LOCUS       NM_001025757            3010 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily V, member 3 (Trpv3), mRNA.
ACCESSION   NM_001025757 XM_573134
VERSION     NM_001025757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3010)
  AUTHORS   Singh,U., Upadhya,M., Basu,S., Singh,O., Kumar,S., Kokare,D.M. and
            Singru,P.S.
  TITLE     Transient Receptor Potential Vanilloid 3 (TRPV3) in the Cerebellum
            of Rat and Its Role in Motor Coordination
  JOURNAL   Neuroscience 424, 121-132 (2020)
   PUBMED   31706959
  REMARK    GeneRIF: Transient Receptor Potential Vanilloid 3 (TRPV3) in the
            Cerebellum of Rat and Its Role in Motor Coordination.
REFERENCE   2  (bases 1 to 3010)
  AUTHORS   Qi,H., Ren,J., E,M., Zhang,Q., Cao,Y., Ba,L., Song,C., Shi,P.,
            Fu,B. and Sun,H.
  TITLE     MiR-103 inhibiting cardiac hypertrophy through inactivation of
            myocardial cell autophagy via targeting TRPV3 channel in rat hearts
  JOURNAL   J Cell Mol Med 23 (3), 1926-1939 (2019)
   PUBMED   30604587
  REMARK    GeneRIF: MiR-103 could attenuate cardiomyocyte hypertrophy partly
            by reducing cardiac autophagy activity through the targeted
            inhibition of TRPV3 signalling.
REFERENCE   3  (bases 1 to 3010)
  AUTHORS   Kozyreva,T.V., Evtushenko,A.A., Voronova,I.P., Khramova,G.M. and
            Kozaruk,V.P.
  TITLE     Effect of Activation of Peripheral Ion Channel TRPM8 on Gene
            Expression of Thermosensitive TRP Ion Channels in the Hypothalamus.
            Comparison with the Effect of Cooling
  JOURNAL   Bull Exp Biol Med 166 (2), 188-191 (2018)
   PUBMED   30488220
  REMARK    GeneRIF: Activation of the peripheral ion channel TRPM8 with
            menthol and rapid cooling (decrease in body temperature by 3C) led
            to 1.5-fold activation of the expression of TRPV3 ion channel gene
            in the posterior hypothalamus, but had no effect on the expression
            of this gene in the anterior hypothalamus.
REFERENCE   4  (bases 1 to 3010)
  AUTHORS   Zhang,Q., Qi,H., Cao,Y., Shi,P., Song,C., Ba,L., Chen,Y., Gao,J.,
            Li,S., Li,B. and Sun,H.
  TITLE     Activation of transient receptor potential vanilloid 3 channel
            (TRPV3) aggravated pathological cardiac hypertrophy via
            calcineurin/NFATc3 pathway in rats
  JOURNAL   J Cell Mol Med 22 (12), 6055-6067 (2018)
   PUBMED   30299584
  REMARK    GeneRIF: the activation of TRPV3 aggravated pathological cardiac
            hypertrophy through calcineurin/NFATc3 signalling pathway and
            correlated with the protein expression levels of calcineurin,
            phosphorylated CaMKII and NFATc3, revealing that TRPV3 might be a
            potential therapeutic target for cardiac hypertrophy.
REFERENCE   5  (bases 1 to 3010)
  AUTHORS   Zhang,Q., Cao,Y., Luo,Q., Wang,P., Shi,P., Song,C., E,M., Ren,J.,
            Fu,B. and Sun,H.
  TITLE     The transient receptor potential vanilloid-3 regulates
            hypoxia-mediated pulmonary artery smooth muscle cells proliferation
            via PI3K/AKT signaling pathway
  JOURNAL   Cell Prolif 51 (3), e12436 (2018)
   PUBMED   29359496
  REMARK    GeneRIF: TRPV3 is involved in hypoxia-induced pulmonary vascular
            remodeling and promotes proliferation of pulmonary artery smooth
            muscle cells and the effect is, at least in part, mediated via the
            PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 3010)
  AUTHORS   Frederick,J., Buck,M.E., Matson,D.J. and Cortright,D.N.
  TITLE     Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia
            by nerve injury
  JOURNAL   Biochem Biophys Res Commun 358 (4), 1058-1064 (2007)
   PUBMED   17517374
REFERENCE   7  (bases 1 to 3010)
  AUTHORS   Asakawa,M., Yoshioka,T., Matsutani,T., Hikita,I., Suzuki,M.,
            Oshima,I., Tsukahara,K., Arimura,A., Horikawa,T., Hirasawa,T. and
            Sakata,T.
  TITLE     Association of a mutation in TRPV3 with defective hair growth in
            rodents
  JOURNAL   J Invest Dermatol 126 (12), 2664-2672 (2006)
   PUBMED   16858425
  REMARK    GeneRIF: TRPV3 was the gene responsible for Nh and Ht mutations,
            and mutation in TRPV3 possibly correlated with increased mast cell
            numbers.
REFERENCE   8  (bases 1 to 3010)
  AUTHORS   Gu,Q., Lin,R.L., Hu,H.Z., Zhu,M.X. and Lee,L.Y.
