LOCUS       NM_001004246            2236 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Rattus norvegicus tetratricopeptide repeat domain 12 (Ttc12), mRNA.
ACCESSION   NM_001004246 XM_217142
VERSION     NM_001004246.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Macare,C., Ducci,F., Zhang,Y., Ruggeri,B., Jia,T., Kaakinen,M.,
            Kalsi,G., Charoen,P., Casoni,F., Peters,J., Bromberg,U., Hill,M.,
            Buxton,J., Blakemore,A., Veijola,J., Buchel,C., Banaschewski,T.,
            Bokde,A.L.W., Conrod,P., Flor,H., Frouin,V., Gallinat,J.,
            Garavan,H., Gowland,P.A., Heinz,A., Ittermann,B., Lathrop,M.,
            Martinot,J.L., Paus,T., Desrivieres,S., Munafo,M., Jarvelin,M.R.
            and Schumann,G.
  CONSRTM   IMAGEN Consortium
  TITLE     A neurobiological pathway to smoking in adolescence:
            TTC12-ANKK1-DRD2 variants and reward response
  JOURNAL   Eur Neuropsychopharmacol 28 (10), 1103-1114 (2018)
   PUBMED   30104163
REFERENCE   2  (bases 1 to 2236)
  AUTHORS   Bidwell,L.C., McGeary,J.E., Gray,J.C., Palmer,R.H., Knopik,V.S. and
            MacKillop,J.
  TITLE     NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate
            phenotypes for nicotine dependence
  JOURNAL   Psychopharmacology (Berl) 232 (7), 1177-1186 (2015)
   PUBMED   25273375
REFERENCE   3  (bases 1 to 2236)
  AUTHORS   Nelson,E.C., Lynskey,M.T., Heath,A.C., Wray,N., Agrawal,A.,
            Shand,F.L., Henders,A.K., Wallace,L., Todorov,A.A., Schrage,A.J.,
            Saccone,N.L., Madden,P.A., Degenhardt,L., Martin,N.G. and
            Montgomery,G.W.
  TITLE     ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence:
            importance of considering drug exposure
  JOURNAL   JAMA Psychiatry 70 (3), 325-333 (2013)
   PUBMED   23303482
REFERENCE   4  (bases 1 to 2236)
  AUTHORS   Hoh,R.A., Stowe,T.R., Turk,E. and Stearns,T.
  TITLE     Transcriptional program of ciliated epithelial cells reveals new
            cilium and centrosome components and links to human disease
  JOURNAL   PLoS One 7 (12), e52166 (2012)
   PUBMED   23300604
REFERENCE   5  (bases 1 to 2236)
  AUTHORS   Ducci,F., Kaakinen,M., Pouta,A., Hartikainen,A.L., Veijola,J.,
            Isohanni,M., Charoen,P., Coin,L., Hoggart,C., Ekelund,J.,
            Peltonen,L., Freimer,N., Elliott,P., Schumann,G. and Jarvelin,M.R.
  TITLE     TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different
            pathways leading to smoking behavior from adolescence to
            mid-adulthood
  JOURNAL   Biol Psychiatry 69 (7), 650-660 (2011)
   PUBMED   21168125
REFERENCE   6  (bases 1 to 2236)
  AUTHORS   Yang,B.Z., Kranzler,H.R., Zhao,H., Gruen,J.R., Luo,X. and
            Gelernter,J.
  TITLE     Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated
            with comorbid alcohol and drug dependence
  JOURNAL   Alcohol Clin Exp Res 32 (12), 2117-2127 (2008)
   PUBMED   18828801
REFERENCE   7  (bases 1 to 2236)
  AUTHORS   Yang,B.Z., Kranzler,H.R., Zhao,H., Gruen,J.R., Luo,X. and
            Gelernter,J.
  TITLE     Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1
            to alcohol dependence in independent case control and family
            samples
  JOURNAL   Hum Mol Genet 16 (23), 2844-2853 (2007)
   PUBMED   17761687
REFERENCE   8  (bases 1 to 2236)
  AUTHORS   Wattanawaraporn,R., Singhsilarak,T., Nuchprayoon,I. and
            Mutirangura,A.
  TITLE     Hypermethylation of TTC12 gene in acute lymphoblastic leukemia
  JOURNAL   Leukemia 21 (11), 2370-2373 (2007)
   PUBMED   17657212
REFERENCE   9  (bases 1 to 2236)
  AUTHORS   Gelernter,J., Yu,Y., Weiss,R., Brady,K., Panhuysen,C., Yang,B.Z.,
            Kranzler,H.R. and Farrer,L.
  TITLE     Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1
            loci, is strongly associated to nicotine dependence in two distinct
            American populations
  JOURNAL   Hum Mol Genet 15 (24), 3498-3507 (2006)
   PUBMED   17085484
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079409.1.
