LOCUS       NM_053787               4836 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily V, member 5 (Trpv5), mRNA.
ACCESSION   NM_053787 XM_346696
VERSION     NM_053787.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4836)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   2  (bases 1 to 4836)
  AUTHORS   Bokhovchuk,F.M., Bate,N., Kovalevskaya,N.V., Goult,B.T.,
            Spronk,C.A.E.M. and Vuister,G.W.
  TITLE     The Structural Basis of Calcium-Dependent Inactivation of the
            Transient Receptor Potential Vanilloid 5 Channel
  JOURNAL   Biochemistry 57 (18), 2623-2635 (2018)
   PUBMED   29584409
  REMARK    GeneRIF: We demonstrate that under these conditions the TRPV5
            C-terminus is exclusively bound to the CaM C-lobe only, while it
            confers conformational freedom to the CaM N-lobe. We also show that
            at elevated calcium levels, additional interactions between the
            TRPV5 C-terminus and CaM N-lobe occur, resulting in formation of a
            tight 1:1 complex, effectively making the N-lobe the calcium
            sensor.
REFERENCE   3  (bases 1 to 4836)
  AUTHORS   Wei,Y., Jin,Z., Zhang,H., Piao,S., Lu,J. and Bai,L.
  TITLE     The Transient Receptor Potential Channel, Vanilloid 5, Induces
            Chondrocyte Apoptosis via Ca2+ CaMKII-Dependent MAPK and Akt/ mTOR
            Pathways in a Rat Osteoarthritis Model
  JOURNAL   Cell Physiol Biochem 51 (5), 2309-2323 (2018)
   PUBMED   30537737
  REMARK    GeneRIF: These results demonstrate that upregulated TRPV5 may be an
            important initiating factor that activates CaMKII phosphorylation
            via the mediation of Ca2+ influx. In turn, activated p-CaMKII plays
            a critical role in chondrocyte apoptosis via MAPK and Akt/mTOR
            pathways.
REFERENCE   4  (bases 1 to 4836)
  AUTHORS   Kumar,S., Singh,U., Goswami,C. and Singru,P.S.
  TITLE     Transient receptor potential vanilloid 5 (TRPV5), a highly Ca2+
            -selective TRP channel in the rat brain: relevance to
            neuroendocrine regulation
  JOURNAL   J Neuroendocrinol 29 (4) (2017)
   PUBMED   28235149
  REMARK    GeneRIF: Study shows that transient receptor potential vanilloid 5
            (TRPV5) neurones were conspicuously seen in the hypothalamic
            paraventricular, supraoptic, accessory neurosecretory, supraoptic
            nucleus, retrochiasmatic part, arcuate and medial tuberal nuclei,
            hippocampus, midbrain, brainstem and cerebellum. Results suggest
            that the TRPV5 ion channel may serve as an important regulator of
            neural and neuroendocrine pathways in the
REFERENCE   5  (bases 1 to 4836)
  AUTHORS   Wei,Y., Wang,Y., Wang,Y. and Bai,L.
  TITLE     Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and
            Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model
  JOURNAL   Cell Physiol Biochem 42 (1), 319-332 (2017)
   PUBMED   28535500
  REMARK    GeneRIF: The up-regulation of TRPV5 stimulated Ca2+ influx, which
            inhibited autophagy by increasing the production of calmodulin,
            phosphorylation of calmodulin dependent protein kinases II (p-CAMK
            II), phosphorylation of Beclin1 (p-Beclin1), and protein of B-cell
            lymphoma-2 (Bcl-2), and attenuating ratio of LC3-II/ LC3-.
REFERENCE   6  (bases 1 to 4836)
  AUTHORS   Hoenderop,J.G., van Leeuwen,J.P., van der Eerden,B.C.,
            Kersten,F.F., van der Kemp,A.W., Merillat,A.M., Waarsing,J.H.,
            Rossier,B.C., Vallon,V., Hummler,E. and Bindels,R.J.
  TITLE     Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in
            mice lacking TRPV5
  JOURNAL   J Clin Invest 112 (12), 1906-1914 (2003)
   PUBMED   14679186
REFERENCE   7  (bases 1 to 4836)
  AUTHORS   Hoenderop,J.G., Voets,T., Hoefs,S., Weidema,F., Prenen,J.,
            Nilius,B. and Bindels,R.J.
