LOCUS       NM_181628               1490 bp    mRNA    linear   ROD 11-AUG-2024
DEFINITION  Rattus norvegicus tumor susceptibility 101 (Tsg101), mRNA.
ACCESSION   NM_181628
VERSION     NM_181628.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Sunohara,M., Kriz,W., Kranzlin,B., Kretzler,M., Gretz,N.,
            Endlich,K. and Endlich,N.
  TITLE     Upregulation of Tumor Susceptibility Gene 101 (TSG101) by
            mechanical stress in podocytes
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 65 (1), 84-88 (2019)
   PUBMED   30782301
  REMARK    GeneRIF: mechanical stress upregulates TSG101 in podocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Tsunemi,T., Hamada,K. and Krainc,D.
  TITLE     ATP13A2/PARK9 regulates secretion of exosomes and alpha-synuclein
  JOURNAL   J Neurosci 34 (46), 15281-15287 (2014)
   PUBMED   25392495
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Colombo,M., Moita,C., van Niel,G., Kowal,J., Vigneron,J.,
            Benaroch,P., Manel,N., Moita,L.F., Thery,C. and Raposo,G.
  TITLE     Analysis of ESCRT functions in exosome biogenesis, composition and
            secretion highlights the heterogeneity of extracellular vesicles
  JOURNAL   J Cell Sci 126 (Pt 24), 5553-5565 (2013)
   PUBMED   24105262
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Wu,S.C., Yang,J.C., Rau,C.S., Chen,Y.C., Lu,T.H., Lin,M.W.,
            Tzeng,S.L., Wu,Y.C., Wu,C.J. and Hsieh,C.H.
  TITLE     Profiling circulating microRNA expression in experimental sepsis
            using cecal ligation and puncture
  JOURNAL   PLoS One 8 (10), e77936 (2013)
   PUBMED   24205035
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   Zheng,Y., Campbell,E.C., Lucocq,J., Riches,A. and Powis,S.J.
  TITLE     Monitoring the Rab27 associated exosome pathway using nanoparticle
            tracking analysis
  JOURNAL   Exp Cell Res 319 (12), 1706-1713 (2013)
   PUBMED   23092844
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   O'Boyle,J.D., Proctor,M.L., Fong,K.M., Lin,W.M., Miller,D.S. and
            Muller,C.Y.
  TITLE     Role of TSG101 in uterine cervix cancer
  JOURNAL   Gynecol Oncol 75 (3), 401-405 (1999)
   PUBMED   10600297
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   Klaes,R., Kloor,M., Willeke,F., Melsheimer,P., von Knebel
            Doeberitz,M. and Ridder,R.
  TITLE     Significant increase of a specific variant TSG101 transcript during
            the progression of cervical neoplasia
  JOURNAL   Eur J Cancer 35 (5), 733-737 (1999)
   PUBMED   10505033
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   Chang,J.G., Su,T.H., Wei,H.J., Wang,J.C., Chen,Y.J., Chang,C.P. and
            Jeng,C.J.
  TITLE     Analysis of TSG101 tumour susceptibility gene transcripts in
            cervical and endometrial cancers
  JOURNAL   Br J Cancer 79 (3-4), 445-450 (1999)
   PUBMED   10027311
REFERENCE   9  (bases 1 to 1490)
  AUTHORS   Sun,Z., Pan,J., Bubley,G. and Balk,S.P.
  TITLE     Frequent abnormalities of TSG101 transcripts in human prostate
            cancer
  JOURNAL   Oncogene 15 (25), 3121-3125 (1997)
   PUBMED   9444960
REFERENCE   10 (bases 1 to 1490)
  AUTHORS   Torres,G., Bitran,M. and Huidobro-Toro,J.P.
  TITLE     Co-release of neuropeptide Y (NPY) and noradrenaline from the
            sympathetic nerve terminals supplying the rat vas deferens;
            influence of calcium and the stimulation intensity
  JOURNAL   Neurosci Lett 148 (1-2), 39-42 (1992)
   PUBMED   1300501
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070951.1.
