LOCUS       NM_001270797            2811 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily V, member 2 (Trpv2), transcript variant 2, mRNA.
ACCESSION   NM_001270797
VERSION     NM_001270797.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2811)
  AUTHORS   Zhou,Y., Cong,T., Chen,J., Chu,Z., Sun,Y., Zhao,D., Chen,X., Li,L.,
            Liu,Y., Cheng,J., Li,Q., Yin,S. and Xiao,Z.
  TITLE     Protective role of TRPV2 in synaptic plasticity through the
            ERK1/2-CREB-BDNF pathway in chronic unpredictable mild stress rats
  JOURNAL   Biochem Biophys Res Commun 721, 150128 (2024)
   PUBMED   38776831
  REMARK    GeneRIF: Protective role of TRPV2 in synaptic plasticity through
            the ERK1/2-CREB-BDNF pathway in chronic unpredictable mild stress
            rats.
REFERENCE   2  (bases 1 to 2811)
  AUTHORS   Gallo,P.N., Mihelc,E., Eisert,R., Bradshaw,G.A., Dimek,F.,
            Leffler,A., Kalocsay,M. and Moiseenkova-Bell,V.
  TITLE     The dynamic TRPV2 ion channel proximity proteome reveals functional
            links of calcium flux with cellular adhesion factors NCAM and L1CAM
            in neurite outgrowth
  JOURNAL   Cell Calcium 121, 102894 (2024)
   PUBMED   38728789
  REMARK    GeneRIF: The dynamic TRPV2 ion channel proximity proteome reveals
            functional links of calcium flux with cellular adhesion factors
            NCAM and L1CAM in neurite outgrowth.
REFERENCE   3  (bases 1 to 2811)
  AUTHORS   Shigemi,S., Sato,T., Sakamoto,M., Yajima,T., Honda,T., Tsumaki,H.,
            Deguchi,T., Ichikawa,H., Fukunaga,T. and Mizoguchi,I.
  TITLE     The role of TRPV2 as a regulator on the osteoclast differentiation
            during orthodontic tooth movement in rats
  JOURNAL   Sci Rep 13 (1), 13718 (2023)
   PUBMED   37608122
  REMARK    GeneRIF: The role of TRPV2 as a regulator on the osteoclast
            differentiation during orthodontic tooth movement in rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2811)
  AUTHORS   Zhang,L., Simonsen,C., Zimova,L., Wang,K., Moparthi,L., Gaudet,R.,
            Ekoff,M., Nilsson,G., Hellmich,U.A., Vlachova,V., Gourdon,P. and
            Zygmunt,P.M.
  TITLE     Cannabinoid non-cannabidiol site modulation of TRPV2 structure and
            function
  JOURNAL   Nat Commun 13 (1), 7483 (2022)
   PUBMED   36470868
  REMARK    GeneRIF: Cannabinoid non-cannabidiol site modulation of TRPV2
            structure and function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2811)
  AUTHORS   O'Hare,M., Esquiva,G., McGahon,M.K., Hombrebueno,J.M.R.,
            Augustine,J., Canning,P., Edgar,K.S., Barabas,P., Friedel,T.,
            Cincola,P., Henry,J., Mayne,K., Ferrin,H., Stitt,A.W., Lyons,T.J.,
            Brazil,D.P., Grieve,D.J., McGeown,J.G. and Curtis,T.M.
  TITLE     Loss of TRPV2-mediated blood flow autoregulation recapitulates
            diabetic retinopathy in rats
  JOURNAL   JCI Insight 7 (18), e155128 (2022)
   PUBMED   36134661
  REMARK    GeneRIF: Loss of TRPV2-mediated blood flow autoregulation
            recapitulates diabetic retinopathy in rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2811)
  AUTHORS   Jung,J., Lee,S.Y., Hwang,S.W., Cho,H., Shin,J., Kang,Y.S., Kim,S.
            and Oh,U.
  TITLE     Agonist recognition sites in the cytosolic tails of vanilloid
            receptor 1
  JOURNAL   J Biol Chem 277 (46), 44448-44454 (2002)
   PUBMED   12228246
  REMARK    GeneRIF: key amino acids, Arg-114 and Glu-761, in the N- and
            C-cytosolic tails, respectively, that determine ligand binding were
            determined in VRL1
REFERENCE   7  (bases 1 to 2811)
  AUTHORS   Suzuki,M., Ohki,G., Mochizuki,T., Somlo,S., Ishibashi,K. and
            Imai,M.