  TITLE     Homo- and heterotetrameric architecture of the epithelial Ca2+
            channels TRPV5 and TRPV6
  JOURNAL   EMBO J 22 (4), 776-785 (2003)
   PUBMED   12574114
REFERENCE   8  (bases 1 to 4836)
  AUTHORS   Hoenderop,J.G., Dardenne,O., Van Abel,M., Van Der Kemp,A.W., Van
            Os,C.H., St -Arnaud,R. and Bindels,R.J.
  TITLE     Modulation of renal Ca2+ transport protein genes by dietary Ca2+
            and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin
            D3-1alpha-hydroxylase knockout mice
  JOURNAL   FASEB J 16 (11), 1398-1406 (2002)
   PUBMED   12205031
REFERENCE   9  (bases 1 to 4836)
  AUTHORS   Hoenderop,J.G.J., Muller,D., VAN DER Kemp,A.W.C.M., Hartog,A.,
            Suzuki,M., Ishibashi,K., Imai,M., Sweep,F., Willems,P.H.G.M.,
            Os,C.H.V. and Bindels,R.J.M.
  TITLE     Calcitriol controls the epithelial calcium channel in kidney
  JOURNAL   J Am Soc Nephrol 12 (7), 1342-1349 (2001)
   PUBMED   11423563
REFERENCE   10 (bases 1 to 4836)
  AUTHORS   Peng,J.B., Chen,X.Z., Berger,U.V., Vassilev,P.M., Brown,E.M. and
            Hediger,M.A.
  TITLE     A rat kidney-specific calcium transporter in the distal nephron
  JOURNAL   J Biol Chem 275 (36), 28186-28194 (2000)
   PUBMED   10875938
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053787.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032019.1, AF209196.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000004.1  71529111-71529382   c
            273-370             JAXUCZ010000004.1  71525357-71525454   c
            371-493             JAXUCZ010000004.1  71525099-71525221   c
            494-631             JAXUCZ010000004.1  71524442-71524579   c
            632-730             JAXUCZ010000004.1  71523979-71524077   c
            731-903             JAXUCZ010000004.1  71523614-71523786   c
            904-1050            JAXUCZ010000004.1  71523336-71523482   c
            1051-1263           JAXUCZ010000004.1  71520891-71521103   c
            1264-1350           JAXUCZ010000004.1  71512428-71512514   c
            1351-1427           JAXUCZ010000004.1  71512244-71512320   c
            1428-1593           JAXUCZ010000004.1  71511827-71511992   c
            1594-1660           JAXUCZ010000004.1  71511575-71511641   c
            1661-1929           JAXUCZ010000004.1  71509649-71509917   c
            1930-2036           JAXUCZ010000004.1  71506603-71506709   c
            2037-4836           JAXUCZ010000004.1  71503085-71505884   c
FEATURES             Location/Qualifiers
     source          1..4836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..4836
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 5"
                     /db_xref="GeneID:116469"
                     /db_xref="RGD:620636"
     exon            1..272
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2334
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /note="OTRPC3; calcium transporter 2; osm-9-like TRP
                     channel 3; epithelial calcium channel 1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 5"
                     /protein_id="NP_446239.3"
                     /db_xref="GeneID:116469"
                     /db_xref="RGD:620636"
                     /translation="MGVKKPWIQLQKRLNWWVREQDWNQHVDQLHMLQQKSIWESPLL
                     RAAKENDMCTLKRLQHDQNCDFRQRGALGETALHVAALYDNLDAAIMLMETAPYLVTE
                     STLCEPFVGQTALHIAIMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHP
                     LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSHDG
                     GDHLKSLELVPNNQGLTPFKLAGVEGNTVMFQHLMQKRKHIQWSLGPLTSSIYDLTEI
                     DSWGEDLSFLELVVSSKKKEARQILEQTPVKELVSLKWKKYGQPYFCLLGMLYIFYMI
                     CFTTCCVYRPLKFRDANRTHVRDNTVLEQKPLQEAYVTYQDKVRLVGELVTVIGAVVI
