LOCUS       NM_001134619            3804 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus TELO2 interacting protein 1 (Tti1), mRNA.
ACCESSION   NM_001134619 XM_001068226 XM_575280
VERSION     NM_001134619.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3804)
  AUTHORS   Fernandez-Saiz,V., Targosz,B.S., Lemeer,S., Eichner,R., Langer,C.,
            Bullinger,L., Reiter,C., Slotta-Huspenina,J., Schroeder,S.,
            Knorn,A.M., Kurutz,J., Peschel,C., Pagano,M., Kuster,B. and
            Bassermann,F.
  TITLE     SCFFbxo9 and CK2 direct the cellular response to growth factor
            withdrawal via Tel2/Tti1 degradation and promote survival in
            multiple myeloma
  JOURNAL   Nat Cell Biol 15 (1), 72-81 (2013)
   PUBMED   23263282
REFERENCE   2  (bases 1 to 3804)
  AUTHORS   Laplante,M. and Sabatini,D.M.
  TITLE     mTOR signaling in growth control and disease
  JOURNAL   Cell 149 (2), 274-293 (2012)
   PUBMED   22500797
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_575280.2, XM_001068226.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3804
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /note="TELO2 interacting protein 1"
                     /db_xref="GeneID:499935"
                     /db_xref="RGD:1562582"
     exon            1..2341
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..3309
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /note="TEL2-interacting protein 1 homolog; Tel2
                     interacting protein 1 homolog"
                     /codon_start=1
                     /product="TELO2-interacting protein 1 homolog"
                     /protein_id="NP_001128091.1"
                     /db_xref="GeneID:499935"
                     /db_xref="RGD:1562582"
                     /translation="MAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTQLQAISDTA
                     LQELQQYILFPLRFALKTPGPKRERLVQSVVECLTFVLSSTCVREQELLQELFSELSA
                     CLYSPNSQKPAALSEELKLAVIQGLSTLMHSAYRDIILTFYEPSILPRLGFAVSLLLG
                     LAEQEKSKQIKIAALQCLQVLLLQCDCQDHPRPLDELEQQQLGDLLASFLPGISTALT
                     RVITGDFKQGHSIVVSSLKVFYKTVGFIMADEQLTRIPKVRAKPAVEHKVAALMIHRE
                     ADWVKSTGGKLAILIKKIIDCVSVHPHWKVRLELVEFVEVLLFKCSQSLVESTGPLLK
                     VLVGLVNDESSEVQAQCNTVLRRLADQKVVVGSRALADILSESLHSLATSLPRLMNTQ
                     DDQGKFSTLSLLLGYLKLLGPKVHVILNSVAHVQRLSRALIQVLELEVADVKMVEERR
                     WNSDNLSASAEASAARPWSRVQRRYFRCFTDERVFLLLRKICQLLGYYGDLYLLVDHF
                     MELYHTSIVYRKQAAMILNELVVGAAGLDVEDIHYECASTSPEELREIVKSILEEYTS
                     QENWYLITCIEAEEEEEVMMKQQGLQAVTSGVHTCQVVSFPALSKPSPTICSMNSNIW
                     QICIQLEGIGQFAYALGKDFRLLLMSALYPVLEKAGDQTLLISQVAASTMVDICHACG
                     YNSVQHLINQNSDYLVNGISLNLRHLALHPHTPKVLEVMLRNSDASLLPLVADVVQDV
                     LATLDQFYDKRAASFVSVLHALLAALAHWFPDSGSTGQLQQHSLEEVARQTPAASKAS
