LOCUS       NM_001134837            4577 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus transcriptional repressor GATA binding 1 (Trps1),
            mRNA.
ACCESSION   NM_001134837 XM_001064835 XM_235264
VERSION     NM_001134837.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4577)
  AUTHORS   Fantauzzo,K.A., Kurban,M., Levy,B. and Christiano,A.M.
  TITLE     Trps1 and its target gene Sox9 regulate epithelial proliferation in
            the developing hair follicle and are associated with hypertrichosis
  JOURNAL   PLoS Genet 8 (11), e1003002 (2012)
   PUBMED   23133399
REFERENCE   2  (bases 1 to 4577)
  AUTHORS   Stinson,S., Lackner,M.R., Adai,A.T., Yu,N., Kim,H.J., O'Brien,C.,
            Spoerke,J., Jhunjhunwala,S., Boyd,Z., Januario,T., Newman,R.J.,
            Yue,P., Bourgon,R., Modrusan,Z., Stern,H.M., Warming,S., de
            Sauvage,F.J., Amler,L., Yeh,R.F. and Dornan,D.
  TITLE     TRPS1 targeting by miR-221/222 promotes the
            epithelial-to-mesenchymal transition in breast cancer
  JOURNAL   Sci Signal 4 (177), ra41 (2011)
   PUBMED   21673316
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4577)
  AUTHORS   Wuelling,M., Kaiser,F.J., Buelens,L.A., Braunholz,D.,
            Shivdasani,R.A., Depping,R. and Vortkamp,A.
  TITLE     Trps1, a regulator of chondrocyte proliferation and
            differentiation, interacts with the activator form of Gli3
  JOURNAL   Dev Biol 328 (1), 40-53 (2009)
   PUBMED   19389374
REFERENCE   4  (bases 1 to 4577)
  AUTHORS   Itoh,S., Kanno,S., Gai,Z., Suemoto,H., Kawakatsu,M., Tanishima,H.,
            Morimoto,Y., Nishioka,K., Hatamura,I., Yoshida,M. and Muragaki,Y.
  TITLE     Trps1 plays a pivotal role downstream of Gdf5 signaling in
            promoting chondrogenesis and apoptosis of ATDC5 cells
  JOURNAL   Genes Cells 13 (4), 355-363 (2008)
   PUBMED   18363966
REFERENCE   5  (bases 1 to 4577)
  AUTHORS   Westman,B.J., Perdomo,J., Matthews,J.M., Crossley,M. and
            Mackay,J.P.
  TITLE     Structural studies on a protein-binding zinc-finger domain of Eos
            reveal both similarities and differences to classical zinc fingers
  JOURNAL   Biochemistry 43 (42), 13318-13327 (2004)
   PUBMED   15491138
REFERENCE   6  (bases 1 to 4577)
  AUTHORS   van den Bemd,G.J., Jhamai,M., Brinkmann,A.O. and Chang,G.T.
  TITLE     The atypical GATA protein TRPS1 represses androgen-induced
            prostate-specific antigen expression in LNCaP prostate cancer cells
  JOURNAL   Biochem Biophys Res Commun 312 (3), 578-584 (2003)
   PUBMED   14680804
REFERENCE   7  (bases 1 to 4577)
  AUTHORS   Kaiser,F.J., Moroy,T., Chang,G.T., Horsthemke,B. and Ludecke,H.J.
  TITLE     The RING finger protein RNF4, a co-regulator of transcription,
            interacts with the TRPS1 transcription factor
  JOURNAL   J Biol Chem 278 (40), 38780-38785 (2003)
   PUBMED   12885770
REFERENCE   8  (bases 1 to 4577)
  AUTHORS   Perdomo,J. and Crossley,M.
  TITLE     The Ikaros family protein Eos associates with C-terminal-binding
            protein corepressors
  JOURNAL   Eur J Biochem 269 (23), 5885-5892 (2002)
   PUBMED   12444977
REFERENCE   9  (bases 1 to 4577)
  AUTHORS   Momeni,P., Glockner,G., Schmidt,O., von Holtum,D., Albrecht,B.,
            Gillessen-Kaesbach,G., Hennekam,R., Meinecke,P., Zabel,B.,
            Rosenthal,A., Horsthemke,B. and Ludecke,H.J.
