LOCUS       NM_012515                857 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus translocator protein (Tspo), mRNA.
ACCESSION   NM_012515
VERSION     NM_012515.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 857)
  AUTHORS   Guillemain,G., Khemtemourian,L., Brehat,J., Morin,D., Movassat,J.,
            Tourrel-Cuzin,C. and Lacapere,J.J.
  TITLE     TSPO in pancreatic beta cells and its possible involvement in type
            2 diabetes
  JOURNAL   Biochimie 224, 104-113 (2024)
   PUBMED   38908539
  REMARK    GeneRIF: TSPO in pancreatic beta cells and its possible involvement
            in type 2 diabetes.
REFERENCE   2  (bases 1 to 857)
  AUTHORS   Brehat,J., Leick,S., Musman,J., Su,J.B., Eychenne,N., Giton,F.,
            Rivard,M., Barel,L.A., Tropeano,C., Vitarelli,F., Caccia,C.,
            Leoni,V., Ghaleh,B., Pons,S. and Morin,D.
  TITLE     Identification of a mechanism promoting mitochondrial sterol
            accumulation during myocardial ischemia-reperfusion: role of TSPO
            and STAR
  JOURNAL   Basic Res Cardiol 119 (3), 481-503 (2024)
   PUBMED   38517482
  REMARK    GeneRIF: Identification of a mechanism promoting mitochondrial
            sterol accumulation during myocardial ischemia-reperfusion: role of
            TSPO and STAR.
REFERENCE   3  (bases 1 to 857)
  AUTHORS   Mahemuti,Y., Kadeer,K., Su,R., Abula,A., Aili,Y., Maimaiti,A.,
            Abulaiti,S., Maimaitituerxun,M., Miao,T., Jiang,S., Axier,A.,
            Aisha,M., Wang,Y. and Cheng,X.
  TITLE     TSPO exacerbates acute cerebral ischemia/reperfusion injury by
            inducing autophagy dysfunction
  JOURNAL   Exp Neurol 369, 114542 (2023)
   PUBMED   37717810
  REMARK    GeneRIF: TSPO exacerbates acute cerebral ischemia/reperfusion
            injury by inducing autophagy dysfunction.
REFERENCE   4  (bases 1 to 857)
  AUTHORS   Ceyzeriat,K., Nicolaides,A., Amosse,Q., Fossey,C., Cailly,T.,
            Fabis,F., Garibotto,V., Escartin,C., Tournier,B.B. and Millet,P.
  TITLE     Reactive astrocytes mediate TSPO overexpression in response to
            sustained CNTF exposure in the rat striatum
  JOURNAL   Mol Brain 16 (1), 57 (2023)
   PUBMED   37408083
  REMARK    GeneRIF: Reactive astrocytes mediate TSPO overexpression in
            response to sustained CNTF exposure in the rat striatum.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 857)
  AUTHORS   Gao,N., Ma,B., Jia,H., Hao,C., Jin,T. and Liu,X.
  TITLE     Translocator protein alleviates allodynia and improves Schwann cell
            function against diabetic peripheral neuropathy via activation of
            the Nrf2-dependent antioxidant system and promoting autophagy
  JOURNAL   Diabet Med 40 (6), e15090 (2023)
   PUBMED   37013248
  REMARK    GeneRIF: Translocator protein alleviates allodynia and improves
            Schwann cell function against diabetic peripheral neuropathy via
            activation of the Nrf2-dependent antioxidant system and promoting
            autophagy.
REFERENCE   6  (bases 1 to 857)
  AUTHORS   Lacor,P., Benavides,J. and Ferzaz,B.
  TITLE     Enhanced expression of the peripheral benzodiazepine receptor (PBR)
            and its endogenous ligand octadecaneuropeptide (ODN) in the
            regenerating adult rat sciatic nerve
  JOURNAL   Neurosci Lett 220 (1), 61-65 (1996)
   PUBMED   8977149
REFERENCE   7  (bases 1 to 857)
  AUTHORS   Masonis,A.E. and McCarthy,M.P.
  TITLE     Direct interactions of androgenic/anabolic steroids with the
            peripheral benzodiazepine receptor in rat brain: implications for
            the psychological and physiological manifestations of
            androgenic/anabolic steroid abuse
  JOURNAL   J Steroid Biochem Mol Biol 58 (5-6), 551-555 (1996)
   PUBMED   8918981
REFERENCE   8  (bases 1 to 857)
  AUTHORS   Bar-Ami,S., Amiri,Z., Fares,F. and Gavish,M.
