LOCUS       NM_001400982            2115 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus TSC22 domain family, member 3 (Tsc22d3),
            transcript variant 1, mRNA.
ACCESSION   NM_001400982 XM_006234250
VERSION     NM_001400982.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Jia,H., Yu,Z., Ge,X., Chen,Z., Huang,X. and Wei,Y.
  TITLE     Glucocorticoid-induced leucine zipper protects noise-induced
            apoptosis in cochlear cells by inhibiting endoplasmic reticulum
            stress in rats
  JOURNAL   Med Mol Morphol 53 (2), 73-81 (2020)
   PUBMED   31485805
  REMARK    GeneRIF: Glucocorticoid-induced leucine zipper protects
            noise-induced apoptosis in cochlear cells by inhibiting endoplasmic
            reticulum stress in rats.
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Gu,R., Tang,W., Lei,B., Ding,X., Jiang,C. and Xu,G.
  TITLE     Glucocorticoid-Induced Leucine Zipper Protects the Retina From
            Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats
  JOURNAL   Invest Ophthalmol Vis Sci 58 (9), 3656-3668 (2017)
   PUBMED   28728173
  REMARK    GeneRIF: Overexpression of GILZ by OE-GILZ-rLV transduction
            protected the retina from light-induced cellular damage by
            activating antiapoptotic pathways.
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Xiong,J., Xu,L., Qu,W.M., Li,Z.L., Shang,Z.H., Li,Y.H., Yang,S.H.
            and Yang,Z.H.
  TITLE     Roles of GILZ in protein metabolism of L6 muscle cells exposed to
            serum from septic rats
  JOURNAL   Genet Mol Res 13 (4), 8209-8219 (2014)
   PUBMED   25299205
  REMARK    GeneRIF: GILZ may be sensitive to the elevated expression of GC in
            septic muscle, promoting the expression and activation of GR
            involved in GC/GR-mediated proteolysis in septic skeletal muscle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Aguilar,D.C., Strom,J., Xu,B., Kappeler,K. and Chen,Q.M.
  TITLE     Expression of glucocorticoid-induced leucine zipper (GILZ) in
            cardiomyocytes
  JOURNAL   Cardiovasc Toxicol 13 (2), 91-99 (2013)
   PUBMED   23090754
  REMARK    GeneRIF: Our data demonstrate GILZ induction in cardiomyocytes both
            in vivo and in vitro by glucocorticoids, pointing to H9c2(2-1)
            cells as a valid model for studying the biological function of GILZ
            in cardiomyocytes.
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Wang,Y., Ma,Y.Y., Song,X.L., Cai,H.Y., Chen,J.C., Song,L.N.,
            Yang,R. and Lu,J.
  TITLE     Upregulations of glucocorticoid-induced leucine zipper by hypoxia
            and glucocorticoid inhibit proinflammatory cytokines under hypoxic
            conditions in macrophages
  JOURNAL   J Immunol 188 (1), 222-229 (2012)
   PUBMED   22124125
  REMARK    GeneRIF: GILZ has an important role not only in adjusting adaptive
            responses to hypoxia by negatively regulating the activation of
            macrophages and the expression of proinflammatory cytokines
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Soundararajan,R., Wang,J., Melters,D. and Pearce,D.
  TITLE     Differential activities of glucocorticoid-induced leucine zipper
            protein isoforms
  JOURNAL   J Biol Chem 282 (50), 36303-36313 (2007)
   PUBMED   17956870
  REMARK    GeneRIF: multiple GILZ isoforms are expressed in most cells and
            tissues and that these play distinct roles in regulating
            proliferation and ion transport.
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Fiol,D.F., Mak,S.K. and Kultz,D.
  TITLE     Specific TSC22 domain transcripts are hypertonically induced and
            alternatively spliced to protect mouse kidney cells during osmotic
            stress
  JOURNAL   FEBS J 274 (1), 109-124 (2007)
   PUBMED   17147695
REFERENCE   8  (bases 1 to 2115)
  AUTHORS   Muller,O.G., Parnova,R.G., Centeno,G., Rossier,B.C., Firsov,D. and
            Horisberger,J.D.
