LOCUS       NM_012888               5265 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus thyroid stimulating hormone receptor (Tshr),
            mRNA.
ACCESSION   NM_012888
VERSION     NM_012888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5265)
  AUTHORS   Taglietti,V., Kefi,K., Rivera,L., Bergiers,O., Cardone,N.,
            Coulpier,F., Gioftsidi,S., Drayton-Libotte,B., Hou,C.,
            Authier,F.J., Pietri-Rouxel,F., Robert,M., Bremond-Gignac,D.,
            Bruno,C., Fiorillo,C., Malfatti,E., Lafuste,P., Tiret,L. and
            Relaix,F.
  TITLE     Thyroid-stimulating hormone receptor signaling restores skeletal
            muscle stem cell regeneration in rats with muscular dystrophy
  JOURNAL   Sci Transl Med 15 (685), eadd5275 (2023)
   PUBMED   36857434
  REMARK    GeneRIF: Thyroid-stimulating hormone receptor signaling restores
            skeletal muscle stem cell regeneration in rats with muscular
            dystrophy.
REFERENCE   2  (bases 1 to 5265)
  AUTHORS   Previde,R.M., Wang,K., Smiljanic,K., Janjic,M.M., Nunes,M.T. and
            Stojilkovic,S.S.
  TITLE     Expression and Role of Thyrotropin Receptors in
            Proopiomelanocortin-Producing Pituitary Cells
  JOURNAL   Thyroid 31 (5), 850-858 (2021)
   PUBMED   33191870
  REMARK    GeneRIF: Expression and Role of Thyrotropin Receptors in
            Proopiomelanocortin-Producing Pituitary Cells.
REFERENCE   3  (bases 1 to 5265)
  AUTHORS   Panda,S., Sikdar,M., Biswas,S., Sharma,R. and Kar,A.
  TITLE     Allylpyrocatechol, isolated from betel leaf ameliorates
            thyrotoxicosis in rats by altering thyroid peroxidase and
            thyrotropin receptors
  JOURNAL   Sci Rep 9 (1), 12276 (2019)
   PUBMED   31439949
  REMARK    GeneRIF: Allylpyrocatechol, isolated from betel leaf ameliorates
            thyrotoxicosis in rats by altering thyroid peroxidase and
            thyrotropin receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5265)
  AUTHORS   Yang,J., Yi,N., Zhang,J., He,W., He,D., Wu,W., Xu,S., Li,F.,
            Fan,G., Zhu,X., Xue,Z. and Zhou,W.
  TITLE     Generation and characterization of a hypothyroidism rat model with
            truncated thyroid stimulating hormone receptor
  JOURNAL   Sci Rep 8 (1), 4004 (2018)
   PUBMED   29507327
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5265)
  AUTHORS   Burgos,J.R., Iresjo,B.M., Warnaker,S. and Smedh,U.
  TITLE     Presence of TSH receptors in discrete areas of the hypothalamus and
            caudal brainstem with relevance for feeding controls-Support for
            functional significance
  JOURNAL   Brain Res 1642, 278-286 (2016)
   PUBMED   27059392
  REMARK    GeneRIF: Data suggest that functional thyroid-stimulating hormone
            receptor is present in the caudal brainstem and hypothalamic nuclei
            of relevance for feeding control as a possibly uncleaved
            holoreceptor, and highlights a hindbrain component to central
            thyroid-stimulating hormone inhibition of food intake.
REFERENCE   6  (bases 1 to 5265)
  AUTHORS   Kikuoka,S., Shimojo,N., Yamaguchi,K.I., Watanabe,Y., Hoshioka,A.,
            Hirai,A., Saito,Y., Tahara,K., Kohn,L.D., Maruyama,N., Kohno,Y. and
            Niimi,H.
  TITLE     The formation of thyrotropin receptor (TSHR) antibodies in a
            Graves' animal model requires the N-terminal segment of the TSHR
            extracellular domain
  JOURNAL   Endocrinology 139 (4), 1891-1898 (1998)
   PUBMED   9528975
REFERENCE   7  (bases 1 to 5265)
  AUTHORS   Koshiyama,H., Sellitti,D.F., Akamizu,T., Doi,S.Q., Takeuchi,Y.,
            Inoue,D., Sakaguchi,H., Takemura,G., Sato,Y., Takatsu,Y. and
            Nakao,K.
  TITLE     Cardiomyopathy associated with Graves' disease
  JOURNAL   Clin Endocrinol (Oxf) 45 (1), 111-116 (1996)
   PUBMED   8796147
REFERENCE   8  (bases 1 to 5265)
  AUTHORS   Rieu,M., Raynaud,A., Richard,A., Laplanche,S., Sambor,B. and
            Berrod,J.L.
