LOCUS       NM_001415701           10896 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus tau tubulin kinase 2 (Ttbk2), mRNA.
ACCESSION   NM_001415701 XM_006234833
VERSION     NM_001415701.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10896)
  AUTHORS   Watanabe,T., Kakeno,M., Matsui,T., Sugiyama,I., Arimura,N.,
            Matsuzawa,K., Shirahige,A., Ishidate,F., Nishioka,T., Taya,S.,
            Hoshino,M. and Kaibuchi,K.
  TITLE     TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells
            through KIF2A phosphorylation
  JOURNAL   J Cell Biol 210 (5), 737-751 (2015)
   PUBMED   26323690
REFERENCE   2  (bases 1 to 10896)
  AUTHORS   Ye,X., Zeng,H., Ning,G., Reiter,J.F. and Liu,A.
  TITLE     C2cd3 is critical for centriolar distal appendage assembly and
            ciliary vesicle docking in mammals
  JOURNAL   Proc Natl Acad Sci U S A 111 (6), 2164-2169 (2014)
   PUBMED   24469809
REFERENCE   3  (bases 1 to 10896)
  AUTHORS   Goetz,S.C., Liem,K.F. Jr. and Anderson,K.V.
  TITLE     The spinocerebellar ataxia-associated gene Tau tubulin kinase 2
            controls the initiation of ciliogenesis
  JOURNAL   Cell 151 (4), 847-858 (2012)
   PUBMED   23141541
REFERENCE   4  (bases 1 to 10896)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 10896)
  AUTHORS   Bouskila,M., Esoof,N., Gay,L., Fang,E.H., Deak,M., Begley,M.J.,
            Cantley,L.C., Prescott,A., Storey,K.G. and Alessi,D.R.
  TITLE     TTBK2 kinase substrate specificity and the impact of
            spinocerebellar-ataxia-causing mutations on expression, activity,
            localization and development
  JOURNAL   Biochem J 437 (1), 157-167 (2011)
   PUBMED   21548880
REFERENCE   6  (bases 1 to 10896)
  AUTHORS   Tomizawa,K., Omori,A., Ohtake,A., Sato,K. and Takahashi,M.
  TITLE     Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites
            found in paired helical filament-tau
  JOURNAL   FEBS Lett 492 (3), 221-227 (2001)
   PUBMED   11257498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 23, 2022 this sequence version replaced XM_006234833.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.18328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               JAXUCZ010000003.1  128256066-128256416 c
            352-425             JAXUCZ010000003.1  128230146-128230219 c
            426-561             JAXUCZ010000003.1  128227693-128227828 c
            562-709             JAXUCZ010000003.1  128220199-128220346 c
            710-783             JAXUCZ010000003.1  128196556-128196629 c
            784-924             JAXUCZ010000003.1  128192441-128192581 c
            925-1029            JAXUCZ010000003.1  128189873-128189977 c
            1030-1095           JAXUCZ010000003.1  128184245-128184310 c
            1096-1188           JAXUCZ010000003.1  128182270-128182362 c
            1189-1314           JAXUCZ010000003.1  128181180-128181305 c