  TITLE     Mutations in a new gene, encoding a zinc-finger protein, cause
            tricho-rhino-phalangeal syndrome type I
  JOURNAL   Nat Genet 24 (1), 71-74 (2000)
   PUBMED   10615131
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Sep 10, 2008 this sequence version replaced
            XM_235264.4, XM_001064835.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132264, SAMD00132266
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..4577
                     /gene="Trps1"
                     /note="transcriptional repressor GATA binding 1"
                     /db_xref="GeneID:299897"
                     /db_xref="RGD:1311883"
     exon            1..168
                     /gene="Trps1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..190
                     /gene="Trps1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..1119
                     /gene="Trps1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..4038
                     /gene="Trps1"
                     /note="trichorhinophalangeal syndrome I homolog"
                     /codon_start=1
                     /product="zinc finger transcription factor Trps1"
                     /protein_id="NP_001128309.1"
                     /db_xref="GeneID:299897"
                     /db_xref="RGD:1311883"
                     /translation="MVRKKNPPLRNVASEGEGQTLEPTATESKASGKNKEFSADQMSE
                     NTDQSDVAELNTKEEHSTHGQEPSSSSKKDLQISGLSEKAGFNYESPSKGGNLASFPH
                     DEVTDRNMLAFSSPAAGGVCEPLKSPQRAEADDPQDMACTPSGDSLETKEDHKMSPKA
                     TEETGPVQSGQANCQGLSPVSVASKNPQVPSDGGVRLSKPKSDLLVSDNPDPAPLSPE
                     LQDFKCNICGYGYYGNDPTDLIKHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHS
                     KDFQKVNRSVLSGVLQDISSSRPALLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFR
                     CKFCNFTYMGNSSTELEQHFLQTHPNKIKVSLPSSEGVKASEKNSNKSIPALRASDSG
                     DVGKWQDKMTVKAGDDTPVGYSVPIKPLDSSRQNGTEATSYYWCKFCSFSCESSSSLK
                     LLEHYGKQHGAVQSGGLNPELNDKLPRGSVINQNDLAKSVEGEPLTKPEKGLSGAKKK
                     DFPSKGAEDNMVTSYNCQFCDFRYSKSHGPDVIVVGPLLRHYQQLHNIHKCTIKHCPF
                     CPRGLCSPEKHLGEITYPFACRKSNCSHCALLLLHLSPGVAGSSRVKHQCHQCSFSTP
                     DVDVLLFHYETMHESQASDVKQEVNHLLGSEGQQAARDSKEHSCTKCDFITQVEEEIS
                     RHYRRAHSCYKCRQCSFTAGDTQSLLEHFNTVHCQEQEVATANGEEDGHAIPTIKEEP
                     KIDLKVYSLLNPDSKMGETVPESIVKREKLDDKEGLKDKIWTESSTDDLRGVTWRGAD
                     ILRGSPSYTQASLGLLTPVSSSQEQTKTLRDSPNVEAAHLARPMYGLAVDTKGFLQGA
                     PAGGEKSASLTQQYPASGEGKTKDESQSLLRRRRGSGVFCANCLTTKTSLWRKNANGG
                     YVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQAEQLNKQQRGSGE
                     EQVNGSPLERRSEDHLSESHQREIPLPSLSKYEAQGSLTKSHSAQQPVLVSQTLDIHK
                     RMQPLHIQIKSPQESTGDPGNSSSVSDGKGSSERGSPIEKYMRPAKHPNYSPPGSPIE
                     KYQYPLFGVPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQNYVPYPT
                     FNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGAAKEKSKAPSNVKNEGPLNVVKTEK
                     VDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTTHI
