LOCUS       NM_001191737            4484 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tetratricopeptide repeat domain 21B (Ttc21b),
            mRNA.
ACCESSION   NM_001191737 XM_229983
VERSION     NM_001191737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4484)
  AUTHORS   Driver,A.M., Shumrick,C. and Stottmann,R.W.
  TITLE     Ttc21b Is Required in Bergmann Glia for Proper Granule Cell Radial
            Migration
  JOURNAL   J Dev Biol 5 (4), 18 (2017)
   PUBMED   29615573
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4484)
  AUTHORS   Snedeker,J., Schock,E.N., Struve,J.N., Chang,C.F., Cionni,M.,
            Tran,P.V., Brugmann,S.A. and Stottmann,R.W.
  TITLE     Unique spatiotemporal requirements for intraflagellar transport
            genes during forebrain development
  JOURNAL   PLoS One 12 (3), e0173258 (2017)
   PUBMED   28291836
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4484)
  AUTHORS   Hirano,T., Katoh,Y. and Nakayama,K.
  TITLE     Intraflagellar transport-A complex mediates ciliary entry and
            retrograde trafficking of ciliary G protein-coupled receptors
  JOURNAL   Mol Biol Cell 28 (3), 429-439 (2017)
   PUBMED   27932497
REFERENCE   4  (bases 1 to 4484)
  AUTHORS   Jacobs,D.T., Silva,L.M., Allard,B.A., Schonfeld,M.P.,
            Chatterjee,A., Talbott,G.C., Beier,D.R. and Tran,P.V.
  TITLE     Dysfunction of intraflagellar transport-A causes
            hyperphagia-induced obesity and metabolic syndrome
  JOURNAL   Dis Model Mech 9 (7), 789-798 (2016)
   PUBMED   27482817
REFERENCE   5  (bases 1 to 4484)
  AUTHORS   Gascue,C., Tan,P.L., Cardenas-Rodriguez,M., Libisch,G.,
            Fernandez-Calero,T., Liu,Y.P., Astrada,S., Robello,C., Naya,H.,
            Katsanis,N. and Badano,J.L.
  TITLE     Direct role of Bardet-Biedl syndrome proteins in transcriptional
            regulation
  JOURNAL   J Cell Sci 125 (Pt 2), 362-375 (2012)
   PUBMED   22302990
REFERENCE   6  (bases 1 to 4484)
  AUTHORS   Hong,W., Li,J., Wang,B., Chen,L., Niu,W., Yao,Z. and Baniahmad,A.
  TITLE     Epigenetic involvement of Alien/ESET complex in thyroid
            hormone-mediated repression of E2F1 gene expression and cell
            proliferation
  JOURNAL   Biochem Biophys Res Commun 415 (4), 650-655 (2011)
   PUBMED   22079090
REFERENCE   7  (bases 1 to 4484)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
REFERENCE   8  (bases 1 to 4484)
  AUTHORS   Stottmann,R.W., Tran,P.V., Turbe-Doan,A. and Beier,D.R.
  TITLE     Ttc21b is required to restrict sonic hedgehog activity in the
            developing mouse forebrain
  JOURNAL   Dev Biol 335 (1), 166-178 (2009)
   PUBMED   19732765
REFERENCE   9  (bases 1 to 4484)
  AUTHORS   Tran,P.V., Haycraft,C.J., Besschetnova,T.Y., Turbe-Doan,A.,
            Stottmann,R.W., Herron,B.J., Chesebro,A.L., Qiu,H., Scherz,P.J.,
            Shah,J.V., Yoder,B.K. and Beier,D.R.