            
            On Aug 31, 2012 this sequence version replaced NM_001004246.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2236              BC079409.1         3-2238
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..2236
                     /gene="Ttc12"
                     /note="tetratricopeptide repeat domain 12"
                     /db_xref="GeneID:300696"
                     /db_xref="RGD:1303264"
     exon            1..75
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2132
                     /gene="Ttc12"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 12"
                     /protein_id="NP_001004246.1"
                     /db_xref="GeneID:300696"
                     /db_xref="RGD:1303264"
                     /translation="MADDQERDLQRFLENVDEITNLIQEMNSDDPFIQQKAVLDTEKK
                     LLLMEREQEEDGCRTTLNKTMISPPQAPENANEMNPDAFLASVEKDAKERAKRRRENR
                     VLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALV
                     DCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPKLKAQVKEHLNQVT
                     LREKADLQEKKARESLDSGKNTAMTTRNLLETLSKPGQTPLFYAGGIEILTEMMTDCT
                     ERTLFRTYGGFSIINDHEVIKRCLFLAGKDAVEEIVCVSVLKLWQEVCIDNEENQRLL
                     LSHPDMAKLLPSFMDSRILVIQQQSLALLLQLTQTDNGRNQVIKHLDMTRLCEALLSF
                     LDFSDKKANTAIGLFTDLALEERFQVWFHANLPDVLPALTGALKREPKLTSPSALCQC
                     IALMGNISAEPTARRHMLAYEEFGDACLDLLVKCEEDMDLYREVTYTLLGLIMNLCLE
                     VPFLSESWAMKISRKCLSLLNSQDGGILTRAAGVLSRTLSSSQTIVEEALTAGVVKKM
                     IKFLKTGGPTASRYAMKTLAVCTNSYHAAREEVMRLDKKFNVLMTLLASEDEVVVGNA
                     ALCLGNCMEVPSAASSLLKTDIMRVLLKLAGGDSQETAVQLNAGIALGKLCTAEPRFA
                     VQLQELHGIQILNSTMKHLNDS"
     exon            76..236
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            237..258
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            259..336
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            337..458
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            459..518
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            519..590
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            591..651
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            652..840
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            841..910
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            911..999
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1168
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1261
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1322
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1460
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1559
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1628
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1730
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1830
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2056
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2215
                     /gene="Ttc12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagatttgt gtctgcaatg gctgatgatc aagagagaga cttgcagaga tttctggaaa
       61 atgtggatga aataaccaat ttaatccaag agatgaattc cgatgatccc ttcatacagc
      121 agaaagctgt cctggacacg gaaaagaaac tcctgctgat ggagagagag caagaggagg
      181 acgggtgcag gaccactctg aacaagacca tgatcagtcc tccacaagct cctgagaatg
      241 caaatgaaat gaacccagat gccttcttgg catctgtgga gaaggacgcc aaggaacgag
      301 ccaagagaag acgagaaaac agagtcctag cagatgccct aaaggagaag gggaatgagg
      361 cctttgtcaa gggcgactat gaaacagcca ttttcttcta cagtgagggg ttagggaagc
      421 tcaaggacat gaaggtgctg tacaccaacc gagcccaggc ttatataaaa cttggggatt
      481 atcagaaggc tctcgtggat tgtgactggg ctctcaagtg tgatgaaaat tgcacaaagg
      541 cctatttcca catggggaag gcccacttgg ctctgaagaa ctacagcaag tctaaagagt
      601 gttatcagaa gatcggagag ataaacccca agctgaaggc acaggtgaaa gaacacctaa
      661 atcaagtaac tcttcgagaa aaagcagatc tccaagagaa gaaagcccgg gaatctctag
      721 attcaggaaa gaacacagcc atgacaacca gaaatctcct ggagacccta tccaagcccg
      781 gccagacacc cttgttctat gcaggaggca ttgagattct gacagaaatg atgactgact
      841 gcacagagcg aacactgttc agaacatatg gtggattcag catcatcaat gaccatgagg
      901 tcattaaaag gtgcctcttc ttagcaggga aagatgcagt tgaggagatt gtctgcgtat
      961 ctgttctaaa gctctggcaa gaagtgtgca ttgacaacga ggagaaccag cgcctgcttt
     1021 tgtcccaccc tgatatggcc aagctgctgc cttccttcat ggactccaga atcctggtga
     1081 ttcaacagca gagcctggcc ctactgctgc agctcaccca gacggataat ggccggaacc
     1141 aagtgatcaa gcaccttgac atgacccgac tgtgtgaagc attgctgtcg tttcttgact
     1201 tctcagataa gaaggccaat acggccatcg gacttttcac agatttggct ctagaagaaa
     1261 gattccaagt gtggttccat gccaaccttc cagatgtcct ccctgctctc acgggtgctc
     1321 tgaaacgaga gcccaagtta accagcccct cggccctctg ccagtgcatt gctctgatgg
     1381 gaaacatcag tgctgagcct actgccagaa gacacatgct agcctatgaa gagtttgggg
     1441 atgcctgctt ggacctcctg gtcaagtgtg aggaggacat ggacctgtac agagaggtca
     1501 cctatactct cttaggactc atcatgaact tgtgtcttga ggtccccttc ctctccgagt
     1561 cgtgggcaat gaagataagc cggaagtgcc tgtctctact gaacagccag gatggaggaa
     1621 tcttaacaag agcggcgggt gttctgagcc ggaccctttc ctcctctcag accattgtgg
     1681 aggaggccct gacagcagga gtggtcaaga aaatgattaa attcctgaag acgggaggcc
     1741 cgactgcatc acgttatgcc atgaagacac tggctgtctg cacaaacagc taccacgcag
     1801 ctcgagaaga agtaatgaga cttgataaaa agttcaatgt tttgatgaca ctgcttgcct
     1861 cagaggatga agttgtggtg ggcaatgcag ccctctgcct tggcaactgt atggaagtgc
     1921 ccagtgcagc ctcttccttg ctgaagacag acatcatgag ggtgctgttg aagctggcag
     1981 gcggcgactc acaggagacg gctgtccagc tgaatgcagg catcgctctg gggaagctgt
     2041 gcactgctga gcccaggttc gctgtccaac tgcaagagct tcatgggata caaatactca
     2101 actctacaat gaaacacttg aatgattctt gaaagacaca gtgagcacac acaactctgg
     2161 gtcaaagggg tcactgctct actaataaat tctttttaaa tgtttagctc caaaaaaaaa
     2221 aaaaaaaaaa aaaaaa
//
