LOCUS       NM_001401052            2917 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Ttk protein kinase (Ttk), transcript variant 1,
            mRNA.
ACCESSION   NM_001401052 XM_039081525
VERSION     NM_001401052.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2917)
  AUTHORS   Foijer,F., Xie,S.Z., Simon,J.E., Bakker,P.L., Conte,N., Davis,S.H.,
            Kregel,E., Jonkers,J., Bradley,A. and Sorger,P.K.
  TITLE     Chromosome instability induced by Mps1 and p53 mutation generates
            aggressive lymphomas exhibiting aneuploidy-induced stress
  JOURNAL   Proc Natl Acad Sci U S A 111 (37), 13427-13432 (2014)
   PUBMED   25197064
REFERENCE   4  (bases 1 to 2917)
  AUTHORS   Hached,K., Xie,S.Z., Buffin,E., Cladiere,D., Rachez,C., Sacras,M.,
            Sorger,P.K. and Wassmann,K.
  TITLE     Mps1 at kinetochores is essential for female mouse meiosis I
  JOURNAL   Development 138 (11), 2261-2271 (2011)
   PUBMED   21558374
REFERENCE   5  (bases 1 to 2917)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 2917)
  AUTHORS   Douville,E.M., Afar,D.E., Howell,B.W., Letwin,K., Tannock,L.,
            Ben-David,Y., Pawson,T. and Bell,J.C.
  TITLE     Multiple cDNAs encoding the esk kinase predict transmembrane and
            intracellular enzyme isoforms
  JOURNAL   Mol Cell Biol 12 (6), 2681-2689 (1992)
   PUBMED   1375325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Feb 1, 2022 this sequence version replaced XM_039081525.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.46573.1,
                                           SRR26643429.31409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000008.1  93634639-93634706
            69-222              JAXUCZ010000008.1  93635818-93635971
            223-436             JAXUCZ010000008.1  93640079-93640292
            437-543             JAXUCZ010000008.1  93641321-93641427
            544-687             JAXUCZ010000008.1  93644636-93644779
            688-802             JAXUCZ010000008.1  93645277-93645391
            803-875             JAXUCZ010000008.1  93645506-93645578
            876-970             JAXUCZ010000008.1  93645671-93645765
            971-1058            JAXUCZ010000008.1  93647319-93647406
            1059-1176           JAXUCZ010000008.1  93648458-93648575
            1177-1331           JAXUCZ010000008.1  93651475-93651629
            1332-1465           JAXUCZ010000008.1  93654486-93654619
            1466-1592           JAXUCZ010000008.1  93656463-93656589
            1593-1685           JAXUCZ010000008.1  93658822-93658914
            1686-1843           JAXUCZ010000008.1  93663600-93663757
            1844-1995           JAXUCZ010000008.1  93663893-93664044
            1996-2120           JAXUCZ010000008.1  93664864-93664988
            2121-2201           JAXUCZ010000008.1  93666414-93666494
            2202-2378           JAXUCZ010000008.1  93669471-93669647
            2379-2463           JAXUCZ010000008.1  93670010-93670094
            2464-2561           JAXUCZ010000008.1  93670625-93670722
            2562-2917           JAXUCZ010000008.1  93672308-93672663
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2917
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /note="Ttk protein kinase"
                     /db_xref="GeneID:315852"
                     /db_xref="RGD:1305558"
     exon            1..68
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            69..222
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2645
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity protein kinase TTK; Monopolar spindle 1"
                     /codon_start=1
                     /product="dual specificity protein kinase TTK isoform 1"
                     /protein_id="NP_001387981.1"
                     /db_xref="GeneID:315852"
                     /db_xref="RGD:1305558"
                     /translation="MEAEELIGRNLTIDSIMNKVRDIKNKINEDLTDELNSIKVCVDP
                     TETVNQIMMVENTPENWLNFLLKLEKNSPPLNDALLNKLIGRYSQAIEALPPDKYGQN
                     ESFARIQVRLAELKAIQEPDDAHDYFQMARENCKKFAFVHVSFAQFELSQGNLKKSEQ
                     LLHKAVETGAVPLQMLETAIRNLHLQKKQLLSEEDKKSLSASTVLTAQESFSSSLGNL
                     QSRKSSCDPKVQAAAARILYGENMPPKDAEVSHRNPLKQTNKTKRSCPFGRVPVNLLN
                     SPDYYVKTDGSAVPQFTKRKISGSEYRDSIMPGSKSSGNDSYELRGLKPIQAIHLKDS
                     LVSNEKSSELMSDLVTLKSKTDSSLTKLEVSEPKVRQEPEIPERRHKQWQSARKPGCG
                     IQNSAAFAPQWHVPDVTPKADKEKCTTVEQLAFSVSKQSPPLSVPKWIDPKSVCETPS
                     SSSLDDYMKCFKTSVVKNEFPPACPSSTPYSQLARHQQHQQQGLSTPLQNLQISGSSS
                     MSECISVNGRIYSILKQIGSGGSSKVFQVLNEKKQINAIKYVNLEDADSQTIDSYRNE
                     IAYLNKLQQHSDKIIRLYDYEITDRYIYMVMECGNIDLNSWLKKKKSINPWERKSYWK
                     NMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTV
                     NYMAPEAIRDMSSSRENGKIKTKISPRSDVWSLGCILYYMTYGKTPFQHIINQVSKLH
                     AIIDPSHEIEFPEISEKDLRDVLKCCLVRNPKERISIPELLAHPYVQIQPHPGSQMAK
