LOCUS       NM_001012019            1379 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus testis-specific serine kinase 2 (Tssk2), mRNA.
ACCESSION   NM_001012019 XM_221760
VERSION     NM_001012019.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Zhang K, Fu L, An Q, Hu W, Liu J, Tang X, Ding Y, Lu W, Liang X,
            Shang X and Gu Y.
  TITLE     Effects of Qilin pills on spermatogenesis, reproductive hormones,
            oxidative stress, and the TSSK2 gene in a rat model of
            oligoasthenospermia
  JOURNAL   BMC Complement Med Ther 20 (1), 42 (2020)
   PUBMED   32046715
  REMARK    GeneRIF: Effects of Qilin pills on spermatogenesis, reproductive
            hormones, oxidative stress, and the TSSK2 gene in a rat model of
            oligoasthenospermia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Jha KN, Coleman AR, Wong L, Salicioni AM, Howcroft E and Johnson
            GR.
  TITLE     Heat shock protein 90 functions to stabilize and activate the
            testis-specific serine/threonine kinases, a family of kinases
            essential for male fertility
  JOURNAL   J Biol Chem 288 (23), 16308-16320 (2013)
   PUBMED   23599433
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Li Y, Sosnik J, Brassard L, Reese M, Spiridonov NA, Bates TC,
            Johnson GR, Anguita J, Visconti PE and Salicioni AM.
  TITLE     Expression and localization of five members of the testis-specific
            serine kinase (Tssk) family in mouse and human sperm and testis
  JOURNAL   Mol Hum Reprod 17 (1), 42-56 (2011)
   PUBMED   20729278
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Xu B, Hao Z, Jha KN, Zhang Z, Urekar C, Digilio L, Pulido S,
            Strauss JF 3rd, Flickinger CJ and Herr JC.
  TITLE     Targeted deletion of Tssk1 and 2 causes male infertility due to
            haploinsufficiency
  JOURNAL   Dev Biol 319 (2), 211-222 (2008)
   PUBMED   18533145
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Xu B, Hao Z, Jha KN, Zhang Z, Urekar C, Digilio L, Pulido S,
            Strauss JF 3rd, Flickinger CJ and Herr JC.
  TITLE     TSKS concentrates in spermatid centrioles during flagellogenesis
  JOURNAL   Dev Biol 319 (2), 201-210 (2008)
   PUBMED   18495105
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Zhang Z, Shen X, Jones BH, Xu B, Herr JC and Strauss JF 3rd.
  TITLE     Phosphorylation of mouse sperm axoneme central apparatus protein
            SPAG16L by a testis-specific kinase, TSSK2
  JOURNAL   Biol Reprod 79 (1), 75-83 (2008)
   PUBMED   18367677
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Gong W, Emanuel BS, Collins J, Kim DH, Wang Z, Chen F, Zhang G, Roe
            B and Budarf ML.
  TITLE     A transcription map of the DiGeorge and velo-cardio-facial syndrome
            minimal critical region on 22q11
  JOURNAL   Hum Mol Genet 5 (6), 789-800 (1996)
   PUBMED   8776594
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079037.1.
            
            On Feb 11, 2005 this sequence version replaced XM_221760.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC079037.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1379
                     /gene="Tssk2"
                     /gene_synonym="Stk22b"
                     /note="testis-specific serine kinase 2"
                     /db_xref="GeneID:304181"
                     /db_xref="RGD:1304951"
     exon            1..1356
                     /gene="Tssk2"
                     /gene_synonym="Stk22b"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1145
                     /gene="Tssk2"
                     /gene_synonym="Stk22b"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine kinase 22B (spermiogenesis
                     associated)"
                     /codon_start=1
                     /product="testis-specific serine/threonine-protein kinase
                     2"
                     /protein_id="NP_001012019.1"
                     /db_xref="GeneID:304181"
                     /db_xref="RGD:1304951"
                     /translation="MDDAAVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIID
                     RKKTPTDFVERFLPREMDILATVNHRSIIKTYEIFETSDGRIYIVMELGVQGDLLEFI
                     KCRGALHEDVARKMFRQLSSAVKYCHDLDVVHRDLKCENLLLDKDFNIKLSDFGFSKR
                     CLRDGSGRIVLSKTFCGSAAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDD
                     SDIKKMLRIQKEHRVDFPRSKNLTGECKDLIYRILQPDVNRRLHIDEILSHSWLQPPK
                     PKAMSSASFKREGEGKYRADCKLDTRPGSRPEHRPDHKLGSKPQHRLLVAPENEDRME
                     ERLAETSRAKDHHISGAEVGKAST"
ORIGIN      
        1 ggacaatgcc tgctggcccg tgtggggagg ggatgtagag ggcggcggca ccggccgctc
       61 ctggcaccat ggacgatgcc gcggtcctaa ggaagaaggg ttacatcgtg ggaatcaatc
      121 tgggcaaggg ctcctatgca aaagtcaaat ctgcctactc agagcgcctc aagttcaatg
      181 tggcagtcaa gatcatagac cgcaagaaaa cacccactga ctttgtggag agattccttc
      241 ctagggagat ggacatcctg gcgactgtca accaccgttc catcattaag acctatgaga
      301 tctttgagac ctctgatgga cgcatctaca ttgtcatgga gctgggcgtc cagggcgacc
      361 tcctcgagtt catcaagtgc cgaggagccc tgcacgagga tgtggcacgc aagatgttcc
      421 gccagctctc ctcagccgtc aagtactgcc atgatctgga tgtcgtccac cgagacctca
      481 agtgtgagaa ccttctgctt gacaaggact tcaacatcaa gctgtctgac ttcggcttct
      541 ccaagcgctg cctgcgggac gggagcgggc gcatcgtcct cagcaaaacc ttctgtgggt
      601 cagcagctta tgcggccccc gaggtgctgc agggcatccc ctaccagccc aaggtgtatg
      661 acatctggag cctgggtgtg atcctctaca tcatggtctg tggctccatg ccctacgatg
      721 actctgacat caaaaagatg ctgcgcatcc agaaggagca ccgagtggac ttcccacgct
      781 ccaagaatct aactggtgag tgcaaggacc tcatctaccg catcctacag ccagatgtca
      841 accggaggct gcacattgat gagatcctca gccactcgtg gcttcagccc cccaagccca
      901 aagccatgtc ttctgcctcc ttcaagaggg agggggaagg caagtatcga gctgattgca
      961 agttggatac tcgaccaggc tcaagacccg aacaccggcc tgaccacaaa ctggggagca
     1021 aaccccagca ccggctgctg gtagcacctg agaatgaaga caggatggag gagaggctgg
     1081 cggagacttc cagagctaaa gaccatcaca tctctggagc tgaggtgggg aaagcaagta
     1141 cctagtggcg gagagggccc tgggggatca tggtgtgcag tctgcaccca cataagctaa
     1201 gtaggaggta ggagctgaag aaggcacagg tgcaaggaac aagtaaaatc cgtcaattaa
     1261 accactattt tgattacgtt ctattagctt tcttccactt cgtagcaaag ccattaatta
     1321 ctgaccacca aataaaccac aaagtgtata caagcaaaaa aaaaaaaaaa aaaaaaaaa
//
