LOCUS       NP_001258159            1307 aa            linear   ROD 24-JUN-2024
DEFINITION  tau-tubulin kinase 1 [Rattus norvegicus].
ACCESSION   NP_001258159 XP_001066190 XP_038939447 XP_244043
VERSION     NP_001258159.1
DBSOURCE    REFSEQ: accession NM_001271230.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1307)
  AUTHORS   Watanabe,T., Kakeno,M., Matsui,T., Sugiyama,I., Arimura,N.,
            Matsuzawa,K., Shirahige,A., Ishidate,F., Nishioka,T., Taya,S.,
            Hoshino,M. and Kaibuchi,K.
  TITLE     TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells
            through KIF2A phosphorylation
  JOURNAL   J Cell Biol 210 (5), 737-751 (2015)
   PUBMED   26323690
REFERENCE   2  (residues 1 to 1307)
  AUTHORS   Chen,S., Lu,F.F., Seeman,P. and Liu,F.
  TITLE     Quantitative proteomic analysis of human substantia nigra in
            Alzheimer's disease, Huntington's disease and Multiple sclerosis
  JOURNAL   Neurochem Res 37 (12), 2805-2813 (2012)
   PUBMED   22926577
REFERENCE   3  (residues 1 to 1307)
  AUTHORS   Sato,S., Xu,J., Okuyama,S., Martinez,L.B., Walsh,S.M.,
            Jacobsen,M.T., Swan,R.J., Schlautman,J.D., Ciborowski,P. and
            Ikezu,T.
  TITLE     Spatial learning impairment, enhanced CDK5/p35 activity, and
            downregulation of NMDA receptor expression in transgenic mice
            expressing tau-tubulin kinase 1
  JOURNAL   J Neurosci 28 (53), 14511-14521 (2008)
   PUBMED   19118186
REFERENCE   4  (residues 1 to 1307)
  AUTHORS   Sato,S., Cerny,R.L., Buescher,J.L. and Ikezu,T.
  TITLE     Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase
            candidate, is involved in tau phosphorylation and aggregation
  JOURNAL   J Neurochem 98 (5), 1573-1584 (2006)
   PUBMED   16923168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Oct 18, 2022 this sequence version replaced
            XP_038939447.1, XP_244043.5, XP_001066190.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1307
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     Protein         1..1307
                     /product="tau-tubulin kinase 1"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=141459
     Region          33..294
                     /region_name="STKc_TTBK1"
                     /note="Catalytic domain of the Serine/Threonine protein
                     kinase, Tau-Tubulin Kinase 1; cd14130"
                     /db_xref="CDD:271032"
     Site            order(40..44,48,61,63,91,107..110,113,115,154,156,
                     158..159,161,176,179,201..204)
                     /site_type="active"
                     /db_xref="CDD:271032"
     Site            order(40..44,48,61,63,91,107..110,113,154,156,158..159,
                     161,176)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271032"
     Site            order(44,113,115,154,156,158,179,201..204)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271032"
     Site            order(175..181,201..204)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271032"
     Region          324..>682
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          962..>1304
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     CDS             1..1307
                     /gene="Ttbk1"
                     /gene_synonym="RGD1559518"
                     /coded_by="NM_001271230.2:322..4245"
                     /db_xref="GeneID:316229"
                     /db_xref="RGD:1559518"
ORIGIN      
        1 mqclaaalkd etnmsgggeq adilpanyvv kdrwkvlkki ggggfgeiye amdlltrenv
       61 alkvesaqqp kqvlkmevav lkklqgkdhv crfigcgrne kfnyvvmqlq grnladlrrs
      121 qprgtftlst tlrlgkqile sieaihsvgf lhrdikpsnf amgrlpstyr kcymldfgla
      181 rqytnttgdv rpprnvagfr gtvryasvna hknremgrhd dlwslfymlv efavgqlpwr
      241 kikdkeqvgm ikekyehrml lkhmpsefhl fldhiasldy ftkpdyqlim svfensmker
      301 giaeneafdw ekagtdalls tststppqqn trqtaamfgv vnvtpvpgdl lrentedvlq
      361 gehlsdqena ppilpgrppe glgpgphlvp hpggpeaevw eetdvnrnkl rinigktpcv
      421 eeeqsrgvgv psspvrappd spttpvrslr yrrvnspese rlstaadgra elqerrsrmd
      481 lpgspsrqac ssqpaqmlsv dtghadrqas grmdvsasve qealsnafrs vplaeeedfd
      541 skewviidke telkdfppga epstsgttde epeelrplpe egeerrrlgt eptvrprgrg
      601 mqtlaeedpr qmlpqpappq lsqadgrset sqpptpgsps hsplhsgprp rrresdptgp
      661 qrqvfsvapp fevnglprav plglpyqdfk rdlsdyrera rllnrvrrvg fshmllttpq
      721 vplapfqpqa ngkegeeeee edeeeeeeee eedeedeeee deededeeee eagalgevlg
      781 prsgsssegs ersqegapst lladdqkear grasmadgdl epeegsktlv lvspgdmkks
      841 pvtaelapdp dlgtlaaltp qherpqptgs qldvsepgtl ssilksepkp sgpgagvgvg
      901 lvapgagvta vtspftkver tfvhiaeksh lnvmssggqa prpeelstgg elglemlsev
      961 gaaeegapqp lengmalvgp dgtemescal sgppgetpse vvtdslpdgp aladepapas
     1021 pqepitkkgt iispsrhamp gsrprsripv llseedtgse psgslsaker wskrarpqqd
     1081 larlvmekrq grlllrlasg assssseeqr rasetlsgtg seedtpasep aaalprkagr
     1141 aattrsripr pisvsmpaeg qqlpgrphga asatdsaits rlqlqkppgl ataadhrpkq
     1201 pasrasgpgr aqvskpaapr spglptstar hssgsprsqs lsrkesssps hqarpgfpps
     1261 rgvlqvrsqs easpggpkkg pkgkqlqtlr aatkgrpavs egrpgnr
//