  TITLE     Opening of ligand-gated cation channel families by calpain
            inhibitors
  JOURNAL   FEBS Lett 517 (1-3), 219-224 (2002)
   PUBMED   12062441
REFERENCE   8  (bases 1 to 2811)
  AUTHORS   Kanzaki,M., Zhang,Y.Q., Mashima,H., Li,L., Shibata,H. and Kojima,I.
  TITLE     Translocation of a calcium-permeable cation channel induced by
            insulin-like growth factor-I
  JOURNAL   Nat Cell Biol 1 (3), 165-170 (1999)
   PUBMED   10559903
REFERENCE   9  (bases 1 to 2811)
  AUTHORS   Caterina,M.J., Rosen,T.A., Tominaga,M., Brake,A.J. and Julius,D.
  TITLE     A capsaicin-receptor homologue with a high threshold for noxious
            heat
  JOURNAL   Nature 398 (6726), 436-441 (1999)
   PUBMED   10201375
REFERENCE   10 (bases 1 to 2811)
  AUTHORS   Khuroo,M.S., Zargar,S.A. and Yattoo,G.N.
  TITLE     Efficacy of nifedipine therapy in patients with sphincter of Oddi
            dysfunction: a prospective, double-blind, randomized,
            placebo-controlled, cross over trial
  JOURNAL   Br J Clin Pharmacol 33 (5), 477-485 (1992)
   PUBMED   1524959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1 and BC089215.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF129113.1, SRR26643297.34364.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000010.1  47772223-47772290
            69-290              BC089215.1         1-222
            291-2811            BC089215.1         246-2766
FEATURES             Location/Qualifiers
     source          1..2811
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..2811
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 2"
                     /db_xref="GeneID:29465"
                     /db_xref="RGD:3965"
     exon            1..290
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..590
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..2673
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /note="VRL-1; OTRPC2; osm-9-like TRP channel 2;
                     stretch-activated channel 2B; vanilloid receptor-like
                     protein 1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 2"
                     /protein_id="NP_001257726.1"
                     /db_xref="GeneID:29465"
                     /db_xref="RGD:3965"
                     /translation="MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDR
                     NSSPQIKVNLNFIKRPPKNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWN
                     SKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCIDE
                     FYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAA
                     CTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQ
                     MGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWC
                     YGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSR
                     FFFNFACYLVYMFIFTVVAYHQPSLDQPAIPSSKATFGESMLLLGHILILLGGIYLLL
                     GQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFMETEWYLPLLVLSLVLG
                     WLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPK
                     APEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLL
                     LLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKK
                     HREGRLLKVGTRGDGTPDERWCFRVEEVNWVAWEKTLPTLSEDPSGPGITGNKKNPTS
                     KPGKNSASEEDHLPLQVLQSP"
     exon            591..724
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..1015
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1314
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1488
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1644
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1743
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1814
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1980
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2047
