LOCUS       NM_001013138            1632 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tetraspanin 17 (Tspan17), mRNA.
ACCESSION   NM_001013138 XM_225178
VERSION     NM_001013138.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1632)
  AUTHORS   Haining,E.J., Yang,J., Bailey,R.L., Khan,K., Collier,R., Tsai,S.,
            Watson,S.P., Frampton,J., Garcia,P. and Tomlinson,M.G.
  TITLE     The TspanC8 subgroup of tetraspanins interacts with A disintegrin
            and metalloprotease 10 (ADAM10) and regulates its maturation and
            cell surface expression
  JOURNAL   J Biol Chem 287 (47), 39753-39765 (2012)
   PUBMED   23035126
REFERENCE   2  (bases 1 to 1632)
  AUTHORS   Dornier,E., Coumailleau,F., Ottavi,J.F., Moretti,J., Boucheix,C.,
            Mauduit,P., Schweisguth,F. and Rubinstein,E.
  TITLE     TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and
            promote Notch activation in flies and mammals
  JOURNAL   J Cell Biol 199 (3), 481-496 (2012)
   PUBMED   23091066
  REMARK    Erratum:[J Cell Biol. 2016 May 23;213(4):495-6. doi:
            10.1083/jcb.20120113304262016c.. PMID: 27185832]
REFERENCE   3  (bases 1 to 1632)
  AUTHORS   Ticku,M.K. and Mehta,A.K.
  TITLE     Characterization and pharmacology of the GHB receptor
  JOURNAL   Ann N Y Acad Sci 1139, 374-385 (2008)
   PUBMED   18991884
  REMARK    GeneRIF: Results indicate that ethanol does not affect
            [(3)H]NCS-382 binding in the rat brain, thereby suggesting that
            ethanol does not interact directly with the GHB receptor.
REFERENCE   4  (bases 1 to 1632)
  AUTHORS   Kemmel,V., Miehe,M., Roussel,G., Taleb,O., Nail-Boucherie,K.,
            Marchand,C., Stutz,C., Andriamampandry,C., Aunis,D. and Maitre,M.
  TITLE     Immunohistochemical localization of a GHB receptor-like protein
            isolated from rat brain
  JOURNAL   J Comp Neurol 498 (4), 508-524 (2006)
   PUBMED   16874802
  REMARK    GeneRIF: Immunohistochemical analyses showed receptor protein
            distribution closely resembling the distribution of GHB
            high-affinity binding sites, except for cerebellum. The GHB
            receptor-like protein labeling appears to be distributed
            specifically in neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM038661.1 and BC097431.1.
            
            On May 9, 2012 this sequence version replaced NM_001013138.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097431.1, SRR8487226.94318.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               FM038661.1         1-490
            491-1632            BC097431.1         471-1612
FEATURES             Location/Qualifiers
     source          1..1632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1632
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /note="tetraspanin 17"
                     /db_xref="GeneID:306771"
                     /db_xref="RGD:1311167"
     exon            1..227
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..953
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /EC_number="3.6.5.3"
                     /note="gamma-hydroxybutyrate receptor; tspan-17; F-box
                     only protein 23"
                     /codon_start=1
                     /product="tetraspanin-17"
                     /protein_id="NP_001013156.2"
                     /db_xref="GeneID:306771"
                     /db_xref="RGD:1311167"
                     /translation="MPGKHQQFQDPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWG
                     EKGVLSNISGLTDLGGLDPVWLFVVIGGIMSVLGFAGCIGALRENTFLLKFFSVFLGL
                     IFFLELAAGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARG
                     PNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDIRLKLELEQQGSI
                     YTKGCVGQFEKWLQDNLIVVAGVLVAIALLQICGICLAQNLVSDIEAVKANW"
     exon            228..278
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /inference="alignment:Splign:2.1.0"
     exon            279..425
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /inference="alignment:Splign:2.1.0"
     exon            426..596
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /inference="alignment:Splign:2.1.0"
     exon            597..722
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /inference="alignment:Splign:2.1.0"
     exon            723..770
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /inference="alignment:Splign:2.1.0"
     exon            771..887
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1598
                     /gene="Tspan17"
                     /gene_synonym="Fbxo23; GHB-R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagccagtg agctgtgtgg ctctggccat gaagccgcag ccgccgggct aggcccgggg
       61 cggctccacg cctgggcagc ccgcagaggg ctgggccggt tcccggctcg ggttcccagg
      121 gcggcaggtg gccgctcacc atgcccggca agcatcagca attccaggac cctgaggttg
      181 gctgctgcgg gaaatacttt ctgtttggct tcaacattgt cttctgggtg ctgggagccc
      241 tgttcctggc catcggcctc tgggcctggg gtgagaaggg cgttctttcc aacatctcag
      301 ggctgacaga tctaggcggt cttgaccccg tgtggctgtt tgtggtgatt gggggaatca
      361 tgtcagtgct gggctttgcc ggctgcattg gggccctccg ggaaaacacc ttcctgctca
      421 aatttttctc tgtgttcctc ggcctcatct tcttcctgga gctggcggcc gggatcctgg
      481 ccttcgtgtt caaggattgg atccgagacc aacttaacct cttcatcaac aacaatgtca
      541 aagcctaccg ggacgatatt gaccttcaga accttatcga ctttgctcag gaatactggt
      601 cttgctgtgg agcccgaggg cccaatgact ggaacctcaa catctacttc aactgcactg
      661 acttgaaccc aagccgcgag cgctgtgggg tgcccttctc ctgctgtgtt agggaccctg
      721 cggaagacgt cctcaatacc cagtgtggct atgacatccg actcaaactg gagctggagc
      781 agcaaggctc catctacacc aaaggctgcg tgggccagtt tgagaagtgg ctccaagata
      841 acctgattgt ggtggccggg gtcttggtgg ccattgccct cctccagata tgtggcatct
      901 gcttggccca gaacctcgtg agtgacatcg aggcagtaaa ggccaactgg tgaggctgcc
      961 gggggtgatg gccacatgcc tggcccacag ggctgtagtg ggggcctcct aggacgctct
     1021 gcctcactca caatggcaag gcctgtggga cgtctgttat gacctgagcc cgaggctctg
     1081 tgagcatggt actcaggaag ccactgaggc tggactgggg ctgaactggg gctgtactgg
     1141 ggctggactg gggctgttta ccacagagct gtgtgtgtgg ggtgtacaca tgtgtgtgtg
     1201 tgtgtgtgtg tgtgtgtgtg tgcgtgtgcc tgtgcctgtg tgtgcgtgtg cgtggcatgc
     1261 acgtgtgcgc actcgtgagt acacctggag tctccacccc gctgctgtga ggtggtggcc
     1321 cttccagagc tctaagggag atggagccag gagggtaggg catgtacctg cgtcccctag
     1381 tctactgtgg gatgtatccc tgtgtggctt aggagcctgc tgtctcagac cactccatat
     1441 tcaccatgac cttgaacctg cctggagctc accttggcct cagtgtcaca gcctctgaaa
     1501 tgggtccaag aatcctctct gtctctctct ctcgcttgcc tctcaggacc acacatggtg
     1561 atggctacga gcgactcaat aaacactttg aaaaacagaa aaaaaaaaaa aaaaaaaaaa
     1621 aaaaaaaaaa aa
//
