LOCUS       NM_031982               2847 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily V, member 1 (Trpv1), mRNA.
ACCESSION   NM_031982
VERSION     NM_031982.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2847)
  AUTHORS   Gualdani,R., Barbeau,S., Yuan,J.H., Jacobs,D.S., Gailly,P.,
            Dib-Hajj,S.D. and Waxman,S.G.
  TITLE     TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin
            sensitization, and capsaicin desensitization
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2406186121 (2024)
   PUBMED   39226353
  REMARK    GeneRIF: TRPV1 corneal neuralgia mutation: Enhanced pH response,
            bradykinin sensitization, and capsaicin desensitization.
REFERENCE   2  (bases 1 to 2847)
  AUTHORS   Rumbus,Z., Fekete,K., Kelava,L., Gardos,B., Klonfar,K.,
            Keringer,P., Pinter,E., Pakai,E. and Garami,A.
  TITLE     Ammonium chloride-induced hypothermia is attenuated by transient
            receptor potential channel vanilloid-1, but augmented by ankyrin-1
            in rodents
  JOURNAL   Life Sci 346, 122633 (2024)
   PUBMED   38615746
  REMARK    GeneRIF: Ammonium chloride-induced hypothermia is attenuated by
            transient receptor potential channel vanilloid-1, but augmented by
            ankyrin-1 in rodents.
REFERENCE   3  (bases 1 to 2847)
  AUTHORS   Li,Z., Li,Y. and Li,Z.
  TITLE     Low-Level miR-199 Contribute to Neuropathic Low Back Pain via TRPV1
            by Regulating the Production of Pro-Inflammatory Cytokines on
            Macrophage
  JOURNAL   Turk Neurosurg 34 (2), 299-307 (2024)
   PUBMED   38497183
  REMARK    GeneRIF: Low-Level miR-199 Contribute to Neuropathic Low Back Pain
            via TRPV1 by Regulating the Production of Pro-Inflammatory
            Cytokines on Macrophage.
REFERENCE   4  (bases 1 to 2847)
  AUTHORS   Anselmi,L., Ducrocq,G.P., Ruiz-Velasco,V., Stocker,S.D.,
            Higgins,S.P. and Kaufman,M.P.
  TITLE     Functional knockout of the TRPV1 channel has no effect on the
            exercise pressor reflex in rats
  JOURNAL   J Physiol 601 (23), 5241-5256 (2023)
   PUBMED   37878364
  REMARK    GeneRIF: Functional knockout of the TRPV1 channel has no effect on
            the exercise pressor reflex in rats.
REFERENCE   5  (bases 1 to 2847)
  AUTHORS   Tessier,N., Ducrozet,M., Dia,M., Badawi,S., Chouabe,C., Crola Da
            Silva,C., Ovize,M., Bidaux,G., Van Coppenolle,F. and Ducreux,S.
  TITLE     TRPV1 Channels Are New Players in the Reticulum-Mitochondria Ca2+
            Coupling in a Rat Cardiomyoblast Cell Line
  JOURNAL   Cells 12 (18), 2322 (2023)
   PUBMED   37759544
  REMARK    GeneRIF: TRPV1 Channels Are New Players in the
            Reticulum-Mitochondria Ca[2+] Coupling in a Rat Cardiomyoblast Cell
            Line.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2847)
  AUTHORS   Caterina,M.J., Leffler,A., Malmberg,A.B., Martin,W.J., Trafton,J.,
            Petersen-Zeitz,K.R., Koltzenburg,M., Basbaum,A.I. and Julius,D.
  TITLE     Impaired nociception and pain sensation in mice lacking the
            capsaicin receptor
  JOURNAL   Science 288 (5464), 306-313 (2000)
   PUBMED   10764638
REFERENCE   7  (bases 1 to 2847)
  AUTHORS   Schumacher,M.A., Moff,I., Sudanagunta,S.P. and Levine,J.D.