  TITLE     Mineralocorticoid effects in the kidney: correlation between
            alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of
            Na+ and K+
  JOURNAL   J Am Soc Nephrol 14 (5), 1107-1115 (2003)
   PUBMED   12707381
  REMARK    GeneRIF: Induction of GILZ mRNA may play a permissive role in the
            enhancement of the early and/or late responses; these effects may
            be necessary for a full response but do not by themselves promote
            early changes in urinary Na(+) and K(+) excretion.
REFERENCE   9  (bases 1 to 2115)
  AUTHORS   Umriukhin,P.E.
  TITLE     Delta sleep-inducing peptide blocks excitatory effects of glutamate
            on rat brain neurons
  JOURNAL   Bull Exp Biol Med 134 (1), 5-7 (2002)
   PUBMED   12459854
  REMARK    GeneRIF: a role in blocking excitatory effects of glutamate on rat
            brain neurons
REFERENCE   10 (bases 1 to 2115)
  AUTHORS   D'Adamio,F., Zollo,O., Moraca,R., Ayroldi,E., Bruscoli,S.,
            Bartoli,A., Cannarile,L., Migliorati,G. and Riccardi,C.
  TITLE     A new dexamethasone-induced gene of the leucine zipper family
            protects T lymphocytes from TCR/CD3-activated cell death
  JOURNAL   Immunity 7 (6), 803-812 (1997)
   PUBMED   9430225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jan 31, 2022 this sequence version replaced XM_006234250.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK594821.1, SRR26360181.2827397.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                JAXUCZ010000021.1  109066318-109066389 c
            73-494              JAXUCZ010000021.1  109064255-109064676 c
            495-546             JAXUCZ010000021.1  109008971-109009022 c
            547-2115            JAXUCZ010000021.1  109006410-109007978 c
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..2115
                     /gene="Tsc22d3"
                     /gene_synonym="Dsipi; Gilz"
                     /note="TSC22 domain family, member 3"
                     /db_xref="GeneID:83514"
                     /db_xref="RGD:621654"
     exon            1..72
                     /gene="Tsc22d3"
                     /gene_synonym="Dsipi; Gilz"
                     /inference="alignment:Splign:2.1.0"
     exon            73..494
                     /gene="Tsc22d3"
                     /gene_synonym="Dsipi; Gilz"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..777
                     /gene="Tsc22d3"
                     /gene_synonym="Dsipi; Gilz"
                     /note="isoform 1 is encoded by transcript variant 1; TSC22
                     domain family protein 3; glucocorticoid-induced leucine
                     zipper protein; TSC22 domain family 3; delta sleep
                     inducing peptide, immunoreactor"
                     /codon_start=1
                     /product="TSC22 domain family protein 3 isoform 1"
                     /protein_id="NP_001387911.1"
                     /db_xref="GeneID:83514"
                     /db_xref="RGD:621654"
                     /translation="MAQPKIECRSPVGLDCCNCCLDLANRCDLQKGRSGENNPGSPTV
                     SNFRQLQEKLVFENLNTDKLNNIMRQDSLEPVLRDPCYLINEGICNRNIDQTMLSILL
