LOCUS       NM_001399499            2351 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus tetratricopeptide repeat domain 8 (Ttc8),
            transcript variant 3, mRNA.
ACCESSION   NM_001399499 XM_006240422
VERSION     NM_001399499.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2351)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2351)
  AUTHORS   Hartley,S.W., Mullikin,J.C., Klein,D.C., Park,M. and Coon,S.L.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Alternative Isoform Analysis of Ttc8 Expression in the Rat Pineal
            Gland Using a Multi-Platform Sequencing Approach Reveals Neural
            Regulation
  JOURNAL   PLoS One 11 (9), e0163590 (2016)
   PUBMED   27684375
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2351)
  AUTHORS   May-Simera,H.L., Petralia,R.S., Montcouquiol,M., Wang,Y.X.,
            Szarama,K.B., Liu,Y., Lin,W., Deans,M.R., Pazour,G.J. and
            Kelley,M.W.
  TITLE     Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the
            cochlea
  JOURNAL   Development 142 (3), 555-566 (2015)
   PUBMED   25605782
REFERENCE   4  (bases 1 to 2351)
  AUTHORS   Broekhuis,J.R., Verhey,K.J. and Jansen,G.
  TITLE     Regulation of cilium length and intraflagellar transport by the
            RCK-kinases ICK and MOK in renal epithelial cells
  JOURNAL   PLoS One 9 (9), e108470 (2014)
   PUBMED   25243405
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2351)
  AUTHORS   Chamling,X., Seo,S., Searby,C.C., Kim,G., Slusarski,D.C. and
            Sheffield,V.C.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2351)
  AUTHORS   Tadenev,A.L., Kulaga,H.M., May-Simera,H.L., Kelley,M.W.,
            Katsanis,N. and Reed,R.R.
  TITLE     Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory
            function, protein localization, and axon targeting
  JOURNAL   Proc Natl Acad Sci U S A 108 (25), 10320-10325 (2011)
   PUBMED   21646512
REFERENCE   7  (bases 1 to 2351)
  AUTHORS   Seo,S., Baye,L.M., Schulz,N.P., Beck,J.S., Zhang,Q., Slusarski,D.C.
            and Sheffield,V.C.
  TITLE     BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family
            chaperonins and mediate BBSome assembly
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1488-1493 (2010)
   PUBMED   20080638
REFERENCE   8  (bases 1 to 2351)
  AUTHORS   Nachury,M.V., Loktev,A.V., Zhang,Q., Westlake,C.J., Peranen,J.,
            Merdes,A., Slusarski,D.C., Scheller,R.H., Bazan,J.F.,
            Sheffield,V.C. and Jackson,P.K.
  TITLE     A core complex of BBS proteins cooperates with the GTPase Rab8 to
            promote ciliary membrane biogenesis
  JOURNAL   Cell 129 (6), 1201-1213 (2007)
   PUBMED   17574030
REFERENCE   9  (bases 1 to 2351)
  AUTHORS   Forti,E., Aksanov,O. and Birk,R.Z.
  TITLE     Temporal expression pattern of Bardet-Biedl syndrome genes in
            adipogenesis
  JOURNAL   Int J Biochem Cell Biol 39 (5), 1055-1062 (2007)
   PUBMED   17379567
REFERENCE   10 (bases 1 to 2351)
  AUTHORS   Ansley,S.J., Badano,J.L., Blacque,O.E., Hill,J., Hoskins,B.E.,
            Leitch,C.C., Kim,J.C., Ross,A.J., Eichers,E.R., Teslovich,T.M.,
            Mah,A.K., Johnsen,R.C., Cavender,J.C., Lewis,R.A., Leroux,M.R.,
            Beales,P.L. and Katsanis,N.
  TITLE     Basal body dysfunction is a likely cause of pleiotropic
            Bardet-Biedl syndrome
  JOURNAL   Nature 425 (6958), 628-633 (2003)
   PUBMED   14520415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 10, 2022 this sequence version replaced XM_006240422.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KX218322.1, SRR26360172.1347542.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840108, SAMN14984024
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000006.1  123927909-123928115
            208-237             JAXUCZ010000006.1  123938769-123938798
            238-358             JAXUCZ010000006.1  123943922-123944042
            359-422             JAXUCZ010000006.1  123944833-123944896
            423-582             JAXUCZ010000006.1  123944989-123945148
            583-672             JAXUCZ010000006.1  123945359-123945448
            673-717             JAXUCZ010000006.1  123946766-123946810
            718-803             JAXUCZ010000006.1  123956799-123956884
            804-891             JAXUCZ010000006.1  123960668-123960755
            892-1002            JAXUCZ010000006.1  123962989-123963099
            1003-1142           JAXUCZ010000006.1  123972524-123972663
            1143-1317           JAXUCZ010000006.1  123973965-123974139
            1318-1440           JAXUCZ010000006.1  123974537-123974659
            1441-1524           JAXUCZ010000006.1  123977750-123977833
            1525-2351           JAXUCZ010000006.1  123981291-123982117
FEATURES             Location/Qualifiers
     source          1..2351
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2351
                     /gene="Ttc8"
                     /note="tetratricopeptide repeat domain 8"
                     /db_xref="GeneID:299246"
                     /db_xref="RGD:1307769"
     exon            1..207