  TITLE     Molecular cloning of an N-terminal splice variant of the capsaicin
            receptor. Loss of N-terminal domain suggests functional divergence
            among capsaicin receptor subtypes
  JOURNAL   J Biol Chem 275 (4), 2756-2762 (2000)
   PUBMED   10644739
REFERENCE   8  (bases 1 to 2847)
  AUTHORS   Caterina,M.J., Rosen,T.A., Tominaga,M., Brake,A.J. and Julius,D.
  TITLE     A capsaicin-receptor homologue with a high threshold for noxious
            heat
  JOURNAL   Nature 398 (6726), 436-441 (1999)
   PUBMED   10201375
REFERENCE   9  (bases 1 to 2847)
  AUTHORS   Suzuki,M., Sato,J., Kutsuwada,K., Ooki,G. and Imai,M.
  TITLE     Cloning of a stretch-inhibitable nonselective cation channel
  JOURNAL   J Biol Chem 274 (10), 6330-6335 (1999)
   PUBMED   10037722
REFERENCE   10 (bases 1 to 2847)
  AUTHORS   Caterina,M.J., Schumacher,M.A., Tominaga,M., Rosen,T.A.,
            Levine,J.D. and Julius,D.
  TITLE     The capsaicin receptor: a heat-activated ion channel in the pain
            pathway
  JOURNAL   Nature 389 (6653), 816-824 (1997)
   PUBMED   9349813
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF029310.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF029310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345329
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2847
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2847
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 1"
                     /db_xref="GeneID:83810"
                     /db_xref="RGD:628841"
     exon            1..47
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            48..364
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..2597
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /note="vanilloid type 1 receptor; vanilloid receptor
                     subtype 1; OTRPC1; capsaicin receptor; vanilloid receptor
                     1; osm-9-like TRP channel 1; transient receptor potential
                     vanilloid 1 supraoptic nucleus; deltaN-TRPV1; vanilloid
                     receptor type 1 like protein 1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily V member 1"
                     /protein_id="NP_114188.1"
                     /db_xref="GeneID:83810"
                     /db_xref="RGD:628841"
                     /translation="MEQRASLDSEESESPPQENSCLDPPDRDPNCKPPPVKPHIFTTR
                     SRTRLFGKGDSEEASPLDCPYEEGGLASCPIITVSSVLTIQRPGDGPASVRPSSQDSV
                     SAGEKPPRLYDRRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLK
                     AMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVT
                     LLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPAD
                     ISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGL
                     TPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEK
                     NSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTA
                     AAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFV
                     DSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYA
                     VMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLPMESTPHKCRGSACKPG
                     NSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALM
                     GETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRW
                     CFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSGRVSGRNWKNFALVPLLRD
                     ASTRDRHATQQEEVQLKHYTGSLKPEDAEVFKDSMVPGEK"
     exon            365..528
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..681
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..822
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1121
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1301
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1460
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1556
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1627
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1793