  TITLE     Evidence for the effect of antibodies to TSH receptors on the
            thyroid ultrasonographic volume in patients with Graves' disease
  JOURNAL   Clin Endocrinol (Oxf) 41 (5), 667-671 (1994)
   PUBMED   7828357
REFERENCE   9  (bases 1 to 5265)
  AUTHORS   Kosugi,S., Okajima,F., Ban,T., Hidaka,A., Shenker,A. and Kohn,L.D.
  TITLE     Mutation of alanine 623 in the third cytoplasmic loop of the rat
            thyrotropin (TSH) receptor results in a loss in the
            phosphoinositide but not cAMP signal induced by TSH and receptor
            autoantibodies
  JOURNAL   J Biol Chem 267 (34), 24153-24156 (1992)
   PUBMED   1332945
REFERENCE   10 (bases 1 to 5265)
  AUTHORS   Akamizu,T., Ikuyama,S., Saji,M., Kosugi,S., Kozak,C., McBride,O.W.
            and Kohn,L.D.
  TITLE     Cloning, chromosomal assignment, and regulation of the rat
            thyrotropin receptor: expression of the gene is regulated by
            thyrotropin, agents that increase cAMP levels, and thyroid
            autoantibodies
  JOURNAL   Proc Natl Acad Sci U S A 87 (15), 5677-5681 (1990)
   PUBMED   1696008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 30, 2020 this sequence version replaced NM_012888.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M34842.1, SRR26643299.28472.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JAXUCZ010000006.1  116072321-116072534
            215-286             JAXUCZ010000006.1  116154171-116154242
            287-361             JAXUCZ010000006.1  116157751-116157825
            362-436             JAXUCZ010000006.1  116163120-116163194
            437-511             JAXUCZ010000006.1  116165619-116165693
            512-589             JAXUCZ010000006.1  116168150-116168227
            590-658             JAXUCZ010000006.1  116172527-116172595
            659-736             JAXUCZ010000006.1  116180701-116180778
            737-925             JAXUCZ010000006.1  116198427-116198615
            926-5265            JAXUCZ010000006.1  116201670-116206009
FEATURES             Location/Qualifiers
     source          1..5265
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..5265
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /note="thyroid stimulating hormone receptor"
                     /db_xref="GeneID:25360"
                     /db_xref="RGD:3911"
     exon            1..214
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2339
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /note="thyrotropin receptor; TSH-R"
                     /codon_start=1
                     /product="thyrotropin receptor precursor"
                     /protein_id="NP_037020.2"
                     /db_xref="GeneID:25360"
                     /db_xref="RGD:3911"
                     /translation="MRPGSLLQLTLLLALPRSLWGRGCTSPPCECHQEDDFRVTCKEL
                     HRIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSK
                     MTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDVFFILEITD
                     NPYMTSVPENAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTAIDK
                     DAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKNTWTLKKLPLSLSFLHLTRAD
                     LSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNVMRGPVYQEYEEGLGDNH
                     VGYKQNSKFQEGPSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGD
                     NEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLMALLGNVFVLFVLLTSHYKLTVPR
                     FLMCNLAFADFCMGVYLLLIASVDLYTHTEYYNHAIDWQTGPGCNTAGFFTVFASELS
                     VYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKV
                     SICLPMDTDTPLALAYIALVLLLNVVAFVIVCSCYVKIYITVRNPQYNPRDKDTKIAK
                     RMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFT
                     KAFQRDVFILLSKFGLCKHQAQAYQAQRVCPNNNTGIQIQKIPQDTRQSLPNVQDTYE
                     PLGSSHLTPKLQGRISEEYTQTAL"
     exon            215..286
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     exon            287..361
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     exon            362..436
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     exon            437..511
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     exon            512..589
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     exon            590..658
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     exon            659..736
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     exon            737..925
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
     exon            926..5265
                     /gene="Tshr"
                     /gene_synonym="TSHRA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacagcgcg caacgatgaa gtagcactgg aggtcccttg gaaaatgagg ccagggtccc
       61 tgctccagct cactctgctg ctcgccctgc ccaggagcct gtggggcaga gggtgtactt
      121 ctccaccctg cgaatgccac caggaggacg acttcagagt cacctgcaag gaactccacc
      181 gaatccccag cctaccgccc agcacccaga ctctgaagct catcgagact cacctgaaga
      241 ccattcccag tcttgccttt tcgagcctgc ccaatatttc caggatctat ctatccatag
      301 atgccactct gcagcgactg gagccacatt ctttctacaa tttgagtaaa atgactcaca
      361 tagaaatccg gaacaccaga agcttgactt acatagaccc tgatgcctta acagagctcc
      421 ccttgctcaa gtttcttgga attttcaata ctggacttag aatattccct gacttgacca
      481 aaatttattc cacggatgtg ttctttatac tagaaatcac agacaaccct tacatgacgt
      541 cagtccctga aaacgcattc cagggactat gcaatgaaac cttgaccctg aaactataca
      601 acaatggatt tacttcaatc caaggacatg ctttcaatgg aacaaagctg gatgctgttt
      661 acctaaacaa gaataaatat ctgacagcta tagacaaaga tgcctttgga ggagtataca
      721 gtggacccac tttgctagac gtgtcttcca ccagcgttac tgctcttcct tccaaaggcc
      781 tggagcacct caaagagctg atcgcgaaga acacctggac tctcaaaaag ctccccctgt
      841 ccttgagctt cctccacctc actcgggctg acctctctta cccaagtcac tgctgtgctt
      901 ttaagaacca gaagaaaatc aggggaatcc tagagtcttt gatgtgtaat gagagtagta
      961 tccggaacct gcgtcaaaga aagtcagtga acgtcatgag gggtcccgtc taccaggaat
     1021 atgaagaagg tctgggtgac aaccatgttg ggtacaaaca aaactccaag ttccaggagg
     1081 gcccgagcaa ctctcactat tacgtcttct ttgaagaaca agaggacgag atcatcggtt
     1141 tcggccaaga gctcaaaaat cctcaggaag agactctcca agccttcgac agccactatg
     1201 actacactgt gtgtggggac aacgaggaca tggtgtgtac ccccaagtca gacgagttta
     1261 acccctgtga agatatcatg ggctacaagt tcctgagaat cgtggtatgg tttgtcagtc
     1321 tgatggctct cctgggcaac gtctttgtcc tgttcgtcct gcttactagc cactacaaac
     1381 tgaccgtgcc acgcttcctg atgtgcaacc tggcctttgc agatttctgc atgggggttt
     1441 acctgcttct cattgcctcc gtagacctgt acacacacac tgagtactac aaccacgcca
     1501 ttgactggca gacgggccct ggatgcaaca cggctggttt cttcactgtt tttgccagcg
     1561 agttatcagt gtacacactg acggtcatca ccctggagcg atggtatgcc atcaccttcg
     1621 ccatgcgcct ggataggaag atccgcctca ggcacgctta taccatcatg gcgggggggt
     1681 gggtttcctg cttccttctc gccttgctcc caatggtggg aataagcagc tacgccaagg
     1741 tcagcatctg cctgccgatg gacacagaca cccctcttgc cctggcgtac atcgcccttg
     1801 ttctcctgct caacgttgtt gcctttgtta ttgtctgctc ctgctatgtg aagatttaca
     1861 tcaccgtccg aaatccccag tacaaccctc gagataaaga caccaagatt gccaagagga
     1921 tggccgtgtt gatcttcact gacttcatgt gcatggcgcc catctccttc tatgccctgt
     1981 cagcgcttat gaacaagcct ctgatcactg tcactaactc caaaatcttg ttggttctct
     2041 tctacccact caactcctgt gctaacccat ttctctatgc cattttcacc aaggccttcc
     2101 agagggatgt gttcatccta ctcagcaagt ttggcctctg caaacaccag gcccaagcct
     2161 atcaggccca gagagtctgt cccaacaaca acactggtat tcagatccaa aagatccccc
     2221 aggacacaag gcagagtctc cccaatgtgc aagataccta tgaaccgctt ggaagctccc
