LOCUS       NM_012680               5653 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus TSC complex subunit 2 (Tsc2), mRNA.
ACCESSION   NM_012680
VERSION     NM_012680.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5653)
  AUTHORS   Kazami,M., Sakamoto,T., Suzuki,T., Inoue,H., Kato,H.,
            Kobayashi,K.I., Tadokoro,T. and Yamamoto,Y.
  TITLE     Ca2+/Calmodulin induces translocation of membrane-associated TSC2
            to the nucleus where it suppresses CYP24A1 expression
  JOURNAL   Biosci Biotechnol Biochem 87 (1), 45-53 (2022)
   PUBMED   36331254
  REMARK    GeneRIF: Ca2+/Calmodulin induces translocation of
            membrane-associated TSC2 to the nucleus where it suppresses CYP24A1
            expression.
REFERENCE   2  (bases 1 to 5653)
  AUTHORS   Joly,F., Jeckel,P., Kriebel,M., Raut,S., El Massioui,N.,
            Vaillend,C., Johnson,L.R., Volkmer,H. and Doyere,V.
  TITLE     Disruption of amygdala Tsc2 in adolescence leads to changed
            prelimbic cellular activity and generalized fear responses at
            adulthood in rats
  JOURNAL   Cereb Cortex 32 (20), 4619-4639 (2022)
   PUBMED   35149865
  REMARK    GeneRIF: Disruption of amygdala Tsc2 in adolescence leads to
            changed prelimbic cellular activity and generalized fear responses
            at adulthood in rats.
REFERENCE   3  (bases 1 to 5653)
  AUTHORS   Petrasek,T., Vojtechova,I., Klovrza,O., Tuckova,K., Vejmola,C.,
            Rak,J., Sulakova,A., Kaping,D., Bernhardt,N., de Vries,P.J.,
            Otahal,J. and Waltereit,R.
  TITLE     mTOR inhibitor improves autistic-like behaviors related to Tsc2
            haploinsufficiency but not following developmental status
            epilepticus
  JOURNAL   J Neurodev Disord 13 (1), 14 (2021)
   PUBMED   33863288
  REMARK    GeneRIF: mTOR inhibitor improves autistic-like behaviors related to
            Tsc2 haploinsufficiency but not following developmental status
            epilepticus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5653)
  AUTHORS   Inoue,T., Kokubo,T., Daino,K., Yanagihara,H., Watanabe,F.,
            Tsuruoka,C., Amasaki,Y., Morioka,T., Homma-Takeda,S., Kobayashi,T.,
            Hino,O., Shimada,Y. and Kakinuma,S.
  TITLE     Interstitial chromosomal deletion of the tuberous sclerosis complex
            2 locus is a signature for radiation-associated renal tumors in
            Eker rats
  JOURNAL   Cancer Sci 111 (3), 840-848 (2020)
   PUBMED   31925975
  REMARK    GeneRIF: Reduced expression of Tsc2 was also observed in the
            majority of the LOH-negative carcinomas.
REFERENCE   5  (bases 1 to 5653)
  AUTHORS   Yan,Z., Grenert,J.P., Joseph,N.M., Ren,C., Chen,X., Shafizadeh,N.
            and Kakar,S.
  TITLE     Hepatic angiomyolipoma: mutation analysis and immunohistochemical
            pitfalls in diagnosis
  JOURNAL   Histopathology 73 (1), 101-108 (2018)
   PUBMED   29512829
REFERENCE   6  (bases 1 to 5653)
  AUTHORS   Mizuguchi,M., Kato,M., Yamanouchi,H., Ikeda,K. and Takashima,S.
  TITLE     Loss of tuberin from cerebral tissues with tuberous sclerosis and
            astrocytoma
  JOURNAL   Ann Neurol 40 (6), 941-944 (1996)
   PUBMED   9007104
REFERENCE   7  (bases 1 to 5653)
  AUTHORS   Wienecke,R., Maize,J.C. Jr., Shoarinejad,F., Vass,W.C., Reed,J.,
            Bonifacino,J.S., Resau,J.H., de Gunzburg,J., Yeung,R.S. and
            DeClue,J.E.