            1315-1472           JAXUCZ010000003.1  128168510-128168667 c
            1473-1689           JAXUCZ010000003.1  128166820-128167036 c
            1690-1901           JAXUCZ010000003.1  128162420-128162631 c
            1902-2490           JAXUCZ010000003.1  128160674-128161262 c
            2491-3758           JAXUCZ010000003.1  128156720-128157987 c
            3759-10896          JAXUCZ010000003.1  128144851-128151988 c
FEATURES             Location/Qualifiers
     source          1..10896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..10896
                     /gene="Ttbk2"
                     /note="tau tubulin kinase 2"
                     /db_xref="GeneID:311349"
                     /db_xref="RGD:1311661"
     exon            1..351
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..425
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..561
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..4221
                     /gene="Ttbk2"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="tau-tubulin kinase 2"
                     /protein_id="NP_001402630.1"
                     /db_xref="GeneID:311349"
                     /db_xref="RGD:1311661"
                     /translation="MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTR
                     ENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLA
                     DLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCF
                     MLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE
                     FVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSTFLDHISSLDYFTKPDYQLL
                     TSVFDNSIKTFGVIESDPFDWEKSGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPI
                     PGDLLRENTDEVFPDEQLSDGENGIPAGVSPDKLPGSLGHPRPQEKDVWEEMDINKNK
                     IKLGICKAATEEENSHGQVNGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFE
                     LEKRLTLEPKPDTDKFLETCMEKMQKDSSAGKEPVLPALPHKPCVPAVPRTDHVWHYD
                     EEYPPDASKPASANTPEQADGGGSHGFIAVNLSSCKQEVDSKEWVIVDKEQDLRDFRT
                     NEVLGHKTTGSPSDEEPEVLQVLEGSPQDEKIQVGPWTDNQHLKKESSGVILALSAEC
                     PATAASELYTDRLDLQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSG
                     SFHYGPQPEKKDLQPLEPTVELFSPRENFSGLAVTEGELGSGGSRVDLGLQIDHIGHG
                     MLPNMKDGDASQDLGPRDLPDSNRLVVKEFENLPGETEEKSILLGSDNEDEKLNKGQH
                     CIEISLPGDLVTTERDQSATTEPLDVSKTQNFSVVPNQDKNHEIMKLLAVGTSEMSPQ
                     AIDPHAEGQIGQVATVQKHKLFKDDTKSESLPGQQGDLATFLHQEGKREKVAPRNGEL
                     YHCVSESEHGPPTRKDMLRSSLVTRHSRIPVLAQEIDSTFESSSAVSAKEKLLQKKAY
                     QPEIVKLLVEKRQFKSFLGDLSSASEKLMEEKLAAAAVPFSEEEVFAPFSRLAVDPQL
                     SRSVEDGFLSPIVSQSRKSKIPRPVSWVSTDQINSSASPQFLPRPPPGKPPVRPGVEA
                     RLRRYKVLGSSNSDSDLFSRLAQILQNGSQKSRSTTQCKSPGSPHNPKTPPKSPVVPR
                     RSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQ
