LOCUS       NP_001402630            1242 aa            linear   ROD 01-APR-2024
DEFINITION  tau-tubulin kinase 2 [Rattus norvegicus].
ACCESSION   NP_001402630 XP_006234895
VERSION     NP_001402630.1
DBSOURCE    REFSEQ: accession NM_001415701.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1242)
  AUTHORS   Watanabe,T., Kakeno,M., Matsui,T., Sugiyama,I., Arimura,N.,
            Matsuzawa,K., Shirahige,A., Ishidate,F., Nishioka,T., Taya,S.,
            Hoshino,M. and Kaibuchi,K.
  TITLE     TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells
            through KIF2A phosphorylation
  JOURNAL   J Cell Biol 210 (5), 737-751 (2015)
   PUBMED   26323690
REFERENCE   2  (residues 1 to 1242)
  AUTHORS   Ye,X., Zeng,H., Ning,G., Reiter,J.F. and Liu,A.
  TITLE     C2cd3 is critical for centriolar distal appendage assembly and
            ciliary vesicle docking in mammals
  JOURNAL   Proc Natl Acad Sci U S A 111 (6), 2164-2169 (2014)
   PUBMED   24469809
REFERENCE   3  (residues 1 to 1242)
  AUTHORS   Goetz,S.C., Liem,K.F. Jr. and Anderson,K.V.
  TITLE     The spinocerebellar ataxia-associated gene Tau tubulin kinase 2
            controls the initiation of ciliogenesis
  JOURNAL   Cell 151 (4), 847-858 (2012)
   PUBMED   23141541
REFERENCE   4  (residues 1 to 1242)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (residues 1 to 1242)
  AUTHORS   Bouskila,M., Esoof,N., Gay,L., Fang,E.H., Deak,M., Begley,M.J.,
            Cantley,L.C., Prescott,A., Storey,K.G. and Alessi,D.R.
  TITLE     TTBK2 kinase substrate specificity and the impact of
            spinocerebellar-ataxia-causing mutations on expression, activity,
            localization and development
  JOURNAL   Biochem J 437 (1), 157-167 (2011)
   PUBMED   21548880
REFERENCE   6  (residues 1 to 1242)
  AUTHORS   Tomizawa,K., Omori,A., Ohtake,A., Sato,K. and Takahashi,M.
  TITLE     Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites
            found in paired helical filament-tau
  JOURNAL   FEBS Lett 492 (3), 221-227 (2001)
   PUBMED   11257498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 23, 2022 this sequence version replaced XP_006234895.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.18328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     Protein         1..1242
                     /product="tau-tubulin kinase 2"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=136301
     Region          20..281
                     /region_name="STKc_TTBK2"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Tau-Tubulin Kinase 2; cd14129"
                     /db_xref="CDD:271031"
     Site            order(27..31,35,48,50,78,94..97,100,102,141,143,145..146,
                     148,163,166,188..191)
                     /site_type="active"
                     /db_xref="CDD:271031"
     Site            order(27..31,35,48,50,78,94..97,100,141,143,145..146,148,
                     163)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271031"
     Site            order(31,100,102,141,143,145,166,188..191)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271031"
     Site            order(162..168,188..191)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271031"
     CDS             1..1242
                     /gene="Ttbk2"
                     /coded_by="NM_001415701.1:493..4221"
                     /db_xref="GeneID:311349"
                     /db_xref="RGD:1311661"
ORIGIN      
        1 msgggeqpdi lsvgilvker wkvlrkiggg gfgeiydald mltrenvalk vesaqqpkqv
       61 lkmevavlkk lqgkdhvcrf igcgrndrfn yvvmqlqgrn ladlrrsqsr gtftisttlr
      121 lgkqilesie sihsvgflhr dikpsnfamg rfpstcrkcf mldfglarqf tnscgdvrpp
      181 ravagfrgtv ryasinahrn remgrhddlw slfymlvefv vgqlpwrkik dkeqvgsike
      241 rydhrlmlkh lppefstfld hissldyftk pdyqlltsvf dnsiktfgvi esdpfdweks
      301 gtdgsltttt tsatpqlhtr ltpaaigian atpipgdllr entdevfpde qlsdgengip
      361 agvspdklpg slghprpqek dvweemdink nkiklgicka ateeenshgq vngilnapsl
      421 gspirvrsei tqpdrdvplv rklrsihsfe lekrltlepk pdtdkfletc mekmqkdssa
      481 gkepvlpalp hkpcvpavpr tdhvwhydee yppdaskpas antpeqadgg gshgfiavnl
      541 ssckqevdsk ewvivdkeqd lrdfrtnevl ghkttgspsd eepevlqvle gspqdekiqv
      601 gpwtdnqhlk kessgvilal saecpataas elytdrldlq agaasqfitv tptspmeaqa
      661 egpltaitip rpsvastqst sgsfhygpqp ekkdlqplep tvelfspren fsglavtege
      721 lgsggsrvdl glqidhighg mlpnmkdgda sqdlgprdlp dsnrlvvkef enlpgeteek
      781 sillgsdned eklnkgqhci eislpgdlvt terdqsatte pldvsktqnf svvpnqdknh
      841 eimkllavgt semspqaidp haegqigqva tvqkhklfkd dtkseslpgq qgdlatflhq
      901 egkrekvapr ngelyhcvse sehgpptrkd mlrsslvtrh sripvlaqei dstfesssav
      961 sakekllqkk ayqpeivkll vekrqfksfl gdlssasekl meeklaaaav pfseeevfap
     1021 fsrlavdpql srsvedgfls pivsqsrksk iprpvswvst dqinssaspq flprpppgkp
     1081 pvrpgvearl rrykvlgssn sdsdlfsrla qilqngsqks rsttqckspg sphnpktppk
     1141 spvvprrsps asprssslpr tsssspsrag rphhdqrsss phlgrskspp shsgssssrr
     1201 scqqehckps kngpkgsgsl hhhsassktp pgkskpaskl sr
//
