LOCUS       NM_013048               2114 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus alpha tocopherol transfer protein (Ttpa), mRNA.
ACCESSION   NM_013048
VERSION     NM_013048.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2114)
  AUTHORS   Takitani,K., Inoue,K., Koh,M., Miyazaki,H., Kishi,K., Inoue,A. and
            Tamai,H.
  TITLE     alpha-Tocopherol status and altered expression of
            alpha-tocopherol-related proteins in streptozotocin-induced type 1
            diabetes in rat models
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 60 (6), 380-386 (2014)
   PUBMED   25866300
  REMARK    GeneRIF: The reduced expression of hepatic alpha-TTP and CYP4F2
            genes probably leads to decreased plasma alpha-tocopherol levels
            and elevated alpha-tocopherol levels in the liver of streptozotocin
            rats.
REFERENCE   2  (bases 1 to 2114)
  AUTHORS   Koh,M., Takitani,K., Miyazaki,H., Yamaoka,S. and Tamai,H.
  TITLE     Liver X receptor up-regulates alpha-tocopherol transfer protein
            expression and alpha-tocopherol status
  JOURNAL   J Nutr Biochem 24 (12), 2158-2167 (2013)
   PUBMED   24231105
  REMARK    GeneRIF: Liver X receptor regulates alpha-TTP expression through
            direct interaction with the alpha-TTP gene promoter, and it
            modulates circulating alpha-tocopherol levels.
REFERENCE   3  (bases 1 to 2114)
  AUTHORS   Kono,N., Ohto,U., Hiramatsu,T., Urabe,M., Uchida,Y., Satow,Y. and
            Arai,H.
  TITLE     Impaired alpha-TTP-PIPs interaction underlies familial vitamin E
            deficiency
  JOURNAL   Science 340 (6136), 1106-1110 (2013)
   PUBMED   23599266
REFERENCE   4  (bases 1 to 2114)
  AUTHORS   Miyazaki,H., Takitani,K., Koh,M., Takaya,R., Yoden,A. and Tamai,H.
  TITLE     alpha-Tocopherol status and expression of alpha-tocopherol transfer
            protein in type 2 diabetic Goto-Kakizaki rats
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 59 (1), 64-68 (2013)
   PUBMED   23535541
  REMARK    GeneRIF: The Goto-Kakizaki (GK) rats showed an increase of the
            hepatic expression of the alpha-TTP gene as compared with ...
            controls. ... the increased hepatic alpha-TTP gene expression
            levels may influence plasma alpha-tocopherol levels in the diabetic
            animals.
REFERENCE   5  (bases 1 to 2114)
  AUTHORS   Shichiri,M., Kono,N., Shimanaka,Y., Tanito,M., Rotzoll,D.E.,
            Yoshida,Y., Hagihara,Y., Tamai,H. and Arai,H.
  TITLE     A novel role for alpha-tocopherol transfer protein (alpha-TTP) in
            protecting against chloroquine toxicity
  JOURNAL   J Biol Chem 287 (4), 2926-2934 (2012)
   PUBMED   22147702
  REMARK    GeneRIF: alpha-TTP protects against CQ toxicity by preventing CQ
            accumulation in acidic organelles through a mechanism distinct from
            vitamin E transport.
REFERENCE   6  (bases 1 to 2114)
  AUTHORS   Arita,M., Nomura,K., Arai,H. and Inoue,K.
  TITLE     alpha-tocopherol transfer protein stimulates the secretion of
            alpha-tocopherol from a cultured liver cell line through a
            brefeldin A-insensitive pathway
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12437-12441 (1997)
   PUBMED   9356467
REFERENCE   7  (bases 1 to 2114)
  AUTHORS   Wu,C.G., Hoek,F.J., Groenink,M., Reitsma,P.H., van Deventer,S.J.
            and Chamuleau,R.A.
