LOCUS       NM_053686               2910 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily V, member 6 (Trpv6), mRNA.
ACCESSION   NM_053686
VERSION     NM_053686.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2910)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   2  (bases 1 to 2910)
  AUTHORS   Suzuki,Y., Chitayat,D., Sawada,H., Deardorff,M.A., McLaughlin,H.M.,
            Begtrup,A., Millar,K., Harrington,J., Chong,K., Roifman,M.,
            Grand,K., Tominaga,M., Takada,F., Shuster,S., Obara,M., Mutoh,H.,
            Kushima,R. and Nishimura,G.
  TITLE     TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport
            through the Placenta and Cause Transient Neonatal
            Hyperparathyroidism
  JOURNAL   Am J Hum Genet 102 (6), 1104-1114 (2018)
   PUBMED   29861107
REFERENCE   3  (bases 1 to 2910)
  AUTHORS   Bate,N., Caves,R.E., Skinner,S.P., Goult,B.T., Basran,J.,
            Mitcheson,J.S. and Vuister,G.W.
  TITLE     A Novel Mechanism for Calmodulin-Dependent Inactivation of
            Transient Receptor Potential Vanilloid 6
  JOURNAL   Biochemistry 57 (18), 2611-2622 (2018)
   PUBMED   29505720
  REMARK    GeneRIF: we present a model for TRPV6 CaM-dependent inactivation,
            which involves a novel so-called 'two-tail' mechanism whereby CaM
            bridges two TRPV6 monomers resulting in closure of the channel
            pore.
REFERENCE   4  (bases 1 to 2910)
  AUTHORS   Song,T., Ma,J., Guo,L., Yang,P., Zhou,X. and Ye,T.
  TITLE     Regulation of chondrocyte functions by transient receptor potential
            cation channel V6 in osteoarthritis
  JOURNAL   J Cell Physiol 232 (11), 3170-3181 (2017)
   PUBMED   28063212
  REMARK    GeneRIF: TRPV6 could regulate certain chondrocyte functions,
            including ECM secretion, cell proliferation, and apoptosis I
            osteoarthritis.
REFERENCE   5  (bases 1 to 2910)
  AUTHORS   Gao da,Y., Zhang,B.L., Leung,M.C., Au,S.C., Wong,P.Y. and Shum,W.W.
  TITLE     Coupling of TRPV6 and TMEM16A in epithelial principal cells of the
            rat epididymis
  JOURNAL   J Gen Physiol 148 (2), 161-182 (2016)
   PUBMED   27481714
REFERENCE   6  (bases 1 to 2910)
  AUTHORS   Wissenbach,U., Niemeyer,B.A., Fixemer,T., Schneidewind,A.,
            Trost,C., Cavalie,A., Reus,K., Meese,E., Bonkhoff,H. and
            Flockerzi,V.
  TITLE     Expression of CaT-like, a novel calcium-selective channel,
            correlates with the malignancy of prostate cancer
  JOURNAL   J Biol Chem 276 (22), 19461-19468 (2001)
   PUBMED   11278579
REFERENCE   7  (bases 1 to 2910)
  AUTHORS   Yue,L., Peng,J.B., Hediger,M.A. and Clapham,D.E.
  TITLE     CaT1 manifests the pore properties of the calcium-release-activated
            calcium channel
  JOURNAL   Nature 410 (6829), 705-709 (2001)
   PUBMED   11287959
REFERENCE   8  (bases 1 to 2910)
  AUTHORS   Peng,J.B., Chen,X.Z., Berger,U.V., Weremowicz,S., Morton,C.C.,
            Vassilev,P.M., Brown,E.M. and Hediger,M.A.
  TITLE     Human calcium transport protein CaT1
  JOURNAL   Biochem Biophys Res Commun 278 (2), 326-332 (2000)
   PUBMED   11097838
REFERENCE   9  (bases 1 to 2910)
  AUTHORS   Peng,J.B., Chen,X.Z., Berger,U.V., Vassilev,P.M., Brown,E.M. and
            Hediger,M.A.
  TITLE     A rat kidney-specific calcium transporter in the distal nephron
  JOURNAL   J Biol Chem 275 (36), 28186-28194 (2000)
   PUBMED   10875938
REFERENCE   10 (bases 1 to 2910)
  AUTHORS   Peng,J.B., Chen,X.Z., Berger,U.V., Vassilev,P.M., Tsukaguchi,H.,
            Brown,E.M. and Hediger,M.A.