                     EHCKPSKNGPKGSGSLHHHSASSKTPPGKSKPASKLSR"
     exon            562..709
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            710..783
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            784..924
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1029
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1095
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1188
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1314
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1472
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1689
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1901
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2490
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..3758
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
     exon            3759..10896
                     /gene="Ttbk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgtcgggc cgggtcagcg ggcgctgcag tagtcgccgc agcggcgatg ggagcggtgg
       61 ggacgaggcg gcggcggcgg caggaggagg aggaggagca ggggctggta ccagagcagc
      121 ggcccggggc aatccgcagc aatacccgca gccgccgccg ccgcctttag acgcggacgg
      181 catccgaggg gaccgccggc cgtctaagcc gcgctcgggt cccgccgcag tgggcggcgg
      241 gggatgggca ggcggtggcg ggcccgcctg ctcagcggtg actcctgcgg gtgcggaccc
      301 tgagctggac cccagccctc cgccagagat cctgcgtccg ccgcggccca gaattgtaaa
      361 actggtaaga tcaagtgcct gttgaaagag actcactctt ggctaagaag agaagtagga
      421 aataggttaa atggaaacca cccttgggag ctagatgctt gtgtagctgt tttacctcat
      481 cagtgttttg caatgagtgg aggaggagag cagccagata tcctcagtgt tggaatcctg
      541 gtcaaagaaa gatggaaagt gttaagaaag attgggggtg ggggctttgg agaaatttac
      601 gatgccttgg acatgctcac cagggagaat gtggcactga aggtggagtc agctcagcag
      661 ccaaagcagg ttctgaagat ggaggttgct gtgttgaaga aactgcaagg gaaagaccat
      721 gtttgtagat ttattggttg tgggagaaat gaccgtttca actacgtggt catgcaattg
      781 cagggtcgga atctggcaga tcttcgacgt agccaatctc ggggcacatt cactattagc
      841 actactcttc gtctcgggaa acagattctg gagtctattg aaagcataca ttctgtggga
      901 ttccttcaca gagacatcaa accgtcaaat ttcgccatgg gacgctttcc cagtacatgt
      961 agaaaatgtt ttatgcttga ttttggcttg gcccgacaat ttaccaattc ctgtggtgac
     1021 gtcagaccac ctcgtgctgt ggcaggcttc cgagggacag ttcgctatgc atccatcaat
     1081 gctcatcgga acagggaaat gggaagacat gatgaccttt ggtctttatt ctacatgctg
     1141 gtagagtttg tggttggcca actgccttgg aggaaaataa aggacaagga gcaagtaggt
     1201 tccattaagg agaggtatga ccataggctc atgttgaaac acctccctcc agaattcagc
     1261 acctttcttg accatatttc ctctttggat tattttacaa aaccggacta ccagcttcta
     1321 acatccgtgt ttgacaatag catcaagacc tttggagtaa ttgaaagtga cccttttgac
     1381 tgggagaaga gtggaactga cggctcccta acgaccacca ccacctctgc cacccctcag
     1441 ctgcacaccc gcctgacccc tgctgcaatc ggaattgcaa atgccacccc tatcccagga
     1501 gacttgcttc gagaaaatac agacgaagtg tttccagatg agcagcttag tgatggggag
     1561 aatggaatcc ctgctggtgt gtccccagat aaattgcctg gatctctggg gcaccctcgc