     2281 acctgactcc gaaactacag ggacggatct cagaagagta cacgcaaaca gccctgtaaa
     2341 ggaaggctac gctagtcatg gtgggactta caaaaggctg gtttctagaa catgcactcc
     2401 agttccagga cacgtgaatg cctaggtcca cggggtcaga gttcatctct agggagtatt
     2461 gcctccaaga agggagagaa gctatcggcg tgactgagtc ctaggtgatc taaaagtcgt
     2521 ccaatctctc tggaagattt gctcgatgct tgcctgtgat gccgggcaac gcgctccact
     2581 gataaccagc tggactgttc ccacagctct ctactccatt ctacggagtg ttttatatga
     2641 aagattcagc aagtggccag tgttcattta cgcgagcagc tccacattag ctcccctgag
     2701 gtaaccaaag aaagtctttg ttccttaaaa ataaaatgcc atacttggga ggtggaggca
     2761 gggggaccca gttcatactt aactacccag aaaattccaa gccaacctat gctccaacaa
     2821 tagcactggt attcagatcc aaaagatccc ccaggacgca aggcagagtc cttctccatc
     2881 tcaagagacc aaaagaaccc tgaaacgcca aacataactt gatgtcacat aattgctttt
     2941 attaaactga aaaaagagaa agtctagttt tgagagttct ttttttcctt tgactctgaa
     3001 acagttatct cttcaccggg ctcgatgagc tcgatgtaac ccagctgtta cacattggct
     3061 agagaaactg ctaagatttc agcttttgtg gctgagcgaa ctaagaatta tcttctcgga
     3121 caagacatga gccctgggag agatttctaa ggagcatatg gtgaggacag ggcgcactta
     3181 gtcacctgtt gaataagaca actatacccc agttaaccgt caggctttga gcaagtccct
     3241 ggacctctaa attctgtaga aatggggaga cttgatgccc tctcctactt aaaaaaaacc
     3301 ctcagtatat ctctccctca aaagatatgt gtctgtgaca aagagaaaaa agcattactt
     3361 aagtggaatc taattttttt tttctacctt gtgaggctgc tggctgcttc tttttggaac
     3421 cgggacatgt gaccgaaaac actttttctt tatttcattt tgatcattgc gtctgagcca
     3481 atactattga gtggctatac ggagccagat cttaattatt catctaatta ttatatctgt
     3541 actgctctca agtccaaaac ataacagaac ttagagaatc tgttactaat acagcctggc
     3601 ttggtagtgt acgcctttaa tctcagcact ggggaggcag aggctgaatt tgaggccagc
     3661 ctggtccaag acagccaggt ctacacagag aaaccctgtt tcaaagaaaa caaaacaaaa
     3721 tagactaata atggagttaa cacgtgactg tgtaggctca cttcaaaaca tctttttctt
     3781 ttactttttt ttatagctct ctgggctcac accacactaa cactgtcaag agagaagtcg
     3841 tttcacccga cactgccagt tccttctatc cctgccagtc acatgagaca tgtgtgccct
     3901 gatagtagcc ttgcttccaa caggaactgt acctacaggt gttccttcta ggttgcctgt
     3961 ctggttagct ccttaccata ttgttacggt gtccccccaa gcagatctgc catttgcttc
     4021 tcagtactca tgaaccaaac aggaaagata agggttttgc caccttaagt ctgtgaagta
     4081 gggtttatgg gtcacctgac atggctccta tctgactggc ctggaactct gtcacagtca
     4141 cgtaagtgta ggctttccca ggtgctcgct tgtaactact gaaataaata aatgtggtgc
     4201 cctgaggcat ccgtttctct cttacgtcac ttttggaatg tcacatctgg acagataaaa
     4261 tatttcatct cgagtagccg atctaatgct ttgaaaacca agtcctagaa gagtgacttc
     4321 gacaaaattg ctagtaaaat tcaacttgac agcatgaagt aaagtttcct cctgtagtga
     4381 gatatatagt attttttttt aatttgtcaa tttcttttga ggttaacctt gtatgtgcat
     4441 gtgttaaaag caaaaaggga acatctgctg tggcactcag gagagtaggc cctgcccctc
     4501 cccttggtca tacaatagat ctgaccccgg atgtgggagt tgcaggtgag ctggcccgga
     4561 ggacatgaat tcagaagagc gggccctgcc ctttgccttc tgtgcatgca gtggcataga
     4621 ctagggaaag atgtccttct cccctctctt attacttgtc acctatggca ggcaggagag
     4681 ctgtccccaa agacatgaga gcaggggtat ggccctgtcc ctcactatct gcaacactct
     4741 ggagagcagg ccctacacct tgcctgggca gcagggtaga gctggccctg gttatgggag
     4801 tcactggtga gccagttctg aaggcaggag aaccagtgga ctgaccagct cagataccac
     4861 tcagccccag atccagggct ttaaattggc tcactctaac atctacccat cagtgaacta
     4921 ctggagtaca tgaagcaggc agtcctacag atccaaaact acacacagga tctccatgat
     4981 gcacgacaac aacaggatat ccaagaagag ccctggtgag gttccagcat tgatggtgga
     5041 gcagaaggca gagggcttat accagaacaa ggactcgctg caatgaacat ttgcaagcaa
     5101 aagaagtgtg gacaaaaggg tatactggac actacagcat ctgcagtgag gttttgtccc
     5161 tctgttgggg acaggttgca tgcgtggagg atggatatga ggggggaaga tgagtgggat
     5221 tggggtacag ggtgtaaagt tcacaaagaa tcaataaaaa atttt
//
