LOCUS       NM_023970               3211 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily V, member 4 (Trpv4), mRNA.
ACCESSION   NM_023970
VERSION     NM_023970.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3211)
  AUTHORS   Chen,Z., Liu,B., Zhou,D., Lei,M., Yang,J., Hu,Z. and Duan,W.
  TITLE     AQP4 regulates ferroptosis and oxidative stress of Muller cells in
            diabetic retinopathy by regulating TRPV4
  JOURNAL   Exp Cell Res 439 (1), 114087 (2024)
   PUBMED   38735619
  REMARK    GeneRIF: AQP4 regulates ferroptosis and oxidative stress of Muller
            cells in diabetic retinopathy by regulating TRPV4.
REFERENCE   2  (bases 1 to 3211)
  AUTHORS   Bihari,S., Costell,M.H., Bouchier,T., Behm,D.J., Burgert,M., Ye,G.,
            Bersten,A.D., Puukila,S., Cavallaro,E., Sprecher,D.L. and
            Dixon,D.L.
  TITLE     Evaluation of GSK2789917-induced TRPV4 inhibition in animal models
            of fluid induced lung injury
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 397 (5), 3461-3475 (2024)
   PUBMED   37966569
  REMARK    GeneRIF: Evaluation of GSK2789917-induced TRPV4 inhibition in
            animal models of fluid induced lung injury.
REFERENCE   3  (bases 1 to 3211)
  AUTHORS   Philip,N., Yun,X., Pi,H., Murray,S., Hill,Z., Fonticella,J.,
            Perez,P., Zhang,C., Pathmasiri,W., Sumner,S., Servinsky,L.,
            Jiang,H., Huetsch,J.C., Oldham,W.M., Visovatti,S., Leary,P.J.,
            Gharib,S.A., Brittain,E., Simpson,C.E., Le,A., Shimoda,L.A. and
            Suresh,K.
  TITLE     Fatty acid metabolism promotes TRPV4 activity in lung microvascular
            endothelial cells in pulmonary arterial hypertension
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (3), L252-L265 (2024)
   PUBMED   38226418
  REMARK    GeneRIF: Fatty acid metabolism promotes TRPV4 activity in lung
            microvascular endothelial cells in pulmonary arterial hypertension.
REFERENCE   4  (bases 1 to 3211)
  AUTHORS   Li,X., Lu,K., Guo,S., Xue,S. and Lian,F.
  TITLE     TRPV4 blockade alleviates endoplasmic reticulum stress mediated
            apoptosis in hypoxia-induced cardiomyocyte injury
  JOURNAL   Cell Signal 114, 110973 (2024)
   PUBMED   37981067
  REMARK    GeneRIF: TRPV4 blockade alleviates endoplasmic reticulum stress
            mediated apoptosis in hypoxia-induced cardiomyocyte injury.
REFERENCE   5  (bases 1 to 3211)
  AUTHORS   Shen,X., Zhang,H., Chen,D.T. and Cao,Y.L.
  TITLE     [Preliminary study of TRPV4 affects chondrocyte degeneration]
  JOURNAL   Zhongguo Gu Shang 36 (10), 990-995 (2023)
   PUBMED   37881934
  REMARK    GeneRIF: [Preliminary study of TRPV4 affects chondrocyte
            degeneration].
REFERENCE   6  (bases 1 to 3211)
  AUTHORS   Strotmann,R., Schultz,G. and Plant,T.D.
  TITLE     Ca2+-dependent potentiation of the nonselective cation channel
            TRPV4 is mediated by a C-terminal calmodulin binding site
  JOURNAL   J Biol Chem 278 (29), 26541-26549 (2003)
   PUBMED   12724311
REFERENCE   7  (bases 1 to 3211)
  AUTHORS   Mizuno,A., Matsumoto,N., Imai,M. and Suzuki,M.
  TITLE     Impaired osmotic sensation in mice lacking TRPV4
  JOURNAL   Am J Physiol Cell Physiol 285 (1), C96-C101 (2003)
   PUBMED   12777254
REFERENCE   8  (bases 1 to 3211)
  AUTHORS   Xu,H., Zhao,H., Tian,W., Yoshida,K., Roullet,J.B. and Cohen,D.M.
