LOCUS       NM_012808               1119 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus thiosulfate sulfurtransferase (Tst), mRNA.
ACCESSION   NM_012808 XM_343284
VERSION     NM_012808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Smirnov,A., Entelis,N., Martin,R.P. and Tarassov,I.
  TITLE     Biological significance of 5S rRNA import into human mitochondria:
            role of ribosomal protein MRP-L18
  JOURNAL   Genes Dev 25 (12), 1289-1305 (2011)
   PUBMED   21685364
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Smirnov,A., Comte,C., Mager-Heckel,A.M., Addis,V.,
            Krasheninnikov,I.A., Martin,R.P., Entelis,N. and Tarassov,I.
  TITLE     Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA
            import into human mitochondria
  JOURNAL   J Biol Chem 285 (40), 30792-30803 (2010)
   PUBMED   20663881
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1119)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1119)
  AUTHORS   Nagahara,N., Okazaki,T. and Nishino,T.
  TITLE     Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily
            related to mitochondrial rhodanese. Striking similarity in active
            site amino acid sequence and the increase in the mercaptopyruvate
            sulfurtransferase activity of rhodanese by site-directed
            mutagenesis
  JOURNAL   J Biol Chem 270 (27), 16230-16235 (1995)
   PUBMED   7608189
REFERENCE   8  (bases 1 to 1119)
  AUTHORS   Weiland,K.L. and Dooley,T.P.
  TITLE     Molecular cloning, sequencing and characterization of cDNA to rat
            liver rhodanese, a thiosulphate sulphurtransferase
  JOURNAL   Biochem J 275 (Pt 1) (Pt 1), 227-231 (1991)
   PUBMED   2018478
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088449.1.
            
            On Jan 13, 2005 this sequence version replaced XM_343284.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088449.1, FQ216517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1119
                     /gene="Tst"
                     /gene_synonym="RHODAN"
                     /note="thiosulfate sulfurtransferase"
                     /db_xref="GeneID:25274"
                     /db_xref="RGD:3913"
     exon            1..626
                     /gene="Tst"
                     /gene_synonym="RHODAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..925
                     /gene="Tst"
                     /gene_synonym="RHODAN"
                     /EC_number="2.8.1.1"
                     /note="rhodanese; Thiosulfate sulphurtransferase
                     (rhodanese); thiosulfate sulfurtransferase, mitochondrial"
                     /codon_start=1
                     /product="thiosulfate sulfurtransferase"
                     /protein_id="NP_036940.1"
                     /db_xref="GeneID:25274"
                     /db_xref="RGD:3913"
                     /translation="MVHQVLYRALVSTKWLAESIRSGKVGPSLRVLDASWYSPGTRQA
                     RKEYQERHVPGASFFDIEECRDTTSPYEMMLPSEAHFGDYVGNLGISNDTHVVVYDGD
                     DLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLNRS
                     LLKTYEQVLENLQSKRFQLVDSRAQGRYLGTQPEPDAVGLDSGHIRGSVNVPFMNFLT
                     EDGFEKSPEELRAIFQDKKVDLSQPLIATCRKGVTACHIALAAYLCGKPDVAVYDGSW
                     SEWFRRAPPETRVSQGKSGKA"
     exon            627..1094
                     /gene="Tst"
                     /gene_synonym="RHODAN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcgccag gtgacacgca gagctgacac tatggttcat caggtgctct atcgagcgct
       61 ggtctccacc aagtggctgg cggaatccat tcggtccggc aaggtggggc caagccttcg
      121 ggtgctggac gcgtcatggt actcaccagg gacccgccag gcacgcaaag agtaccagga
      181 gcgacacgtg cctggcgcgt ccttctttga tatagaggag tgccgggaca cgacttcgcc
      241 ttacgagatg atgctgccca gtgaggccca ctttggggac tacgtgggca acctgggcat
      301 aagcaacgac acacacgtcg tggtatacga tggagacgac ctgggcagct tctatgcacc
      361 cagagtatgg tggatgtttc gtgtgtttgg ccaccgcaca gtatcagtgc tcaatggtgg
      421 tttccggaac tggctgaagg agggccaccc ggtgacatct gaaccctcgc ggccagagcc
      481 agccgttttc aaagccacac tgaaccgctc cctgctcaag acctatgagc aggtcctgga
      541 gaacctccag tctaaaaggt tccagctggt ggattctcgg gcccagggac ggtacctggg
      601 cacacaaccg gagcccgatg cagtaggact ggactcaggc cacatccgtg gctctgtcaa
      661 cgtgcccttc atgaacttcc tgacagaaga tggcttcgag aagagcccag aggagctgcg
      721 tgccatattc caggacaaga aggtggacct ctcccagccc cttatcgcca catgccgcaa
      781 aggggtcact gcttgccaca ttgccctggc tgcctacctt tgtggcaagc ccgatgtggc
      841 tgtttacgat ggctcctggt cagagtggtt tcgcagggcc cccccggaga cccgtgtgtc
      901 ccaggggaag agtgggaagg cctgagtgtg tgcagcctcc tcttccgccc accagatcca
      961 gccagttccc ttcagtcagg cttgtatgac ctgctgaagg ttcgcctctt acgcaatgga
     1021 gattgacagg attttagaat tcctcttggt gccttccccc ctccctctac actggaataa
     1081 agtgcctttt ctcaaaaaaa aaaaaaaaaa aaaaaaaaa
//
