LOCUS       NM_001108315            7364 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tetratricopeptide repeat domain 3 (Ttc3), mRNA.
ACCESSION   NM_001108315 XM_001054505 XM_340973
VERSION     NM_001108315.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7364)
  AUTHORS   Berto,G.E., Iobbi,C., Camera,P., Scarpa,E., Iampietro,C.,
            Bianchi,F., Gai,M., Sgro,F., Cristofani,F., Gartner,A., Dotti,C.G.
            and Di Cunto,F.
  TITLE     The DCR protein TTC3 affects differentiation and Golgi compactness
            in neurons through specific actin-regulating pathways
  JOURNAL   PLoS One 9 (4), e93721 (2014)
   PUBMED   24695496
  REMARK    GeneRIF: high levels of the TTC3 protein, encoded by one of the
            genes of the Down Syndrome Critical Region (DCR), prevent neurite
            extension and disrupt Golgi compactness in differentiating primary
            neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7364)
  AUTHORS   Suizu,F., Hiramuki,Y., Okumura,F., Matsuda,M., Okumura,A.J.,
            Hirata,N., Narita,M., Kohno,T., Yokota,J., Bohgaki,M., Obuse,C.,
            Hatakeyama,S., Obata,T. and Noguchi,M.
  TITLE     The E3 ligase TTC3 facilitates ubiquitination and degradation of
            phosphorylated Akt
  JOURNAL   Dev Cell 17 (6), 800-810 (2009)
   PUBMED   20059950
REFERENCE   3  (bases 1 to 7364)
  AUTHORS   Berto,G., Camera,P., Fusco,C., Imarisio,S., Ambrogio,C.,
            Chiarle,R., Silengo,L. and Di Cunto,F.
  TITLE     The Down syndrome critical region protein TTC3 inhibits neuronal
            differentiation via RhoA and Citron kinase
  JOURNAL   J Cell Sci 120 (Pt 11), 1859-1867 (2007)
   PUBMED   17488780
  REMARK    Erratum:[J Cell Sci. 2023 Oct 15;136(20):jcs261622. doi:
            10.1242/jcs.261622.. PMID: 37855734]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474083.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001054505.1, XM_340973.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7364
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..7364
                     /gene="Ttc3"
                     /note="tetratricopeptide repeat domain 3"
                     /db_xref="GeneID:360702"
                     /db_xref="RGD:1308654"
     exon            1..214
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..6171
                     /gene="Ttc3"
                     /EC_number="2.3.2.27"
                     /note="TPR repeat protein D; RING-type E3 ubiquitin
                     transferase TTC3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TTC3"
                     /protein_id="NP_001101785.1"
                     /db_xref="GeneID:360702"
                     /db_xref="RGD:1308654"
                     /translation="MPGHRGAPHLPPWVCGLCSMDDFAEGGLSLADDILLEDYPYEDD
                     CICTPDFTTDDYVRVTQLYYEGVGMQYKDYAQSEKNLEYDICNIWCSKPLSILQDYCD
                     AIKLYIFWPLLFQHQHSSIISRLHPCVEAIRSRAAEISLKKLQHLELMEDIVDLAKKV
                     ANDSFLIEGLLKIGYKIENKILAMEDALNWIKYTGDVTILPKLGSVDSGWPMLSIFFT
                     EYKYHITRVVTENCNLLEEFRRHSCMQCVKQGELMKMRGNEEFAKEKFEIAVIYYTRA
                     IEYRPENHLLYGNRALCFLRMGQFRNALSDGKRAIVLKNTWPKGHYRYCDALSMLGEY
                     DWALQANIKAQKLCKNDPEGIKDLIQQHIKLQKQIEDLQGRTSNRNPIKAFYESRAYI
                     PRNSSAPAFRTSLNFVETERGFRKTKYRMANGGGHQNQKVADEALKGDDCDCHPEFLP
                     PPSQPPRHKGKQKSRNNESEKPSSNSQVTLQVDLKSILEKQFSKSSRAAHQDFANIMK
                     MLRSLIQDGYTALLEQRCRSAAQAFTELLNGLDPQKIKQLNLAMINYVLVVYGLAVSL