                     PTAEDIERFVLSYLQEKDMAEGNVSDLEAEEVLSEEQSVPPRVDESDALPDVEPPLPV
                     HIQIAKDVMERCIHLLSDKNLKVRLKVLDVLGLCVEVLQTHKNQLLPLAHRAWPSLVH
                     RLTSDDPLAVLRAFKVLQTLGSRCGDFLRSRFCKDVLPKLASSLVTQAPISARAGPVY
                     SHTLAFKLQLAVLQGLGPLCESLDLGEGDLNKVADACLIYLSTKQPVKLQEAARSVFL
                     HLIKVDPDSTWLLLHQLHCPVQQFTAPHPSLHPVQWQGATKPQNPYATNVCHLLLQLQ
                     "
     exon            2342..2530
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2688
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2829
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3034
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3122
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3804
                     /gene="Tti1"
                     /gene_synonym="RGD1562582"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctgcaga atgtttcctc agtaggggaa agaggttgta caatggcagt gtttgacact
       61 cccgaggagg cttttggtgt cttacgtcca gtctgcgttc agctcacaaa gacccagaca
      121 gtggagaacg tggaacatct gcagacacag ttacaagcca taagtgacac tgcccttcag
      181 gaactacagc agtacattct cttccccttg cgatttgccc tgaagacccc agggcccaaa
      241 agagagcgtc tcgtacagag tgtggtggaa tgcctcacct ttgtcctctc ttcaacatgt
      301 gtgagagagc aggagcttct ccaggaactc ttctcagaac tttcagcttg tctgtactct
      361 cccaactccc agaaacccgc agctttgtca gaggagttaa aattggctgt gatccaggga
      421 cttagcacct taatgcactc agcttacagg gacatcattc tgacttttta tgagccctcc
      481 attctgcctc gtttaggatt tgctgtgtct ttactgttgg gcctggcaga gcaggagaag
      541 tcaaaacaga ttaaaattgc tgccttacag tgtctacagg ttctcctcct tcaatgtgat
      601 tgtcaggacc atccaaggcc tttggatgaa ctggagcagc aacagctggg ggacttgttg
      661 gcatctttct tacctggaat ctcaactgca ctgaccagag tcatcacagg agactttaaa
      721 caaggtcata gcattgtcgt gtcttcccta aaggtcttct acaaaaccgt gggcttcatc
      781 atggctgatg aacagctcac aaggatccca aaggtgcgag caaagcccgc agttgagcac
      841 aaagtagcag ccctgatgat tcacagagaa gcagactggg taaaaagtac tggtggcaag
      901 ttggcaatcc ttattaaaaa gataattgac tgtgtctctg ttcatccaca ctggaaggtg
      961 aggctggaac tggtagagtt tgtggaggtc ctgcttttta agtgcagtca gtccctggtt
     1021 gaatccacag gtcccctctt gaaggtgtta gttggcctgg tgaatgatga aagttctgaa
     1081 gtgcaggccc agtgcaatac agtgctaagg cgtcttgcag atcagaaggt agtagtgggc
     1141 agcagagcct tggctgatat cttgtcagaa agcctgcatt cattggccac atctcttccc
     1201 cgcctgatga acacacaaga tgatcagggc aagttctcta ccctttccct gttacttggg
     1261 tatctgaaac tgttgggccc caaagtacat gtaattctca attctgtggc ccatgtgcag
     1321 cgcctttcca gggcactcat ccaagtattg gagctagagg tggctgatgt caaaatggtg
     1381 gaagagcggc gatggaattc tgacaacctc agtgcttctg cagaggcctc agctgcacgg
     1441 ccatggagca gagtccagag gcgatatttc cgatgcttta ctgacgagag ggtcttcctg
     1501 ctccttcgaa agatctgtca gcttctgggt tattatgggg acctgtattt gcttgtggat
