LOCUS       NM_022589               3833 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus tetraspanin 2 (Tspan2), mRNA.
ACCESSION   NM_022589
VERSION     NM_022589.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3833)
  AUTHORS   de Monasterio-Schrader,P., Patzig,J., Mobius,W., Barrette,B.,
            Wagner,T.L., Kusch,K., Edgar,J.M., Brophy,P.J. and Werner,H.B.
  TITLE     Uncoupling of neuroinflammation from axonal degeneration in mice
            lacking the myelin protein tetraspanin-2
  JOURNAL   Glia 61 (11), 1832-1847 (2013)
   PUBMED   24038504
REFERENCE   2  (bases 1 to 3833)
  AUTHORS   Wansleeben,C., Feitsma,H., Montcouquiol,M., Kroon,C., Cuppen,E. and
            Meijlink,F.
  TITLE     Planar cell polarity defects and defective Vangl2 trafficking in
            mutants for the COPII gene Sec24b
  JOURNAL   Development 137 (7), 1067-1073 (2010)
   PUBMED   20215345
REFERENCE   3  (bases 1 to 3833)
  AUTHORS   Gobert,R.P., Joubert,L., Curchod,M.L., Salvat,C., Foucault,I.,
            Jorand-Lebrun,C., Lamarine,M., Peixoto,H., Vignaud,C., Fremaux,C.,
            Jomotte,T., Francon,B., Alliod,C., Bernasconi,L., Abderrahim,H.,
            Perrin,D., Bombrun,A., Zanoguera,F., Rommel,C. and Hooft van
            Huijsduijnen,R.
  TITLE     Convergent functional genomics of oligodendrocyte differentiation
            identifies multiple autoinhibitory signaling circuits
  JOURNAL   Mol Cell Biol 29 (6), 1538-1553 (2009)
   PUBMED   19139271
REFERENCE   4  (bases 1 to 3833)
  AUTHORS   Birling,M.C., Tait,S., Hardy,R.J. and Brophy,P.J.
  TITLE     A novel rat tetraspan protein in cells of the oligodendrocyte
            lineage
  JOURNAL   J Neurochem 73 (6), 2600-2608 (1999)
   PUBMED   10582623
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_022589.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ271442.1, BC085733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000002.1  192866280-192866372
            94-196              JAXUCZ010000002.1  192881412-192881514
            197-294             JAXUCZ010000002.1  192888838-192888935
            295-369             JAXUCZ010000002.1  192890773-192890847
            370-468             JAXUCZ010000002.1  192891902-192892000
            469-540             JAXUCZ010000002.1  192893482-192893553
            541-624             JAXUCZ010000002.1  192897674-192897757
            625-3833            JAXUCZ010000002.1  192904930-192908138
FEATURES             Location/Qualifiers
     source          1..3833
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3833
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /note="tetraspanin 2"
                     /db_xref="GeneID:64521"
                     /db_xref="RGD:620982"
     exon            1..93
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..690
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /note="tetraspan 2"
                     /codon_start=1
                     /product="tetraspanin-2"
                     /protein_id="NP_072111.1"
                     /db_xref="GeneID:64521"
                     /db_xref="RGD:620982"
                     /translation="MGRFRGGLRCIKYLLLGFNLLFWLAGSAVIAFGLWFRFGGTIKD
                     LSSEEKSPEYFYVGLYVLVGAGALMMAVGFFGCCGAMRESQCVLGSFFTCLLVIFAAE
                     VTTGVFAFIGKDVAIRHVQSMYEEAYSDYVRDRGRGNGTLITFHSAFQCCGKESSEQV
                     QPTCPKELPGHKNCIDKIETIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRNSR
                     DVI"
     exon            94..196
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            197..294
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..369
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            370..468
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            469..540
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            541..624
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /inference="alignment:Splign:2.1.0"
     exon            625..3833
                     /gene="Tspan2"
                     /gene_synonym="Tspan-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcccgcc gccggggtcg cagcatgggg cgttttcgcg ggggcctgcg gtgcatcaag
       61 tatttgctgc tcggcttcaa cctgctgttc tggctagccg gatcggccgt tattgcattt
      121 ggactatggt ttcgatttgg aggtaccata aaggatttat catcagagga gaagtcccca
      181 gagtatttct atgtggggct gtatgtgctg gttggagctg gagccctaat gatggctgtg
      241 ggtttctttg ggtgctgtgg agccatgcgt gagtcacagt gtgtgctcgg atcttttttt