  TITLE     THM1 negatively modulates mouse sonic hedgehog signal transduction
            and affects retrograde intraflagellar transport in cilia
  JOURNAL   Nat Genet 40 (4), 403-410 (2008)
   PUBMED   18327258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 27, 2022 this sequence version replaced NM_001191737.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.16892.1,
                                           SRR26643297.11379.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               JAXUCZ010000003.1  71343818-71343936   c
            120-249             JAXUCZ010000003.1  71338862-71338991   c
            250-360             JAXUCZ010000003.1  71338656-71338766   c
            361-527             JAXUCZ010000003.1  71334472-71334638   c
            528-650             JAXUCZ010000003.1  71332764-71332886   c
            651-808             JAXUCZ010000003.1  71326869-71327026   c
            809-893             JAXUCZ010000003.1  71323818-71323902   c
            894-992             JAXUCZ010000003.1  71322116-71322214   c
            993-1185            JAXUCZ010000003.1  71319720-71319912   c
            1186-1283           JAXUCZ010000003.1  71319237-71319334   c
            1284-1484           JAXUCZ010000003.1  71318755-71318955   c
            1485-1614           JAXUCZ010000003.1  71315383-71315512   c
            1615-1772           JAXUCZ010000003.1  71313150-71313307   c
            1773-1994           JAXUCZ010000003.1  71311451-71311672   c
            1995-2233           JAXUCZ010000003.1  71310631-71310869   c
            2234-2306           JAXUCZ010000003.1  71308182-71308254   c
            2307-2417           JAXUCZ010000003.1  71307577-71307687   c
            2418-2556           JAXUCZ010000003.1  71306712-71306850   c
            2557-2663           JAXUCZ010000003.1  71301344-71301450   c
            2664-2852           JAXUCZ010000003.1  71293778-71293966   c
            2853-2963           JAXUCZ010000003.1  71292465-71292575   c
            2964-3045           JAXUCZ010000003.1  71291505-71291586   c
            3046-3196           JAXUCZ010000003.1  71285604-71285754   c
            3197-3358           JAXUCZ010000003.1  71285249-71285410   c
            3359-3554           JAXUCZ010000003.1  71282159-71282354   c
            3555-3779           JAXUCZ010000003.1  71275812-71276036   c
            3780-3900           JAXUCZ010000003.1  71272290-71272410   c
            3901-3968           JAXUCZ010000003.1  71271178-71271245   c
            3969-4484           JAXUCZ010000003.1  71269425-71269940   c
FEATURES             Location/Qualifiers
     source          1..4484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..4484
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /note="tetratricopeptide repeat domain 21B"
                     /db_xref="GeneID:295654"
                     /db_xref="RGD:1565122"
     exon            1..119
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..4046
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /note="tetratricopeptide repeat protein 21B-like"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 21B"
                     /protein_id="NP_001178666.1"
                     /db_xref="GeneID:295654"
                     /db_xref="RGD:1565122"
                     /translation="MDSQGLKTLINYYCQERYYHHVLLVASEGMKKYSSDPVFRFYHA
                     YGTLMEGKAQEALREFEAIKNKQDVSLCSLMALMYVHKMSPNPDREAILELDTKMKEQ
                     RKEAGRKALYHAGLFLWHIGRHDKAREYIDRMSKMPHDSNEGPILKAWLDITRGKEPY
                     AKKALRYFEEGLQDGNDIFALLGKVLCLEMRQNYSGALETVSQIIVNFPSFLPAFEKK
                     MKLQLALQDWDQTVETAQRLLLQDGHNVEALRMLALYYLCREGDIEKAAAKLENLGNA
                     LDVMEPQNAQLFYKITIAFSRTCGRNQLILQKVQSFLEKAFSLTPQQAEIATELGYQM
                     ILQGKVKEAWKWYRTAMTLNESNISAVTGLIRCQLIEGQLQDADQQLEFFSEFQQSMG
                     RSAELMYLHAVLATKKNNRQEEVINLLNDVVNTHFSHLEDLPLGIQYFEKLNPDFLLE
                     VVNEYLNLCPIQPAGPGQPLSPVLRRCSSVLETIIRSVPGLPQAVFLMAKVKYLSGDT
                     EAAYNNLQHCLEHSPSYAEAHLLMAQVYLSQDKVQLCSQSLELCLSYNFNVRDYPLYH
                     LIKAQSQKKMGEVAEAIKTLHMAMNLPGMRRSRASSKSKHRSEVDGSHRLSIFLELVE
                     VHRLNGEQHEAAKVLQDAIHEFSGTCEELRVTIANADLALAQGDTERALSMLRNVTTE