                     ETTDEMKYMLGQLVCLNSPNSILKAAKTLYERYNCGESQAPSSSKTSDKKRERE"
     exon            223..436
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..543
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..687
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            688..802
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..875
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..970
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1058
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1176
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1331
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1465
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1592
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1685
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1843
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1995
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2120
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2201
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2378
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2463
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2561
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2917
                     /gene="Ttk"
                     /gene_synonym="Mps1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaattcaaa cgtgtttccg gagaggggat gcggtaccgc tgttttgtct gcagcctgga
       61 tttctgagac gagttgcagt ttagagatgg aggctgaaga gttaattggc agaaatttga
      121 caattgattc catcatgaac aaagtgagag acattaaaaa taagataaat gaagacctta
      181 ctgatgagct aaactcgatc aaagtctgtg ttgaccccac agaaactgtt aaccaaatta
      241 tgatggttga gaacacacca gagaactggt tgaatttctt gctgaaacta gagaaaaaca
      301 gcccacctct aaacgatgct cttttaaata agctgattgg tcggtatagt caagccattg
      361 aagcacttcc tccagataaa tatggccaga atgagagctt tgctcgaata caagtgagac
      421 ttgcagaatt aaaggctatt caagaacctg acgatgctca cgactacttc caaatggccc
      481 gagagaactg caagaagttt gctttcgtgc atgtctcttt cgcacagttt gaactgtctc
      541 aaggcaatct taagaaaagc gaacagcttc ttcataaagc tgtagagacg ggggcagtgc
      601 cgctgcagat gctggagact gccatccgta acctacacct ccagaaaaag cagctgctct
      661 cagaggagga caaaaagagt ttatcagcat ctacagtact aactgcccaa gaatcattct
      721 ccagttcact tgggaattta cagagtagga agagcagctg cgatcccaaa gtacaggctg
      781 ctgcagccag gattttatat ggggagaaca tgcctccaaa agatgcggaa gtaagtcatc
      841 gaaatccctt aaagcaaact aacaaaacta aacggtcatg cccctttgga agagtcccag
      901 ttaatcttct aaatagccca gattactatg tgaagacaga tggttcagct gtgccacagt
      961 ttacaaaaag aaaaatatct ggatcagaat accgagattc gattatgcct ggatccaaat
     1021 caagtggaaa tgattcctat gaattgagag gtttaaagcc cattcaagct atccatttga
     1081 aagactctct ggtgtccaat gaaaaaagtt ctgaacttat gtctgattta gtaaccttga
     1141 agagtaaaac ggattcaagt ctaacaaagt tggaagtttc agaacctaaa gtgcgtcaag
     1201 aaccggagat tccagaaaga aggcacaagc agtggcagtc tgccagaaag ccaggctgtg
     1261 ggatccagaa ctcggctgcc tttgcccccc agtggcacgt tccagatgta accccaaagg
     1321 ctgataaaga gaagtgtacc actgttgagc aacttgcctt ttctgtttca aagcagtcac
     1381 caccattatc agttcctaaa tggattgatc caaagtctgt ctgtgagaca cctagtagca
     1441 gttccttgga tgattacatg aaatgtttta agacttcagt tgtaaagaat gaattcccac
     1501 ctgcctgtcc atcatcaaca ccttacagcc aacttgcccg ccaccagcag catcagcagc
     1561 aagggctcag cactcctctt caaaacttac agatttcagg atcctcatca atgagtgaat
     1621 gcatttcagt taacggaaga atttattcca tattaaaaca gataggcagt ggaggttcaa
     1681 gtaaggtgtt tcaggtattg aatgagaaga aacagataaa cgctatcaaa tacgtgaacc
     1741 ttgaagacgc agatagccaa actattgaca gctaccgcaa tgagatagct tacttgaaca
     1801 agttacagca gcacagtgat aagatcatcc gcctctatga ctatgaaatc acggatcggt
     1861 acatctacat ggtgatggaa tgtggaaaca ttgacctgaa cagttggctt aaaaagaaga
     1921 aatccatcaa tccatgggaa cgcaagagct actggaaaaa catgttggag gccgtacaca
     1981 cgatccatca acatggcatt gttcatagtg atctcaagcc tgctaacttt ctaatagttg
     2041 acggaatgct aaagctaatt gattttggga ttgcaaacca aatgcagcca gatacaacaa
     2101 gcattgttaa agattctcag gttggcacag taaactacat ggccccagaa gcaatcagag
     2161 acatgtcttc ttcaagagaa aatgggaaaa tcaagaccaa gataagtccc agaagtgatg
     2221 tgtggtcctt ggggtgcatt ttgtactata tgacctacgg gaaaacacca tttcagcata
     2281 tcattaatca ggtctctaaa ctacatgcca taattgaccc tagtcatgaa attgagtttc
     2341 ctgagatttc agaaaaagat cttcgagatg tgctaaagtg ctgcctagta cggaacccta
     2401 aagagaggat atctatcccc gagctcctcg cacatccata tgttcagatt cagccccatc
     2461 caggcagcca aatggctaag gagaccactg atgagatgaa atatatgttg ggtcaacttg
     2521 tttgcctgaa ttctcctaac tccatcctga aagctgcgaa aaccttgtat gaacgttata
     2581 attgtggtga aagtcaagct ccttcatcat ccaagacttc tgacaaaaag agagaaagag
     2641 agtgatgcac agctttgcac aaaccaaaac actaaacgga tttgtctgct actcctgaat
     2701 ctgaggagat ttacctgtgg ggaacaaccc aaactttagt agattatcct cagctgtaag
     2761 ttaaccactc atggcacgtg tatattaagt catagagttg tgcttttgtt ctacttttct
     2821 gtaactctaa tctgtctggt aacatttcac atttgaaaca gtggatgata gctggaatgt
     2881 tgaagatctc tgtaaataaa gctttaccac agttcta
//
