LOCUS       NM_022262               2290 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus translin-associated factor X (Tsnax), mRNA.
ACCESSION   NM_022262
VERSION     NM_022262.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2290)
  AUTHORS   Garwain,O. and Scarlata,S.
  TITLE     Phospholipase Cbeta-TRAX Association Is Required for PC12 Cell
            Differentiation
  JOURNAL   J Biol Chem 291 (44), 22970-22976 (2016)
   PUBMED   27624933
  REMARK    GeneRIF: PLCbeta through its ability to bind TRAX plays a key role
            in switching PC12 cells to their differentiated state.
REFERENCE   2  (bases 1 to 2290)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2290)
  AUTHORS   Aisiku,O.R., Runnels,L.W. and Scarlata,S.
  TITLE     Identification of a novel binding partner of phospholipase cbeta1:
            translin-associated factor X
  JOURNAL   PLoS One 5 (11), e15001 (2010)
   PUBMED   21124736
  REMARK    GeneRIF: Studies show that TRAX, localized in the cytosol and
            nucleus, competes with plasma-membrane bound Galpha(q) for PLCbeta1
            binding thus stabilizing PLCbeta1 in other cellular compartments.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2290)
  AUTHORS   Sun,C.N., Cheng,H.C., Chou,J.L., Lee,S.Y., Lin,Y.W., Lai,H.L.,
            Chen,H.M. and Chern,Y.
  TITLE     Rescue of p53 blockage by the A(2A) adenosine receptor via a novel
            interacting protein, translin-associated protein X
  JOURNAL   Mol Pharmacol 70 (2), 454-466 (2006)
   PUBMED   16617164
  REMARK    GeneRIF: A(2A)-R modulates the differentiation ability of trophic
            factors through a novel interacting protein, TRAX.
REFERENCE   5  (bases 1 to 2290)
  AUTHORS   Bray,J.D., Chennathukuzhi,V.M. and Hecht,N.B.
  TITLE     Identification and characterization of cDNAs encoding four novel
            proteins that interact with translin associated factor-X
  JOURNAL   Genomics 79 (6), 799-808 (2002)
   PUBMED   12036294
REFERENCE   6  (bases 1 to 2290)
  AUTHORS   Chennathukuzhi,V.M., Kurihara,Y., Bray,J.D. and Hecht,N.B.
  TITLE     Trax (translin-associated factor X), a primarily cytoplasmic
            protein, inhibits the binding of TB-RBP (translin) to RNA
  JOURNAL   J Biol Chem 276 (16), 13256-13263 (2001)
   PUBMED   11278549
REFERENCE   7  (bases 1 to 2290)
  AUTHORS   Taira,E., Finkenstadt,P.M. and Baraban,J.M.
  TITLE     Identification of translin and trax as components of the GS1
            strand-specific DNA binding complex enriched in brain
  JOURNAL   J Neurochem 71 (2), 471-477 (1998)
   PUBMED   9681436
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081715.1.
            
            On Sep 16, 2004 this sequence version replaced NM_022262.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081715.1, AF262357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2290
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /note="translin-associated factor X"
                     /db_xref="GeneID:64028"
                     /db_xref="RGD:621574"
     exon            1..96
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..953
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /codon_start=1
                     /product="translin-associated protein X"
                     /protein_id="NP_071598.1"
                     /db_xref="GeneID:64028"
                     /db_xref="RGD:621574"
                     /translation="MNGKEGPGGFRKRKHDNFPHNQRREGKDASSSSPVMLAFKSFQQ
                     ELDTRHDKYERLVKLSRDITVESKRTIFLLHRITSAPDMEEILTESESKLDGVRQKML
                     QVAQELSGEDMHQFHRAVTTGLQEYVEAVSFQHFIRTRSLISMEEINRQLTFTTDDSG