                     QPYFIEAKEKMADIYLKHRKEKMLYITCYREIAERMPSPRSFLLLGDAYMNIQEPEEA
                     IVAYEQALNQNPKDGTLARKIGKALVKTHNYSKAITYYEAALKSGQQNCLCYDLAELL
                     LRLKLYEKAEKVLQHSLAHDPVNELSALMVDGRSQVLLAKVYSKMERPGDAIAALQQA
                     RELQARILKRVQMEQPDAVPSQRHFAAEICAEIAKHSAAQRDYEKAITFYREALVHCE
                     TDSKIMLELAQLYLAQEDLDASLRHCALLLQRDQDNEPATMLMADLMFRKQDYEQAVF
                     HLQQLLERKPDNFMTLSRLIDLLRRCGKLEEVPRFFLMAEKHNSRTKLEPGFQYCKGL
                     HFWYTGEPNDALRHFNKARKDSDWGQNALYNMIEICLNPDNETIGGEVFENLNGDLGT
                     SPEKQESVQLAVRTAEKLLKELKPQTVQGRLQLRIMENCCLMATKQKSSVEQALNTFT
                     EIAASEKDHIPALLGMATAYMILKQTPKARNQLKRIAKMTWNPIEAEELEKSWLLLAD
                     IYIQSAKYDMAEELLKRCLCHNRSCCKAYEYMGYIMEKEQAYTDAAFNYEMAWKHSNQ
                     TNPAVGYKLAFNYLKAKRYVDAIDVCHQVLEAHPTYPKIRKDILDKARASLRP"
     exon            120..249
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            250..360
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            361..527
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            528..650
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            651..808
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            809..893
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            894..992
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1185
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1283
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1484
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1614
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1772
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1994
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2233
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2306
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2417
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2556
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2663
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2852
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..2963
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3045
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3196
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3358
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3554
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3779
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3900
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            3901..3968
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
     exon            3969..4484
                     /gene="Ttc21b"
                     /gene_synonym="RGD1565122"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgccttg tccccagtgt tttagggccc gggaagtggg tcggaacccc taaccctaca
       61 gtgggcagtg gtggggaccc tccgggcagc tggcggccat ggactcccag gggctgaaga
      121 cactgatcaa ttactattgt caagagagat actatcacca tgtgctcctt gtggccagtg
      181 aagggatgaa gaagtatagc agtgacccag tcttccgatt ttaccatgcc tacggcacac
      241 taatggaggg taaagctcaa gaagcccttc gggagtttga ggccattaaa aataaacaag
      301 acgtgtcact gtgttccctg atggcgctga tgtatgtcca taaaatgagc cccaatccag
      361 atagagaagc tatcctggaa ttagatacca aaatgaagga gcaacgtaag gaagccggac
      421 gcaaagcctt gtaccatgca ggcctgtttc tgtggcacat tggtcgccat gataaggcga
      481 gagaatatat tgacagaatg tcaaaaatgc cacatgatag caatgaggga ccgattttga
      541 aagcatggct tgatattaca agagggaagg aaccttatgc taaaaaagcc ctacggtatt
      601 ttgaggaggg attacaagat ggaaacgata tttttgctct gctgggtaag gtactgtgcc
      661 ttgagatgcg acagaattat tctggagctc tggagactgt gagtcagata attgtgaact
      721 tcccgagctt ccttcctgct tttgagaaga aaatgaaatt acaactggct ttgcaggatt
      781 gggatcagac ggtggagacg gcgcaaaggt tgctgcttca ggacggccac aatgtggagg
      841 cgctgagaat gctggcttta tattatctgt gtagggaagg ggacatagag aaggctgctg
      901 ccaagctgga aaatttagga aatgcattgg atgtcatgga accacagaat gctcaacttt
      961 tttataagat tacaatagcc ttcagcagaa cttgtggacg taatcaactc attcttcaaa
     1021 aagttcaaag tttcctagaa aaagcattta gtttaacccc ccagcaagca gaaattgcta
     1081 cagagcttgg ctaccaaatg attctccaag gcaaagtcaa ggaggcctgg aagtggtaca