  TITLE     Correlation of repressed transcription of alpha-tocopherol transfer
            protein with serum alpha-tocopherol during hepatocarcinogenesis
  JOURNAL   Int J Cancer 71 (4), 686-690 (1997)
   PUBMED   9178827
REFERENCE   8  (bases 1 to 2114)
  AUTHORS   Ouahchi,K., Arita,M., Kayden,H., Hentati,F., Ben Hamida,M.,
            Sokol,R., Arai,H., Inoue,K., Mandel,J.L. and Koenig,M.
  TITLE     Ataxia with isolated vitamin E deficiency is caused by mutations in
            the alpha-tocopherol transfer protein
  JOURNAL   Nat Genet 9 (2), 141-145 (1995)
   PUBMED   7719340
REFERENCE   9  (bases 1 to 2114)
  AUTHORS   Sato,Y., Arai,H., Miyata,A., Tokita,S., Yamamoto,K., Tanabe,T. and
            Inoue,K.
  TITLE     Primary structure of alpha-tocopherol transfer protein from rat
            liver. Homology with cellular retinaldehyde-binding protein
  JOURNAL   J Biol Chem 268 (24), 17705-17710 (1993)
   PUBMED   8349655
REFERENCE   10 (bases 1 to 2114)
  AUTHORS   Yoshida,H., Yusin,M., Ren,I., Kuhlenkamp,J., Hirano,T., Stolz,A.
            and Kaplowitz,N.
  TITLE     Identification, purification, and immunochemical characterization
            of a tocopherol-binding protein in rat liver cytosol
  JOURNAL   J Lipid Res 33 (3), 343-350 (1992)
   PUBMED   1569384
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_013048.4.
            
            On Nov 27, 2020 this sequence version replaced NM_013048.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.20731.1,
                                           SRR26643298.26647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000005.1  38294421-38294629
            210-363             JAXUCZ010000005.1  38300784-38300937
            364-557             JAXUCZ010000005.1  38307590-38307783
            558-668             JAXUCZ010000005.1  38310890-38311000
            669-2114            JAXUCZ010000005.1  38313496-38314941
FEATURES             Location/Qualifiers
     source          1..2114
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..2114
                     /gene="Ttpa"
                     /gene_synonym="TTP"
                     /note="alpha tocopherol transfer protein"
                     /db_xref="GeneID:25571"
                     /db_xref="RGD:3915"
     exon            1..209
                     /gene="Ttpa"
                     /gene_synonym="TTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..842
                     /gene="Ttpa"
                     /gene_synonym="TTP"
                     /note="alpha-TTP; Tocopherol transfer protein alpha;
                     tocopherol (alpha) transfer protein; alpha-tocopherol
                     transfer protein-like"
                     /codon_start=1
                     /product="alpha-tocopherol transfer protein"
                     /protein_id="NP_037180.1"
                     /db_xref="GeneID:25571"
                     /db_xref="RGD:3915"
                     /translation="MAEMRPGPVVGKQLNEQPDHSPLVQPGLAELRRRAQEEGVPETP
                     QPLTDAFLLRFLRARDFDLDLAWRLMKNYYKWRAECPELSADLHPRSILGLLKAGYHG
                     VLRSRDPTGSRVLIYRISYWDPKVFTAYDVFRVSLITSELIVQEVETQRNGVKAIFDL
                     EGWQISHAFQITPSVAKKIAAVVTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKI
                     KGRIHLHGNNYKSSLLQHFPDILPLEYGGNESSMEDICQEWTNFIMKSEDYLSSISET