                     LGIGRPEELSEAENQFKRIIEHYPNEGLDCLAYCGIGKVYLKKNRFLEALNHFEKAKT
                     LICRLPGILTWPTSNVIIEESKPEKVKVMLEKFVEECKFPPVPDAVCCYQKCRGFSKI
                     QIYLTDPDFKGFIRISCCQYCKVEFHMNCWKKLKTTTFNDKIDKDFLQGICLTPDCEG
                     IISKIIIFSSGGQVKCEFEHKVVKEKAPSRPVLKQKCSSLEKLRLKEDKKLKRKIQKQ
                     EAKKLAQERMEEDLRESNPPKPEEPEETVESAQSCQFLDDRILQCIKQNADKIKSVVL
                     NTSTLLKELLSWKVLSTEDYTTCFSSKNFVHEAVDYVIGHLIQEKNRVKTRIFLHVLS
                     ELKELDPKLAPWIQRLNSFGLDATGPFFTRYGASLKELDFNIVTFLWSEKYGHKLGSI
                     EGKQLDYFCEPASVMEARCLIWLLEEHRDKFPALHSALDEFFDIMDSRCTVLRKQDSD
                     EMPFGCIKVKNKGKKKKPKDSKPMLVGSGTASVTPSSETVTPEDHNRRNSDSAGPFAV
                     PDHLRQDVEEFEALYDQHSSEYVVRNKKLWDINPKQKCSTLYDYFSQLLEEHGPLDMS
                     DRMFSEEYEFFPEETRQILEKAGGLKSFLLGCPRFVVIDNCIALKKVASRLKKKRKKK
                     NIKTKVEEISKTGEYLRVKLPLNPTAREFQPDVKSEAAAEDVTSIPGPADSSAPAAED
                     LKPQLDSDSSSGSASEDSRLEVVSPDLPTPLCEDASPSPTPAPEDAKPTYWTQSHLVT
                     GFCTYLPFQGFGIAQSRPAYINMVPSLSQFTSIYTPLANISSEYPMPRSMPVVPSFVA
                     SERADGNAAAYFESHRLNTENASDDHTASETQILEGPLGMCVKSQSSTADARTALSEP
                     EGNSRHSGSSDSLWEASLENVSGITDVPPAPSVAIQVSRSLIHQEVNTEPYAPFERQQ
                     GDLSQKEKECHLLREQLQVACEECEQMELRSSQETRDLEEKLQRHAEENKISKTELDW
                     FLQDLDREIKKWHQEKKEIQERLKALKKKIKKVINTSDMSAQKNDGLDKECESQPDQS
                     LGISSALTDEKAKVEESVRKGKELYEESQQRAVAAEVSVLENWKEREVCKLQGVATQA
                     EACLKSLKLMNSDSAAYPDVECDILSWETFLSTVTEEIENTKCQFEEQIKAIKSGSRL
                     SDLSSVQVSELLFPACSMIHPQLLSESSRHEDHGLVACVDSMTGAVLNDPYVGPDSGC
                     SEEVPELSLGSPTHHPEGAQQLEVKKASQVSPSEQNPEADEKPSGQATRSSQSQKNPF
                     NSIIEHLSVIFPCYASSELSGFIKKVRNKSKNSFSGLSIEEIVERVTEHIVEEQKKKK
                     PNPGKDKKTSEAHPAASVSKSSPSPPLAAAGPSAKTKGQKKDDVPAPDGNSCQICHEI
                     FKSKNMRVLKCGHKFHKGCFKQWLKGQSTCPTCGSSDLLSEE"
     exon            215..369
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..412
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            413..563
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..651
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            652..705
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            706..826
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            827..912
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1007
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1070
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1125
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1288
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1334
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1461
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1525
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1586
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1671
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1806
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1887
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2000
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2121
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2244
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2346
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2439
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2504
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2641
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2968