  TITLE     Molecular cloning and characterization of a channel-like
            transporter mediating intestinal calcium absorption
  JOURNAL   J Biol Chem 274 (32), 22739-22746 (1999)
   PUBMED   10428857
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            [WARNING] On Jan 24, 2025 this sequence was replaced by
            NM_053686.3.
            
            On Nov 26, 2020 this sequence version replaced NM_053686.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF160798.1, SRR26643291.12269.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               JAXUCZ010000004.1  71489256-71489667   c
            413-510             JAXUCZ010000004.1  71481201-71481298   c
            511-633             JAXUCZ010000004.1  71480933-71481055   c
            634-771             JAXUCZ010000004.1  71480455-71480592   c
            772-870             JAXUCZ010000004.1  71480069-71480167   c
            871-1043            JAXUCZ010000004.1  71479552-71479724   c
            1044-1190           JAXUCZ010000004.1  71478961-71479107   c
            1191-1403           JAXUCZ010000004.1  71478670-71478882   c
            1404-1490           JAXUCZ010000004.1  71478311-71478397   c
            1491-1567           JAXUCZ010000004.1  71478134-71478210   c
            1568-1733           JAXUCZ010000004.1  71477624-71477789   c
            1734-1800           JAXUCZ010000004.1  71477206-71477272   c
            1801-2069           JAXUCZ010000004.1  71476229-71476497   c
            2070-2176           JAXUCZ010000004.1  71475056-71475162   c
            2177-2910           JAXUCZ010000004.1  71474006-71474739   c
FEATURES             Location/Qualifiers
     source          1..2910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2910
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 6"
                     /db_xref="GeneID:114246"
                     /db_xref="RGD:69335"
     exon            1..412
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..2468
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /note="epithelial apical membrane calcium
                     transporter/channel CaT1; transient receptor potential
                     cation channel, subfamily 5, member 6; calcium transport
                     protein 1; osmosensitive transient receptor potential
                     channel 3; epithelial calcium channel 2"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 6"
                     /protein_id="NP_446138.2"
                     /db_xref="GeneID:114246"
                     /db_xref="RGD:69335"
                     /translation="MGWSLPKEKGLILCLWNKFCRWFHRRESWAQSRDEQNLLQQKRI
                     WESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAA
                     PELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLI
                     YYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNL
                     LLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTL
                     YDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVKELVSLKWKRYGRPYFCVLGAI
                     YVLYIICFTMCCVYRPLKPRITNRTNPRDNTLLQQKLLQEAYVTPKDDLRLVGELVSI
                     VGAVIILLVEIPDIFRLGVTRFFGQTILGGPFHVIIVTYAFMVLVTMVMRLTNSDGEV
                     VPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFY
                     IIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSITYAAFAIIAT
                     LLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLERKLPRCLWPRSGICGREYGL
                     GDRWFLRVEDRQDLNRQRIRRYAQAFQQQDDLYSEDLEKDSGEKLEMARPFGAYLSFP
                     TPSVSRSTSRSSTNWERLRQGALRKDLQGIINRGLEDGEGWEYQI"
     exon            413..510
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..633
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            634..771
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            772..870
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1043
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1190
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1403
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1490