     1621 cctcaggaaa aggatgtctg ggaagagatg gacatcaaca agaacaagat aaagctcgga
     1681 atttgtaaag cagctactga agaagaaaat agccatggtc aagtgaatgg aattcttaat
     1741 gctccaagcc ttggctcacc aattcgtgtc cgatcagaga ttactcagcc agacagagat
     1801 gttcctttag taaggaagtt acgttccatt cacagctttg agctggaaaa acgtctgact
     1861 ctcgagccaa agccagatac tgataagttt cttgagacct gcatggagaa aatgcagaaa
     1921 gattccagtg caggaaagga acctgttctc cctgctctgc ctcataagcc ttgtgtccct
     1981 gctgtgcccc gcactgacca cgtctggcac tatgatgaag aatatcctcc tgatgcctcc
     2041 aagcctgcct ctgccaacac cccagagcag gccgatggtg gtggcagcca cggatttata
     2101 gctgttaact taagctcttg taagcaggag gttgattcca aagaatgggt gattgtggac
     2161 aaggagcaag accttcggga ctttaggaca aatgaggtgt taggccataa aacaactgga
     2221 agcccttcag atgaggagcc ggaagtgctt caggtccttg aggggtcgcc tcaagatgaa
     2281 aagatccaag taggtccttg gactgacaac cagcacttaa agaaggaaag ctcaggtgtg
     2341 attttagccc tttctgctga atgccctgct actgctgctt cagaactgta cacagatagg
     2401 ctagacctcc aggctggagc tgcaagtcag ttcatcacag tgactcccac aagtcccatg
     2461 gaggcacaag cagaaggacc cctgactgcg attacaattc ctcgaccttc tgtggcatca
     2521 acacagtcaa cttcaggaag ttttcactat ggcccacaac cagagaagaa agatcttcag
     2581 cccttggagc ccaccgtaga actcttctct ccaagggaga acttctcggg cttggctgtg
     2641 acagagggtg aactaggaag cggaggaagc agagtggatt tgggacttca gatagatcac
     2701 attggtcatg gcatgttacc caacatgaaa gatggtgacg cgtctcaaga cttaggacca
     2761 agagaccttc ctgacagtaa tagattagtt gtgaaagaat ttgaaaatct ccctggagaa
     2821 acagaagaga aaagcattct tctgggctca gataatgaag atgagaagct aaataaaggg
     2881 caacactgta ttgagatctc tctcccagga gatttagtga ccacagaaag ggatcagtca
     2941 gctaccacag aacctctgga tgtgtcaaag acacagaatt tcagtgtggt gcctaatcag
     3001 gacaaaaacc atgagataat gaagcttttg gcagttggaa cgtcagaaat gtctccacaa
     3061 gccattgacc cacatgctga agggcagata ggccaggtgg caacagtgca aaaacacaag
     3121 ctatttaaag atgacactaa gagtgagagc ttgccaggcc agcagggaga ccttgctact
     3181 tttttgcacc aagagggtaa gagagagaaa gttgccccta gaaatggaga gctctatcac
     3241 tgtgtctcag agagtgagca tgggcctcct acccggaagg acatgcttcg gtcgtccttg
     3301 gtgaccaggc acagccggat ccctgtttta gcacaagaaa tagactcaac ttttgaatca
     3361 tcctctgcag tctctgcaaa agaaaagctt ttacagaaga aagcctatca gccagaaata
     3421 gtcaaacttc tggtagaaaa aaggcaattc aagtctttcc tcggggacct ctcaagtgcc
     3481 tctgagaagc tgatggagga gaagctagct gctgctgcag ttcccttttc tgaggaggaa
     3541 gtcttcgccc ccttttccag actggcagta gacccccagc tgagtaggtc agttgaagat
     3601 ggctttctgt cacccatcgt ctcccagtct agaaagagca agattccgag gccagtatcc
     3661 tgggtcagca cagatcaaat caatagctca gcttcacctc agttcttgcc tcggccgcca
     3721 ccgggaaagc caccagtaag gcctggagta gaagccaggc tacgcagata taaagttcta
     3781 gggagtagta actctgattc agaccttttc tctcgcctgg cccaaattct tcaaaatgga
     3841 tctcagaaat cccggagtac tacacaatgc aagagcccag gatctcctca caatccaaaa
     3901 acaccaccca agagtccagt tgtacctcga aggagtccca gtgcctctcc tcgaagctct
