            sequence, and gene expression in liver and brain
  JOURNAL   J Biol Chem 260 (13), 8214-8219 (1985)
   PUBMED   3839240
REFERENCE   10 (bases 1 to 701)
  AUTHORS   Navab,M., Mallia,A.K., Kanda,Y. and Goodman,D.S.
  TITLE     Rat plasma prealbumin. Isolation and partial characterization
  JOURNAL   J Biol Chem 252 (14), 5100-5106 (1977)
   PUBMED   873934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1 and BC086946.1.
            
            On May 14, 2011 this sequence version replaced NM_012681.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK841462.1, FQ210502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000018.1  12218758-12218864
            108-701             BC086946.1         1-594
FEATURES             Location/Qualifiers
     source          1..701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..701
                     /gene="Ttr"
                     /gene_synonym="Lr1; Tbpa; TT"
                     /note="transthyretin"
                     /db_xref="GeneID:24856"
                     /db_xref="RGD:3916"
     exon            1..180
                     /gene="Ttr"
                     /gene_synonym="Lr1; Tbpa; TT"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..555
                     /gene="Ttr"
                     /gene_synonym="Lr1; Tbpa; TT"
                     /note="prealbumin, amyloidosis type I"
                     /codon_start=1
                     /product="transthyretin precursor"
                     /protein_id="NP_036813.2"
                     /db_xref="GeneID:24856"
                     /db_xref="RGD:3916"
                     /translation="MASLRLFLLCLAGLIFASEAGPGGAGESKCPLMVKVLDAVRGSP
                     AVDVAVKVFKKTADGSWEPFASGKTAESGELHGLTTDEKFTEGVYRVELDTKSYWKAL
                     GISPFHEYAEVVFTANDSGHRHYTIAALLSPYSYSTTAVVSNPQN"
     exon            181..311
                     /gene="Ttr"
                     /gene_synonym="Lr1; Tbpa; TT"
                     /inference="alignment:Splign:2.1.0"
     exon            312..447
                     /gene="Ttr"
                     /gene_synonym="Lr1; Tbpa; TT"
                     /inference="alignment:Splign:2.1.0"
     exon            448..701
                     /gene="Ttr"
                     /gene_synonym="Lr1; Tbpa; TT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggtttgg agtcagattg gcagggatca gcaggctgcc ttgggaggag ggggtatata
       61 agccccttca ccaggagaag tcatcgtaga gatccgctgg ctcctgacag gatggcttcc
      121 cttcgcctgt tcctcctctg cctcgctgga ctgatatttg cgtctgaagc tggccctggg
      181 ggtgctggag aatccaagtg tcctctgatg gtcaaagtcc tggatgctgt ccgaggcagc
      241 cctgctgtcg atgtggccgt gaaagtgttc aaaaagactg cagacggaag ctgggagccg
      301 tttgcctctg ggaagaccgc cgagtctgga gagctgcacg ggctcaccac agatgagaag
      361 ttcacggaag gggtgtacag ggtagaactg gacaccaaat cgtactggaa ggctcttggc
      421 atttccccat tccatgaata cgcagaggtg gttttcacag ccaatgactc tggtcatcgc
      481 cactacacca tcgcagccct gctcagcccg tactcctaca gcaccactgc tgtcgtcagt
      541 aacccccaga actgagggac ccagcccagg aggaccagga tcttgccaaa gcagtagctt
      601 cccatttgta ctgaaacagt gttcttgctc tataaaccgt gttagcaact cgggaagatg
      661 ccgtgaaacg ttcttattaa accaccttta tttcattcaa a
//