                     QRGLHRNNAQAEKNGKPKE"
     exon            1120..2249
                     /gene="Trps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2853
                     /gene="Trps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2976
                     /gene="Trps1"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..4577
                     /gene="Trps1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccactccc cctcgctgtc tcttgctggc tgattttaat tctctcctac cgggagcagc
       61 agaggatctg gaggtggctg gacccgaggg gccgccgccg ccgccgctgc aagttttctg
      121 ggggctcctg gcaaacgggg agcagactag gcaccggcat gcagagtaaa gcagtattgt
      181 ttgaacaaag atatggtccg gaaaaagaac ccccctctga gaaacgttgc tagtgaaggc
      241 gagggtcaaa ccctggagcc aacagctaca gagagcaagg catctgggaa gaacaaagaa
      301 ttttctgcag atcagatgtc agaaaataca gatcagagtg atgttgcaga attgaacacg
      361 aaggaggaac acagcacgca tggccaagag ccgtcttcga gcagtaagaa ggacttgcaa
      421 atctcaggcc tgagtgagaa ggctggcttc aattatgaaa gccccagtaa gggagggaac
      481 cttgcctcct tcccacatga tgaggtaaca gacagaaata tgttggcttt ctcatctcca
      541 gctgctgggg gagtctgcga gcccttgaag tctcctcaaa gagcagaggc agatgaccct
      601 caagatatgg cctgcacccc atcaggggat tcactggaga caaaggaaga tcataaaatg
      661 tcaccaaagg ccactgagga aacagggcca gtgcagagtg gtcaagccaa ttgtcaaggt
      721 ttgagtccag tttccgtggc ctcaaaaaac ccacaagtgc cttcagatgg gggtgtcaga
      781 ctgagtaaac ccaaaagtga cttactggtg agtgacaacc cagacccggc acctctgtct
      841 ccagagcttc aggactttaa atgcaatatc tgtggatacg gttactatgg caatgacccc
      901 acagatctga ttaagcactt ccgaaagtat cacttaggac tgcataatcg caccaggcag
      961 gatgctgagc tggacagcaa aatcttggcc cttcataaca tggtgcagtt cagccattcc
     1021 aaagacttcc agaaggtcaa ccgttctgtg ctttctggcg tgctgcagga tatcagctct
     1081 tcacggcctg cgctactaaa tgggacctat gatgtacagg tcacttcagg tggaacgttc
     1141 attggcattg gacggaaaac tcccgattgc caaggcaaca ccaagtattt ccgctgcaaa
     1201 ttctgcaatt tcacttacat gggcaactcg tcaactgaac tagaacaaca ttttcttcag
     1261 actcacccga ataaaatcaa agtgtctctc ccgtcctccg agggcgtgaa agcttcagag
     1321 aaaaactcta acaaatccat ccctgcgctt cgagccagtg actctgggga tgtaggaaaa
     1381 tggcaggaca aaatgacagt caaagctgga gatgacaccc ctgtcggcta ctcagtgccc
     1441 atcaagcccc tcgattcctc acgacaaaat ggtacagagg ccaccagtta ttactggtgt
     1501 aaattttgta gtttcagctg tgagtcatct agctcgctta agctgctaga acattacggc
     1561 aagcagcatg gagcagtgca gtcgggcggc cttaatccag agttgaatga caaacttccc
     1621 aggggctctg tcattaatca aaatgatcta gccaaaagtg tagaaggaga gccattgacc
     1681 aagccagaaa agggcttgag tggggctaaa aagaaggact tccccagcaa gggagcagag
     1741 gataatatgg taacgagcta taactgtcag ttctgtgact ttagatattc caaaagccat
     1801 ggccctgatg tgattgtagt gggtccactt ctccgtcatt atcagcaact ccataacatc
     1861 cacaagtgta ccattaagca ttgtccattc tgtcccagag gcctttgcag cccagaaaag
     1921 caccttggag aaattactta tccgtttgct tgtagaaaaa gtaattgttc ccactgtgca
     1981 ctcttgctgt tacacttgtc tcctggggtg gccggaagtt ccagagtcaa acaccaatgc
     2041 caccagtgtt ccttctctac ccccgatgta gatgtgctcc tctttcacta tgagaccatg
