LOCUS       NM_001004090            2877 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tetraspanin 5 (Tspan5), mRNA.
ACCESSION   NM_001004090 XM_342350
VERSION     NM_001004090.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Moretto,E., Miozzo,F., Longatti,A., Bonnet,C., Coussen,F.,
            Jaudon,F., Cingolani,L.A. and Passafaro,M.
  TITLE     The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting
            with the AP4 complex
  JOURNAL   Elife 12, e76425 (2023)
   PUBMED   36795458
  REMARK    GeneRIF: The tetraspanin TSPAN5 regulates AMPAR exocytosis by
            interacting with the AP4 complex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Haining,E.J., Yang,J., Bailey,R.L., Khan,K., Collier,R., Tsai,S.,
            Watson,S.P., Frampton,J., Garcia,P. and Tomlinson,M.G.
  TITLE     The TspanC8 subgroup of tetraspanins interacts with A disintegrin
            and metalloprotease 10 (ADAM10) and regulates its maturation and
            cell surface expression
  JOURNAL   J Biol Chem 287 (47), 39753-39765 (2012)
   PUBMED   23035126
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Dornier,E., Coumailleau,F., Ottavi,J.F., Moretti,J., Boucheix,C.,
            Mauduit,P., Schweisguth,F. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and
            promote Notch activation in flies and mammals
  JOURNAL   J Cell Biol 199 (3), 481-496 (2012)
   PUBMED   23091066
  REMARK    Erratum:[J Cell Biol. 2016 May 23;213(4):495-6. doi:
            10.1083/jcb.20120113304262016c.. PMID: 27185832]
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Hemler,M.E.
  TITLE     Specific tetraspanin functions
  JOURNAL   J Cell Biol 155 (7), 1103-1107 (2001)
   PUBMED   11756464
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100135.1.
            
            On Aug 21, 2005 this sequence version replaced NM_001004090.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100135.1, AF540877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..2877
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /note="tetraspanin 5"
                     /db_xref="GeneID:362048"
                     /db_xref="RGD:1303176"
     exon            1..86
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..812
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /note="tetraspan 5; transmembrane 4 superfamily member 9"
                     /codon_start=1
                     /product="tetraspanin-5"
                     /protein_id="NP_001004090.2"
                     /db_xref="GeneID:362048"
                     /db_xref="RGD:1303176"
                     /translation="MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEK
                     GVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIF
                     FLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGAD
                     DWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYT
                     KGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW"
     exon            87..137
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /inference="alignment:Splign:2.1.0"
     exon            138..284
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /inference="alignment:Splign:2.1.0"
     exon            285..455
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /inference="alignment:Splign:2.1.0"
     exon            456..581
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /inference="alignment:Splign:2.1.0"
     exon            582..629
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /inference="alignment:Splign:2.1.0"
     exon            630..746
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /inference="alignment:Splign:2.1.0"
     exon            747..2852