  TITLE     Co-localization of the TSC2 product tuberin with its target Rap1 in
            the Golgi apparatus
  JOURNAL   Oncogene 13 (5), 913-923 (1996)
   PUBMED   8806680
REFERENCE   8  (bases 1 to 5653)
  AUTHORS   Xiao,G.H., Jin,F. and Yeung,R.S.
  TITLE     Identification of tuberous sclerosis 2 messenger RNA splice
            variants that are conserved and differentially expressed in rat and
            human tissues
  JOURNAL   Cell Growth Differ 6 (9), 1185-1191 (1995)
   PUBMED   8519695
REFERENCE   9  (bases 1 to 5653)
  AUTHORS   Kobayashi,T., Nishizawa,M., Hirayama,Y., Kobayashi,E. and Hino,O.
  TITLE     cDNA structure, alternative splicing and exon-intron organization
            of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat
            model
  JOURNAL   Nucleic Acids Res 23 (14), 2608-2613 (1995)
   PUBMED   7651821
REFERENCE   10 (bases 1 to 5653)
  AUTHORS   Kobayashi,T., Hirayama,Y., Kobayashi,E., Kubo,Y. and Hino,O.
  TITLE     A germline insertion in the tuberous sclerosis (Tsc2) gene gives
            rise to the Eker rat model of dominantly inherited cancer
  JOURNAL   Nat Genet 9 (1), 70-74 (1995)
   PUBMED   7704028
  REMARK    Erratum:[Nat Genet 1995 Feb;9(2):218]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U24150.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_012680.4.
            
            On Feb 21, 2013 this sequence version replaced NM_012680.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U24150.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5653              U24150.1           1-5653
FEATURES             Location/Qualifiers
     source          1..5653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..5653
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /note="TSC complex subunit 2"
                     /db_xref="GeneID:24855"
                     /db_xref="RGD:3908"
     exon            1..54
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            55..221
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..5513
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /note="tuberous sclerosis 2 homolog protein; tuberous
                     sclerosis 2 protein homolog; renal carcinoma"
                     /codon_start=1
                     /product="tuberin"
                     /protein_id="NP_036812.2"
                     /db_xref="GeneID:24855"
                     /db_xref="RGD:3908"
                     /translation="MAKPTSKDSGLKEKFKILLGLGTSRPNPRCAEGKQTEFIITAEI
                     LRELSGECGLNNRIRMIGQICDVAKTKKLEEHAVEALWKAVSDLLQPERPPEARHAVL
                     ALLKAIVQGQGDRLGVLRALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEEL
                     AEFVLQWMDVGLSSEFLLVLVNLVKFNSCYLDEYIAPMVHMICLLCIRTVSSVDIEVS
                     LQVLDAVVCYNCLPAESLPLFIITLCRTVNVKELCEPCWKLMRNLLGTHLGHSAIYNM
                     CRIMENRSYMEDAPLLRGAVFFVGMALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVV
                     SYEIVLSITRLIKKYRKELQAVTWDILLDIIERLLQQLQNLDSPELRTIVHDLLTTVE
                     ELCDQNEFHGSQERYYELVESYADQRPESSLLNLITYRAQSIHPAKDGWIQNLQLLME
                     RFFRNECRSAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKLA
                     TQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPLELEERDLAVYSASLEDVKTAVLG
                     LLVILQTKLYTLPASHATRVYETLISHIQLHYKHGYSLPIASSIRLQAFDFLLLLRAD
                     SLHRLGLPNKDGVVRFSPYCLCDCAELDRASEKKASGPLSPPTGPPSPVPTGPAVRLG
                     HLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYKVLIFTSPCSVDQLSSALCSM
                     LSAPKTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYLDKTRQREMVYCLEQGLIY
                     RCASQCVVALAICSVEMPDIIIKALPVLVVKLTHISATASMAIPLLEFLSTLARLPHL