  TITLE     Regulation of a transient receptor potential (TRP) channel by
            tyrosine phosphorylation. SRC family kinase-dependent tyrosine
            phosphorylation of TRPV4 on TYR-253 mediates its response to
            hypotonic stress
  JOURNAL   J Biol Chem 278 (13), 11520-11527 (2003)
   PUBMED   12538589
REFERENCE   9  (bases 1 to 3211)
  AUTHORS   Liedtke,W., Choe,Y., Marti-Renom,M.A., Bell,A.M., Denis,C.S.,
            Sali,A., Hudspeth,A.J., Friedman,J.M. and Heller,S.
  TITLE     Vanilloid receptor-related osmotically activated channel (VR-OAC),
            a candidate vertebrate osmoreceptor
  JOURNAL   Cell 103 (3), 525-535 (2000)
   PUBMED   11081638
REFERENCE   10 (bases 1 to 3211)
  AUTHORS   Strotmann,R., Harteneck,C., Nunnenmacher,K., Schultz,G. and
            Plant,T.D.
  TITLE     OTRPC4, a nonselective cation channel that confers sensitivity to
            extracellular osmolarity
  JOURNAL   Nat Cell Biol 2 (10), 695-702 (2000)
   PUBMED   11025659
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF263521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF263521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3211
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3211
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 4"
                     /db_xref="GeneID:66026"
                     /db_xref="RGD:69337"
     exon            1..54
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            55..479
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..2709
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /note="transient receptor potential cation channel,
                     subfamily 5, member 4; VR-OAC; osm-9-like TRP channel 4;
                     vanilloid receptor-related osmotically-activated channel;
                     osmosensitive transient receptor potential channel 4;
                     vanilloid receptor-related osmotically activated channel
                     (Vroac); transient receptor potential cation channel subf
                     V memb 4"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 4"
                     /protein_id="NP_076460.1"
                     /db_xref="GeneID:66026"
                     /db_xref="RGD:69337"
                     /translation="MADPGDGPRAAPGDVAEPPGDESGTSGGEAFPLSSLANLFEGEE
                     GSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKA
                     PMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSR
                     GSTADLDGLLSYLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAE
                     RTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPK
                     DEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADN
                     TRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRR
                     EVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEML
                     AVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDY
                     LRLAGEVITLLTGVLFFFTSIKDLFMKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAAL
                     YLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLF
                     MIGYASALVTLLNPCTNMKVCNEDQSNCTVPSYPACRDSETFSAFLLDLFKLTIGMGD
                     LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATT
                     ILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINED
                     PGKSEIYQYYGFSHTMGRLRRDRWSSVVPRVVELNKNSGTDEVVVPLDNLGNPNCDGH
                     QQGYAPKWRAEDAPL"
     exon            480..652
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            653..805
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            806..946
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1245
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1425
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1584
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1677
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1751
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1917
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..1984
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2301
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2429
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2551