  TITLE     2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the
            activation of TRPV channels
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 288 (5), L932-L941 (2005)
   PUBMED   15653710
  REMARK    GeneRIF: TRPV1, V2, and V3 channels are expressed on these sensory
            neurons and their terminals.
REFERENCE   9  (bases 1 to 3010)
  AUTHORS   Hu,H.Z., Gu,Q., Wang,C., Colton,C.K., Tang,J., Kinoshita-Kawada,M.,
            Lee,L.Y., Wood,J.D. and Zhu,M.X.
  TITLE     2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2,
            and TRPV3
  JOURNAL   J Biol Chem 279 (34), 35741-35748 (2004)
   PUBMED   15194687
REFERENCE   10 (bases 1 to 3010)
  AUTHORS   Peier,A.M., Reeve,A.J., Andersson,D.A., Moqrich,A., Earley,T.J.,
            Hergarden,A.C., Story,G.M., Colley,S., Hogenesch,J.B., McIntyre,P.,
            Bevan,S. and Patapoutian,A.
  TITLE     A heat-sensitive TRP channel expressed in keratinocytes
  JOURNAL   Science 296 (5575), 2046-2049 (2002)
   PUBMED   12016205
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 13, 2012 this sequence version replaced NM_001025757.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY325813.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                JAXUCZ010000010.1  58382054-58382126
            74-201              JAXUCZ010000010.1  58384077-58384204
            202-306             JAXUCZ010000010.1  58391814-58391918
            307-393             JAXUCZ010000010.1  58392026-58392112
            394-548             JAXUCZ010000010.1  58392747-58392901
            549-725             JAXUCZ010000010.1  58393585-58393761
            726-866             JAXUCZ010000010.1  58395541-58395681
            867-1147            JAXUCZ010000010.1  58397326-58397606
            1148-1324           JAXUCZ010000010.1  58399537-58399713
            1325-1483           JAXUCZ010000010.1  58400584-58400742
            1484-1585           JAXUCZ010000010.1  58401368-58401469
            1586-1659           JAXUCZ010000010.1  58402422-58402495
            1660-1825           JAXUCZ010000010.1  58405336-58405501
            1826-1892           JAXUCZ010000010.1  58408085-58408151
            1893-2167           JAXUCZ010000010.1  58409271-58409545
            2168-2280           JAXUCZ010000010.1  58410487-58410599
            2281-2360           JAXUCZ010000010.1  58410777-58410856
            2361-3010           JAXUCZ010000010.1  58411151-58411800
FEATURES             Location/Qualifiers
     source          1..3010
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3010
                     /gene="Trpv3"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 3"
                     /db_xref="GeneID:497948"
                     /db_xref="RGD:1564531"
     exon            1..73
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            74..201
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2458
                     /gene="Trpv3"
                     /note="heat sensitive channel TRPV3"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 3"
                     /protein_id="NP_001020928.2"
                     /db_xref="GeneID:497948"
                     /db_xref="RGD:1564531"
                     /translation="MNAHSKEMVPLMGKRTTAPGGNPAVLTEKRPADLTPTKKSAHFF
                     LEIEGFEPNPTVTKTSPPIFSKPMDSNIRQCLSGNCDDMDSPQSPQDDVTETPSNPNS
                     PSANLAKEEQRQKKKRLKKCIFAAVSEGCVRELRELLQDLQELCRRRRGLDASDFLMH
                     KLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTA
                     LNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQPE
                     IVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELE
                     TMRNNDGLTPLQLAAKMGKAEILKYILGREIKEKPLRSLSRKFTDWAYGPVSSSLYDL
                     TNVDTTTDNSVLEIIVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKYMFFLSFCFYFF
                     YNITLTLVSYYRPREDEALPHPLALTHKMSWLQLLGRMFVLIWAMCISVKEGIAIFLL
                     RPSDLQSILSDAWFHFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYT
                     RGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLIEKCSKDKKDCSSYGS
                     FSDAVLELFKLTIGLGDLNIQQNSTYPILFLFLLITYVILTFVLLLNMLIALMGETVE
                     NVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWT
                     EWKTHVSFLNEDPGPIRRTADSNKIQDSSRSNSKTTLYAFDELDEFPETSV"
     exon            202..306
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            307..393
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            394..548
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            549..725
