LOCUS       NM_021762                988 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus translin (Tsn), mRNA.
ACCESSION   NM_021762
VERSION     NM_021762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12 ):965. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Chiaruttini,C., Vicario,A., Li,Z., Baj,G., Braiuca,P., Wu,Y.,
            Lee,F.S., Gardossi,L., Baraban,J.M. and Tongiorgi,E.
  TITLE     Dendritic trafficking of BDNF mRNA is mediated by translin and
            blocked by the G196A (Val66Met) mutation
  JOURNAL   Proc Natl Acad Sci U S A 106 (38), 16481-16486 (2009)
   PUBMED   19805324
  REMARK    GeneRIF: Findings implicate abnormal dendritic trafficking of BDNF
            mRNA in the pathophysiology of neuropsychiatric disorders linked to
            the translin G196A mutation.
REFERENCE   3  (bases 1 to 988)
  AUTHORS   Smyth,L.J., Starkey,C., Gordon,F.S., Vestbo,J. and Singh,D.
  TITLE     CD8 chemokine receptors in chronic obstructive pulmonary disease
  JOURNAL   Clin Exp Immunol 154 (1), 56-63 (2008)
   PUBMED   18727632
REFERENCE   4  (bases 1 to 988)
  AUTHORS   Cho,Y.S., Iguchi,N., Yang,J., Handel,M.A. and Hecht,N.B.
  TITLE     Meiotic messenger RNA and noncoding RNA targets of the RNA-binding
            protein Translin (TSN) in mouse testis
  JOURNAL   Biol Reprod 73 (4), 840-847 (2005)
   PUBMED   15987823
REFERENCE   5  (bases 1 to 988)
  AUTHORS   Chennathukuzhi,V.M., Kurihara,Y., Bray,J.D. and Hecht,N.B.
  TITLE     Trax (translin-associated factor X), a primarily cytoplasmic
            protein, inhibits the binding of TB-RBP (translin) to RNA
  JOURNAL   J Biol Chem 276 (16), 13256-13263 (2001)
   PUBMED   11278549
REFERENCE   6  (bases 1 to 988)
  AUTHORS   Taira,E., Finkenstadt,P.M. and Baraban,J.M.
  TITLE     Identification of translin and trax as components of the GS1
            strand-specific DNA binding complex enriched in brain
  JOURNAL   J Neurochem 71 (2), 471-477 (1998)
   PUBMED   9681436
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF262356.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF262356.1, FN801894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984036, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q11"
     gene            1..988
                     /gene="Tsn"
                     /note="translin"
                     /db_xref="GeneID:60381"
                     /db_xref="RGD:621107"
     exon            1..172
                     /gene="Tsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..793
                     /gene="Tsn"
                     /codon_start=1
                     /product="translin"
                     /protein_id="NP_068530.1"
                     /db_xref="GeneID:60381"
                     /db_xref="RGD:621107"
                     /translation="MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQG
                     VHQGTGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLA
                     AFVVYLETETLVTREAVTEILGIEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVT
                     AGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFN
                     KETAAACGEK"
     exon            173..266
                     /gene="Tsn"
                     /inference="alignment:Splign:2.1.0"
     exon            267..363
                     /gene="Tsn"
                     /inference="alignment:Splign:2.1.0"
     exon            364..479
                     /gene="Tsn"
                     /inference="alignment:Splign:2.1.0"
     exon            480..559
                     /gene="Tsn"
                     /inference="alignment:Splign:2.1.0"
     exon            560..961
                     /gene="Tsn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcagtag cggcagcgac gggcgttgag agagagaccg ctacttgtct gtgggtcgta
       61 ctgtggcggt gctccggtgc tgactgattg tagggcagcc ggcgccatgt ctgtgagcga
      121 gatcttcgtg gagctgcagg gctttttggc tgccgagcag gacatccgag aggaaatacg
      181 aaaagttgtg cagagtttag aacaaactgc tcgagagatt ttgaccttac tccaaggggt
      241 ccatcagggc actgggtttc aggacattcc aaagaggtgc ttgaaagctc gagaacattt
      301 tggcacggta aaaacacatc taacatccct gaagaccaag ttccctgctg aacagtatta
      361 caggtttcat gagcactgga ggtttgtgct tcagcgcctg gtcttcctgg cggcctttgt
      421 agtgtatttg gaaacagaga ctctggtgac ccgagaggct gttacagaga ttcttggcat
      481 tgaaccggat cgggaaaaag ggtttcatct ggatgtggaa gattatctct caggagtttt
      541 gattcttgcc agtgaactgt ccaggctgtc tgtcaacagt gtcactgctg gagattactc
      601 ccggcccctt cacatctcta ctttcatcaa tgagttggat tcaggttttc gccttctcaa
      661 tctgaaaaac gactccctga ggaaacgcta cgacggctta aagtatgatg tgaagaaagt
      721 agaggaggtg gtctatgacc tttccatccg aggcttcaat aaggagacag cagcggcttg
      781 tggtgaaaaa taggagcttt cccctgcggc tggccttgct ggcttggcag ttgccgggga
      841 gggctagcat agtgcctctt cctgtagtta gcacaccagt tgctaaacac tgcgctttat
      901 tttcttaatc agctgtgtgg tgtgagtatc agaattgaaa tacttttttg gatctaaaaa
      961 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
