LOCUS       NM_001004236            1256 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus tetraspanin 1 (Tspan1), mRNA.
ACCESSION   NM_001004236 XM_216507
VERSION     NM_001004236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1256)
  AUTHORS   Ferrero Restelli,F., Fontanet,P.A., De Vincenti,A.P., Falzone,T.L.,
            Ledda,F. and Paratcha,G.
  TITLE     Tetraspanin1 promotes NGF signaling by controlling TrkA receptor
            proteostasis
  JOURNAL   Cell Mol Life Sci 77 (11), 2217-2233 (2020)
   PUBMED   31440771
  REMARK    GeneRIF: This study identified Tetraspanin 1 (Tspan1) as a critical
            regulator of TrkA signaling and neuronal differentiation induced by
            nerve growth factor.
REFERENCE   2  (bases 1 to 1256)
  AUTHORS   Wang,G.L., Chen,L., Wei,Y.Z., Zhou,J.M., Wu,Y.Y., Zhang,Y.X.,
            Qin,J. and Zhu,Y.Y.
  TITLE     The effect of NET-1 on the proliferation, migration and endocytosis
            of the SMMC-7721 HCC cell line
  JOURNAL   Oncol Rep 27 (6), 1944-1952 (2012)
   PUBMED   22378020
REFERENCE   3  (bases 1 to 1256)
  AUTHORS   Nabokina,S.M., Senthilkumar,S.R. and Said,H.M.
  TITLE     Tspan-1 interacts with the thiamine transporter-1 in human
            intestinal epithelial cells and modulates its stability
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 301 (5), G808-G813 (2011)
   PUBMED   21836059
REFERENCE   4  (bases 1 to 1256)
  AUTHORS   Kesimer,M., Scull,M., Brighton,B., DeMaria,G., Burns,K., O'Neal,W.,
            Pickles,R.J. and Sheehan,J.K.
  TITLE     Characterization of exosome-like vesicles released from human
            tracheobronchial ciliated epithelium: a possible role in innate
            defense
  JOURNAL   FASEB J 23 (6), 1858-1868 (2009)
   PUBMED   19190083
REFERENCE   5  (bases 1 to 1256)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1256)
  AUTHORS   Wollscheid,V., Kuhne-Heid,R., Stein,I., Jansen,L., Kollner,S.,
            Schneider,A. and Durst,M.
  TITLE     Identification of a new proliferation-associated protein NET-1/C4.8
            characteristic for a subset of high-grade cervical intraepithelial
            neoplasia and cervical carcinomas
  JOURNAL   Int J Cancer 99 (6), 771-775 (2002)
   PUBMED   12115476
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078938.1.
            
            On Sep 10, 2004 this sequence version replaced XM_216507.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078938.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1256
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1256
                     /gene="Tspan1"
                     /note="tetraspanin 1"
                     /db_xref="GeneID:298436"
                     /db_xref="RGD:1303308"
     exon            1..120
                     /gene="Tspan1"
                     /inference="alignment:Splign:2.1.0"
     exon            121..185
                     /gene="Tspan1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..854
                     /gene="Tspan1"
                     /note="tspan-1; tetraspan 1"
                     /codon_start=1
                     /product="tetraspanin-1"
                     /protein_id="NP_001004236.1"
                     /db_xref="GeneID:298436"
                     /db_xref="RGD:1303308"
                     /translation="MQCFKFIKVMMILFNLLIFLCGAALLAVGIWVSVDGTSFLKAFG
                     SLSSSAMQFVNVGYFLIAAGAVLFILGFLGCYGAHSENKCVLMMFFSILLIIFIAEIA
                     GAVVALVYTTMAEQFLTFLVVPAIEKDYGYQTEFTQVWNSTMEGLHCCGFNNYTDFNS
                     SRFVKENKVFPPFCCANNTDSHTVEPCTEDKAKSMNVQGCFKQILQKIRTNAVTVGGV
                     AVGVAALELAAMVVSMYLYCNLK"
     exon            186..392
                     /gene="Tspan1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..467
                     /gene="Tspan1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..566
                     /gene="Tspan1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..722
                     /gene="Tspan1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..806
                     /gene="Tspan1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1233
                     /gene="Tspan1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacttgcgg ttccttcagc attctgcccg cgcactgagt ggctgtttcc tggagctact
       61 gtgttccttc gggagtgcag cagatcccgt tcagaaccta ttaccaagag ccccgagcag
      121 gacccaccat gcagtgcttc aaattcatta aggtcatgat gatcctcttc aatctactca
      181 tctttctctg tggtgcagcc ctgttggctg tgggaatctg ggtgtccgtc gacgggacat
      241 ctttcctgaa ggccttcgga tcactatcat cgagtgccat gcagtttgtc aacgtgggct
      301 acttcctcat cgccgctggt gctgtactct ttattcttgg tttcctgggc tgctatggtg
      361 ctcactccga gaacaagtgt gtgctcatga tgttcttttc cattctcctc atcatcttca
      421 ttgcggagat tgcaggggcc gtggttgctt tggtgtacac cacaatggct gaacaattcc
      481 tgacatttct ggtggtgcct gctatcgaaa aggactatgg ttaccagact gaattcaccc
      541 aagtgtggaa ctctacgatg gaggggctgc attgctgtgg cttcaacaat tacacagatt
      601 ttaactcctc acgtttcgtc aaagagaaca aagtctttcc tccgttctgt tgcgccaaca
      661 acactgacag tcatacagtt gaaccatgca ccgaggacaa ggccaaaagt atgaatgtac
      721 agggttgttt caaacagatt ctgcagaaaa tcagaaccaa tgcagttacc gtgggtggtg
      781 tggcagttgg agttgcggcc ctagagctgg ctgccatggt ggtatccatg tatctatact
      841 gcaatctgaa gtaagactgc ttcttcctcc tgacttgtcg tcacatggaa accaggaaga
      901 ggcacttggc acagctaagc agcagcaatg ggtggagatg aaacgtcatt tgggctggag
      961 tggatctgcc tttgctgctc tggacttcgg gctaattagg gaccaccgct cgggctgtgt
     1021 ctgtcttgtt cttccactac tggggcgagg ggggcattgg tcccagtctc tgaggtagcc
     1081 atgtctgccc atctcctgag attcttgatg atcccagcac tccactggtg gatgaaggca
     1141 cttatagcct gggcatattc tagcactgca aagtcataga aggaatgtac agaaggtgtt
     1201 ttggaactta taaaccaatg aaaatacttc taaaaaaaaa aaaaaaaaaa aaaaaa
//