     1561 cactttatgg aactgtatca tacatctata gtttatcgga agcaagctgc catgatcctt
     1621 aatgaactgg ttgtaggggc tgctggactg gatgtggaag atattcatta tgaatgtgca
     1681 agcacgagcc cagaggaatt gagagagatt gtgaaatcta tactagagga atacacgagc
     1741 caagaaaact ggtacttgat tacctgtatt gaagctgagg aggaggagga ggtgatgatg
     1801 aagcagcaag gcctccaggc tgtcacatct ggtgtccaca cctgccaagt tgtatccttt
     1861 ccagccctgt caaagccgag tcccactatc tgctccatga acagtaacat ctggcagata
     1921 tgcattcagt tggaagggat tggccagttt gcttatgcac taggaaaaga ctttcgtttg
     1981 cttttgatgt cagctctcta tccagtacta gagaaggctg gagaccaaac cttgctcatt
     2041 agtcaagtgg ctgctagcac catggtagat atttgccatg cttgtggcta taactctgta
     2101 cagcacctga tcaatcaaaa ttcagactat ttggtgaatg gaatctcttt aaatctgcgt
     2161 caccttgctc tacacccaca taccccaaaa gtcctggaag tcatgcttcg gaactcagat
     2221 gctagcctcc ttcctttggt agcagatgtg gttcaagatg tcttggccac cctggaccaa
     2281 ttttatgata agagagctgc atcctttgtc agcgttctgc acgctctact ggcagcattg
     2341 gcacattggt tcccagactc gggttctact gggcaactcc aacagcacag tttagaagaa
     2401 gtggcgaggc aaacgccagc agctagcaag gctagcccca cagctgagga catcgagcgg
     2461 tttgtgctga gctatctcca ggagaaggat atggcagagg ggaatgtttc tgatcttgaa
     2521 gctgaagaag ttctttcaga ggagcagtct gtccctccca gagtggatga gagtgacgcc
     2581 cttccagacg tggagccacc actgccagtg cacatccaga tagccaagga cgtgatggag
     2641 cgctgtatcc acctgttatc agataaaaac ctgaaagtcc gcctgaaggt cttggacgtg
     2701 ctgggattgt gtgtggaagt tctacagacc cacaagaacc agcttcttcc cctggctcac
     2761 cgagcctggc cttcactcgt gcaccgactc acaagtgatg accccctggc agtgctcaga
     2821 gctttcaagg ttttgcagac ccttggaagc agatgtggcg attttctccg gagccggttc
     2881 tgcaaagatg tcctgccaaa attggccagc tccttagtca cccaggcccc catcagtgcc
     2941 agggctggac cagtttattc tcacacactg gccttcaagc tacagctggc tgtcctgcag
     3001 ggcctgggcc ccctctgtga aagtctggac ttaggtgagg gtgacctgaa taaagtggct
     3061 gatgcctgct tgatttacct cagcaccaaa cagcccgtga aattacaaga ggctgccagg
     3121 agcgtcttcc tccacctgat aaaggtggac cccgactcca cctggctcct cctgcaccag
     3181 ctgcactgcc ctgtgcagca gttcacagcc ccgcacccga gccttcaccc agtgcagtgg
     3241 cagggggcca ctaagccaca gaacccctat gccaccaatg tttgccacct gcttcttcaa
     3301 ctgcagtgat cctgccagaa cctgccagct aggagctgag ctgagccacc cctgctggat
     3361 acagttgcgg caacacagag agcggtgaag gtggattaga caaccaccaa tatataaatt
     3421 gatcgatcac acaactgctt agaaattggg ttgaaggaaa agtcgcttac tgttacttat
     3481 gtttcactct ttgtgttttc agatgacatt gattggtggc tctaagagtt caactcttta
     3541 gcctactgtc tgcacagccc ctctgccaca caagtccttc aaacacacac aaacacacac
     3601 acacacacac acacacacac acaccccttg tgctctaagt ccaagttcga ttctcagcac
     3661 ccattagtag ctctcaaccg tccatgactc cagtttcaag ggatccaacc ccctcctctg
     3721 acctcaagca ccagacttgc acatggtgca cagacactca tgagccaaac acatataaga
     3781 taaataaatc ttttcaaaaa tgtc
//