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3220
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3267
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3324
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3395
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3560
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..4584
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4585..4650
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4651..4800
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4801..4940
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            4941..5009
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5010..5106
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5107..5207
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5208..5298
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5299..5400
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5401..5741
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5742..5868
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            5869..6003
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            6004..6096
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
     exon            6097..7364
                     /gene="Ttc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgcctca ggagcggctc agcgctcgct ctgcgggtct ggttgacgtg gagggccgga
       61 ggcgtcggca gcccgcgtcc gaggctcgcg ggctgcgggc ccgggtgagt gcagaccctg
      121 cgcgcggcgg ggctcccgga agcgtctgcg catcccgccg cagccgagat gcctgggcat
      181 cggggcgctc cacacctccc tccgtgggtg tgtggactgt gcagcatgga tgactttgct
      241 gagggaggtc tcagtttggc agatgatatc ttactggaag attaccctta tgaggatgac
      301 tgtatctgta ctcctgactt taccactgat gattatgttc gagtaaccca gctttactat
      361 gaaggcgtgg gtatgcaata taaagattat gcccaaagtg agaaaaattt agagtatgac
      421 atctgcaata tatggtgcag taagccactg tccatcctgc aagattactg tgatgccatt
      481 aagctgtaca tcttctggcc acttctcttt caacatcagc acagttctat aatatcaaga
      541 ttgcacccct gtgtagaagc catccgttct cgtgctgctg agataagttt gaagaaatta
      601 caacatcttg agttgatgga agacattgtg gatttggcaa agaaagttgc aaatgattca
      661 ttccttattg aaggcttatt gaaaattggt tataaaatag aaaataaaat cttggcaatg
      721 gaagatgctt taaattggat aaaatacacg ggtgatgtaa caattctacc taaattagga
      781 tcagttgaca gtggctggcc catgttaagt attttcttta ctgaatataa gtaccatatt
      841 actagagttg taactgaaaa ttgcaacttg ctagaagaat ttagaaggca tagttgcatg
      901 cagtgtgtga agcaaggaga actcatgaaa atgagaggaa atgaagagtt tgcaaaggaa
      961 aagtttgaaa tagctgttat ttattacacc agagccattg aatatagacc tgaaaaccat
     1021 cttctttatg gtaaccgagc tctctgtttt cttcgtatgg ggcagtttag aaatgcactt
     1081 agtgatggaa agagggccat tgttttgaag aacacctggc cgaagggtca ttatcgttat
     1141 tgtgatgctc tttctatgct gggggaatat gactgggccc tgcaagcaaa cataaaagct
     1201 caaaaactct gtaaaaatga ccctgaggga atcaaggatc taattcagca gcatataaag
     1261 ttacaaaaac aaatagaaga cctacaaggt cggacatcaa ataggaatcc aattaaagct
     1321 ttttatgaaa gcagggctta catacctaga aactcatcag cacctgcttt tagaacatca
     1381 cttaactttg tggaaacaga aagaggtttc aggaaaacta agtacagaat ggcaaatggc
     1441 ggtggccatc agaatcaaaa ggtggcagat gaggctttga agggggacga ttgtgactgt
     1501 catcctgaat ttctgccacc tccaagtcag cctccaagac ataaaggaaa acaaaagtca
     1561 cggaacaatg aatcagaaaa gcccagttct aattctcaag tgactttaca agtagatttg
     1621 aaaagcattt tggagaaaca attttcaaaa tcttccagag ctgcacacca ggattttgct
     1681 aacatcatga aaatgttaag aagcttgatt caggatgggt acacggcctt gttggagcag
     1741 cgctgccgca gtgctgccca ggcctttaca gagttactca atggcttaga tcctcagaaa
