LOCUS       NM_001012200            1957 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TTL family tubulin polyglutamylase complex
            subunit L1 (Ttll1), transcript variant 1, mRNA.
ACCESSION   NM_001012200 XM_343300
VERSION     NM_001012200.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1957)
  AUTHORS   Magiera,M.M., Bodakuntla,S., Ziak,J., Lacomme,S., Marques Sousa,P.,
            Leboucher,S., Hausrat,T.J., Bosc,C., Andrieux,A., Kneussel,M.,
            Landry,M., Calas,A., Balastik,M. and Janke,C.
  TITLE     Excessive tubulin polyglutamylation causes neurodegeneration and
            perturbs neuronal transport
  JOURNAL   EMBO J 37 (23) (2018)
   PUBMED   30420556
REFERENCE   2  (bases 1 to 1957)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1957)
  AUTHORS   Suzuki,H., Nagatake,T., Nasu,A., Lan,H., Ikegami,K., Setou,M.,
            Hamazaki,Y., Kiyono,H., Yagi,K., Kondoh,M. and Kunisawa,J.
  TITLE     Impaired airway mucociliary function reduces antigen-specific IgA
            immune response to immunization with a claudin-4-targeting nasal
            vaccine in mice
  JOURNAL   Sci Rep 8 (1), 2904 (2018)
   PUBMED   29440671
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1957)
  AUTHORS   Vogel,P., Hansen,G., Fontenot,G. and Read,R.
  TITLE     Tubulin tyrosine ligase-like 1 deficiency results in chronic
            rhinosinusitis and abnormal development of spermatid flagella in
            mice
  JOURNAL   Vet Pathol 47 (4), 703-712 (2010)
   PUBMED   20442420
REFERENCE   5  (bases 1 to 1957)
  AUTHORS   Ikegami,K., Sato,S., Nakamura,K., Ostrowski,L.E. and Setou,M.
  TITLE     Tubulin polyglutamylation is essential for airway ciliary function
            through the regulation of beating asymmetry
  JOURNAL   Proc Natl Acad Sci U S A 107 (23), 10490-10495 (2010)
   PUBMED   20498047
REFERENCE   6  (bases 1 to 1957)
  AUTHORS   van Dijk,J., Rogowski,K., Miro,J., Lacroix,B., Edde,B. and Janke,C.
  TITLE     A targeted multienzyme mechanism for selective microtubule
            polyglutamylation
  JOURNAL   Mol Cell 26 (3), 437-448 (2007)
   PUBMED   17499049
REFERENCE   7  (bases 1 to 1957)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 19, 2021 this sequence version replaced NM_001012200.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087669.1, SRR26643429.28317.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               JAXUCZ010000007.1  116528633-116528833 c
            202-249             JAXUCZ010000007.1  116524396-116524443 c
            250-297             JAXUCZ010000007.1  116523753-116523800 c
            298-414             JAXUCZ010000007.1  116523329-116523445 c
            415-623             JAXUCZ010000007.1  116520398-116520606 c
            624-804             JAXUCZ010000007.1  116518770-116518950 c
            805-939             JAXUCZ010000007.1  116515620-116515754 c
            940-1048            JAXUCZ010000007.1  116514921-116515029 c
            1049-1192           JAXUCZ010000007.1  116512824-116512967 c
            1193-1279           JAXUCZ010000007.1  116508886-116508972 c
            1280-1443           JAXUCZ010000007.1  116506143-116506306 c
            1444-1957           JAXUCZ010000007.1  116499537-116500050 c
FEATURES             Location/Qualifiers
     source          1..1957
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1957
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /note="TTL family tubulin polyglutamylase complex subunit
                     L1"
                     /db_xref="GeneID:362969"
                     /db_xref="RGD:1309124"
     exon            1..201
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            202..249
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            250..297
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            298..414
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1573
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /note="probable tubulin polyglutamylase TTLL1;
                     tubulin--tyrosine ligase-like protein 1; tubulin