      301 acctgtctgc tggtgatatt cgctgctgaa gtaaccactg gagtgtttgc atttataggc
      361 aaggatgtag ctatacgaca cgtacagagc atgtatgagg aggcctacag cgattacgtt
      421 agggacaggg gaaggggaaa tggaactctc attaccttcc actcagcatt tcagtgctgt
      481 ggaaaagaaa gctctgaaca agtccagccc acgtgtccaa aggagcttcc aggccacaag
      541 aattgcatcg acaaaattga aaccataatc agtgttaagc tccagctcat tggaattgtt
      601 ggtattggga ttgcgggtct cacgatcttt ggcatgatat tcagcatggt gctctgctgt
      661 gcaatacgga actcacgcga tgtgatttga agatacttca tgaaaattgc aatctagagt
      721 gttcgtgcta attatcacaa gagctcgtgg ctcattttta atattcagga tattagaagc
      781 taaaataatt ttctgtcaac tgtatatttg cacatgtatg tatgtttgat tcattactga
      841 tttgctcctg gagtgaatgt ctctgtgttt ctggatatgc attgcacata ctgatagctg
      901 tttcctggga aaccctagtt cttgtatgca agaataacct atttaattgc cagaaaaaag
      961 caatgagaga tatttaaaac ttggctattc aggaaatgta ataatgggtc catttctcag
     1021 attttagcca tgaaaatgag atacataaag agaatgcagg atttctagtt aatggaagca
     1081 ataagatata agaattgaag ggccatagat tgactgtgtc tgagttgaat gtaaaggttt
     1141 ctttaaaaaa aaaattctcc ccagaataca gtaaaccaca gttttagaac taaacacatc
     1201 tgtaaaagta aatatagcat ggaaaaatat aatttgaaaa agtcatgctt tcttagcatt
     1261 taaaaacaga aaacctctct ctggaaagag aagtcacata gacaagcatg tgccccataa
     1321 aagcgagtgc ttttaggact aaaaataaca acttttaagg gggaaatgct gttatccagt
     1381 ggcatgtaaa tgttgcttta gccctcttct ctcctgactc tgctttgaac tgctggaagc
     1441 ctcacctttc cacaagggct ttccctcata ctcagtgctt ctccagatgt ggtgacagag
     1501 gaaagcaaga actgtgcagt gtgacagtgg gggacctcgc tggcactgtg cctctggaat
     1561 acctcgtagc ttgagtttac atactttcct cattgttttc catttttctt atttatcagt
     1621 gcagagaatt cttcatagat taagaataca gttttattct ttaaaataag tagaccccct
     1681 gtaattcaga tgtatgttat gagtaccctg actaaaccaa gataaacacc ttcttcaata
     1741 tatatacacg cagcaaaggc aagttaatga atccaaaatg tttcatgcat acagctgcag
     1801 cacaaatata ttctttctta gcaaatccct gtgggaataa atgctcaggc tctgtggata
     1861 cctgagtgat tgattttaag tggggaaacc cacagcgggg tctaaattgg cacatttttt
     1921 agaacagaac aacttgttaa aggatataaa ttgtgaattc ttaagattgt atttgaccac
     1981 acaaaaaaat gaaggtgtga gggattctgg aaaccatcag ggaagcttct gtgcccgcta
     2041 agaacataag actttgatgt gtgctagaac aaagtaccat gtttcaggaa acttttacaa
     2101 gtgttttgct gaggacacac aactgctggg atgtcttgcc cacagagtgc cacctctctc
     2161 ttttcagata tgcttgctac tgctcctagc tttggagaaa aactgaggga gttaaaagtg
     2221 taactgtatg actactttac ctacagatgc aaaagagtat ttaaaaaaca tcacttcttg
     2281 atgtttgtac cccagtggct gacaaaggcc agcttttcag gcagacaaag agcgatcagt
     2341 ccttctttta gctttagtct atctgtcttc ctgaagacag aggacaggct ccagagtgta
     2401 ctcaggttct ccagctcaga gttatttccc gttcctcaga agtaagtttc gttcctcagt
     2461 gagtgagtga gtttaaagaa aaccacagta actatagaca gaagaataat tttttaatgc
     2521 agaggaataa gtctagaaat ccgtatcctg tgtgattagt gtacctctct gagggttaag
     2581 ctttccaaag aatgtactgg gtaaaaatag agaattccat ctctgagtga agatggatat
     2641 atatctttat gtgaatggat aaagctatat ctgtagagat atataacccc tctgtcctga
     2701 acctatacat accttaaata cgtatctctt aaggatatat acatatgtaa cttaatacat
     2761 gtgtgcctgg tggaaactat ggagataaat gtttgtatac atacacatgt acatgtatgt
     2821 aaatttacag ttatttctgt ttacctgaac taatttgaga tcagacccaa acattttaag
     2881 ttattttaaa ttaaattttc tatgtactta cactgtttga gttatcttaa aatcttactg
     2941 tatcttctta acacattcat gtgacttatt caatgtgtta cctaccagtt cacccaaaca
     3001 atatagaaaa agcagactgg taacccttcc atgctgttac ttacagcggg ttcaaaagca
     3061 acacccctag ggttctaatt acatatagtt gtacttcagc tcacactagt tcacccaagt
     3121 tgttcctcct tcctccaaga aaacttggtt atctgtggct tggtctgtgg aggtgatcct
     3181 gggtccaatg tggccctcct gtacagacag ccctcctttc cctctgagga atctaatcga
     3241 tgtagctggg tgaggatgag gcccagagag atgataataa tctcgtaatc agcaaagagg
     3301 atagcgtgtt ctcccttctg aaataagttt accaaatatt tgctctcttg tcattggtaa
     3361 aggtggtttc tatggcccag aggccagcca cagcccagct ttcaaggccc cattgacatg
     3421 ctcttgaaca ccaagcctgt ttcccatacc caggaaagag caatttatgt ctctcgaagg
     3481 tagagccagc ttaagctcac gtgagtcaat ttggtttttg tgtgtatttt aagacttgag
     3541 attttctatt ttttttaaac atcctccatt ttttttacta taaaaggtat tttgtatata
     3601 gatgtctttt aaaagtgaaa atactacaac aatacaaaac attattgttt ggtgttctta
     3661 taacaactaa gggattcaca gtccagatgc tgcccctggg gaaacagaga aacatggcga
     3721 atacaagtaa tatatcctgt ggttcccaaa gtgttgttaa cagaaacatt ctttgtgttt
     3781 gtggtgtgtt tcctgtctat tttatgattt cttttacttc tattaaacag caa
//