     1801 ataaagcaat tgaacctggc catgattaat tatgtattag tagtctatgg acttgctgtt
     1861 tctctccttg gaataggacg acctgaggaa ctgtctgaag ccgaaaacca gtttaagagg
     1921 atcatcgaac actatcccaa tgaggggctt gactgcttgg cctactgtgg aataggaaaa
     1981 gtatatttga aaaaaaacag atttctcgaa gctcttaatc actttgaaaa agcaaaaact
     2041 ttaatttgtc gtctccctgg aattctaact tggcccacaa gtaatgtgat tattgaagaa
     2101 tctaagccag aaaaggtcaa ggtgatgtta gagaagtttg ttgaagaatg caagtttcct
     2161 cctgtgccgg atgctgtttg ttgctatcag aagtgccgtg ggttttccaa aatccagatt
     2221 tacctaactg acccagactt caagggtttt atacgaatta gctgttgcca atactgtaaa
     2281 gtagaatttc acatgaactg ctggaaaaag ttaaaaacaa caacttttaa tgataaaatt
     2341 gacaaggatt ttctacaagg aatttgtctc acccctgact gtgaaggaat catttctaag
     2401 attatcatct ttagcagtgg tggccaagtt aaatgtgaat ttgaacacaa ggtcgtaaaa
     2461 gaaaaggctc cttcaagacc tgttctgaaa cagaaatgtt ctagtctaga gaagttaaga
     2521 ctgaaagaag acaaaaaatt gaagagaaag atccaaaaac aagaggcaaa aaagttggca
     2581 caagaaagaa tggaagagga cttaagagaa agtaatccac ctaaacctga agagccggaa
     2641 gaaactgtag aaagcgctca gagttgtcag tttcttgatg acagaatcct tcagtgcata
     2701 aagcagaatg ctgacaagat taaatctgtt gtgttgaaca cttccacgct tctcaaagag
     2761 ttgctgtctt ggaaggttct gagcacagaa gactacacaa catgtttttc tagcaaaaat
     2821 tttgttcatg aagcagtgga ctatgttatc ggtcacttga ttcaagaaaa gaacagagta
     2881 aagacacgga tatttctgca tgttttgagt gagcttaaag agttagaccc caagttagct
     2941 ccctggatcc agagactgaa tagctttggc ttagatgcca caggaccctt ttttactcgc
     3001 tatggagcat ctctcaaaga gcttgatttt aacattgtga ctttcctttg gagtgagaaa
     3061 tatggccata aactaggttc tatagaagga aagcaacttg attacttctg tgagccagca
     3121 tcagtaatgg aagcacgctg cttaatatgg ctgctggaag agcacaggga caagttcccc
     3181 gccttgcaca gtgctttaga cgagttcttt gatataatgg acagccgatg cactgtgcta
     3241 aggaagcaag acagtgatga aatgccgttt ggttgtatca aggtaaaaaa caaaggcaag
     3301 aaaaagaagc caaaagattc aaagccgatg ttagtgggat ctggaacagc atcagtaaca
     3361 ccaagtagtg agactgtcac tccagaagac cataacaggc gcaattcaga ttctgcagga
     3421 ccatttgcag tgcctgacca ccttcggcaa gatgtggaag agttcgaagc tctttacgac
     3481 cagcacagca gcgagtatgt tgtccgaaat aagaagctgt gggatattaa ccccaaacag
     3541 aaatgttcaa ctctgtatga ttacttctct cagttgctgg aagagcacgg ccccttggat
     3601 atgagtgata ggatgttctc tgaggaatat gagttcttcc ctgaagaaac tcgccagata
     3661 ctggagaagg caggagggct gaagtcgttc ctcctgggct gtcctcgatt tgttgtgatt
     3721 gacaactgca ttgcattgaa aaaagttgcc tcaagactca agaaaaaaag aaagaagaaa
     3781 aacattaaaa ctaaagttga agaaatttca aaaacaggag aatatttacg agttaaactt
     3841 ccactaaatc caactgctag ggaatttcag ccagatgtaa agtctgaagc agcagctgag
     3901 gatgtgacgt ccataccagg acctgctgac tcttcagcac cagctgctga ggatctgaag
     3961 ccccagctgg actctgatag ctcttctggg tcagcttcag aggacagcag actggaagtt
     4021 gtctctcctg acttgcctac accactctgt gaggatgctt ctccttcccc cacaccagct
     4081 cctgaagatg ccaaaccaac ttactggact cagtcacacc tggtcacagg attctgcaca
     4141 taccttcctt ttcaaggatt tggcatcgcc cagtctcggc cagcgtacat taacatggta
     4201 ccaagcctgt cccagttcac tagcatttac acgcctttgg ccaacatttc ttctgagtat
     4261 ccaatgccaa gatccatgcc agtggtacca tcttttgtag ccagcgagag agcagacgga
     4321 aatgccgctg catactttga gagtcatcgt ctgaacactg agaacgcctc tgatgaccac
     4381 actgcctctg aaacacagat cctggagggt cctttgggaa tgtgcgtaaa gtcccagagc
     4441 agcacagctg atgcccggac agctctgagt gagcctgaag gaaacagcag acacagtggg
     4501 agctctgaca gcctgtggga agcttctcta gaaaacgtca gtggaataac agatgttcca
