LOCUS       NM_001015026            2563 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus tetraspanin 12 (Tspan12), mRNA.
ACCESSION   NM_001015026 XM_342647
VERSION     NM_001015026.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Junge,H.J., Yang,S., Burton,J.B., Paes,K., Shu,X., French,D.M.,
            Costa,M., Rice,D.S. and Ye,W.
  TITLE     TSPAN12 regulates retinal vascular development by promoting Norrin-
            but not Wnt-induced FZD4/beta-catenin signaling
  JOURNAL   Cell 139 (2), 299-311 (2009)
   PUBMED   19837033
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092623.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342647.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC092623.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN12840108, SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2563
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /note="tetraspanin 12"
                     /db_xref="GeneID:362326"
                     /db_xref="RGD:1311102"
     exon            1..323
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /inference="alignment:Splign:2.1.0"
     exon            324..459
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..1311
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /note="tspan-12; transmembrane 4 superfamily member 12"
                     /codon_start=1
                     /product="tetraspanin-12"
                     /protein_id="NP_001015026.1"
                     /db_xref="GeneID:362326"
                     /db_xref="RGD:1311102"
                     /translation="MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLT
                     LTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGTLLV
                     IFCVELACGVWTYEQEVMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNYFQREFKCC
                     GVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQEDLSDLYQEGCGKKMYSFLRGTK
                     QLQVLRFLGISIGVTQILAMILTITLLWALYYDRREPGTDQMLSLKNDASQHLSCHSV
                     ELLKPSLSRIFEHTSMANSFNTHFEMEEL"
     exon            460..542
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /inference="alignment:Splign:2.1.0"
     exon            543..678
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /inference="alignment:Splign:2.1.0"
     exon            679..753
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /inference="alignment:Splign:2.1.0"
     exon            754..861
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1005
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..2539
                     /gene="Tspan12"
                     /gene_synonym="Tm4sf12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgagagt ttgtgcagct ggccctggct gctgccgctg ctgccttgtc cggacttggc
       61 gaggacttgg gagggacagc ggcgttggga ggtggcttag cagagacttt ccagcgactg
      121 ctgcccagga tttttttttt ttttttcttc ccttttcttt ttcccaggag tcagcgacgg
      181 cgacggctgg ggagaggaag gcgagcaagc gtctgctgtt ggagccaatg cagccctttg
      241 gctctccgcg aggagcgtct ctccccggat gagtgtctgc cttgtgtccc cgagtgtccc
      301 cccgcaggag cgcagctcga acgatcgctg ctgctctgct tggaccagta gaatgtggtg
      361 agaggatggg gcttctccct cccaagactc acaatggcca gagaagattc cgtgaagtgt
      421 ttgcgctgct tgctctacgc cctcaacctg ctcttctggt taatgtccat cagtgtcttg
      481 gcagtttctg cttggatgag ggactacctg aataacgttt tgactttgac tgcagagaca
      541 agggtagaag aggcggtcat cttaacttac ttccctgtgg ttcaccccgt catgattgct
      601 gtctgctgtt tccttatcat cgtgggaatg ctgggatact gtgggaccgt gaaaaggaat
      661 ctgttgcttc ttgcatggta ctttggaact ttactcgtga tcttctgcgt agaactggct
      721 tgtggtgtgt ggacatacga gcaggaagtt atggtgccag tacagtggtc agatatggtt
      781 actttgaaag ccagaatgac aaattacggc ttacccaggt ataggtggct tacgcatgct
      841 tggaactatt ttcagagaga gtttaagtgc tgcggagtgg tctacttcac cgattggttg
      901 gaaatgacag aaatggactg gcccccagac tcctgctgtg ttagggagtt cccaggatgc
      961 tccaagcagg ctcaccagga agacctcagt gacctgtacc aagagggttg tgggaagaaa
     1021 atgtattcct ttttgagagg aaccaaacaa ttgcaagtac taaggtttct ggggatctcc
     1081 attggtgtga cacaaattct agccatgatt ctcaccatta ctctgctctg ggctctgtat
     1141 tatgatagaa gggagcctgg gacagaccaa atgctatctc taaaaaatga tgcgtcacaa
     1201 cacttgtcct gtcactctgt ggaactgtta aaaccaagcc tttctaggat ctttgaacat
     1261 acatcaatgg caaacagctt caatacccac tttgagatgg aagaattatg aagaatgtca
     1321 aagaaggaaa tcacaaactt gtgggactag tgggttttgg ggtacacagc tatctcagaa
     1381 atttttagac atactaatat tctgaaaagg aatgtctaag cttataattt atccactctt
     1441 taaaacaaag gttccacata ttaatacaca gacaataact agcgtccttt aaaatgctga
     1501 acccagagtt cataacaact gtgtttgttt tctttctttc tttctttttc tttctgagca
     1561 caattatgtt ttgaggtgat acagtttgac cagcgtttct gcatccattc atggaaatga
     1621 actgtcatgg gggcactcat gctgctatga aggttaacta actcctctag ttaggctata
     1681 aactatccac tgactgctaa catagggatt tagtgctaaa gacctttatt acctgatgat
     1741 gtattgcttc gacgatgatt tgattatata taaaaatctt tcaaggttgg taactaccta
     1801 aatatgattt ttgtgggtta ctaaaataat cttattaatg acacttgtaa gagctaacac
     1861 gctgtcttaa acttatcagg gatatatatg tgtataagtc tgtgccatgt ctgtataatt
     1921 cagtagattt cagttcttat aaatgttacg aagaacaata tttgaaaatg acaaaattgt
     1981 cttatatagc accattactt tttttctctc ccaaccacag agcgtttaaa tgccgtcttg
     2041 cttctgtatt gttacccatc actgttaatt taagttgtta accattaatt ttggaaatta
     2101 ccagtgtgat acgtaagaat cattgtaact ctggctgcag gaggtattaa ctacagaatt
     2161 tacacacagt tgattcagcc aaagttcagt tggctttttt ttcaccccaa tctacgcctt
     2221 gtcaaagagc ttacgttttt cttttgcaaa caagaagcga caacttgaag tcaatgtgat
     2281 tttacagagg aggaacattc tgtgcagaga taatcatggg aatctctaaa ataaggggta
     2341 gtctaactag agagaagcct tgctttattt catccatata ctgtagcaaa ttatacagaa
     2401 tattaatttt ttttacaaga gtagaagata tttatttgaa acgggaaaag tgcattttac
     2461 tgtatcttgt gtgttctgtt catttcttga attatggaaa gaaaattaat acaggtgtca
     2521 ataaatattt tctagatcaa aaaaaaaaaa aaaaaaaaaa aaa
//