     3961 tccttgcctc gaacatctag ttcctcacca tctagggctg gacggcccca ccatgaccag
     4021 aggagttctt ccccacatct ggggagaagc aagtcacctc ccagccactc aggatcatca
     4081 tcctccagga ggtcctgcca acaggagcat tgcaaaccca gcaagaatgg ccccaaagga
     4141 tctggcagcc tccaccacca ctcagccagc tctaaaactc ccccagggaa gagtaagcca
     4201 gccagtaaac tcagcagata ggaagtgagc aggctgcatc tctgggaaag gtgtgagatc
     4261 ttccttctag acctgatgca tgtgtgtccc tgtactgtct gtttcaaaca atcagtgttg
     4321 atcttctctt acaaaagaaa gtaacatgat cagttattta taacaagact taagtataat
     4381 tatctagggc aggtaggaag cacatcaaga gcctttgcat aggaagcttc ggtccagcaa
     4441 tgtttaaggg gaagaaactc actgagctct tgtttaaagc tgcatttgaa acagaaaatt
     4501 gaggatagga aatagaatgg gattttaagt gatttttttc ataatttgtt aaacctctac
     4561 tcaaaaagta tatagcaaaa gtgtttgata tttttattta aaacttccta accttggaga
     4621 gtcattgcac agacattcaa atataagaag cctgttgcca ggaaaccatt acctgggtat
     4681 atttggtttg tgtgtttatt tagtgaatct acatcttttc cactcattct tagtatcttt
     4741 cctggatttt acatttttta aagttaatgt ttttaccttt tattttaaca acacaccgta
     4801 atgtgtgtta cagcagtaca caataacact ctaacatcca gttaccttta tttattcaaa
     4861 cctggctatt ttcctttgag caacagttct tattcttacc tcctatattt ttatctcaaa
     4921 aaggaaagaa tgtctagcta gagctatttt gggccggtgt gctttgagag gggcagagag
     4981 tggcacaatg gctttcaaag gtagaagtgt ccctcccccg actacatgtc ctcctcgaag
     5041 aaggagacgg accggaggag acagctttcc tgggttcttt ctagtgtcag ctctcagggt
     5101 gatgctagga aagaacaata cttcagattg tggcttatac tttttagaaa tttagaaata
     5161 aaatatgtta ctgaggttta ccatcagatt ttgtatttta tacatttagc caataaggaa
     5221 tgaatacctg ggaaataaat ttagactaaa tagttttctt tcaatgtttt tattacctgg
     5281 ttcttgtgtt gtttaatgct tgggcttctt agccagattt ccacatttat aagacgacgt
     5341 aagtataatt agggcaggaa ggaagcacat caagagtcga tgcctttgca taggaagctt
     5401 cggtccagca cagtccaagg gggagaaact cactgagctc ttgtttatag ctgccgttga
     5461 catctaaatt tcaatttata aagttgtaag gatgatattt gttctaatct cactctccta
     5521 ctagcagaaa ccaggcaaat taaagacagc agacttttta agtgggctat ttgacgccct
     5581 gtggctgtat aaaaacttta ttgaggacag ggaagttgat gtgcctgctg ttgaggtctg
     5641 ccttttaaca gacgttactt ttgactattg cattgctgcc aaacagtttg aggaggaggg
     5701 ggtaggaatg gaagtgtctt cactaagtgg acatgttccg gtggtgcatc ccaactgccc
     5761 tggcgttgcg ctgtctcagc ttgttctgtg ttgagcgttt gcaaacttgg gacactacac
     5821 tgagacacaa ggtctcccgt gagaaatgtg gcgtagtgtg gaatcttaat tcttcccagg
     5881 ttcaagcact tgtgagcgag gcccactgct gtttctctct cacaactgtg tgctggagac
     5941 tgatccttat gtatcctatt gtataacttt gctgcagaac tgcttgcatg tctttcatgg
     6001 taaattatat aaatatttat aaatagagac atacgcttat ataaatccat tttttctcat
     6061 tttgcatttg taatttcaag atcatagatg ataaaattcc ttttctacta tgtgcctcgg
     6121 gtacacttgg gcattgcctg tcttcatttt ctgaaagtat gttcttggca tgtgatacgt
     6181 aagagtcgtc tgccttccgg gtgcatagtg cagcagctgg cagtttttac caagccgagg