     2101 catgagtccc aagcatcgga tgtcaaacaa gaggtaaacc acctgctagg atctgaaggg
     2161 cagcaggctg ccagggacag caaggaacac tcgtgcacca aatgtgattt tataacccag
     2221 gtggaagaag agatctctag acactacagg agagcacaca gctgctataa atgtcgtcag
     2281 tgcagtttca cagctggtga cactcagtca ctgttggagc acttcaacac ggttcactgc
     2341 caggaacagg aagtagctac tgctaatggc gaagaggatg gccatgccat acccaccatc
     2401 aaggaagagc ccaaaattga tctcaaggtc tacagtctgc taaacccaga ctctaaaatg
     2461 ggagagacag ttcccgagag catagttaag agagagaaac ttgatgacaa ggaagggcta
     2521 aaagataaaa tctggacgga gagttcaact gatgaccttc gtggtgtgac ttggagagga
     2581 gccgacatcc tacggggtag tccatcctat actcaagcaa gtctggggct cttgacgcct
     2641 gtgtccagct cccaagagca gacaaagact ctgagggaca gccccaatgt cgaagctgcc
     2701 cacctggccc gacctatgta tggcttggct gtcgatacca agggcttcct gcaaggggct
     2761 cctgctggtg gcgagaagtc tgcatctctc actcagcagt atcctgcttc tggagagggc
     2821 aagaccaagg acgaatccca gtcgctgtta cggaggcgaa gaggctctgg tgttttttgt
     2881 gccaattgcc tgaccacaaa gacctctctc tggcgaaaga atgcaaatgg cggatatgta
     2941 tgcaacgcat gtggcctcta ccagaaactt cactcgactc ccaggccttt aaacatcatt
     3001 aaacaaaaca acggcgagca gattattaga agacggacaa gaaagcgcct taacccagag
     3061 gcacttcagg ctgagcaact caacaaacag cagaggggaa gtggggagga gcaggtcaat
     3121 ggaagcccct tagagaggag gtcagaagat cacttaagtg aaagtcatca gagagaaatt
     3181 ccacttccga gcctgagtaa atacgaagcc cagggttcat tgactaaaag ccattctgct
     3241 caacagccgg tcctggtcag ccaaactctg gatattcaca aaaggatgca gcctttgcac
     3301 attcagataa aaagtcctca ggaaagtact ggagatccag gaaacagttc atccgtatct
     3361 gatgggaaag gaagttctga aagaggcagc cccatagaaa agtacatgag gcctgcaaaa
     3421 caccccaact attctccacc aggcagcccc atcgaaaagt accaataccc actttttgga
     3481 gttccttttg tacataatga cttccagagt gaagctgatt ggctacggtt ctggagtaaa
     3541 tataagctct ctgttcctgg gaatccgcac tacttgagtc atgtgcctgg cttaccaaat
     3601 ccttgccaaa actatgtgcc ttatcccacc ttcaatctgc ctcctcattt ctcagctgtt
     3661 ggatcagaca atgacattcc tctagatttg gcgatcaagc attccagacc tgggccaact
     3721 gcaaatggtg ccgccaagga gaaaagcaag gcaccatcaa acgtaaaaaa tgaaggtccc
     3781 ttgaatgtag ttaagacgga gaaagttgac agaagcactc aagatgaact ttcaacgaaa
     3841 tgtgtgcact gtggcattgt tttcctggat gaagtgatgt atgctttgca tatgagttgc
     3901 catggtgaca gtggaccttt ccagtgcagc atatgccagc atctttgcac ggacaaatat
     3961 gacttcacaa cacatatcca gaggggcctg cataggaaca atgcacaagc agaaaaaaat
     4021 ggaaaaccta aagagtaaaa ccttagcact tagcacaatt aaatagaaat aggttttctt
     4081 gatgggaatt caatagcttg taatgtctta tgaagactta ttaaaaaaat aattcataga
     4141 gcctgcctta cccaacatga aattcccttt ttcttaattt ctttcttttg atgagtaggt
     4201 taccaagatt ttaaaatgaa acatatggtc agtgagaaag aatggaattg atagataatt
     4261 ttttaaaaaa aaaaaaggag aactagagtg aaaatgatct tacctaatgt gtactgctga
     4321 atctctgtac agaggcccaa ccaaattata gccatttgtt tgtaaagata caaatgctct
     4381 ctattgtttg aaggagttta catactatca tgtgacagca gtattaggct ggctattggc
     4441 ccatccattc agattaggtt gcctacaact taaaatatca tgagatctca gccaaaggag
     4501 gagaaaaaaa aatctccagg gcaatggaag aaaaaatggc acctctcaaa gtaggctcct
     4561 ctcattgacc atgtttc
//