                     KESKAPPADGQDKQLVTWRLKITPVDYLLGVADLTGELMRMCINSVGNGDIDTPFEVS
                     QFLRQVYDGFSFIGNTGPYEVSKKLYTLKQSLSKVENACYALKVRGSEIPKHMLADVF
                     SVKTEMIDQEESIS"
     exon            97..201
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     exon            202..316
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     exon            317..447
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     exon            448..575
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
     exon            576..2265
                     /gene="Tsnax"
                     /gene_synonym="Trax"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagtgtct ggcgacggcc ttttgctgag ctgacccggc ggctgcggtt cctgcgcttg
       61 caaaccgagg ccccgcggtc atgaacggca aagagggacc aggagggttc aggaagagga
      121 agcatgataa cttcccacat aaccaaagga gagaagggaa ggatgccagt tcgtcttcgc
      181 cggtgatgct ggccttcaaa tcgtttcagc aggagctgga cacaagacac gacaaatatg
      241 agcgacttgt gaaactaagc cgggatatta ccgtggaaag taagaggacg atttttcttc
      301 tccataggat cacaagtgct cctgatatgg aggagattct gactgaatca gaaagtaagc
      361 tggatggggt cagacagaaa atgctgcagg tagcccaaga gctctcagga gaagacatgc
      421 accagttcca tcgtgctgtc accacaggac tccaggaata cgtggaggct gtctcctttc
      481 aacacttcat cagaacccga tccctgatca gtatggagga gatcaacagg cagctgacgt
      541 ttacaacaga cgacagtggg aaggagagca aggctcctcc cgctgatgga caagacaagc
      601 agctggttac ctggagactg aagatcacac cggtggacta cctgctgggc gtggccgact
      661 tgactggaga gctgatgcgg atgtgcatta acagcgtggg caacggggac attgacaccc
      721 cctttgaagt gagccagttc ctacgccagg tttacgatgg gttctccttc attggcaaca
      781 ctgggcccta cgaggtctct aagaagctgt acaccttgaa acagagcctg tccaaagtgg
      841 agaacgcttg ctatgccctt aaagtccggg gctctgagat ccctaagcac atgctggccg
      901 atgtgttctc agtgaaaacg gagatgattg accaggaaga gagcatttct taagcaactc
      961 cgctcagttc tctaaggcgt gagctcctgg ggggctgttg tgaggctgtt gtgagtgtgc
     1021 gtttgacttt attgtggctt cttagacgtg tccaggtgta ctagtttgaa gtgtgtacag
     1081 ctgtatataa gtagtccaca gggacgtttc ttacacgcgt gcatttgcat cagtgtttat
     1141 atgtgcttac actattgttg tgtgaacatg cttccgactg ctctctctgc cacacctact
     1201 ttaattcact ttgaacttgg agtgacattt tgggtggaag gaagtctctt aagtgggtga
     1261 tcctttgtat ggagggaaaa cggtgtagcg aagcctctgg agtgagcttc ctgtttcagt
     1321 tcctcggcag tgtcatggca agccttcaaa gtgggcctag cacacggaac aacagtttta
     1381 acgtgcaagc tatcagtatt ttttaagtgc aaattttggt ggtattgaga attcacttaa
     1441 agttttggtc aagtttaggc cattttgaat ttatatgaag cagctttcct gaggaattga
     1501 tgggtccaga tgttcctttc tcagagatgt gggaaggagc tgacattgct cttccctggt
     1561 gatgctgagt atctaaccac acacttgtct gtagggtgtg agcagccagg cccttcgtca
     1621 tgtgttaggt ggactgcact ttcctacccc agccatcctg ggacccacag aagggcagcc
     1681 acagtgcttg gagagctgac agcccaaacc tttacacttg tcccttggtg ttagctagtg
     1741 atgttgccaa agaaaatgac ttgtgtataa ctcagcaata agacaatttc cagctcagga
     1801 gggagtgctg ggagtgagtt cacctcccca gtcagtcagt cagtcagtca gtcagtcagt
     1861 cagtcagtca gtcatccatc gtggtgagag cctggcttga gcgtcgcccg cagctgacac
     1921 caccacatgt tttcatctag ttttgtgagt tttcaggact tggatactgg gttttatttt
     1981 ttggaaagaa tatctacttg taaggctggt tctttgaaag tgtaattttc caaaacttgt
     2041 cacggacagg aaagtgacgt gtgcacatgc ctgctgagtt agctgtttgt cgtgtgatga
     2101 ggctttgtct tccctgcagt aagatagatg ctaagtttca gtcagtcctg ttacctgctg
     2161 tctgtttttc agctacgtca agttgaattt ataatgttaa aataatggat tgaagaatgt
     2221 tttacagaaa tttaaagcaa attttaaata aaatattaaa atacaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa
//