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..3211
                     /gene="Trpv4"
                     /gene_synonym="Otrpc4; Vroac"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggagga cgcggcggga tcaggaagcg gctgcgctgc gcccgcgtcc caagcaggcc
       61 gagaagtcca aacagatctg ctcagggtcc agtatggcag atcctggtga tggcccccgt
      121 gcagcgcctg gggatgtggc tgagccccct ggagacgaga gtggcacttc tggtggggag
      181 gccttccccc tctcttccct ggccaacctg tttgagggag aggaaggctc ctcttctctt
      241 tcaccagtgg atgctagccg ccctgctggc cccggggatg gacgtccaaa cctgcgtatg
      301 aagttccagg gcgctttccg caagggggtt cccaacccca ttgacctgct ggagtccacc
      361 ctgtatgagt cctcagtagt gcctgggccc aagaaagcgc ccatggattc gttgttcgac
      421 tatggcactt accggcacca ccccagtgac aacaagagat ggaggaggaa ggtcgtagag
      481 aagcagccac agagccccaa agctcccgcc ccccagccac cccccatcct caaagtcttc
      541 aaccggccca tcctctttga catcgtgtcc cggggctcca ctgccgacct ggacggactg
      601 ctctcctact tgctgaccca caagaagcgc ctgactgatg aggagttccg ggaaccatcc
      661 acagggaaga cctgcctgcc caaggcactt ctgaacttaa gcaatggccg aaacgacacc
      721 atcccagtgt tgctggacat tgcggaacgc acgggcaaca tgcgggagtt catcaactcg
      781 cccttcagag acatctacta ccgagggcag acggcactgc acatcgccat tgaacggcgc
      841 tgcaagcatt acgtggagct cctggtggcc cagggagccg atgtgcacgc gcaggcccga
      901 gggcggttct tccagcccaa ggatgagggt ggctacttct actttgggga gctgcccttg
      961 tccttggcag cctgcaccaa ccagccgcac atcgtcaact acctgacaga gaaccctcac
     1021 aagaaagccg atatgaggcg acaggactcc agaggcaaca cggtgctcca cgcgctggtg
     1081 gccatcgctg acaacacccg agagaacacc aagtttgtca ccaagatgta tgacctgttg
     1141 cttctcaagt gctcccgcct cttcccagac agcaacctgg agactgtgct taacaatgac
     1201 ggtctttcgc ccctcatgat ggctgccaag actggcaaga tcggggtctt tcagcacatc
     1261 atccgacggg aggtgacaga tgaggacaca cggcacctgt ctcgcaagtt caaggactgg
     1321 gcctacgggc ctgtgtattc ttctctctac gacctctcct ccctggatac gtgcggggag
     1381 gaagtgtccg tgctggagat cctggtttac aacagcaaga tcgagaaccg ccatgagatg
     1441 ctggctgtgg agcccattaa cgaactgctg agggacaagt ggcgtaagtt cggggccgtg
     1501 tccttctaca tcaacgttgt ctcctatctg tgtgccatgg tcatcttcac cctcacagcc
     1561 tactatcagc cactggaggg cacgccaccc tacccttacc gtaccacggt ggactacctg
     1621 aggctggctg gtgaggtcat cacgctcctc acaggagtcc tgttcttctt taccagtatc
     1681 aaagacttgt tcatgaagaa atgccctgga gtgaattctc tcttcgtcga tggctccttc
     1741 cagttgctct acttcatcta ctcagtgctg gtggttgtgt ctgcggcgct ctacctggca
     1801 gggatcgagg cctatctggc tgtgatggtc tttgccctgg tcctgggctg gatgaatgcc
     1861 ctttacttca cccgtgggct gaagctgaca gggacctaca gcatcatgat tcagaagatc
     1921 ctcttcaaag atctcttccg ctttctgctg gtctacctgc tttttatgat tggctatgcc
     1981 tcagctctgg tcaccctcct gaatccgtgc accaacatga aggtctgtaa cgaggaccag
     2041 agcaactgca cggtgccctc ataccccgcg tgccgggaca gcgagacctt cagcgccttc
     2101 ctactggacc tcttcaagct caccatcggc atgggcgacc tggagatgct gagcagcgct
     2161 aagtaccccg tggtcttcat tctcctgctg gttacctaca tcatcctcac cttcgtgctc
     2221 ctgctgaaca tgctcatcgc cctcatgggt gagaccgtgg gccaggtgtc caaggagagc
     2281 aagcacatct ggaagctgca gtgggccacc accatcctgg acatcgagcg ctccttccct
     2341 gtgttcctga ggaaggcctt ccgctccgga gagatggtga cagtgggcaa gagctcggat
     2401 ggcactccag accgcaggtg gtgcttcagg gtggacgagg tgaactggtc tcactggaac
     2461 cagaacctgg gcatcattaa cgaggacccc ggcaagagcg agatctacca gtactatggc
     2521 ttctcccata ccatggggcg cctccgcagg gatcgctggt cctcagtggt gccccgcgtg
     2581 gtggagctga acaagaactc aggcacagat gaagtggtgg tccccctgga taacctaggg
     2641 aaccccaact gtgacggcca ccagcaaggt tatgctccca agtggagggc ggaggacgca
     2701 ccactgtagg ggccatgcca gggctggggt caatggccca ggcttggccc ttgctcccac
     2761 ctacatttca gcatctgtcc tgtgtcttcc cacacccaca cgtgacctcg gaggtgaggg
     2821 cctctgtgga gactctgggg aggccccagg accctctggt ccccacaaag acttttgctc
     2881 ttatttctac tcctccccac atgggggacg gggctcctgg ccacctgtct cactcccatg
     2941 gagtcaccta agccagctca gggcccctcc actcacaggg ctcaggcccc tgtccctctt
     3001 gtgcactatt tattgctctc ctcaggaaaa tgacatcaca ggagtctacc tgcagctgga
     3061 acctggccag ggctgaggct catgcaggga cactgcagcc ctgacccgct gcagatctga
     3121 cctgctgcag cccgggctag ggtgggtctt ctgtactttg tagagatcgg ggctgttggt
     3181 gctcaataaa tgtttgttta ttctcggtgg a
//