                     LLIEIPDIFRVGASRYFGHTVLGGPFHVIIITYASLVLLIMVMRLTSMNGEVVPISMA
                     LVLGWCSVMYFSRGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQTE
                     DPESLGEFSDYPTAMFSTFELFLTIIDGPANYSVDLPFMYHLTYFAFAIIATLLMLNL
                     FIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGCEYGLGDRWFL
                     RVEHHQEQNPYRVLRYVEAFKSSDKEEVQEQLSEKQPSGTETGTLARGSVVLQTPPLS
                     RTTSLSSNSHRGWEILRRNTLGHLNLGQDLGEGDGEEIYHF"
     exon            273..370
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..493
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..631
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..730
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..903
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1050
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1263
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1350
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1427
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1593
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1660
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1929
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2036
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..4836
                     /gene="Trpv5"
                     /gene_synonym="CaT2; Ecac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcacatatt cacacctcac agcaacccac tgcgtgggca acaagttacc aggggatata
       61 tacctttctt caccctagca gacctagact cctcagcttc tgtcacccta gactgactcc
      121 ttccatgaga ttcgaataag tggctggtat ttgcatgaag acatgggggt gaaaaaacct
      181 tggatccaac ttcagaaacg tctcaactgg tgggtcagag aacaagactg gaaccagcat
      241 gtggatcagc ttcatatgct acagcagaaa agtatttggg agtcaccact gcttagagca
      301 gccaaggaaa atgatatgtg cacacttaag agacttcaac atgaccagaa ctgtgacttc
      361 cgacaaagag gagctctggg ggagacagca ctgcatgtag cagccctcta tgacaacctg
      421 gatgctgcta taatgctgat ggagactgct ccatacttgg tcacggagtc tacactgtgt
      481 gagccatttg taggtcagac tgcactgcac atcgcaatta tgaaccagaa tgtgaacctg
      541 gtccgtgccc tgctagcccg aggagccagt gcctccgcca gggctacagg ttctgccttc
      601 catcgaagtt cccacaacct catctactat ggagaacatc ctttgtcctt tgctgcctgt
      661 gtgggtagtg aggagattgt tagactgctc attgagcatg gagctgacat tcgggcccag
      721 gactccttgg gaaatacagt actacacata cttgtcctac agcccaacaa aacctttgcc
      781 tgccagatgt acaacctgct actctcccat gatgggggag accacctgaa gtccctggaa
      841 cttgtgccca acaaccaagg actcaccccc ttcaagctgg ctggggtgga aggcaacact
      901 gtgatgtttc aacacctgat gcaaaaacgg aagcacatcc agtggtcatt aggaccccta
      961 acatcttcca tttatgatct cacagaaatt gactcctggg gtgaggactt gtcctttctg
     1021 gagcttgtgg tttcctccaa gaagaaagag gctcgtcaga ttctagaaca aacccctgtg
     1081 aaggagctgg tgagcctgaa gtggaagaaa tatggacaac cctatttctg cctcctgggt
     1141 atgctgtaca tcttctacat gatctgcttc accacatgct gtgtttaccg ccccctcaag
     1201 ttccgtgatg ccaaccgtac acatgttaga gataacaccg tcctggaaca gaaaccacta
     1261 caggaagcgt atgtgactta ccaggataag gtccggctgg tgggagaact cgtgacagtc
     1321 attggggctg tggttattct actcatagag atcccagaca tcttcagagt tggtgcctct
     1381 cgctactttg gacacacagt tcttgggggt ccattccatg tcattatcat cacatatgcc
     1441 tcccttgtgc tactgattat ggtgatgagg cttaccagta tgaatgggga ggtggtcccc
     1501 atatccatgg ccttggtact gggctggtgt agtgtcatgt acttctcccg aggattccag
     1561 atgctgggcc ccttcacaat catgattcag aagatgattt ttggagacct actgcgcttc
     1621 tgctggctaa tggctatggt catcctcgga tttgcctctg ccttctatat catcttccag
     1681 acagaggatc cagagagtct gggagaattc tccgactacc ctacagcaat gttcagcacc
     1741 tttgagctct tccttaccat cattgacggt ccggccaatt acagtgtgga tctacccttc
     1801 atgtaccacc taacctattt tgcttttgcc atcatcgcca cactactcat gctcaatttg