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            726..866
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1147
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1324
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1483
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1585
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1659
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1825
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1892
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2167
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2280
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2360
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..3010
                     /gene="Trpv3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtgggtt ttgggcccca gacatgcggt gatctcaaag caagggctgc taccaccaac
       61 tggaacctgc caggctccag caatgaatgc ccactccaag gagatggtgc ccctcatggg
      121 caaaagaacc actgcacctg gcgggaaccc tgctgtgctg acagagaaga ggccggcaga
      181 tctcaccccc accaagaaga gtgcacactt cttcctggag atagaaggat ttgagcccaa
      241 ccccactgtt accaagacct ctcccccaat cttctccaag ccgatggact ccaacatccg
      301 gcagtgcctc tctggcaact gtgatgacat ggactctcct cagtctcctc aggatgatgt
      361 gacagagacc ccatccaatc ccaacagtcc aagcgcaaac ctggccaagg aagaacagag
      421 gcagaagaag aagcggctga agaagtgcat cttcgcggct gtatcagagg gctgcgtgag
      481 ggagctgcgg gaactcctgc aggatctgca ggagctctgc agacggcgcc gcggcctgga
      541 tgcgtctgac ttcctcatgc acaagctgac agcctcagac actgggaaga cctgcctgat
      601 gaaagctttg ctcaacatca accccaacac caaagagatc gtgcggattc tgcttgcctt
      661 cgctgaggag aatgacatcc tggacaggtt catcaatgca gagtacacgg aagaggccta
      721 cgaagggcag acagcgctga acattgccat cgagcggcgc cagggagaca tcacagcagt
      781 gctcatagca gcgggtgctg acgtcaacgc tcacgccaag ggggtcttct tcaacccaaa
      841 ataccagcac gaaggcttct attttggtga gacgcccctg gccttggcag catgtaccaa
      901 ccagcctgag atcgtgcagc tgctgatgga gaatgagcag acagacatca cttctcagga
      961 ctctcgggga aacaacatcc tgcatgcgct ggtgacagtg gctgaggact tcaagaccca
     1021 gaatgacttt gttaagcgca tgtatgacat gattctgctg aggagtggca actgggagct
     1081 ggagaccatg cgcaacaatg acggtctcac gccactgcag ctggctgcca agatgggcaa
     1141 ggctgagatc ctgaagtata tccttggccg tgagatcaag gagaagcctc tccggagtct
     1201 gtccagaaag ttcacggact gggcatatgg gcctgtgtca tcctcactct atgacctcac
     1261 caacgtggac acgacgacag ataactctgt gctggagatc atcgtctaca acaccaacat
     1321 tgataaccgg catgagatgc tgaccctgga gcctctgcat acactgctgc atatgaagtg
     1381 gaagaaattt gccaagtaca tgttcttctt gtccttctgc ttctatttct tctacaacat
     1441 caccctgacc ctcgtctctt actaccgtcc tcgggaagat gaggctctcc cacacccctt
     1501 ggccctgaca cataagatga gttggcttca gctcctaggg aggatgtttg ttcttatctg
     1561 ggccatgtgc atctctgtga aagagggtat tgccattttc ctgctgagac cctctgatct
     1621 tcagtccatc ctgtcagatg cctggtttca ttttgtattt tttgtccaag ctgtgcttgt
     1681 gatactgtct gtattcttgt acttgtttgc ctacaaagaa taccttgcct gcctcgtgct
     1741 ggccatggcc ctgggctggg cgaacatgct ctactacacg agaggcttcc agtctatggg
     1801 catgtacagt gtcatgatcc agaaggtcat tttgcacgat gttctcaagt tcttgtttgt
     1861 ttacatcctg ttcttacttg gatttggagt agcgctggcc tcactgattg agaaatgctc
     1921 caaggacaaa aaggactgca gctcctacgg cagcttcagc gatgcggtgc tggagctctt
     1981 caagctcacc ataggcctgg gcgacctgaa catccagcag aactccacct accccatcct
     2041 ctttctcttc ctactcatca cctatgtcat cctcaccttt gtcctgctcc tcaacatgct
     2101 catcgccctg atgggggaga cggtggagaa cgtctccaaa gagagtgagc ggatctggcg
     2161 cttgcagaga gccaggacca tcttggagtt tgagaaaatg ttaccagaat ggctgagaag
     2221 cagattccgc atgggagagc tgtgcaaagt agctgatgag gacttccggc tgtgcctgag
     2281 gatcaacgag gtgaagtgga ctgaatggaa aacacacgtg tctttcctca atgaagatcc
     2341 agggcccata agacggacag cagattcaaa caaaattcaa gattcttcca ggagcaatag
     2401 caaaaccacc ctctatgcat ttgatgaatt agatgaattt ccagaaacat cagtgtagac
     2461 gcatggctga aggctgatgt gaacactgtg gtctgatgct gcaggccaag ccccggcgct
     2521 gaagtgctat gcagagtgct agactagaag caaaacactc ctcacagtgg ctggtggctg
     2581 ctgaagggca gcagtcacga tctgaaagga aggctccttg ggttttgtga ctccagaggt
     2641 cagtagaaat ccatggccag cagttctgag tctggaagtc tcctgatgcc ccaggtgagg
     2701 tacctgcagg ttggcttggc tccaagacgc atgtgctggg gaagacggag ctggggtcgg
     2761 aggagtgggg agagcagtct tctctctact atgttctgtt gttagggcca gctcttcctt
     2821 tgcctccacg actgtgattt gtgggggatc ctgtcctagc atgtctagaa gatctgagct
     2881 aagttgatct acctggggaa taagggaatg agctatgggg aataccctta ttgagtctcc
     2941 atcgagcagg aagctggact ccatccttgg actgaaaccc aaggctaaac ctatctccaa
     3001 cagagagatg
//