                     IQ"
     exon            210..363
                     /gene="Ttpa"
                     /gene_synonym="TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            364..557
                     /gene="Ttpa"
                     /gene_synonym="TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            558..668
                     /gene="Ttpa"
                     /gene_synonym="TTP"
                     /inference="alignment:Splign:2.1.0"
     exon            669..2114
                     /gene="Ttpa"
                     /gene_synonym="TTP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcatggc agagatgcgg ccggggccag tggttggaaa acagctcaac gagcagcccg
       61 accactcgcc cctggtccag ccgggcctgg ccgaactgag gcgccgggcg caggaggagg
      121 gcgtcccaga gaccccgcag ccgctcacag acgctttctt gttgcgattc ctgcgtgccc
      181 gggatttcga cctggacctg gcctggcgct taatgaaaaa ctattacaaa tggcgagcag
      241 aatgtccaga actaagtgca gatctacacc ctagaagtat ccttggactt ctgaaggctg
      301 gctaccatgg agttctgagg tccagggatc cgactggcag tagagttctc atttaccgaa
      361 tttcctattg ggacccaaaa gtttttacag cctatgatgt atttcgtgta agtctgatca
      421 catcagagct cattgtacag gaggtggaaa ctcaacggaa tggagtcaag gctatatttg
      481 acctggaagg ctggcagatt tctcatgctt ttcaaattac cccatctgta gccaagaaga
      541 ttgctgctgt agttacagat tcctttccat tgaaagttcg tgggatccat ttgataaatg
      601 agccggtcat tttccatgct gtcttttcca tgattaaacc atttctgact gaaaagatta
      661 agggtcggat tcatctgcat gggaacaatt ataaatcaag cctacttcag cacttcccag
      721 acattcttcc tctggaatat ggtggtaacg agtcctccat ggaggatatt tgtcaggagt
      781 ggacaaattt tataatgaag tctgaagatt atctcagcag catttctgag accatccaat
      841 gagaagttgt ttcctgtgaa tgacttcatc taaaattcaa ggatgggatt ctatctggtt
      901 actaaactca agaccaaacc ttctaaacga attgatcctt atctgatctt taaacacgca
      961 acatggatat ttggaggatg ttttaatttc aacaatgctc tgttcctttt aaattaatta
     1021 aatgttagga aagaagatat ttctgttttc ccttgaagag caaacatagc ttcatctaaa
     1081 gtagttgttc cagtgtttct ttgtatggtt caggaaattt tatattaaac aaaactttat
     1141 gatcccattg tttaatatta gattgatggt tatctactgg aaagaaatac tgtacgcatc
     1201 aactgatggt gaaacaatat taatgctcag ctgagattgg tatcagctca taaatcaggt
     1261 tgcagtctga atacagatta attagttcat ctcaggtaaa tccgacttta gcatatgcac
     1321 aatagaagcc tttcaatgtc agtctacaca ctataatatt gcaatcaatg aaatcactat
     1381 ggttgataaa ggtgattcag aacttaagaa aaatttctgg gcacagtaga tggtttctca
     1441 tactgtcttg tattttcaaa taagtaaaga atataattat ggcttctgtt tatagacagg
     1501 gaagtagatg tatatgtttt ttacatagac ttgaaaattt aagagaacta cataaatgaa
     1561 aggaggtgtt tacattttaa accatcagca gtgataccta gtatttttca gattattcat
     1621 aaataatttg attttattct gagataattg actattacct cagaatattc tgtttagttt
     1681 aaatagtcgg cagctgggat gtgcagtctc taccatagtg cagttcattt ctaagacttt
     1741 cattcattga gaaaggtgtg atctgatcct gtattcagcc cagccttcaa tttggcacat
     1801 aggtttatac ttgatgtttc taattaattt tattttaaac tggaactaat acaaggtaaa
     1861 gaacttaatg aatttatgtt caaatagtta gacttctaca ttaatttcat aagagtatct
     1921 ttgtacaagg atatttttca ttgtacaagg gtgtttttct ttataagaaa ataagtctaa
     1981 tcagataagc tgatactcat gattctctgt acatatactt ctgacaaaac tgaaaggtgc
     2041 agatagatgt tctttagaga actgtttaat tttgatttag caactagacg ttaactttac
     2101 tatttaattt tact
//
