LOCUS       NM_001399519            1178 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Rattus norvegicus TSR3 ribosome maturation factor (Tsr3),
            transcript variant 2, mRNA.
ACCESSION   NM_001399519 XM_006245996
VERSION     NM_001399519.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Meyer,B., Wurm,J.P., Sharma,S., Immer,C., Pogoryelov,D., Kotter,P.,
            Lafontaine,D.L., Wohnert,J. and Entian,K.D.
  TITLE     Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl
            transferase responsible for 18S rRNA hypermodification in yeast and
            humans
  JOURNAL   Nucleic Acids Res 44 (9), 4304-4316 (2016)
   PUBMED   27084949
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 10, 2022 this sequence version replaced XM_006245996.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.12906.1,
                                           SRR26643298.59353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000010.1  14761666-14761829
            165-384             JAXUCZ010000010.1  14761909-14762128
            385-578             JAXUCZ010000010.1  14762538-14762731
            579-755             JAXUCZ010000010.1  14763127-14763303
            756-819             JAXUCZ010000010.1  14763412-14763475
            820-1178            JAXUCZ010000010.1  14763703-14764061
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1178
                     /gene="Tsr3"
                     /gene_synonym="RGD1565744"
                     /note="TSR3 ribosome maturation factor"
                     /db_xref="GeneID:360494"
                     /db_xref="RGD:1565744"
     exon            1..164
                     /gene="Tsr3"
                     /gene_synonym="RGD1565744"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1027
                     /gene="Tsr3"
                     /gene_synonym="RGD1565744"
                     /EC_number="2.5.1.157"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ribosome biogenesis protein TSR3 homolog; TSR3, 20S rRNA
                     accumulation; TSR3, acp transferase ribosome maturation
                     factor; 18S rRNA aminocarboxypropyltransferase"
                     /codon_start=1
                     /product="18S rRNA aminocarboxypropyltransferase isoform
                     2"
                     /protein_id="NP_001386448.1"
                     /db_xref="GeneID:360494"
                     /db_xref="RGD:1565744"
                     /translation="MGRKKVARGSKTEGGRVRRPPGRSLDAFAEEVGAALRASVQTEE
                     AENQSGPDPAALPCALAMWELGHCDPKRCTGRKLARLGLVRCLRLSQRFGGLVLSPVG
                     TQYVSPADRQLVAQSGIAVIDCSWAKLDETPFGKMRGSHLRLLPYLVAANPVNYGRPC
                     KLSCVEAFAAAFCIVGFSDLAVILLRKFKWGKGFLDLNRQLLDKYAACCGPEEVLEAE
                     QGYLASTKDTPEEENIDPFDVDSGREFANLNRPVASTRLPMDTDDTDESEDHSEDSGE
                     DSDECEEQGPGANGGDSSYSQAEEIPEQEAQARDSTEIWKGIKKRQRD"
     exon            165..384
                     /gene="Tsr3"
                     /gene_synonym="RGD1565744"
                     /inference="alignment:Splign:2.1.0"
     exon            385..578
                     /gene="Tsr3"
                     /gene_synonym="RGD1565744"
                     /inference="alignment:Splign:2.1.0"
     exon            579..755
                     /gene="Tsr3"
                     /gene_synonym="RGD1565744"
                     /inference="alignment:Splign:2.1.0"
     exon            756..819
                     /gene="Tsr3"
                     /gene_synonym="RGD1565744"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1178
                     /gene="Tsr3"
                     /gene_synonym="RGD1565744"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgcacat gctttggaac gacccacgga gctgaggatt tcacataaca ttatgggccg
       61 caagaaggtt gctcgcgggt ccaagacaga gggcggtcgt gttcggcgac cccctggccg
      121 ctctctggat gctttcgctg aggaggtggg cgctgcgctg cgcgcatcgg tgcagactga
      181 agaggccgag aaccagagtg gcccggaccc tgcggcgctg ccttgtgcct tggctatgtg
      241 ggagcttggc cactgtgacc ccaagcgctg cacgggccgc aaactggccc gtctgggtct
      301 tgtgcgctgc ctgcgcctga gccaaagatt tggcggtctg gtgctcagcc cagtaggcac
      361 tcagtacgtg tctccggcag acagacaact ggtggcacag tcagggatcg ctgtcataga
      421 ctgctcttgg gccaaattgg atgagacacc ctttggaaag atgcgaggga gccacttgcg
      481 gctcctacct tacctcgtag ctgcgaaccc tgtcaactat ggccggccct gcaaactttc
      541 ctgtgtggaa gctttcgctg ctgccttctg cattgtaggc ttttcagacc ttgctgtcat
      601 tttgcttcgg aagtttaagt ggggcaaggg cttcttggac ctgaaccgac agcttctgga
      661 taagtacgct gcctgctgtg gcccagagga ggtgctagag gctgaacagg ggtacttggc
      721 tagcaccaag gacacccctg aggaggagaa catcgatccc tttgacgtgg actccgggcg
      781 ggagtttgca aacctcaaca gacctgtggc cagcacccgt ctgcctatgg acacggatga
      841 cactgatgag tcagaggacc acagtgagga ttctggggag gacagtgatg agtgtgagga
      901 acaaggacct ggtgctaatg gaggggacag cagctactct caagcagaag agatcccaga
      961 acaagaggct caggccagag actccactga aatttggaaa ggaatcaaga aacgacagag
     1021 agactgaagg ttgcaaacaa tattattgaa gatggtgtgc actaatcaga agtggcagta
     1081 ggacctgggg atggacaggc ctgttgggac aattctggga cagccttgtt tggagtcttg
     1141 ccttagagct ctcaataaag ccaaggaggt gcccccac
//
