LOCUS       NM_001014057            1782 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus tRNA splicing endonuclease subunit 2 (Tsen2),
            mRNA.
ACCESSION   NM_001014057 XM_232279
VERSION     NM_001014057.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Yoshihisa,T.
  TITLE     Handling tRNA introns, archaeal way and eukaryotic way
  JOURNAL   Front Genet 5, 213 (2014)
   PUBMED   25071838
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Weitzer,S. and Martinez,J.
  TITLE     The human RNA kinase hClp1 is active on 3' transfer RNA exons and
            short interfering RNAs
  JOURNAL   Nature 447 (7141), 222-226 (2007)
   PUBMED   17495927
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 26, 2021 this sequence version replaced NM_001014057.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087631.1, SRR26643292.19331.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000004.1  150275482-150275517
            37-245              JAXUCZ010000004.1  150278810-150279018
            246-327             JAXUCZ010000004.1  150280855-150280936
            328-364             JAXUCZ010000004.1  150285903-150285939
            365-881             JAXUCZ010000004.1  150289889-150290405
            882-959             JAXUCZ010000004.1  150291653-150291730
            960-1010            JAXUCZ010000004.1  150298918-150298968
            1011-1149           JAXUCZ010000004.1  150301719-150301857
            1150-1186           JAXUCZ010000004.1  150307618-150307654
            1187-1298           JAXUCZ010000004.1  150308919-150309030
            1299-1388           JAXUCZ010000004.1  150309834-150309923
            1389-1782           JAXUCZ010000004.1  150310453-150310846
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1782
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /note="tRNA splicing endonuclease subunit 2"
                     /db_xref="GeneID:312649"
                     /db_xref="RGD:1309946"
     exon            1..36
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            37..245
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1448
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /EC_number="4.6.1.16"
                     /note="tRNA-intron nuclease 2; tRNA-intron endonuclease
                     Sen2; TSEN2 tRNA splicing endonuclease subunit"
                     /codon_start=1
                     /product="tRNA-splicing endonuclease subunit Sen2"
                     /protein_id="NP_001014079.1"
                     /db_xref="GeneID:312649"
                     /db_xref="RGD:1309946"
                     /translation="MAEAVFRAPKRKRRVYESYESPLPIPFSQDQSPRKEFRIFQAEM
                     ISNNVVVRGTEDMEQLYGKGYFGKGILSRSRPNFTISNPKLAARWKGVQTDMPIITSE
                     KYQHRVEWARDFMRRQGHDESTVQKILTDYTEPLEPPYRERKGESPQHEPLSSKADSS
                     LEGREGKDELSVTTGGAGQSDDLQGLNTHSDCRQEGPGHATLTVASPSSLNGHAIEDP
                     EALSQIPCCSQEALGQQDDLWPEASSQIAGESRAAHEYVLIEEELCDVQEGAAPHDEL
                     LKRKRLVCRRNPYRIFEYLQLSLEEAFFLAYALGCLSIYYEKEPLTIVKLWQAFTAVQ
                     PTFRTTYMAYHYFRSKGWVPKVGLKYGTDLLLYRKGPPFYHASYSVIIELVDDNFEGS
                     LRRPFSWKSLAALSRVSGNVSKELMLCYLIKPSTMTNEDMETPECMRRIQVQEVILSR
                     WVSSRERSDQDEL"
     exon            246..327
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            328..364
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            365..881
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            882..959
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1010
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1149
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1186
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1298
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1388
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1782
                     /gene="Tsen2"
                     /gene_synonym="RGD1309946"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgccgggta accgtgggcg cgcgtggccg ggtaagagac ctgttatcct tgaagaatgg
       61 cagaggcagt cttccgtgct ccaaagagga aaaggagagt gtacgagagt tacgagtcac
      121 cgctgcccat cccctttagt caggaccaaa gtcccaggaa ggaattccga atattccagg
      181 ctgaaatgat tagcaacaat gtggtggtga ggggcacaga ggacatggag cagctgtatg
      241 ggaagggtta ctttggaaag gggatccttt caagaagtcg tccgaacttc acaatctcca
      301 atcccaagct ggctgccaga tggaaaggtg tgcagacaga catgcctata atcacctcag
      361 agaagtatca gcaccgagtg gaatgggcca gggatttcat gcggaggcag ggccatgatg
      421 agagcactgt gcagaagatc cttacggact acacagaacc attggagcct ccttacaggg
      481 agaggaaagg agagagccca cagcatgaac ccctgagctc caaggccgac tcctccctgg
      541 aaggcagaga gggaaaggat gaactttctg tgaccaccgg aggtgctgga caatcagatg
      601 acctgcaggg cctcaacaca cactcagact gccggcagga ggggcctggc catgccacac
      661 tcactgtggc tagtccttct agccttaatg ggcatgcgat agaggacccc gaggctctgt
      721 cccagatccc ctgctgtagc caggaagccc tcggtcagca ggatgacctt tggcctgaag
      781 ccagcagcca gatagcagga gagagtaggg ctgctcacga gtatgtgctc atagaggaag
      841 agctgtgtga tgtccaggag ggggcagcac cacatgacga gttgctgaaa agaaagagac
      901 ttgtgtgcag aaggaaccca tacaggatct ttgagtatct acagctcagc ctagaagagg
      961 ctttcttcct ggcatacgcc ctgggatgtt taagtatcta ctatgagaag gagcctttga
     1021 ccatagtgaa gctctggcaa gccttcactg cagtccagcc caccttcagg actacctaca
     1081 tggcctacca ctacttccga agcaaaggct gggtgcccaa agtggggctc aagtacggaa
     1141 cagatctgtt gctgtatcgg aaaggccctc cattttacca tgcaagctac tctgtcatca
     1201 ttgagctcgt ggatgacaac tttgaagggt ccctccgaag gcctttcagc tggaagtcac
     1261 tggccgcctt gagcagagtc tcagggaacg tctcaaagga gctgatgctg tgttacttga
     1321 ttaagccctc taccatgact aacgaagaca tggagacccc agaatgcatg aggaggattc
     1381 aagttcagga ggtgattctc agccgatggg tgtcttcccg agagagaagt gaccaagatg
     1441 agctttgacc tttcaatccc agagtccaca gttcaccatc agcctgccct aaaggagcat
     1501 tagcgcattt ggggatcaca ggaccccgtg ctctgttgct ttaatagaga aatctactcc
     1561 tgtagctcag cccacccaag gacttcaacc aattacccac gtgactggaa acccattgac
     1621 ggtttggaaa ccttgaaacg tgactggtgc atcctcagtg aactccttgt ttgacaggtt
     1681 ggtgcattga acacagaact atgtagtact gactattaaa gatgcatctc gctttggaga
     1741 aatcttataa aataaaaata agcagtgggg tttttgagag aa
//
