LOCUS       NM_001106665            2676 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tetratricopeptide repeat domain 39B (Ttc39b),
            mRNA.
ACCESSION   NM_001106665 XM_001060174 XM_238399
VERSION     NM_001106665.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2676)
  AUTHORS   Wang,W., Zhang,Z.Z., Wu,Y., Wang,R.Q., Chen,J.W., Chen,J.,
            Zhang,Y., Chen,Y.J., Geng,M., Xu,Z.D., Dai,M., Li,J.H. and Pan,L.L.
  TITLE     (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and
            Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein
            E Knockout Mice: Involvement of TTC39B
  JOURNAL   Front Pharmacol 9, 195 (2018)
   PUBMED   29593532
  REMARK    Erratum:[Front Pharmacol. 2018 May 01;9:459. doi:
            10.3389/fphar.2018.00459.. PMID: 29745376]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2676)
  AUTHORS   Hsieh,J., Koseki,M., Molusky,M.M., Yakushiji,E., Ichi,I.,
            Westerterp,M., Iqbal,J., Chan,R.B., Abramowicz,S., Tascau,L.,
            Takiguchi,S., Yamashita,S., Welch,C.L., Di Paolo,G., Hussain,M.M.,
            Lefkowitch,J.H., Rader,D.J. and Tall,A.R.
  TITLE     TTC39B deficiency stabilizes LXR reducing both atherosclerosis and
            steatohepatitis
  JOURNAL   Nature 535 (7611), 303-307 (2016)
   PUBMED   27383786
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473978.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060174.1, XM_238399.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..2676
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /note="tetratricopeptide repeat domain 39B"
                     /db_xref="GeneID:298186"
                     /db_xref="RGD:1305797"
     exon            1..173
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1985
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /note="TPR repeat protein 39B"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 39B"
                     /protein_id="NP_001100135.1"
                     /db_xref="GeneID:298186"
                     /db_xref="RGD:1305797"
                     /translation="MALVGSRVELDADEDIFEDALETISRSPSDMATSGFHFVPCDTK
                     RTSRQLGAPAVGRAEGSSAKVDLKSGLEECAAALNLFLSNRFKDALELLRPWAKESMY
                     HALGYSTIVVLQAVMTFEQQDIQNGISAMKDALQTCQKYRKKCTVVESFSSLLSRGSL
                     EQLSEEEMHAEICYAECLLQKAALTFVQDENMINFIKGGLKIRTSYQIYKECLSILHV
                     IQKNKEEQHFFYEFEGGVKLGTGAFNLMLSLLPARIIRLLEFIGFSGNRDLGLLQLRE
                     GASGSSMRSPLCCLTILAFHTYISLILGTGEVNVAEAESLLAPFLQQFPNGSLILFYH
                     ARIELLKGNAEKAQETFRKCISVQEEWKQFHHLCYWELMWIYIYQQNWMQAYYYSDLL
                     CKESKWSKATYVFLKAAILSMLPEEEVAVTKENVVSLFRQVDGLKQRIAGKSLPTEKF
                     AVRKARRYSPSSGVPGKLVLPALEMMYVWNGFSIVGKRKDLSENLLVTVEKAEEALQN
                     QNFTDYSVDDECLVKLLKGCCLKNLQRPLQAELCFNHVLESEKLLKYDHYLVPFTLFE
                     LAFLYKSQGEIDKAIKVLETARNNYKDYSLESRLHFRIQAALHLWKKPSSD"
     exon            174..208
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            209..310
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            311..418
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            419..550
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            551..627
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            628..695
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            696..760
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            761..866
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            867..932
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1041
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1109
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1169
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1331
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1423