                     FFHSASGASVVALDNKIEQAMDLVKNHLMYAVREEVEVLKEQIRELVEKNSQLERENT
                     LLKTLASPEQLEKFQSRLSPEEPAPEAPETPEAPGGSAV"
     exon            495..546
                     /gene="Tsc22d3"
                     /gene_synonym="Dsipi; Gilz"
                     /inference="alignment:Splign:2.1.0"
     exon            547..2115
                     /gene="Tsc22d3"
                     /gene_synonym="Dsipi; Gilz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctgcgtg cgtgcagacg gctggagaag tctctggaga gatcgacgga gaccgatcac
       61 ctgaagtagc agcttgtttt gccgggcacc ctggagtccg aaaaggccaa ctccgcaggt
      121 gcgcacctgc ccgccgcccc tgacgtccct gagcaggcag cctctgagcc ccagaagatg
      181 gcccagccca agatcgagtg ccgctcacct gtcggcctcg actgctgcaa ctgctgcctg
      241 gacctggcca accgctgcga tctccagaaa gggagaagcg gcgaaaacaa cccaggcagc
      301 cccaccgtga gcaactttcg gcagctgcag gaaaagctgg tcttcgagaa cctcaacact
      361 gacaagctca acaacataat gcggcaggat tcgctggagc ccgtgcttcg tgacccctgc
      421 tacctgatca atgagggcat ctgcaaccgc aacatcgacc agaccatgct ctccattctg
      481 ctcttcttcc acagtgcctc tggagccagc gtggtggccc tagacaacaa gattgagcag
      541 gccatggatc tagtgaagaa tcatttgatg tatgctgtga gagaggaggt ggaggtccta
      601 aaggagcaga ttcgtgagct ggttgagaag aactcgcagc tggagcgtga gaataccctc
      661 ctgaagacgc tggcgagccc agagcagctg gagaagttcc agtcccggct gagccccgaa
      721 gagccagctc ctgaagcccc agaaacccca gaagcccctg gcggttctgc ggtgtaagtg
      781 gctctgtcct tagggtgggc agagccacaa cttgttctac ctagttcttt ccagtttgtt
      841 ttttggctcc ccaagcgtca tctcatgtgg agaactttac acctaacata gctggtgcca
      901 agagatgtcc caaggacatg cccatctggg tccactccag tgacagaccc ctgacaaaga
      961 gcaggtttgg agactgagtt gcacggggcc tagtaacccc aagccagtga gcttgtcgtg
     1021 ccaccgggcc ctgggggctc ccagggtctg ggcaacttag ttccagctgg ccaaggagaa
     1081 agtagttttg agatggaatg ccaatatgct ccagaaagta taaggggtct gttttcattt
     1141 ccatggacat cttccacagc ttcacctgac aacgactgtt cctatgaaga agccacttgt
     1201 gttttaagca gaagcaacct ctctcttctc ctctgtcttc cagacgggga cagagatggg
     1261 agagattgag ccaaatcagc cttctgttgg ttaatattgt ataatgcatg gctttgtgca
     1321 cagcccagtg tgggattaca gctttgggat gactgcttat aaagttctgt ttggttagta
     1381 ttggcatagt ttttctatat agccataaat gcgtatatat atatacccat agggctagaa
     1441 ctatatatta gtgtagtgat gtatacatat acacatacac atacatgttg aagggcctaa
     1501 ccagctttgg gagtactgac tggtctctta tctcttaaag ctaagttttt gactgtgcta
     1561 atttaccaaa ttgatccagt ttgtccttta gattaaataa gactcgagat ataagggagg
     1621 gagagggaga ccagcctcac catgcggcca cagatgcctt gctgctgcag ccctccccaa
     1681 tctgtccact gaagacatga agtccttttg aatgccaaac ccaccattca ttggtgctga
     1741 ctacatagaa tggggttgag agaagatcag tttggacttc acatttttgt ttaagcttta
     1801 ggtcgttttt ttttttgttt tgttttcgtt tgtttttgtt tgttttttct tttctttttt
     1861 ttttaagttc ttgtgggaaa ctttgggatt agtcaaagga tggagtcctg tggtagacaa
     1921 gaagagtaaa tagttttgat cccttcgggg cctggaaaat gcacccagga agcttgtgaa
     1981 agaaggttct gtgacagtga acactttcca ctttctgaca ccttatcctg ctgtatgtct
     2041 ccaggatttg gattttgatt tttcagatgt agcttgaaat ttcaataaac tttgctcttt
     2101 ttttcaaaaa atcaa
//