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2376
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2504
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2584
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2781
                     /gene="Trpv2"
                     /gene_synonym="Vrl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtggccac tggtcctgaa gatcagccgg gtggccagtc actggtcttt gacaggtcgg
       61 cgttaaacct gctctgtcca ctgtgtgaga cgaacaggtg gagggtggac gacgcagaga
      121 aagctcggag cgggccgcgg aggttcccac agccccatta ctgtcagcgt tgagccgcac
      181 ccctccgggc cgcacttcct ctctcagtcc ccgctgccgg agagccccgc taggctcggt
      241 gatcctagcc tgcagtttgc cgccgctaca ccttggcttc agcctgcggg gtcccagcca
      301 ggcctgcccc tgcggtatga gagaggaacc ttaacatctc catctctaca gaggtttcag
      361 ctgtaaggag catcctcctc tctcaggatg acttcagcct ccagcccccc agctttcagg
      421 ctggagactt ccgatggaga tgaagagggc aatgctgagg tgaacaaggg gaagcaggaa
      481 ccgcccccca tggagtcacc attccagagg gaggaccgga attcctcccc tcagatcaaa
      541 gtgaacctca acttcataaa gagacctcct aaaaacactt ctgctcccag ccagcaggag
      601 ccagatcggt ttgaccgtga ccgactcttc agtgtggtct cccggggtgt ccccgaggaa
      661 ctgactggac tgctagaata cctgcgctgg aacagcaagt acctcactga ctctgcatac
      721 acagaaggct ccactggaaa gacgtgcctg atgaaggctg tgctgaacct tcaggatggg
      781 gtcaatgcct gcatcatgcc gctgctgcag attgacaagg attccggcaa tcccaagccc
      841 ctcgtcaatg cccagtgcat cgatgagttc taccaaggcc acagtgcgct gcacatcgcc
      901 atagagaaga ggagcctgca gtgcgtgaag ctgctggtag agaatggagc ggatgttcac
      961 ctccgagcct gtggccgctt cttccaaaag caccaaggaa cttgtttcta ttttggagag
     1021 ctacctcttt ctctggctgc gtgcaccaag cagtgggatg tggtgaccta cctcctggag
     1081 aacccacacc agccggccag cctggaggcc accgactccc tgggcaacac agtcctgcat
     1141 gctctggtaa tgattgcaga taactcgcct gagaacagtg ccctggtgat ccacatgtac
     1201 gacgggcttc tacaaatggg ggcgcgcctc tgccccactg tgcagcttga ggaaatctcc
     1261 aaccaccaag gcctcacacc cctgaaacta gccgccaagg aaggcaaaat cgagattttc
     1321 aggcacattc tgcagcggga attctcagga ccgtaccagc ccctttcccg aaagtttact
     1381 gagtggtgtt acggtcctgt gcgggtatcg ctgtacgacc tgtcctctgt ggacagctgg
     1441 gaaaagaact cggtgctgga gatcatcgct tttcattgca agagcccgaa ccggcaccgc
     1501 atggtggttt tagaaccact gaacaagctt ctgcaggaga aatgggatcg gctcgtctca
     1561 agattcttct tcaacttcgc ctgctacttg gtctacatgt tcatcttcac cgtcgttgcc
     1621 taccaccagc cttccctgga tcagccagcc atcccctcat caaaagcgac ttttggggaa
     1681 tccatgctgc tgctgggcca cattctgatc ctgcttgggg gtatttacct cttactgggc
     1741 cagctgtggt acttttggcg gcggcgcctg ttcatctgga tctcattcat ggacagctac
     1801 tttgaaatcc tctttctcct tcaggctctg ctcacagtgc tgtcccaggt gctgcgcttc
     1861 atggagactg aatggtacct acccctgcta gtgttatccc tagtgctggg ctggctgaac
     1921 ctgctttact acacacgggg ctttcagcac acaggcatct acagtgtcat gatccagaag
     1981 gtcatccttc gagacctgct ccgtttcctg ctggtctacc tggtcttcct tttcggcttt
     2041 gctgtagccc tagtaagctt gagcagagag gcccgaagtc ccaaagcccc tgaagataac
     2101 aactccacag tgacggaaca gcccacggtg ggccaggagg aggagccagc tccatatcgg
     2161 agcattctgg atgcctccct agagctgttc aagttcacca ttggtatggg ggagctggct
     2221 ttccaggaac agctgcgttt tcgtggggtg gtcctgctgt tgctgttggc ctacgtcctt
     2281 ctcacctacg tcctgctgct caacatgctc attgctctca tgagcgaaac tgtcaaccac
     2341 gttgctgaca acagctggag catctggaag ttgcagaaag ccatctctgt cttggagatg
     2401 gagaatggtt actggtggtg ccggaggaag aaacatcgtg aagggaggct gctgaaagtc
     2461 ggcaccaggg gggatggtac ccctgatgag cgctggtgct tcagggtgga ggaagtaaat
     2521 tgggttgctt gggagaagac tcttcccacc ttatctgagg atccatcagg gccaggcatc
     2581 actggtaata aaaagaaccc aacctctaaa ccggggaaga acagtgcctc agaggaagac
     2641 catctgcccc ttcaggtcct ccagtccccc tgatggccca gatgcagcag caggctggca
     2701 ggatggagta gggaatcttc ccagccacac cagaggctac tgagttttgg tggaaatata
     2761 aatatttttt tgcataacca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
