LOCUS       NM_001415772            2055 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus tetratricopeptide repeat domain 19 (Ttc19),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001415772 XM_006246530
VERSION     NM_001415772.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Ghezzi,D., Arzuffi,P., Zordan,M., Da Re,C., Lamperti,C., Benna,C.,
            D'Adamo,P., Diodato,D., Costa,R., Mariotti,C., Uziel,G.,
            Smiderle,C. and Zeviani,M.
  TITLE     Mutations in TTC19 cause mitochondrial complex III deficiency and
            neurological impairment in humans and flies
  JOURNAL   Nat Genet 43 (3), 259-263 (2011)
   PUBMED   21278747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 29, 2022 this sequence version replaced XM_006246530.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.37070.1,
                                           SRR22399492.507604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               JAXUCZ010000010.1  47469043-47469263
            222-325             JAXUCZ010000010.1  47469361-47469464
            326-436             JAXUCZ010000010.1  47471153-47471263
            437-475             JAXUCZ010000010.1  47471692-47471730
            476-532             JAXUCZ010000010.1  47472378-47472434
            533-594             JAXUCZ010000010.1  47473149-47473210
            595-689             JAXUCZ010000010.1  47479142-47479236
            690-841             JAXUCZ010000010.1  47493403-47493554
            842-1004            JAXUCZ010000010.1  47494872-47495034
            1005-2055           JAXUCZ010000010.1  47495873-47496923
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..2055
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /note="tetratricopeptide repeat domain 19"
                     /db_xref="GeneID:691506"
                     /db_xref="RGD:1582808"
     exon            1..221
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1138
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tetratricopeptide repeat protein 19, mitochondrial; TPR
                     repeat protein 19"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 19,
                     mitochondrial isoform 1"
                     /protein_id="NP_001402701.1"
                     /db_xref="GeneID:691506"
                     /db_xref="RGD:1582808"
                     /translation="MFRLLRWRLGRTLLRAAGRRCGGCTARLLPERAGDAGPGAERLR
                     TRGAPARGHRVLPLLAALAWFSRTAAAEEQPGEDATDEAEAEIIQLLKRAKLSIMKDE
                     PEAAELILHDALRLAYESDNKKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGG
                     GMKQEDNAIVEISLKLANIYAAQNKQEFALAGYEFCISTLEGKIEREKELAEDIMSEE
                     RANTYLLLGMCLDSCARYLLFSKQLSQAQRMYEKALQICQEIQGERHPQTIVLMSDLA
                     TALDAQGHFDDAYIYMQRASDLAREINHPELHMVLSNLAAILIHRERYTQAKEIYQEA
                     LKQAELKRDEFSVQHIREELAELSRKSRLLT"
     exon            222..325
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     exon            326..436
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     exon            437..475
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     exon            476..532
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     exon            533..594
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     exon            595..689
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     exon            690..841
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1004
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..2055
                     /gene="Ttc19"
                     /gene_synonym="RGD1311797"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccagccg cggctagtgg agctgtgagg acgcgtcggc atgttccggc tgcttcgctg
       61 gcgtctgggt cgaaccctgc tgcgggccgc gggccggcgg tgcgggggct gtactgcgcg
      121 cctactgccg gagcgggccg gtgacgcggg tccgggcgcg gagcggctgc ggacccgagg
      181 cgcgccggcg cgggggcacc gagtgctgcc gctgttggca gcgctcgcct ggttctcgcg
      241 aaccgcggcg gcagaggagc agccgggaga ggacgcgaca gacgaggcgg aggcagagat
      301 catccagctg ctgaagcgag ccaagttgag catcatgaaa gatgagccag aagcagccga
      361 gctgattttg catgacgctc ttcgccttgc gtatgagagt gacaacaaga aggccatcac
      421 gtacacttat gacttgatgg ccaacttggc ttttatacga gggcagcttg aaaacgcaga
      481 acaacttttt aaagctacaa tgagctacct gcttggagga ggcatgaagc aggaagacaa
      541 tgcgatagtt gaaatctctc tgaaactggc caacatctac gctgctcaga ataaacagga
      601 gtttgccctg gctggctatg aattctgcat ttcaactcta gaggggaaaa ttgaaagaga
      661 aaaggaatta gcagaagata ttatgtcaga agaaagagcc aatacttacc tcctccttgg
      721 catgtgctta gactcttgtg cacgctacct gctattctcc aagcagctgt cacaggcaca
      781 aaggatgtat gaaaaagccc tgcagatttg tcaagaaata caaggagaaa gacacccaca
      841 gaccattgtg ctgatgagtg acttggctac tgctctggat gcgcagggcc actttgatga
      901 tgcctacatt tatatgcaga gggcgtcaga tctggcaagg gagataaatc accctgagct
      961 gcacatggtg ctcagcaatc tggctgccat cttgatacac agagaacgat acacacaagc
     1021 aaaggagatc taccaggaag cactgaagca agcagagctg aaaagagatg agttttctgt
     1081 tcagcacatc agggaagaat tggctgagct gtcaagaaaa agtagacttt tgacttaatg
     1141 tttgttgtta agctatagaa gttcattttg tcatagagag gtaacctctg ataacccaaa
     1201 ggagtaactg ttccttcatt gtctggacct caatcggtgg tgtaaatcat tgttgaaatt
     1261 caactttctt caactcagct tcggtgaagg acaagtccta tacactgcca cttctgtttc
     1321 taaattttac tttgagatgg gcatctctat gtgtaggctg gcctggaaat tgctgtatgc
     1381 ttgacgttgg cctccaactt ggagtactcc tccctcagcc ttgcaagtgc ctggccctac
     1441 ttttgttttt aaaggtgaaa cagcctttag gtacagtcca tgctggtctg agaaaactgt
     1501 agactacagt tggccaagtt ccccatgata tggtcattat accttccatc agattttggt
     1561 tcatgcttaa ctcttctcta tctgtctctg ccaaacaagt tacttgtgtc attacacatg
     1621 aggattgtgg tgagttctta cacactattt tattgaagca ttgtgagatt taatgactat
     1681 gaagggcaat gataattcta gttggccacc attaggcagc attcacttct caaatggaaa
     1741 tgagacactt gaactgtgta cctgtttata tataactact ggcaatggtg gtggcagaag
     1801 gaaggaagcc cccaccatgc catccgagca ctagggttcc tttataaaga caggcacata
     1861 cgggagtcag gcactgctgc cagcaccggc gtacaccaag gtaacgtgca acccctacct
     1921 ggatcctgtt tagctctttt ttcttttgca gtctctgtat ttacagctgt gaagtgtgaa
     1981 accaattaga ttgtccgacg actgtatcac tgcctcagag tatataaata caagatacat
     2041 ggatgaatgc tttta
//