     6241 tataaggtac ttaattttca cttaaaaagt attttaacag gggaaaattg taaccagata
     6301 tgcttgtaat acaggctcaa agatgactca tgtcagccac atagttctgt cattatggct
     6361 aaagtggata gatgggcatc ataattatgg atctggcatc aactttttta aacatttcct
     6421 ggaagttgcc tctttcgtgt cactcttttg aaggggatgg gatgtaggat aactgaaatt
     6481 atctctttct gttacattag ctaaatgatg ctaaaagtag ccagctttct cactgtcctc
     6541 tctagtcaga aatgtgctga tagtaactgg gaaagctaat cgggcccagc ctttttcttt
     6601 gtgaatttat ctgctggcag tcatgctgac acacaggatg ttttctgtct gggtttactt
     6661 tctccagcct ttcagtgtgt tgcctccttt tctacacgtt gttaacaaat tcatcaaatt
     6721 ccagagacaa aaggcctctc attatgtgag aatgctttat tttgtatgta gtgaaaagag
     6781 ccaaccaaag atgtttctgc tctgaaggaa aggaaacaga ctgagtaatt atgtcttgtg
     6841 tatcagtaat tacatttatt aagtgttgtc ctgatataga ggttagaaag tggagctggg
     6901 cgtggcaaca cacactttga tcctagcact ctggatctct gagtttgaag ccagcctggt
     6961 ctacagagtg agttccagca cagccagggc tacacagaga aatcctgtct tgaagaaaca
     7021 aacaaacaga caaaggatta aaacatatag tttgtgcttt tagatgttac atttctttca
     7081 ggttaaaaat agaagttggc agccttaagc caactcttgg ctcaggagta tggtctacag
     7141 agaatcaagc ttttgttttg gtttggattt tcagttattt tgagatttat tttgaggttt
     7201 ttgttgatgg catattccac atttcaatca caaatcatcc aagtatagtg aagaacatga
     7261 ctatagccat aatggaagta gtgcatgaca gaagaaatct tttgggaaac aagtacctcc
     7321 tggcttctat ctgcacaggt tactagctca agcctgtcct taccttattt agtctgtgtg
     7381 attatttcag tggagcaaag aatggacact tagttcctaa ttttaggtaa tgttgccccc
     7441 ccaattatac tactgacctg taggctctgt gaattgctta aaatattaaa ttcatacctt
     7501 gtaatcttgc acagcctaaa gatatctgac tttaatggat agtgaaaaca ggaaggaatt
     7561 ggatcctatc tgattcaaca ttaagctcaa gatcttaagt cacctttcaa tgaagcactt
     7621 atctcagctt tggtacacaa gctggccttg caaacaggag cacagccacc tttagttctt
     7681 tagttgcatg ctttgcaatg aatgtttttg gtaaaagttg caacaagtta atcaaggcct
     7741 aaaaaaatag caacaaaatg gtcaaagact tgttgccatc actgtaggtt atttgctcta
     7801 gcacaccaaa ccactgaatg ctgatgttgt gtcctacaca tgtaggacct ctgtctattt
     7861 tattcctggc cactgtggga acttgagggg ctgcagcaga taccagagac tttctcgcag
     7921 tcacagattc ctaggctgct gtttgtgtgg ttgcatccat tgtacaaagg aaaaggtata
     7981 cattgctgca tgttttataa acctagacca catagctagc tagctaagta ataatgagat
     8041 tttctacacc caataacctt gacaaacagg tgccttttcc ttaagggcag aaaattttac
     8101 atttctaatc taacattagg aattggtgat aggagaaaca ggatccacaa tttagtggtt
     8161 taaggaaaaa aattgcatct tgaaaatgct atcttaaaat gtatttatag ataatctaga
     8221 ttcatctgtg gagatcagtt tctcatattt taaaaacttg ttagctaggt gtgatggctc
     8281 atgtttctaa ccaatctttg agggactgag gtgggacgat ggaagagagc ctgaagccac
     8341 cctctgcttc atagtgattt caagtccacc tgggctgtag tgtgggaccc tctcccccca
     8401 aaaacaaaac aaaaacatta ttttttaatt attaagtttt catacatgta tgtatatatt
     8461 atatgttgag tgtacctctc atttgtatct gtcatggcat gtctttaaga atgacttctg
     8521 tcatgtttat ggtttgcatt cactttttta caatgtgcct atttatggct ttgggatatt