     1861 ttcattgcca tgatgggtga cactcactgg cgagtggccc aggagaggga cgaactctgg
     1921 agagcacagg ttgtagccac cacagtgatg ctggagagga aaatgccccg tttcctgtgg
     1981 cctcgctctg gtatctgtgg ttgcgaatat ggcctgggag accgctggtt cttacgggtt
     2041 gaacaccacc aggagcagaa tccgtatcga gtacttcgct atgtggaagc tttcaaatct
     2101 tcagacaagg aggaagtaca agaacaacta tctgagaagc agccttctgg gactgagact
     2161 gggactttag ctagaggctc tgtggttctg caaacgcctc ctttgtccag gactacatcc
     2221 ctaagcagca atagccaccg tggatgggaa attctccgtc gaaacaccct gggacatttg
     2281 aatcttggac aagaccttgg tgagggagac ggagaggaga tctaccattt ctgaagagaa
     2341 ttctgtttct ctagacctag ccccaggtgg gccagggtgt agaagagaaa ggggtagtta
     2401 ggggtgggca gggagaagga gagagctgat ttgcaagaat ctgaattcta tggttatgaa
     2461 tagttggagg gtatgggcag tggccatctt gtgttgtatg taccttataa gttcctctaa
     2521 agctcatttc ctgagaacca ggcatctgag catatgaaat ggaggctaat tgtcatcttg
     2581 ggttgacatc tagaccatct attttgtgcc ttgaatagaa ccagaaagca gtaagtcagg
     2641 aaacttgccc gattctataa cgtataatgt ggaaagaacc atcataccat gaacatcctt
     2701 cccatctctt tagacttcct aggactctct tcccagctag caaatcccaa tgtagaaaac
     2761 tacaggaaaa aaatatttcc ttatcctgtt ttaatttttc tcttatgtca aaaaaatata
     2821 cattacataa aacttatcat ttttactatt ttcagtataa agtacattca gattattgta
     2881 taaatatcac tagtattcat ctacaaaagg ttttcatctc agacaccaaa actcctgtcc
     2941 accaataact ctctactatt ccttctcgtt agtcctcaat aaccattatt ttacttcctg
     3001 actatgaatt gattgtaggt gctttattta aaaaccgact ggaaaagaca tgatccgttg
     3061 cacttgcctt gttttgttta atatagtagt ttcaaggttt cttctattct ctagaggtat
     3121 cagaatttca tttctcttta agtctgaata tctacacctt acttcattca tccatctatc
     3181 aatgagtttt cttatcttct gtttactgtg aacattgctg ctatgaaaat aaagtgtgca
     3241 tgtctataga ggcccttgtc tctaattctt tgctgttgta gaagaatcat atgcctagaa
     3301 attgaactga tgtattgcat gacagcccca tgtttaatac tttagataaa ctaccataat
     3361 gtttccatag tagccttcag cattttatag cttctgctag tgggtatgaa atgctatctc
     3421 attgtagttt tgatttgcct ttccctaaag actaaggata ttgagtctct tttcatgcta
     3481 ttatttatgg actaattttt atcactgcac tgccttctgg ttttcagagg ctgagtctga
     3541 ggtgctagta tctcctttga atcctaatgt actttataat tggtgaggca tatttttctt
     3601 tgtttaaatg gctcgatcat ttttttctat aggaccgtct attctttagg ttctactttg
     3661 caagttatcc tctttgatgc tgaaagcata ggttcctgtt tttatcttga gactgccata
     3721 ctccacaccc ttctctcatc acctcagtca gagagtcaaa catgctgttg ctgttggcaa
     3781 agcaaagaaa taagtaaggt ctgggaagtt ttagacaggt gcattccaat acaaatattc
     3841 aaagctgtat gccaatagta aactatcaca aaaaatgttc acagacctct gttggtatga
     3901 aacttaacag ggctgagtta cgattaagtt ttattttctt tcatagtgga agcccttcca
     3961 tcttatgtat agttaaactt catctgtgtt ttagactgtc caagatctag ttccttctgc
     4021 attttcagat gccagggatg tacctatctc tgcttcttct gacctttctc atttgtgaca
     4081 tctctaacct ctctttctcc atcaccttcg acagcaagga cgttgtatta tttaaacacc
     4141 ctccttcaaa tccaactccc tccaacagtt gctgaacgcc catcactttt attccctctt
     4201 caaaacgaaa tgtcttagga gtcgattcca ctatctactg gcttcccctg atttctcagc
     4261 cctttgtgat ttgatctagt tttctgtatg ctacagattc cactcttgtt atctccctaa
     4321 agataaacct actcattcat ctcagttttt gctgatctct atatattaca aaagactatt
     4381 caacactctt cactttccta ccagtccggc tgattttgct ttaccacaac ttataaaaat
     4441 tttggtctac agggcttttt ctttcttatt accttactta ctgccataga tcccacacac
     4501 gcgctcatgg ttttgaaggg tttattttca tctcacatct gtcttctgag ctccaggcat
     4561 gaacaactta gatgtcccac tgttagactt gttctactgt gatgttttat agacacctag
     4621 agctcaggtt ttactcatca tcaaacttgc atctctatcc atatcctcaa ccatgttaaa
     4681 tgtcagagta acaggcaaga tttcctaaac cacagttctg ggaatcatcc ttaatactcg
     4741 gtctcaaccc tcatatcaag gacgttcaag accaatggat agacagccca ttacttatcg
     4801 ttaaagtaaa ctaattctga ttaagcacac aaaaaa
//