                     YRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPYITK
                     GLRSNVLLSFDDTPEKDKFRARSTSLNERPKSLRIARAPKQGLNNSPPVKEFKESCAA
                     EAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHLELTETCLDMM
                     ARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGLDSGDL
                     QGGSASSSDPGTHVRQTKEAPAKLESQAGQQVSRGARDRVRSMSGGHGLRVGVLDTSA
                     PYTPGGPASLGAQAAPAARPEKPCAGAQLPAAEKANLAAYVPLLTQGWAEILVRRPTG
                     NTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAGTAK
                     PPTLPRSNTVASFSSLYQPSCQGQLHRSVSWADSAVVLEEGSPGEAHVPVEPPELEDF
                     EAALGTDRHCQRPDAYSRSSSASSQEEKSHLEELAAGGIPIERAISSEGARPTVDLSF
                     QPSQPLSKSSSSPELQTLQDILGDLGDKTDIGRLSPEAKVRSQSGILDGEAATWSAPG
                     EESRITVPPEGPLPSSSPRSPSGLRPRGYTISDSAPSRRGKRVERDNFKSRTAASSAE
                     KVPGINPSFVFLQLYHSPFCGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYV
                     GEGQSSSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTY
                     CWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIIYNDSGEDFKLGTIKGQF
                     NFVHVIITPLDYKCNLLTLQCRKDMEGLVDTSVAKIVSDRNLSFVARQMALHANMASQ
                     VHHRRSNPTDIYPSKWIARLRHIKRLRQRIREEVHYSNPSLPLMHPPAHTKVPAQAPT
                     EATPTYETGQRKRLISSVDDFTEFV"
     exon            222..308
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            309..419
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            420..564
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            565..682
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            683..731
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            732..857
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            858..931
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1058
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1202
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1340
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1444
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1526
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1682
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1799
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1922
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2029
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2180
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2303
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2438
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2628
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2722
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2825
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2920
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3049
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            3050..3214
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3367
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3480
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3693
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3897
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..3966
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4097
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            4098..4588
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            4589..4664
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4751
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..4938
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            4939..5078
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            5079..5157
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            5158..5249