                     /gene="Tspan5"
                     /gene_synonym="Tm4sf9; Tspan-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggatgtc cgggaagcac tacaagggtc ctgaagtcag ttgttgcatc aaatacttca
       61 tttttggctt caatgtcata ttttggtttt tgggaataac gtttcttgga attggactgt
      121 gggcgtggaa tgaaaaaggt gtcctgtcca atatctcgtc catcaccgac ctcggtggct
      181 ttgacccagt ctggcttttc ctcgtggtgg gaggagtgat gttcattctg gggtttgcag
      241 ggtgcatcgg agcactgcgg gaaaacacct tccttctcaa gtttttttct gtgttcctgg
      301 gaattatttt cttcctggaa ctcactgctg gggtgttggc atttgttttc aaagactgga
      361 tcaaagacca gctgtatttc tttattaaca acaacatcag agcctacaga gatgacattg
      421 atctgcagaa cctcatagac ttcacccagg aatactggca gtgctgcggg gcttttggag
      481 ctgacgattg gaacctaaat atttacttca actgcacaga ctccaatgca agccgagagc
      541 gatgtggtgt gccattctcc tgctgcacta aagaccccgc ggaagacgtc atcaacactc
      601 agtgtggcta tgatgccagg caaaaaccag aagttgacca acagattgtg atctacacaa
      661 aaggctgtgt gccccagttt gagaagtggc tacaggacaa tttaaccatt gtggctggta
      721 ttttcatagg aattgcactg cttcagattt ttgggatatg cctggcacag aatttggtga
      781 gtgacattga agctgtcagg gctagctggt agaaccctgc aaccactgct gtcagacact
      841 ggactgatcc cccctcgctg actgaccctc tgtgcgccgg ccggctgatg gcgggttgca
      901 gagacctggt cacaggcttg cagtctcacc caatggagct gccaagaact taactttctg
      961 caggggtaga acttggaaat gctgctcacg gacggtccct tgaacaagaa aaatgaaaca
     1021 gcgtgcaagt caccgagtcg ctgtgcggtg aatctctact gtagccgtga attgatggac
     1081 agatggatgc taccagaagg ggggaagggg gaggttgggc accgcatgta cttgacttta
     1141 tggagaatac agtgctgtcc acatcttggc taaaacttgg gtccttatcc gccagggcca
     1201 ggtgtcctga aatccctcaa tgcacatttc cagaaactgt tgcaactgtc ctccagagaa
     1261 gaaaacagcg ccccggtgtt cagattctgc gaggggtgga agaggtcatt tacagagtcc
     1321 gctctccttc ccaagtttac ccctaagaga gctgggtgtt ggtggcaaac tgaggccttg
     1381 atccacattt ccacaggact gatctttcct gagtggccag ccggagtctg agttttatca
     1441 gtgacatctg aggagaaaat gaggttaatg agagacacta attaaacacc ccctcgcccc
     1501 accttatcag actatctatc gggttcttct gatattctgg aatattctgg gctgcgtttt
     1561 gtgttctctc tctctctctc tctctctctc tctctctctc tctctttctc tctcttttta
     1621 tgactggttg ttgttttggt tcttttttcg tctcccaaag gcaaaggcta tatgacacag
     1681 tcctctgtaa tggtttccta ttcaacttaa acagtaagtt tctgtagaca cttcacctgc
     1741 atgtaccgtg acgcccccaa acccatgttc ttttcagaga gacatttgcg agtgtttgtt
     1801 ggtgttcacg ccttgggtgg tcgtggcatg ttgtcctaac tttgtcttca tacgccccat
     1861 gggctcactg cctctcccag catccagctc ggcttctgtc cactccccca tcctccataa
     1921 agcccagttc caaagcaggg ttgtcacggt caaaaagcat ttaatggggc tttcctttct
     1981 tttctctctc tctctctctc tctctctctc tctctctctc tctctctctc tctccctttt
     2041 tgcaacttca gttttgttgt atattaaata aaaaagcaag ccaagtatag tgcatggcag
     2101 agctctgtcc tcgctgaggt ggcctcaggg cagtaacaaa gcacaaatat ttgtgagtct
     2161 gcaccgaaag cccagccagg gttctgtgat gctaggtggg aagccacctc cgggtccttc
     2221 tcgtgcccac cgggaggatg ggattgagcc ccaggctttc acccagcttg tgataacccg
     2281 tggatgttgc tttcatgggg agcagatttt agtttgtggg tcgctgggaa gaccacagcc
     2341 tctgtgatag cagctcctct ttcgccagcc agcattctga gcaatgctat tttccacgtc
     2401 cacagcacgt gcgtgcattg tgtggctggt ggacacggtc cactcacagg gaggtcaggc
     2461 attcctctga agtctcatct ccacagtttg ggtgtatgtg gccctgcatg tttgtattgg
     2521 tgtctgttgt aggtagatat agtcattcca tccatggctg tgaggtcacg tgacttcacc
     2581 tctgcccata ccacagccgt cgcttgtgat gcccttcaac atggacacgc gtgctctcgg
     2641 attggcactt gtgtcttctt tattacctca ttctccagtg aactacatct ggccagttga
     2701 ttcagaatca ggcaagatcc ccaccccgtg gcacatacag tgaaagccaa aacacaagcc
     2761 caagtgagtt ttaaatttta atcacccttt attttttaca ctcgagagtg attgtaataa
     2821 aagctgtcat taataaactc ggttctacct taaaaaaaaa aaaaaaaaaa aaaaaaa
//