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1550
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1659
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1777
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1894
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2676
                     /gene="Ttc39b"
                     /gene_synonym="RGD1305797"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggaca gctcggtcca gtcgctcggg gccgcctggt tcctcctcca ccggcgctgg
       61 gctgaaccca gagcccagaa aagagtcggt tctgagttcc ctgtgggtgt gcggccgccg
      121 cggaggggaa catggcgctc gtgggcagcc gagtggaatt ggacgcggac gaggacatct
      181 ttgaagatgc cttggagacc atctctaggt ctccatcaga catggcaacc agcggctttc
      241 actttgtacc gtgtgacacc aaacggactt ccagacagct gggagcgcct gctgtgggaa
      301 gagcagaagg ttcatcagcc aaggtggatc tcaagagcgg cttggaggag tgtgcagcgg
      361 cgctgaactt gtttctcagt aacagattca aagatgcctt agagttgctt cgcccatggg
      421 ccaaggagag catgtaccac gccttgggct acagtactat tgtggtgttg caggctgtca
      481 tgacctttga gcaacaggac atccagaatg gcatttccgc catgaaggac gctttacaaa
      541 cgtgccaaaa atacaggaag aagtgcacag ttgtggagtc cttctccagt ctcctttctc
      601 gggggtcact ggaacaactg agtgaagagg agatgcatgc cgaaatctgt tatgccgagt
      661 gtctcctaca gaaagcagca ctcacgtttg tgcaggatga aaatatgatc aacttcatca
      721 aaggtggact caaaattaga acaagttacc aaatatataa agagtgcctt tctatcctgc
      781 acgtcattca gaagaacaaa gaagagcagc atttcttcta cgagtttgaa ggaggagtca
      841 agcttggaac gggggccttt aatttgatgc tgtctctttt accagcaaga atcatccgat
      901 tactagaatt tattggattt tctggaaaca gggacctggg ccttctgcag ctacgggaag
      961 gtgcatcagg aagcagcatg cggtccccac tctgttgcct tacaattctg gctttccata
     1021 cctacatttc cctgattctc ggtacaggag aagtgaatgt tgcggaagca gagagtctcc
     1081 ttgcaccgtt ccttcagcag ttcccaaatg gctccctcat cctcttctat catgcccgaa
     1141 tcgagctgct gaaaggcaac gctgaaaagg ctcaagaaac atttcgaaaa tgcatttcag
     1201 ttcaagaaga gtggaaacag tttcaccatc tttgttactg ggaattaatg tggatttata
     1261 tataccaaca aaattggatg caggcgtatt actattcaga tctactttgc aaagagagta
     1321 aatggtccaa ggcaacatat gtgttcttga aagctgccat tttgagcatg cttccagagg
     1381 aagaagtggc agtgactaag gagaatgtag tgtctctgtt cagacaggta gatggcttga
     1441 agcagagaat cgccgggaaa tctctcccaa ccgagaagtt cgctgtgagg aaggctcgga
     1501 ggtactctcc ctcttcgggt gtcccaggaa aactcgtctt gccagccctg gaaatgatgt
     1561 acgtctggaa cggcttttca atagtgggca aaagaaagga cctttctgaa aacctcttgg
     1621 tgactgtgga gaaggctgaa gaggccttac aaaatcaaaa ctttactgac tactccgtgg
     1681 acgacgaatg cttggtgaag ttactgaaag gatgttgcct caaaaactta cagcggccct
     1741 tgcaagccga gctgtgtttc aaccatgttt tggaaagtga gaagctattg aagtatgacc
     1801 actacctggt gccattcact ctgtttgagt tggcattttt gtataaaagt caaggggaaa
     1861 tcgacaaggc catcaaggtc ctcgaaaccg caagaaacaa ctacaaagat tactccttgg
     1921 agtccagact acacttcaga attcaagcag ctcttcatct ctggaagaag ccatcctcag
     1981 attgatccag aagacgcagg atggaatctt gccccccagt taacgttgac tcttgctgtg
     2041 gagatcagct cgtgtcaaat aagaaacaga aaagctgttg ccaggccctt cctgccacca
     2101 gagtgactta ttgttggtct acatacgctc ccctatggaa ggacattcag tactatatag
     2161 aaattcttat actctgcctt tgaaaaggac ttcacgctag atttcaattg aggggtcacg
     2221 tcttttaaaa gactggcagg tacaataaag cctagttaga ttatttattt ttttaatgta
     2281 aaaatgaata ttgttcaagt agcaaatggc tttatcacct gagccatttt tagattggct
     2341 tgtcctttaa acctcagata ttttactgct gtttaaatct cagagagtaa ataaatatca
     2401 cacctctaat aatacaacag tgggtttgtg aagattctgg aagggggagt ggaggtcctg
     2461 aggtgggtac agtgttccta ggcagaaggg acttgtatct ctacatgatg ttacagtcgt
     2521 aagtttcagg gtttccagtt ggttgaaggt ggtggcattt ttcagaaact atcctgtatt
     2581 tgaatgtact catttcagat ccaataatag cattcaatca tctagacaca cttcttatga
     2641 atctaaggga agaaaaagct gtcctttaga actccc
//