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            5250..5348
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
     exon            5349..5653
                     /gene="Tsc2"
                     /gene_synonym="Rc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtgcgccc tttcctgggt gcaggaggcc gtgcgcgcga aaggcgcgcg cgggagcagt
       61 tctctaccac cgccctgccc accatggcca aaccaactag caaagattca ggtttgaagg
      121 agaagttcaa gatactatta ggactgggaa cgtcaaggcc aaatcctagg tgtgcagaag
      181 gcaaacagac ggagtttatc atcacagcgg aaatcttgag agaactgagt ggtgaatgcg
      241 gcctcaacaa tcgaatccgg atgatagggc agatctgtga tgtggcaaaa actaagaaac
      301 ttgaagagca tgcagtggag gcactttgga aggctgtctc agacttgcta cagccagagc
      361 ggccaccgga ggcccgacat gcagttctgg ccttgttgaa ggccattgtg cagggacagg
      421 gtgatcgttt gggggttctc cgagccctct tcttcaaagt gatcaaggac tatccttcca
      481 acgaagacct ccatgaaagg ctagaggttt ttaaggccct cacagacaat ggaaggcata
      541 ttacctactt ggaagaagaa ctggcagagt ttgtcctgca gtggatggat gttggcttgt
      601 cctcagaatt ccttctggta ctcgtgaacc tggtcaagtt caacagctgc taccttgacg
      661 aatacattgc gccaatggtt cacatgattt gtctgttatg tatccggaca gtgtcctctg
      721 tggacatcga ggtgtccttg caagtgctgg atgctgtggt ctgctacaac tgcctgcctg
      781 ctgagagcct gcctctgttc attatcaccc tgtgccgcac cgtcaacgtc aaggagctgt
      841 gtgagccgtg ctggaagctg atgcgaaacc ttctaggtac ccatctaggc cacagtgcca
      901 tttacaacat gtgccgtatc atggagaaca gatcctacat ggaagacgcc cccttgttga
      961 ggggagccgt gttctttgtt gggatggcgc tctggggagc tcaccgactc tattcgctca
     1021 agaactcccc cacatctgtg ctgccgtctt tttatgaggc catgacctgt cccaatgagg
     1081 tggtgtcata tgagattgtt ctgtccataa caagactcat caagaagtac aggaaggagc
     1141 tccaggctgt gacatgggac attctgctgg acattattga acgactgctc cagcaactcc
     1201 agaacctgga cagcccggaa ctcaggacca ttgtccatga cctgctgacc actgtggagg
     1261 agctgtgtga ccagaacgag ttccacggat cgcaagaaag atactatgaa ctggtggaga
     1321 gctatgcaga ccagaggcct gaatcctctc tcttaaacct gataacctac agagcccagt
     1381 ctatccaccc agccaaggat ggctggatcc agaacctgca gttgttgatg gagaggttct
     1441 tcaggaacga gtgccgcagt gccgtgcgca tcaaggtgct ggacgtcctg tccttcgtgc
     1501 tcctcatcaa caggcagttc tacgaggagg agctgattaa ctcggtggtc atctcacagc
     1561 tctcccacat ccccgaggat aaagaccatc aggttcgaaa gctggctacc cagctgctgg
     1621 tggacctggc agagggctgc cacacccacc acttcaacag tctgttggac atcattgaaa
     1681 aggtgatggc tcgctccctt tctccacccc tggagctgga ggaaagggat ctggctgtgt
     1741 actcggcctc cctggaggat gtgaagacgg cagtcctcgg gctcctggtc atccttcaga
     1801 ccaagctgta taccttgccc gccagccatg ccacacgagt gtatgagaca ctcattagcc
     1861 acatccagct ccattacaag catggctact ccttgcccat tgctagcagc atccggctgc
     1921 aggcctttga cttcctgctg ctactgcggg ctgactcgct gcatcgactg ggcctgccca
     1981 acaaggatgg ggtcgtgcga ttcagccctt actgcctctg tgactgcgcg gaactggaca
     2041 gggcctcaga gaagaaagcc agcggacccc tttcaccgcc aactgggccc cccagccctg
     2101 tgccaacggg ccctgctgtg aggctcggcc acctgcccta ctccctgctt ttccgtgtcc
     2161 tgctgcagtg tttgaagcag gagaccgact ggaaggtgct gaagctggtg ctcagcaaac
     2221 tccctgagtc gctgcgctac aaagtcctca ttttcacctc cccctgcagt gttgaccagc
     2281 tgtcttctgc tctctgctcc atgctttcag ccccgaagac ccttgagcgg ctccgaggca
     2341 ccccagaagg cttctccaga actgacttgc acttggctgt ggtccctgta ctgacagcgt
     2401 taatatctta ccacaactat ttggataaga ctagacagcg tgagatggtt tactgcctag
     2461 aacaaggcct tatctaccgc tgtgccagcc agtgtgtggt agccttggcc atctgcagtg
     2521 tggagatgcc cgacatcatc atcaaggcgc tccctgtcct ggtggtgaag ctgacacaca
     2581 tctctgctac agctagcatg gccatccccc tcctggagtt cctgtctacc ttggccaggc
     2641 tgcctcacct ctacaggaac ttcgccgcag agcagtatgc aagtgtgttt gccatctcct