  TITLE     Modulation of peripheral benzodiazepine receptors in female rat
            genital organs by various gonadal steroids
  JOURNAL   Life Sci 54 (25), 1965-1975 (1994)
   PUBMED   8201845
REFERENCE   9  (bases 1 to 857)
  AUTHORS   Casalotti,S.O., Pelaia,G., Yakovlev,A.G., Csikos,T., Grayson,D.R.
            and Krueger,K.E.
  TITLE     Structure of the rat gene encoding the mitochondrial benzodiazepine
            receptor
  JOURNAL   Gene 121 (2), 377-382 (1992)
   PUBMED   1332914
REFERENCE   10 (bases 1 to 857)
  AUTHORS   Sprengel,R., Werner,P., Seeburg,P.H., Mukhin,A.G., Santi,M.R.,
            Grayson,D.R., Guidotti,A. and Krueger,K.E.
  TITLE     Molecular cloning and expression of cDNA encoding a peripheral-type
            benzodiazepine receptor
  JOURNAL   J Biol Chem 264 (34), 20415-20421 (1989)
   PUBMED   2555358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM047408.1, J05122.1 and BQ194961.1.
            
            On Feb 9, 2012 this sequence version replaced NM_012515.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228784.1, AW913934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               FM047408.1         5-178
            175-838             J05122.1           118-781
            839-857             BQ194961.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..857
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..857
                     /gene="Tspo"
                     /gene_synonym="Bzrp; MBR; Ptbzr; PTBZR02; RATPTBZR02"
                     /note="translocator protein"
                     /db_xref="GeneID:24230"
                     /db_xref="RGD:2228"
     exon            1..62
                     /gene="Tspo"
                     /gene_synonym="Bzrp; MBR; Ptbzr; PTBZR02; RATPTBZR02"
                     /inference="alignment:Splign:2.1.0"
     exon            63..273
                     /gene="Tspo"
                     /gene_synonym="Bzrp; MBR; Ptbzr; PTBZR02; RATPTBZR02"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..601
                     /gene="Tspo"
                     /gene_synonym="Bzrp; MBR; Ptbzr; PTBZR02; RATPTBZR02"
                     /note="PBR; PKBS; mitochondrial benzodiazepine receptor;
                     peripheral-type benzodiazepine receptor; Benzodiazepin
                     receptor (peripheral); benzodiazepine receptor,
                     peripheral"
                     /codon_start=1
                     /product="translocator protein"
                     /protein_id="NP_036647.1"
                     /db_xref="GeneID:24230"
                     /db_xref="RGD:2228"
                     /translation="MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHP
                     PRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGA
                     RQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSG
                     RRGGSRLTE"
     exon            274..412
                     /gene="Tspo"
                     /gene_synonym="Bzrp; MBR; Ptbzr; PTBZR02; RATPTBZR02"
                     /inference="alignment:Splign:2.1.0"
     exon            413..840
                     /gene="Tspo"
                     /gene_synonym="Bzrp; MBR; Ptbzr; PTBZR02; RATPTBZR02"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctacgcg cagcgcagtg tccttcacgg agcagccagc gactgcgtga gcgaggctgt
       61 ggatctttcc agaacagcag ttgcaatcac tatgtctcaa tcctgggtac ccgccgtggg
      121 cctcactctg gtgcccagcc tggggggctt catgggagcc tactttgtgc gtggtgaggg
      181 cctccgctgg tatgctagct tgcagaaacc ctcctggcat ccgcctcgct ggacactcgc
      241 tcccatctgg ggcacactgt attcggccat ggggtatggc tcctacataa tctggaaaga
      301 gctgggaggt ttcacagagg aggctatggt tcccttgggt ctctacactg gtcagctggc
      361 tctgaactgg gcatggcccc ccatcttctt tggtgcccgg cagatgggct gggctttggt
      421 ggacctcatg cttgtcagtg gggtggcaac cgccactacc ctggcttggc accgagtgag
      481 cccaccggct gcccgcttgc tgtatcctta cctggcctgg ctggcctttg ccaccatgct
      541 caactactat gtatggcgtg ataactctgg tcggcgaggg ggctcccggc tcacagagtg
      601 aggacaccta gccatcagga atgcagccct gccagccagg catcatgggt tgaggtcatc
      661 ctgctttcat gaccattggg cctgctggtc tacctggtct tagtccagga agccaccagg
      721 taggtcaagg tggtcagtgc taagtcccat gcggggacag ttgtacctgc ttttctgcac
      781 tgctgcaggc gtgccctagg agcatggggc ctttaaagct aaataaagtc tttaacttca
      841 aaaaaaaaaa aaaaaaa
//