            
            On Jun 6, 2004 this sequence version replaced NM_181628.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070951.1, AY293306.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1490
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /note="tumor susceptibility 101"
                     /db_xref="GeneID:292925"
                     /db_xref="RGD:3909"
     exon            1..83
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1217
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /note="Tumor supressor; ESCRT-I complex subunit TSG101"
                     /codon_start=1
                     /product="tumor susceptibility gene 101 protein"
                     /protein_id="NP_853659.2"
                     /db_xref="GeneID:292925"
                     /db_xref="RGD:3909"
                     /translation="MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVF
                     NDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKH
                     VDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTAAGPP
                     NTSYLPSMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTAGPSR
                     DGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVT
                     RLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYA
                     EENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY"
     exon            84..168
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     exon            169..234
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     exon            235..398
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     exon            399..525
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     exon            526..592
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     exon            593..684
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     exon            685..887
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1127
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1465
                     /gene="Tsg101"
                     /gene_synonym="Rw"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcgccta ccctctgcct gtggggacgg aggagtgcgc catggcggtg tccgagagtc
       61 agctgaagaa gatgatgtcc aagtacaaat acagagatct aaccgtccgt caaactgtca
      121 atgtcatcgc tatgtacaaa gatctcaaac ctgtattgga ttcgtatgtt tttaatgatg
      181 gcagttccag ggagctggtg aacctcactg ggacaatccc tgtgcgctat cgaggtaata
      241 tatataacat tccaatatgc ctgtggctcc tggacacata cccatataac ccccctatct
      301 gttttgttaa gcctactagt tcaatgacta ttaaaacagg aaagcatgtg gatgcaaatg
      361 ggaaaatcta cctgccttac ctacatgact ggaaacaccc acggtcagag ttgctggaac
      421 ttattcagat catgattgtg atatttggcg aggagcctcc agtgttctcc cgacctaccg
      481 tttctgcatc ctacccaccg tacacagcag cagggccacc aaacacctcc tacttgccaa
      541 gcatgccaag tggaatctct gcatatccat ctggataccc tcccaacccc agtggttatc
      601 ctggctgtcc ttacccacct gctggcccat accctgccac aacaagctca cagtaccctt
      661 cccagcctcc tgtgaccact gctggtccca gcagagatgg cacaatcagc gaggacacta
      721 ttcgagcatc tctcatctca gcagtcagtg acaaactgag atggcggatg aaggaggaaa
      781 tggatggtgc ccaggcagag cttaatgcct tgaaacggac agaggaagat ctaaaaaaag
      841 gccaccagaa actggaagag atggtcaccc gcttagatca ggaagtagct gaagttgata
      901 aaaacataga actattgaaa aagaaggatg aagaactaag ttctgctctg gagaaaatgg
      961 aaaatcaatc tgaaaataat gatattgatg aagttatcat tcccacagcc ccattgtata
     1021 aacagattct aaatctgtat gcagaggaaa atgctattga agacactatc ttttaccttg
     1081 gagaagcctt gaggcgggga gtaatagacc tggatgtgtt cctgaagcac gtccgcctcc
     1141 tgtcccgtaa acagttccag ctaagggcac taatgcaaaa agcaagaaag actgcgggcc
     1201 ttagtgacct ctactgacgt gtgctatcag ctggagaccg gcctcttcgt aaagcattct
     1261 tttcttctct ttctttttct catcagtagg aagaacccag aataagttat tgcagtttat
     1321 catttgagtg ttaaatattt tgaattgata atatattttc tgtttccttt gggtaaagac
     1381 tggcttttat taatgcactt tctaccctct gtaagcttct gtgctgtgct gggactgact
     1441 gggctaaata aaatttgttg cataaaaaaa aaaaaaaaaa aaaaaaaaaa
//
