LOCUS       NM_138536               1396 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus tubulin tyrosine ligase (Ttl), mRNA.
ACCESSION   NM_138536
VERSION     NM_138536.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1396)
  AUTHORS   Barisic,M., Silva e Sousa,R., Tripathy,S.K., Magiera,M.M.,
            Zaytsev,A.V., Pereira,A.L., Janke,C., Grishchuk,E.L. and Maiato,H.
  TITLE     Mitosis. Microtubule detyrosination guides chromosomes during
            mitosis
  JOURNAL   Science 348 (6236), 799-803 (2015)
   PUBMED   25908662
REFERENCE   2  (bases 1 to 1396)
  AUTHORS   Erck,C., Peris,L., Andrieux,A., Meissirel,C., Gruber,A.D.,
            Vernet,M., Schweitzer,A., Saoudi,Y., Pointu,H., Bosc,C.,
            Salin,P.A., Job,D. and Wehland,J.
  TITLE     A vital role of tubulin-tyrosine-ligase for neuronal organization
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7853-7858 (2005)
   PUBMED   15899979
REFERENCE   3  (bases 1 to 1396)
  AUTHORS   Mas,C.R., Arregui,C.O., Filiberti,A., Argarana,C.E. and Barra,H.S.
  TITLE     Cloning of rat olfactory bulb tubulin tyrosine ligase cDNA: a
            dominant negative mutant and an antisense cDNA increase the
            proliferation rate of cells in culture
  JOURNAL   Neurochem Res 27 (11), 1453-1458 (2002)
   PUBMED   12512949
REFERENCE   4  (bases 1 to 1396)
  AUTHORS   Arregui,C.O., Mas,C.R., Argarana,C.E. and Barra,H.S.
  TITLE     Tubulin tyrosine ligase: protein and mRNA expression in developing
            rat skeletal muscle
  JOURNAL   Dev Growth Differ 39 (2), 167-178 (1997)
   PUBMED   9108330
REFERENCE   5  (bases 1 to 1396)
  AUTHORS   Ersfeld,K., Wehland,J., Plessmann,U., Dodemont,H., Gerke,V. and
            Weber,K.
  TITLE     Characterization of the tubulin-tyrosine ligase
  JOURNAL   J Cell Biol 120 (3), 725-732 (1993)
   PUBMED   8093886
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138536.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF207605.1, SRR26643292.14476.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               JAXUCZ010000003.1  136752075-136752379
            306-384             JAXUCZ010000003.1  136754854-136754932
            385-617             JAXUCZ010000003.1  136762344-136762576
            618-753             JAXUCZ010000003.1  136767848-136767983
            754-1023            JAXUCZ010000003.1  136768735-136769004
            1024-1167           JAXUCZ010000003.1  136773994-136774137
            1168-1396           JAXUCZ010000003.1  136778416-136778644
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1396
                     /gene="Ttl"
                     /note="tubulin tyrosine ligase"
                     /db_xref="GeneID:171572"
                     /db_xref="RGD:621113"
     exon            1..305
                     /gene="Ttl"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1282
                     /gene="Ttl"
                     /EC_number="6.3.2.25"
                     /codon_start=1
                     /product="tubulin--tyrosine ligase"
                     /protein_id="NP_612545.2"
                     /db_xref="GeneID:171572"
                     /db_xref="RGD:621113"
                     /translation="MYTFVVRDENSSVYAEVSRLLLATGYWKRLRRDNPRFNLMLGER
                     NRLPFGRLGHEPGLAQLVNYYRGADKLCRKASLVKLVKTSPELSESCSWFPESYVIYP
                     TNLKTPVAPAQNGIQLPVSNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGI
                     LISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYRE
                     GVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLTSALN
                     ITLENSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLLGFDFMVDEELKVWLIEVNG
                     APACAQKLYAELCQGIVDIAISSVFPPPDTEQVPQQPAAFMKL"
     exon            306..384
                     /gene="Ttl"
                     /inference="alignment:Splign:2.1.0"
     exon            385..617
                     /gene="Ttl"
                     /inference="alignment:Splign:2.1.0"
     exon            618..753
                     /gene="Ttl"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1023
                     /gene="Ttl"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1167
                     /gene="Ttl"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1396
                     /gene="Ttl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagggcaga caccaggata atccggaggc gcggccctgg aattgggcag acagcgggac
       61 tgagactgaa gctggggcag tgagcacgcg gagccgccgt cccttggact acggcttgtg
      121 gcggctgcgg ggcgcgctgc ccttcgccat gtacaccttc gtggtgcgcg acgagaatag
      181 cagcgtctac gccgaggtct cccggctgct gctggccacc ggctactgga agaggctgcg
      241 gcgggacaac cccaggttca acctgatgct gggcgagagg aaccgactgc ctttcgggag
      301 actaggtcac gaacctgggc tggcacagct ggtgaactac tacagggggg cggacaaact
      361 gtgccgcaaa gcttccttag tgaagctagt caagaccagt ccggaactgt ctgagtcctg
      421 ctcatggttc cccgagtcct atgtgattta tccaactaac ctcaagacgc cagtcgctcc
      481 agcgcagaat ggcatccagc ttccggtcag taactccagg acagatgaga gagaattctt
      541 cttggcttct tataacagaa agaaagagga cggggaaggc aacgtttgga ttgcaaagtc
      601 atcagctggt gccaaaggcg aaggcatcct catctcctca gaggcgtcag agcttctgga
      661 ttttatagac aaccagggcc aagtgcacgt gatccagaaa tacctcgagc accctctgct
      721 cctcgagccc ggtcaccgca agtttgacat tcgaagctgg gtcctggttg accaccagta
      781 taacatctac ctctacagag agggtgtgct tcgaactgct tcagaaccat atcatgttga
      841 taacttccaa gataagacct gccatctgac caatcactgc attcagaaag agtactcaaa
      901 gaactatggg aaatacgaag aagggaacga aatgttcttc gaagagttca atcagtacct
      961 aacaagcgct ctgaacatta ccctagaaaa tagcatcttg ctgcaaatca aacacataat
     1021 aaggagctgc ctcatgagcg tggagcccgc catcagcacc aagcacctcc cttaccagag
     1081 cttccagctc cttggctttg acttcatggt ggatgaggag ctgaaagtct ggctcattga
     1141 ggtcaacggt gcccctgcgt gtgcccagaa gctctatgca gaactgtgtc agggcatcgt
     1201 ggacatagcc atatccagcg tcttcccacc cccagacacg gagcaggtgc cgcagcagcc
     1261 ggctgcgttc atgaagctgt gaaggactgg aaggcacaga gccaccttgg gaaatgtatg
     1321 gggtcctgct ccagaggaac gtgagatggc tggactgctc ctgaccaagg catgctgggg
     1381 aacagatgtg caggaa
//