     2701 tgccctacac caacccctcc aagttcaacc agtacattgt gtgtctggcc catcacgtca
     2761 tagccatgtg gttcattagg tgccgactgc cctttcggaa ggattttgtc ccttatatca
     2821 ctaagggtct gcgttccaat gtcctcctgt cctttgatga tacccctgag aaggacaagt
     2881 tcagagcacg gagcaccagt cttaatgaga gacccaaaag tttgaggata gccagagccc
     2941 ccaaacaagg cctgaataac tctccacctg tgaaagaatt caaagagagc tgtgcagccg
     3001 aggccttccg gtgccgcagc atcagtgtat ctgaacatgt ggtccgcagc agaatacaga
     3061 catctcttac cagtgccagc ttggggtctg cggatgagaa ctctatggcc caggctgatg
     3121 acaacctgaa gaatctccac ttggaactca cagaaacatg tctggacatg atggcccgat
     3181 atgtgttctc caacttcact gcggttccca agaggtcccc tgtgggagaa ttcctcctgg
     3241 cagggggcag gaccaaaacg tggctggttg gaaataagct ggtcactgtg acaacgagtg
     3301 tgggaactgg tacgcggtcg ttgctgggcc tggactccgg ggatctgcag ggtggctcag
     3361 catcaagctc tgatcctggc acacatgtga ggcagacaaa ggaagcaccg gccaaactgg
     3421 agtcccaggc tgggcagcag gtgtcccgtg gggcccggga ccgagtccgc tccatgtcag
     3481 ggggccacgg ccttcgagtt ggtgtcctgg acacttcagc tccctacacc ccaggaggcc
     3541 ctgcttctct gggagcacag gcagcaccag cagcaaggcc tgagaagccc tgtgcaggag
     3601 cccaacttcc ggcagcggag aaggcgaacc tggcagccta tgtgcctttg ctgacccagg
     3661 gctgggcaga gatcctggtc cgcaggccca caggaaacac cagctggctg atgagcttgg
     3721 agaacccgct cagccccttt tcctcagaca tcaacaacat gcccctgcaa gagctgtcta
     3781 atgcccttat ggctgctgag cgcttcaagg agcaccggga cacggcccta tacaagtcat
     3841 tgtcagtgcc agcggctggc acagccaagc ctcctactct cccacgttct aacacagtgg
     3901 cttctttctc ctccctgtac cagcccagct gccaaggaca gctgcacagg agcgtttcct
     3961 gggcagactc ggccgtggtt cttgaggagg gaagtccagg agaggctcat gtgccagtgg
     4021 agccccccga attggaggac tttgaggcag cattaggtac agacaggcac tgccagcggc
     4081 ctgacgccta cagcaggtct tcctcagcat ctagccagga agaaaagtcc cacttggagg
     4141 agctggctgc agggggtatc cccattgagc gggccatctc ctctgagggg gctcggccta
     4201 cagtggacct gtccttccaa ccctcacagc ctttgagcaa gtctagctct tctcctgagt
     4261 tacagacctt acaggacatc cttggagacc taggggacaa gactgacatt ggacggctga
     4321 gtcctgaggc taaggtccga tcccagtcgg ggatcctgga tggggaagca gctacctggt
     4381 cagctccggg tgaagagagc cgtatcacag tcccacctga aggtcccctg ccttccagtt
     4441 ctccccgctc ccctagtggc ctccggcccc gaggctatac catctctgat tcagctccat
     4501 cacgaagggg aaagagggta gaaagggaca acttcaagag cagaactgcg gcctccagtg
     4561 ctgaaaaggt gccaggcatc aaccctagct ttgtgttcct acagctctac cattcaccct
     4621 tttgtggtga tgagtccaat aagcccatcc tgttgcccaa cgagtccttt gaacggtcag
     4681 tgcagctcct tgaccagatc ccatcctatg acactcacaa gattgctgtc ctgtatgtgg
     4741 gagaaggcca gagcagcagt gagctggcca tcctatcaaa tgagcatggc tcttataggt
     4801 acacagagtt tctgacaggc ctgggtcggc ttattgagct gaaggactgc caaccagaca
     4861 aggtgtactt aggtggactg gatgtgtgtg gcgaggatgg acagttcacg tactgctggc
     4921 atgatgacat catgcaagct gttttccaca ttgctaccct gatgcccacc aaggatgtgg
     4981 acaagcaccg ttgtgacaag aaacggcacc tgggcaatga ctttgtttct atcatctaca
     5041 atgattctgg tgaggacttc aagctgggca ccattaaggg ccagttcaac ttcgtccatg
     5101 tgatcatcac accgctggac tataaatgca acctgttgac cctgcagtgc aggaaagaca
     5161 tggagggcct tgtggacacc agtgtggcca agattgtgtc tgaccgcaac ctgtcctttg
     5221 tggcccgaca gatggccctg catgcaaata tggcctcaca ggtacaccac aggcgatcca
     5281 accccacgga catctatccc tccaagtgga tcgcaagact ccgccacatt aagcgtctcc
     5341 gtcagcggat ccgtgaagaa gtgcactatt caaacccaag cttgcctctg atgcaccctc
     5401 cagcccatac caaagtccca gctcaagccc ctacggaggc tacacccacc tacgagacag
     5461 gccagcggaa acgcctcatt tcctctgtgg atgacttcac agagtttgtg tgaggccacc
     5521 agagccacaa ctggagtccc gtggccatgc acctgggcct tccctgaatg acacctcctg
     5581 actgtactct tacatgaaat aaaactgccc gtgcccatct ggcccttgga gttcagagag
     5641 cagcacagac agc
//