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1567
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1733
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1800
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2069
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2176
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2910
                     /gene="Trpv6"
                     /gene_synonym="CaT1; Ecac2; Otrpc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacacagct cctgctcact cccaacagga gctccgatat acaagcccag cagatttcca
       61 gctctgccaa gtggaacaaa gcaggagccc tcttcggact cctaagagca gccacgggaa
      121 gcctcaccag ctccacaggt gaagtaggag gcagaacaca ggagacggga cctctacaga
      181 gagagggtag gccggctctt ggggatgcca atgtggcccc agggtcgagc ccaggtgggg
      241 tctggcatca gcctcagccc cccaaggact cagccttcca ccccatgggg tggtcactgc
      301 ccaaggagaa ggggttaata ctctgcctat ggaacaagtt ctgcagatgg ttccacagac
      361 gagagtcctg ggctcagagc cgagatgagc agaacctgct gcagcagaag aggatctggg
      421 agtcgcctct tcttctagct gccaaagaaa acaatgtcca ggctctgatc aaactgctca
      481 agtttgaagg atgtgaggtg caccagaaag gagccatggg ggaaactgca cttcacatag
      541 ctgccctcta tgataacctg gaggctgcca tggtgctaat ggaggctgcc ccagaactgg
      601 tttttgagcc catgacttca gagctatatg aaggtcagac tgcactgcac attgcagtaa
      661 taaaccagaa tgtgaacttg gtccgtgctc tgcttgcccg aggggccagt gtctccgcca
      721 gagctacggg ctctgtcttc cactacaggc ctcacaatct catttactat ggagaacatc
      781 ctttgtcctt tgctgcctgt gtgggtagtg aggagattgt tagactgctc atcgagcatg
      841 gggctgacat tcgggcccag gactccttgg gaaatacagt actacacata ctcatcttgc
      901 agcccaacaa aacctttgcc tgccagatgt acaacctgct actgtcctat gatgggggag
      961 accacctgaa gtcccttgaa cttgtgccca ataaccaagg actcacccct ttcaagttgg
     1021 ctggggtgga aggcaacatt gtgatgttcc aacacctgat gcagaagcgg aaacacatcc
     1081 agtggactta tgggccattg acttccacac tttatgacct cactgagatt gactcctcag
     1141 gggatgatca atctctactg gaacttattg ttaccaccaa gaagcgggag gctcgccaga
     1201 tcctggacca gacacctgtg aaggaactgg tgagcctcaa gtggaagagg tatgggcggc
     1261 cctacttctg tgtgctgggt gccatctacg tgctctacat catctgcttt accatgtgct
     1321 gtgtctaccg cccactcaag cccaggatca ctaaccgcac caaccccagg gacaataccc
     1381 tcctgcagca gaagctcctt caggaggcct atgtgacccc caaggatgat ctccggctgg
     1441 tgggggagct ggtgagcatc gttggggctg tgatcatcct gctggtggag attccagaca
     1501 tcttcaggtt gggggtcact cgattttttg ggcagaccat tcttgggggg ccattccatg
     1561 tcatcattgt cacttatgcc ttcatggtgc tggtgaccat ggtgatgcgg ctcaccaact
     1621 cagatggaga ggtggtgccc atgtcgtttg ctctggtgtt gggctggtgc aatgtcatgt
     1681 actttgccag aggattccaa atgctgggtc ccttcaccat catgatccag aagatgattt
     1741 ttggtgactt gatgcgattc tgctggctga tggctgtggt aatcttggga tttgcttcag
     1801 ccttctatat catcttccag acagaggacc ccgatgagct gggccatttc tatgactacc
     1861 ccatggcact gttcagcacc tttgaactct tcctcaccat catcgatggc cctgccaact
     1921 atgacgtgga tctgcccttc atgtacagca tcacctacgc tgcctttgcc atcatcgcca
     1981 cactgctcat gctcaacctc ctaattgcca tgatgggtga cactcactgg agagttgccc
     2041 atgagcggga tgagctctgg agagcacagg ttgtggctac taccgtgatg ctagaacgga
     2101 agctgcctcg ctgcctgtgg cctcgatctg ggatatgtgg gcgagagtat ggtcttgggg
     2161 accgctggtt cttgagggtg gaagatagac aagatctcaa cagacaacgc atccgccgct
     2221 atgcacaggc cttccagcaa caagatgacc tctactctga ggacttggaa aaagactcag
     2281 gagaaaaact ggagatggca cgaccctttg gtgcctatct gtcctttcct acaccctcag
     2341 tgtctcgaag tacctcccga agcagcacca attgggaaag gcttcgacaa ggggccctaa
     2401 ggaaggacct tcaagggata atcaaccggg gcctggaaga tggggagggc tgggagtacc
     2461 agatctaaat gttggctctc accaaacatc aaaacagaat gaaagaaaac cagttcaaaa
     2521 ctagaagtca tcctgcaagt ccaaggagaa gggggaggaa catgctaagg aatgtacaat
     2581 aaatccttca gagctccaca actccacctt ggggcagaaa gaagaagatt ctgtggtcct
     2641 tgcctcaacc aagcattcct tgttctctta tggaagctcc cctgcacacc agagcacttt
     2701 aaagacaggc ttcccgtcac aggcacctgt ctccacccag gtctaataag tgggagggca
     2761 cagaactcta cccagagtgc ttcagaggac cggtggagaa cactcagatt gtgggaaagc
     2821 gtgtgatgga gagatacagg caccagtcta ggggtgggga aactaggctg agccttgcca
     2881 ccttccagta aagtcatttc ctgatcccca
//