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1641
                     /gene="Ttc8"
                     /note="isoform 3 is encoded by transcript variant 3;
                     tetratricopeptide repeat protein 8"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 8 isoform 3"
                     /protein_id="NP_001386428.1"
                     /db_xref="GeneID:299246"
                     /db_xref="RGD:1307769"
                     /translation="MGSEMEPLFRAWSYFRRRKFQLCADLCTQMLEKSPYDQDPAPDL
                     AVSQAAWILKARALTEMVYVDEIDVDQEGIAEMTLDENAIAQVPRPGTSLKLPGTNQT
                     GGPTQAVRPITQAGRPITGFLRPSTQSGRPGTMEQAIRTPRTAYTARPITSSSGRFVR
                     LGTASMLTSPDGPFINLSRLNLTKYSQKPKLAKALFEYIFHHENDVKMALDLASLSTE
                     YSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEMVDTFLYLAKVYIILDQPVT
                     ALNLFKQGLDKFPGEVTLLCGIARIYEEMNNSSSAAEYYKEVLKQDNTHVEAIACIGS
                     NHFYSDQPEVALRFYRRLLQMGVYNCQLFNNLGLCCFYAQQYDMTLTSFERALSLAEN
                     EEEAADVWYNLGHIAVGIGDTNLAHQCFRLALVHNNHHAEAYNNLAVLEMRKGHIEQA
                     RALLQTASSLAPHMYEPHFNFATVSDKIGDLQRSYVAAQKSEAAFPEHVDTQHLIKQL
                     KQHFAML"
     exon            208..237
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            238..358
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            359..422
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            423..582
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            583..672
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            673..717
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            718..803
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            804..891
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1002
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1142
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1317
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1440
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1524
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2351
                     /gene="Ttc8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctcccgc tctcagctcc cggaccccgc ccaccccagg ccgggttctg ggcacaggac
       61 ctttgagctc gttgagcgct ctcccggacc accatgggct cagagatgga gccactgttc
      121 cgggcctgga gctattttag acgcaggaag ttccagctct gcgccgatct atgcacgcag
      181 atgctggaga agtcccctta tgaccaggac ccagctccgg acttggcagt gtctcaggcg
      241 gcttggattt tgaaagcgcg agcgctgaca gaaatggtgt acgtagatga aattgacgtg
      301 gaccaggaag ggattgctga gatgaccctg gatgaaaatg ctattgctca ggtcccacgc
      361 cctggcacat ctttgaagct ccctggcact aaccagacag gaggaccgac tcaagctgtc
      421 aggccaatca ctcaagctgg aagacccata acgggcttcc ttaggcccag cacacagagt
      481 ggaagaccgg gtacaatgga gcaggccatc agaacaccca gaacggccta cacagcacga
      541 cctatcacca gctcatctgg aagattcgtc agactgggga ctgcttccat gcttacaagt
      601 cccgatggac catttataaa tttatccaga ctgaatttaa caaaatattc ccagaaacct
      661 aagttggcaa aggctttatt tgaatatatt ttccaccatg aaaacgatgt taagatggct
      721 ttggacttgg cgtccctttc cacggagtat tctcagtaca aggactggtg gtggaaggtg
      781 cagattggaa aatgttacta caggttagga atgtaccgtg aagcagagaa acagttcaaa
      841 tcagccctga agcagcagga aatggtagat acatttctct atctggcaaa agtttatatc
      901 atattggatc aacctgtgac tgctttaaat ctattcaaac aaggcttaga taagtttcca
      961 ggagaggtga ccctgctttg tggaattgcc aggatctacg aggaaatgaa caacagttcg
     1021 tccgcagcag aatactacaa agaggttctc aaacaagaca atactcatgt ggaagccatt
     1081 gcctgcattg gaagcaacca cttttattct gaccagccag aggttgccct ccggttttac
     1141 aggcgcctct tgcagatggg agtttacaac tgccagcttt tcaacaacct ggggctgtgc
     1201 tgcttctatg cccagcagta cgacatgact ctgacctcat tcgagcgcgc cctttccctg
     1261 gccgagaacg aggaagaggc agctgacgtc tggtacaacc tggggcacat tgcagtggga
     1321 ataggagaca caaacctggc ccaccagtgc ttcaggctgg ccctggtcca caacaaccac
     1381 catgctgagg cctacaacaa cctagccgtg ctggagatgc ggaagggtca cattgaacag
     1441 gcacgcgcac tcttacaaac cgcatcgtcc ttggcacccc atatgtatga gccacatttt
     1501 aattttgcaa ccgtctctga taagattgga gatcttcaga gaagctacgt cgctgctcag
     1561 aagtctgaag ccgcatttcc agagcatgtg gacactcagc atttaattaa gcagctaaag
     1621 cagcacttcg ctatgctctg atcaggcctc ggaccaactg cgtcctcagg aagggccagc
     1681 cacaggggag aaaacgtgct gagtgcattt gtatcagtag tgtgacgcag actcagaagg
     1741 cgtcctgcaa gacctaagga ctttgttgtt ttataaggta aaacaacact aaggtaaaag
     1801 tgggtgcact tctgccatgc cctcctcctc attagtcccc tttgtcccct agccacttcc
     1861 gtgccatctg catggacatg gttttagtat ctgggtaaaa cctagaagcc acacattaga
     1921 gaaaaactat gcgtaccgta gtattattac aggttagtct ctagttaact tcaccgcctc
     1981 agcctcctca gtgctgtggt acagacacgc caccatgccc ggctggcttc agcgtttcca
     2041 aggacatgaa atctcctctc acactgcatg gttgatgttt gtatatagtt gttaaacatt
     2101 ttaatgaacc tcaatttttt ttttataaat gtgtatttta aaagtcttta atccaaaaac
     2161 aaaagttctt aagcattagc tatcgttgaa aacttaggtc agaaatctgc tttaaaattt
     2221 tttatggctc ataatgtgtg gttttatcat gagtacttta attagaacgt taaaatttat
     2281 attttaataa actttttatc agaaactttg tattgtatat tgcactttaa aataaatcag
     2341 tatgtaaaat a
//