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1860
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2180
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2308
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2424
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2847
                     /gene="Trpv1"
                     /gene_synonym="TRPV1_SON; VR.5'sv; Vr1; Vr1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctccaag gcacttgctc catttggggt gtgcctgcac ctagctggtt gcaaattggg
       61 ccacagagga tctggaaagg atggaacaac gggctagctt agactcagag gagtctgagt
      121 ccccacccca agagaactcc tgcctggacc ctccagacag agaccctaac tgcaagccac
      181 ctccagtcaa gccccacatc ttcactacca ggagtcgtac ccggcttttt gggaagggtg
      241 actcggagga ggcctctccc ctggactgcc cttatgagga aggcgggctg gcttcctgcc
      301 ctatcatcac tgtcagctct gttctaacta tccagaggcc tggggatgga cctgccagtg
      361 tcaggccgtc atcccaggac tccgtctccg ctggtgagaa gcccccgagg ctctatgatc
      421 gcaggagcat cttcgatgct gtggctcaga gtaactgcca ggagctggag agcctgctgc
      481 ccttcctgca gaggagcaag aagcgcctga ctgacagcga gttcaaagac ccagagacag
      541 gaaagacctg tctgctaaaa gccatgctca atctgcacaa tgggcagaat gacaccatcg
      601 ctctgctcct ggacgttgcc cggaagacag acagcctgaa gcagtttgtc aatgccagct
      661 acacagacag ctactacaag ggccagacag cactgcacat tgccattgaa cggcggaaca
      721 tgacgctggt gaccctcttg gtggagaatg gagcagatgt ccaggctgcg gctaacgggg
      781 acttcttcaa gaaaaccaaa gggaggcctg gcttctactt tggtgagctg cccctgtccc
      841 tggctgcgtg caccaaccag ctggccattg tgaagttcct gctgcagaac tcctggcagc
      901 ctgcagacat cagcgcccgg gactcagtgg gcaacacggt gcttcatgcc ctggtggagg
      961 tggcagataa cacagttgac aacaccaagt tcgtgacaag catgtacaac gagatcttga
     1021 tcctgggggc caaactccac cccacgctga agctggaaga gatcaccaac aggaaggggc
     1081 tcacgccact ggctctggct gctagcagtg ggaagatcgg ggtcttggcc tacattctcc
     1141 agagggagat ccatgaaccc gagtgccgac acctatccag gaagttcacc gaatgggcct
     1201 atgggccagt gcactcctcc ctttatgacc tgtcctgcat tgacacctgt gaaaagaact
     1261 cggttctgga ggtgatcgct tacagcagca gtgagacccc taaccgtcat gacatgcttc
     1321 tcgtggaacc cttgaaccga ctcctacagg acaagtggga cagatttgtc aagcgcatct
     1381 tctacttcaa cttcttcgtc tactgcttgt atatgatcat cttcaccgcg gctgcctact
     1441 atcggcctgt ggaaggcttg cccccctata agctgaaaaa caccgttggg gactatttcc
     1501 gagtcaccgg agagatcttg tctgtgtcag gaggagtcta cttcttcttc cgagggattc
     1561 aatatttcct gcagaggcga ccatccctca agagtttgtt tgtggacagc tacagtgaga
     1621 tacttttctt tgtacagtcg ctgttcatgc tggtgtctgt ggtactgtac ttcagccaac
     1681 gcaaggagta tgtggcttcc atggtgttct ccctggccat gggctggacc aacatgctct
     1741 actatacccg aggattccag cagatgggca tctatgctgt catgattgag aagatgatcc
     1801 tcagagacct gtgccggttt atgttcgtct acctcgtgtt cttgtttgga ttttccacag
     1861 ctgtggtgac actgattgag gatgggaaga ataactctct gcctatggag tccacaccac
     1921 acaagtgccg ggggtctgcc tgcaagccag gtaactctta caacagcctg tattccacat
     1981 gtctggagct gttcaagttc accatcggca tgggcgacct ggagttcact gagaactacg
     2041 acttcaaggc tgtcttcatc atcctgttac tggcctatgt gattctcacc tacatccttc
     2101 tgctcaacat gctcattgct ctcatgggtg agaccgtcaa caagattgca caagagagca
     2161 agaacatctg gaagctgcag agagccatca ccatcctgga tacagagaag agcttcctga
     2221 agtgcatgag gaaggccttc cgctctggca agctgctgca ggtggggttc actcctgacg
     2281 gcaaggatga ctaccggtgg tgtttcaggg tggacgaggt aaactggact acctggaaca
     2341 ccaatgtggg tatcatcaac gaggacccag gcaactgtga gggcgtcaag cgcaccctga
     2401 gcttctccct gaggtcaggc cgagtttcag ggagaaactg gaagaacttt gccctggttc
     2461 cccttctgag ggatgcaagc actcgagata gacatgccac ccagcaggaa gaagttcaac
     2521 tgaagcatta tacgggatcc cttaagccag aggatgctga ggttttcaag gattccatgg
     2581 tcccagggga gaaataatgg acactatgca gggatcaatg cggggtcttt gggtggtctg
     2641 cttagggaac cagcagggtt gacgttatct gggtccactc tgtgcctgcc taggcacatt
     2701 cctaggactt cggcgggcct gctgtgggaa ctgggaggtg tgtgggaatt gagatgtgta
     2761 tccaaccatg atctccaaac atttggcttt caactcttta tggactttat taaacagagt
     2821 gaatggcaaa tctctacttg gacacat
//
