LOCUS       NM_013116                560 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus thyroid stimulating hormone subunit beta (Tshb),
            mRNA.
ACCESSION   NM_013116
VERSION     NM_013116.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 560)
  AUTHORS   Goulart-Silva,F., de Souza,P.B. and Nunes,M.T.
  TITLE     T3 rapidly modulates TSHbeta mRNA stability and translational rate
            in the pituitary of hypothyroid rats
  JOURNAL   Mol Cell Endocrinol 332 (1-2), 277-282 (2011)
   PUBMED   21078364
  REMARK    GeneRIF: These data add new insight to an important role of T3 in
            rapidly regulating TSH beta gene expression at posttranscriptional
            level.
REFERENCE   2  (bases 1 to 560)
  AUTHORS   Wei,L., Sun,S., Zhang,J., Zhu,H., Xu,Y., Ma,Q., McNutt,M.A.,
            Korteweg,C. and Gu,J.
  TITLE     Endocrine cells of the adenohypophysis in severe acute respiratory
            syndrome (SARS)
  JOURNAL   Biochem Cell Biol 88 (4), 723-730 (2010)
   PUBMED   20651845
REFERENCE   3  (bases 1 to 560)
  AUTHORS   Jo,Y.S., Hwang,E.S., Lee,J.H., Lee,Y., Kim,S.Y., Choi,Y.S.,
            Bai,Y.S., Hong,J.H., Kim,Y.J., Lee,I.S., Rha,S.Y., Ro,H.K. and
            Shong,M.
  TITLE     Regulation of inhibitors of differentiation family proteins by
            thyroid-stimulating hormone in FRTL-5 thyroid cells
  JOURNAL   J Korean Med Sci 23 (2), 262-269 (2008)
   PUBMED   18437010
  REMARK    GeneRIF: TSH regulates Id2 expression, but that Id2 does not alter
            the expression of thyroid-specific genes, such as Tg, in FRTL-5
            thyroid cells
REFERENCE   4  (bases 1 to 560)
  AUTHORS   Aizawa,S., Hoshino,S., Sakata,I., Adachi,A., Yashima,S., Hattori,A.
            and Sakai,T.
  TITLE     Diurnal change of thyroid-stimulating hormone mRNA expression in
            the rat pars tuberalis
  JOURNAL   J Neuroendocrinol 19 (11), 839-846 (2007)
   PUBMED   17927662
  REMARK    GeneRIF: Results clearly show that there are diurnal changes in TSH
            expression and accumulation in rat PT-TSH cells and suggest that
            these fluctuations are regulated by melatonin.
REFERENCE   5  (bases 1 to 560)
  AUTHORS   Biebinger,R., Arnold,M., Langhans,W., Hurrell,R.F. and
            Zimmermann,M.B.
  TITLE     Vitamin A repletion in rats with concurrent vitamin A and iodine
            deficiency affects pituitary TSHbeta gene expression and reduces
            thyroid hyperstimulation and thyroid size
  JOURNAL   J Nutr 137 (3), 573-577 (2007)
   PUBMED   17311942
REFERENCE   6  (bases 1 to 560)
  AUTHORS   Dacou-Voutetakis,C., Feltquate,D.M., Drakopoulou,M., Kourides,I.A.
            and Dracopoli,N.C.
  TITLE     Familial hypothyroidism caused by a nonsense mutation in the
            thyroid-stimulating hormone beta-subunit gene
  JOURNAL   Am J Hum Genet 46 (5), 988-993 (1990)
   PUBMED   1971148
REFERENCE   7  (bases 1 to 560)
  AUTHORS   Wolf,O., Kourides,I.A. and Gurr,J.A.
  TITLE     Expression of the gene for the beta subunit of mouse thyrotropin
            results in multiple mRNAs differing in their 5'-untranslated
            regions
  JOURNAL   J Biol Chem 262 (34), 16596-16603 (1987)
   PUBMED   2824501
REFERENCE   8  (bases 1 to 560)
  AUTHORS   Wood,W.M., Gordon,D.F. and Ridgway,E.C.