                     polyglutamylase complex subunit 3; tubulin tyrosine
                     ligase-like family, member 1; tubulin tyrosine ligase like
                     1"
                     /codon_start=1
                     /product="polyglutamylase complex subunit TTLL1"
                     /protein_id="NP_001012200.1"
                     /db_xref="GeneID:362969"
                     /db_xref="RGD:1309124"
                     /translation="MAGRVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTI
                     RNVFSVETGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENG
                     KYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKW
                     SRDSKTSSFVSQSTKEAYVISLYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGF
                     CRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVNNLRLYLESTRGRE
                     VTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLT
                     SSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGA
                     ERELRSRPGQPVGPRTGRSRDSGRNVLTTWK"
     exon            415..623
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            624..804
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            805..939
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1048
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1192
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1279
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1443
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1957
                     /gene="Ttll1"
                     /gene_synonym="PGs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgtgggcg tggccgcgcg tggagattgc gcacgcgcgg gcgggcgcgc cggtggagga
       61 tccgggcggt ttagctcctg ctacttatcc agtcagtgtc ttcgctactc agcgtccttt
      121 ccttcactga tctcctggga cttgcgttgt gccttccgat tgctgtaatt gcatcgttgt
      181 ctttctcacg ggctagtcta gtgacgctga gagactctgg acgctccagg agctgcagaa
      241 ggtcctatgc cctcacgact ctcccgtggt tcctgagaca gatgccattg gatgccagat
      301 catggcggga agggtgaagt gggtcactga cattgagaag tcggtcctaa tcaacaactt
      361 tgagaagaga gggtgggtcc aagtgacaga aaatgaagat tggaattttt actggatgag
      421 cgtgcagacc attcgcaacg tgttcagcgt agagactggg tacaggctct cagacgacca
      481 gatcgtcaac catttcccca accactatga gctgacccgc aaggacctga tggtgaagaa
      541 cattaagaga tacaggaagg aactggagaa ggaaggaagt cccctggcgg agaaagacga
      601 gaatgggaaa tacctctatc tggacttcgt tccggtcacc tacatgctcc ccgctgacta
      661 caacctgttt gtggaagaat tccggaagag cccatccagc acctggatca tgaagccatg
      721 cggcaaagcc cagggaaagg gcatcttcct catcaacaag ctctcacaga tcaaaaagtg
      781 gtctcgggat agcaagacat cctcgtttgt gtcccagtcc acaaaagaag cgtacgtgat
      841 ctcactctat atcaataatc cactgctcat cggtgggagg aagtttgacc ttcgtctgta
      901 tgtcctggtt tccacatacc gcccgctgcg ctgctacatg tacaagcttg ggttctgccg
      961 cttctgcaca gtgaagtaca ctccaagcac tagtgagcta gacaacatgt tcgtccacct
     1021 taccaatgta gccatccaga agcacgggga ggactacaac cacatccatg gtggcaagtg
     1081 gactgtcaac aacctgcgtc tctacctgga gagtacccga ggccgcgagg tgaccagcaa
     1141 actgtttgat gaaatacact ggatcattgt gcagtctctc aaggctgtgg cacctgtgat
     1201 gaacaacgac aagcactgct ttgaatgcta cggctacgac atcatcatcg acgacaagct
     1261 gaagccctgg ctgatcgagg ttaacgcgtc cccatctctc acctccagca ccgccaatga
     1321 tcggatcctt aagtacaacc tgattaacga caccctcaac attgcggtcc ctaacggcga
     1381 gattccagac tgcaaatgga acaagtctcc ccctaaggaa gtgcttggca actatgagat
     1441 cctgtatgac gaggagctgg cccagggtga cggggctgaa cgagagctta gaagtcgccc
     1501 aggtcagcca gtggggccca gaacaggccg ctcgagagac tcaggaagaa atgtcctcac
     1561 aacctggaag tgaccagcag tgagaaggac ccccccccca gcccccgctt ggacctcccc
     1621 acagttactg cacccagacc ctgctaaaca cctgttttgg aatttccttt ttatagagtg
     1681 ctttcctgag caggccttgt aaataaagac tcagagcaag gtggaggagt ccacgtcact
     1741 ggggctcaca cactttcgcg tgcacacata cacacacgga cacgctcgca cacgcgcatg
     1801 aaaacagcag cttcggtgtg tgatggaacg tcctttttta aaagatattt tattattttt
     1861 gaggtaggta gccctggttg ttctggaact tgctatgtag accaggctgt tctagaactc
     1921 tgcctcccaa gtgctgggat taaagtcatg tgccacc
//