     4561 ccagctccgt cggttgccat acaggtgtcc aggagcttga tacatcagga agtcaatact
     4621 gagccatatg caccttttga aagacaacag ggggaccttt cccagaagga gaaggagtgc
     4681 cacctgctca gagagcagct tcaggtggcc tgtgaggagt gtgagcagat ggaactcagg
     4741 agctcacagg agaccaggga cctggaggag aagctgcaaa ggcacgcgga ggagaacaag
     4801 atttcaaaga cggaattaga ctggttcctc caagatttgg acagagagat taaaaagtgg
     4861 catcaagaga aaaaagaaat ccaagaaagg ttaaaagccc tgaagaaaaa aattaaaaag
     4921 gttatcaata ccagtgacat gtctgcacag aaaaatgatg gattagataa agaatgtgaa
     4981 tcacagccgg accagtccct tggaatcagc agtgcactca cagatgagaa ggcaaaagta
     5041 gaggagtctg tcaggaaagg gaaggagctc tatgaagaga gtcagcagag agctgtggct
     5101 gcagaggtgt ctgtgcttga gaactggaag gagcgagaag tctgtaaact gcagggcgtg
     5161 gcaacacaag cagaagcctg tcttaaaagc ctgaagctga tgaacagtga ctctgcagca
     5221 tatcctgatg tggagtgtga tatactttcg tgggaaacat tcctttctac tgtaacagaa
     5281 gaaattgaga acacaaagtg tcagtttgaa gagcaaatta aggctattaa gagtggctct
     5341 cgactcagtg acctttccag tgtacaggtt tctgagcttt tatttcctgc ttgttcaatg
     5401 attcatcctc agttactctc tgagtcttca agacatgagg atcacgggct agtggcttgt
     5461 gtagacagca tgactggagc agtcctcaac gatccgtatg tagggcctga tagtggctgc
     5521 tcagaggaag ttccagaact gtcactggga tcgcctaccc atcatccaga aggtgctcaa
     5581 cagttagagg ttaagaaggc tagccaggtg tctccatcag aacagaaccc tgaggctgat
     5641 gaaaaaccat ctgggcaggc cacgaggtca agccagtctc aaaaaaatcc tttcaacagt
     5701 attattgaac acctgtcagt gatattccca tgttatgcca gctccgagct ttctggtttt
     5761 attaaaaaag ttagaaacaa aagcaagaac tcattctcgg gattaagtat tgaggagatt
     5821 gttgagagag taacagaaca cattgtcgag gaacagaaga agaagaagcc aaatccagga
     5881 aaggacaaga agacatctga ggctcatccc gctgcctctg tgtccaagtc ttccccgagt
     5941 ccacccttgg cagctgctgg accatcagct aaaaccaaag gccagaaaaa agatgatgtc
     6001 cctgcaccag atggaaattc ctgtcaaata tgccatgaaa tattcaagtc aaaaaacatg
     6061 cgtgtgctaa aatgtgggca caagtttcac aaagggtgct ttaagcaatg gctgaaaggg
     6121 cagagcacgt gccccacctg tggcagcagt gacctgctgt cagaagagta acctgttgcg
     6181 ccaccatcac agtcccagcc cagaagaaga tgggaccctc cttcctgttg ctgtaggtag
     6241 tcactcctca ctaatgcacc atgcacttca tgagttaaag aacaacaatg tcctgttgcc
     6301 agtgtaaaga cagcaaacat ggacactctc gcactgtgca tcacaaagct aacaaatcga
     6361 aatcttgaat gcagtctgtc ctaagtccag gcaagtgaca gccatgtgtg tctgcagtgc
     6421 tgtgtcacca cgtcctgcat tgttggagct gctgcaggga cactgagatg agcaggttct
     6481 ttggaaagaa ctgttgtgct cctcaaagca gtgttcagat tttaaaggtt cttagcctcc
     6541 tcagttcctt atgtggaact gtaggatccc cttcataaat ttttaaagtg cttatgtgat
     6601 ccaattggtc tacattttgg taatcaagta taaaatactt tttaaattag tatcagctaa
     6661 gaattttttt taccctggga agatgctgtc tgttcacagg agtcccacac ttgacactta
     6721 cactaaggtt accatgtaag tctcatgagt cagccagtgc ttggaaaggc ccggctgaat
     6781 gcaggacaaa gtgccgagca caggacagtc actctcactc tccttcctta ttcttcctcc
     6841 ggaagggaaa tgtactacag tcctgacgtg ttggtgttaa cattgttctg tttgactttt
     6901 gtgtaaagta atgcatgcaa tcttgtaatg tggcctgaaa aacaagctaa ctgtattaga
     6961 aactattcaa aaactaggta ttttttagtg acctgtaggc agtggcaaat acagacacgt
     7021 gaacccaaga tacattacat ttctttcaaa cacaaagaaa caaaaatgtt tcccaacgtg
     7081 ttctctgctg ccctggagat gctgtcacct tcgacctgtg tccatgtgat ttgtggtgtc
     7141 ttagtgacct agtctgtagc ttactcttta ttctgagaca ctgtccctgg tgtacgtgct
     7201 gtaacagtga atgcaggcca tgctaaagtg cgcgcacagc agcttatggt acccgtcggg
     7261 cacagaggcg tagctattga gacagtgagc tgtgcttcac gtcagcctgt gaacatgcct
     7321 tacacttgtc cagtacctgt caataaagag cattctcaaa gatc
//