     1141 ggaccgccat gacactgaac gaaagcaaca tctctgccgt caccggactt atccgatgtc
     1201 agttaataga aggacaattg caagatgcag accagcagtt ggagttcttc agtgaattcc
     1261 agcagtcaat gggaagatct gcggaattaa tgtatttgca tgcggttctt gctaccaaaa
     1321 aaaataatcg tcaggaggaa gttataaatt tgttgaatga tgttgtgaac actcactttt
     1381 cacacttgga agacctccct ctcggcatac agtattttga gaagctcaac cctgacttct
     1441 tactagaagt tgttaacgag tatctgaatc tctgtccaat tcagcctgca ggtcctgggc
     1501 agcctctctc cccagtcctc agacgttgtt cttcagttct ggagacgatt ataagaagtg
     1561 taccaggtct tccgcaagct gtcttcctaa tggccaaagt gaagtatctg tcaggtgaca
     1621 ccgaggcagc ctacaacaac ctgcagcact gcctggagca cagcccctct tacgcagagg
     1681 ctcacctcct gatggcgcag gtgtacctat cccaagacaa agtccagctg tgttctcagt
     1741 cgcttgaact ttgtctgagc tacaatttca atgtgagaga ctacccactg taccacctaa
     1801 tcaaagcaca gtcacagaag aaaatgggcg aggtagcaga agcaattaaa actctgcaca
     1861 tggcaatgaa tctaccagga atgaggagaa gtagagcttc ctcgaaatcc aagcacagaa
     1921 gtgaagtgga tgggagccat cgcttatcca tctttcttga gttggtggag gttcaccgct
     1981 taaatggaga acagcacgag gcagcaaagg ttttacaaga tgccatccat gagttttctg
     2041 gaacttgcga agaattacgt gtcactattg ctaatgcaga cctggctctg gcccaaggag
     2101 atacagaacg tgcattaagc atgctccgaa atgtcacgac cgaacagcct tatttcatag
     2161 aagccaagga aaaaatggca gacatttacc tgaagcatag gaaagagaaa atgttgtaca
     2221 tcacttgtta cagagaaatt gctgaaagga tgcccagccc ccggtctttc ctgctccttg
     2281 gtgatgcata catgaacatt caagagcccg aggaagccat agtggcctat gagcaagcat
     2341 taaatcagaa cccaaaagat ggaacactgg cgagaaaaat tgggaaagca cttgtcaaaa
     2401 ctcacaacta ctcaaaggca atcacctatt atgaggctgc gctgaaaagt ggacagcaga
     2461 attgcctgtg ctatgacctg gctgagctcc tcctgagact aaagttgtat gagaaagcag
     2521 agaaagttct tcagcattct ctagctcatg atcctgtaaa tgaattgtcg gctctcatgg
     2581 tggatgggcg ttcccaagtc cttctagcaa aagtttactc taaaatggag agacctggcg
     2641 acgcgattgc agcattgcag caggctcgag agctgcaggc tcggatactg aagcgagttc
     2701 agatggagca gccagatgcg gttccctcac agagacactt cgcagctgaa atttgtgcag
     2761 agatcgcaaa acactccgct gctcagcgag actacgaaaa ggcaattaca ttttatagag
     2821 aggccctggt tcattgtgaa acggatagta agataatgtt ggaactggcc cagttatacc
     2881 tggcccaaga agaccttgat gcctccctcc ggcactgtgc actgcttctc cagagggacc
     2941 aggacaacga accggccacc atgctgatgg ccgacctcat gttcagaaaa caggactatg
     3001 agcaagcagt gttccacttg cagcagcttt tagaacgaaa accagataat tttatgactt
     3061 tgtcccgttt gattgatctc ctgagaagat gtgggaaact tgaggaggtt ccgagatttt
     3121 tcttgatggc tgagaaacac aactccagaa caaaattgga gccaggattt cagtactgta
     3181 aaggattaca tttttggtat actggagaac caaatgatgc ccttcgacat tttaataaag
     3241 ctcggaaaga tagtgactgg ggtcaaaatg cactttataa tatgatagaa atctgcttga
     3301 atccagacaa tgaaactatt ggaggtgaag tgtttgaaaa cctgaatgga gacctgggca
     3361 cttccccaga gaagcaggaa tctgtgcagt tagcagtgag gacggcagaa aagctcctta
     3421 aagaactaaa acctcagact gtccagggcc gcctgcaact ccgcatcatg gaaaactgct
     3481 gcttaatggc caccaagcag aagtccagtg tggagcaggc gctgaacacc ttcaccgaaa
     3541 tagcagcctc tgagaaggat catatccctg ctctcctggg aatggccacc gcttatatga
     3601 tcttgaaaca gaccccgaaa gccagaaacc agctgaagcg gattgcaaaa atgacctgga
     3661 atcctattga agccgaggag ctggagaaga gctggctgct gcttgcggat atttatatcc
     3721 agtcagcaaa atatgacatg gcggaagagc tgctgaaacg gtgtctgtgc cataaccggt
     3781 cctgctgcaa agcttatgaa tatatggggt acattatgga gaaggagcaa gcatacacag
     3841 atgcagcctt caactatgag atggcctgga aacatagcaa ccagacaaat cctgctgtgg
     3901 gatataaatt ggcatttaat tacttaaaag caaaacgata tgtggatgca attgacgtat
     3961 gtcaccaggt tcttgaagca catccaactt accccaaaat ccgaaaggat atactggata
     4021 aggcccgtgc atcgttaaga ccttgaaagc gattgttgtt atggaagcgt tgggcaacag
     4081 acggcaggga tccctcagct tttgcagcct ttgcagttca cacaggctcc agctgacagt
     4141 gtcgccgaag tgtgtcctgc cttctccagc agaggctgct gctgtccgtg gacagagctg
     4201 atctgtggta tcattggtgg agtggccgga tgaaagctca tctttctccc tgccattagg
     4261 cacaaacggt agttctctga taaagcctag ctcatttcta cagaggatat ttttgttaaa
     4321 gtctaggtga tatacctttt ctgaagagta ttagattttc caacaatctt aaagtctact
     4381 gttacctgtt aattttctat tatagtttgt gatatgatct catgtaattt atgaaaaaga
     4441 gtaagtattt taaatgtata ttttaataaa gatttttgtg aata
//