     8581 gtttctgagg agaggtcacc tctgtcactg aggtaatagg acatttgtaa ccaactgtac
     8641 tgcttaaatt cttgaatttg gttctataga caacatattt gcagaatagt tatttatgtt
     8701 ttaatccaaa cggattacag gattacagta acaactctgg tggtccttac ataccaacag
     8761 tctttatagt cctaactcag aagccactga agtgcacatt agaccttaag attatagagg
     8821 aaactagagg cagttccaca actaagacaa tgggaggtgt gatgcctggt aagcatgacc
     8881 cctacttctt cactaaaact tgacaaaact cacattattg ggtatttgcc ttattttggc
     8941 catttctcca gaattttaac atactcttgg agccttaagg atcttgttat gcaatattgc
     9001 tttccacaac tgcagaaagt agaaaattcc taggtaagtc ccaagtatgg aacaagaacc
     9061 cctgtttact tagagaatat gggtaaagta tgtaggcttt cagataagtt cttcctcttg
     9121 tgagaggatt tgcatcagaa aattagtgat aaggtcatct cttggtttca caaaaatctc
     9181 aagatgctaa atggcaaaga tttactcagt aatgattcca gtatttgctc ccacacaagt
     9241 actaataacc atgacagcta aggcaagttc aaggtgatgg gatgattttc ctatactgtg
     9301 ctcaatcctt ggttgtaagg agccttgtaa caaaagtggt gtccctttca ttgtccctac
     9361 aatgtaacaa gtttctgcat tttctcattg gaggggataa tatctacact acaggctcat
     9421 gatgatgctg accacatctc ctggtacctt caaccaggat ttctagacca acagcagtat
     9481 gaatgaggga gactaacaga attacagaat ttgctaataa cattatttta cattaacagt
     9541 gggaaagagt tatctcaata atttaaaatg attttgtatt atatacatga ttgtttaaag
     9601 acattagtaa accaagtttt tatgtagact atccttgcca tatgatactt aaaactctta
     9661 taaaatgtaa tttaaaacct caaagttgga atgtgcccgg tgttttttgc tcacgtcaca
     9721 gcagtaaaca aggctataga gtttggctgt gatttatttt agggagtttg caaagaagaa
     9781 agctttgaga ctttattcaa aacagtttgg gtttgggttt ttttgtttgg gttttgtttt
     9841 gtttttaatt ttgggggggg gtggttgttt tgttttgttt tgtttttgag aagaggtttt
     9901 tctgtgtagc cctggcctgg agctccctct gtagaccagg ctggcctcaa actctccagg
     9961 tctgcctgcc tctgcctcct gagtgctgag actaaaggtg tgtgtcacca tgcctggcta
    10021 agacagtttt attaaattat tcatcagtta gtgaaattag ttctctaaca taattaagaa
    10081 attaaaatat aggaaataag tcttttaagg caaaggaaat gtagtatttg ggccactcag
    10141 gggattgaaa ttggattaga tttcctaggc gtgatggtta tgtgcctgta atctcaccat
    10201 gtatgaggtg agggcaggaa caggagttga aggtcatacg tgttgagctg cataggctct
    10261 gaagctgagt agggctctat gaaccctgtc tctaaggggg tggggtctta gatgagagag
    10321 aggagactgt tggattggat gagttttgag actacagatc tgatgacctg ggcttgagcc
    10381 atcttgctgt tccctgatgc agttcttctc ctttgacacc tttcctaaat gctatctatt
    10441 tcatcagacc atttatttca gatttcaagg ttttcagaaa aggaggcaca tctcattttg
    10501 tattaaatat aataagttca taagttatta ttggcaaacg ttatcagatt tagtcacaat
    10561 ctgaattctc ttattgaaca agaaaaataa gtcaatgttt tactgtcctc ctcttagcaa
    10621 gatgaaaaat tgctcttttc aatgtatcac attgtatcct ttctccttcc agcatcttcc
    10681 ctttatgtgt ctttgctcag gcaaccactg gcatagagta ttgaaaaaca tgcagtgctt
    10741 ttgtataggc catctgtaca taaaagtgta attatttatt taattttccc atttgtacca
    10801 tattaaagct ttgtacagtg ttttaagttc tgttttaaaa ttattttgta ttttattttt
    10861 ataatctagt aataaaacat tcagtccgca tgcaaa
//