  TITLE     Expression of the beta-subunit gene of murine thyrotropin results
            in multiple messenger ribonucleic acid species which are generated
            by alternative exon splicing
  JOURNAL   Mol Endocrinol 1 (12), 875-883 (1987)
   PUBMED   2484718
REFERENCE   9  (bases 1 to 560)
  AUTHORS   Carr,F.E., Need,L.R. and Chin,W.W.
  TITLE     Isolation and characterization of the rat thyrotropin beta-subunit
            gene. Differential regulation of two transcriptional start sites by
            thyroid hormone
  JOURNAL   J Biol Chem 262 (3), 981-987 (1987)
   PUBMED   3027091
REFERENCE   10 (bases 1 to 560)
  AUTHORS   Croyle,M.L., Bhattacharya,A., Gordon,D.F. and Maurer,R.A.
  TITLE     Analysis of the organization and nucleotide sequence of the
            chromosomal gene for the beta-subunit of rat thyrotropin
  JOURNAL   DNA 5 (4), 299-304 (1986)
   PUBMED   3017658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, X01454.1, BC058488.1 and CB315383.1.
            
            On Aug 1, 2012 this sequence version replaced NM_013116.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X01454.1, CB315383.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: experimental evidence
                                                (PMID:3027091)
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 JAXUCZ010000002.1  192918048-192918054 c
            8-118               X01454.1           6-116
            119-552             BC058488.1         79-512
            553-560             CB315383.1         512-519
FEATURES             Location/Qualifiers
     source          1..560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..560
                     /gene="Tshb"
                     /note="thyroid stimulating hormone subunit beta"
                     /db_xref="GeneID:25653"
                     /db_xref="RGD:3910"
     exon            1..71
                     /gene="Tshb"
                     /inference="alignment:Splign:2.1.0"
     exon            72..234
                     /gene="Tshb"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..489
                     /gene="Tshb"
                     /note="thyroid stimulating hormone, beta subunit;
                     thyrotropin subunit beta; TSH-B; TSH-beta; thyrotropin
                     beta chain"
                     /codon_start=1
                     /product="thyrotropin subunit beta precursor"
                     /protein_id="NP_037248.2"
                     /db_xref="GeneID:25653"
                     /db_xref="RGD:3910"
                     /translation="MNAVVLFSVLFALACGQVSSFCIPTEYMMYVDRRECAYCLTINT
                     TICAGYCMTRDINGKLFLPKYALSQDVCTYRDFTYRTVEIPGCPHHVAPYFSYPVALS
                     CKCGKCNTDYSDCTHEAVKTNYCTKPQTFYLGGFSG"
     exon            235..560
                     /gene="Tshb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattatcccg aagggtataa aatgaacaga gtctgggtca tcacagcatt aactcgccag
       61 tgcaaagtaa gcatgaatgc tgtcgttctc ttttccgtgc ttttcgctct tgcttgtggg
      121 caagtgtcat cgttttgtat tcccactgag tatatgatgt acgtggacag gagagagtgt
      181 gcctactgcc tgaccatcaa caccaccatc tgcgctgggt attgtatgac acgggatatc
      241 aatggcaaac tgtttcttcc caagtacgca ctctctcagg atgtctgtac atacagagac
      301 ttcacctaca gaacggtgga aataccggga tgcccacacc atgttgctcc ttatttctcc
      361 taccccgttg ccctgagctg caagtgtggc aagtgtaaca ctgactacag cgactgtaca
      421 cacgaggctg tcaaaaccaa ctactgcacc aagccacaga cattctatct ggggggattt
      481 tctggttaac tgtaatggca atgcaatctg gttaaatgtg tttacctgga atagaactaa
      541 taaaatatca ttgatatgtc
//
