LOCUS       NP_001128309            1281 aa            linear   ROD 24-JUN-2024
DEFINITION  zinc finger transcription factor Trps1 [Rattus norvegicus].
ACCESSION   NP_001128309 XP_001064835 XP_235264
VERSION     NP_001128309.1
DBSOURCE    REFSEQ: accession NM_001134837.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1281)
  AUTHORS   Fantauzzo,K.A., Kurban,M., Levy,B. and Christiano,A.M.
  TITLE     Trps1 and its target gene Sox9 regulate epithelial proliferation in
            the developing hair follicle and are associated with hypertrichosis
  JOURNAL   PLoS Genet 8 (11), e1003002 (2012)
   PUBMED   23133399
REFERENCE   2  (residues 1 to 1281)
  AUTHORS   Stinson,S., Lackner,M.R., Adai,A.T., Yu,N., Kim,H.J., O'Brien,C.,
            Spoerke,J., Jhunjhunwala,S., Boyd,Z., Januario,T., Newman,R.J.,
            Yue,P., Bourgon,R., Modrusan,Z., Stern,H.M., Warming,S., de
            Sauvage,F.J., Amler,L., Yeh,R.F. and Dornan,D.
  TITLE     TRPS1 targeting by miR-221/222 promotes the
            epithelial-to-mesenchymal transition in breast cancer
  JOURNAL   Sci Signal 4 (177), ra41 (2011)
   PUBMED   21673316
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1281)
  AUTHORS   Wuelling,M., Kaiser,F.J., Buelens,L.A., Braunholz,D.,
            Shivdasani,R.A., Depping,R. and Vortkamp,A.
  TITLE     Trps1, a regulator of chondrocyte proliferation and
            differentiation, interacts with the activator form of Gli3
  JOURNAL   Dev Biol 328 (1), 40-53 (2009)
   PUBMED   19389374
REFERENCE   4  (residues 1 to 1281)
  AUTHORS   Itoh,S., Kanno,S., Gai,Z., Suemoto,H., Kawakatsu,M., Tanishima,H.,
            Morimoto,Y., Nishioka,K., Hatamura,I., Yoshida,M. and Muragaki,Y.
  TITLE     Trps1 plays a pivotal role downstream of Gdf5 signaling in
            promoting chondrogenesis and apoptosis of ATDC5 cells
  JOURNAL   Genes Cells 13 (4), 355-363 (2008)
   PUBMED   18363966
REFERENCE   5  (residues 1 to 1281)
  AUTHORS   Westman,B.J., Perdomo,J., Matthews,J.M., Crossley,M. and
            Mackay,J.P.
  TITLE     Structural studies on a protein-binding zinc-finger domain of Eos
            reveal both similarities and differences to classical zinc fingers
  JOURNAL   Biochemistry 43 (42), 13318-13327 (2004)
   PUBMED   15491138
REFERENCE   6  (residues 1 to 1281)
  AUTHORS   van den Bemd,G.J., Jhamai,M., Brinkmann,A.O. and Chang,G.T.
  TITLE     The atypical GATA protein TRPS1 represses androgen-induced
            prostate-specific antigen expression in LNCaP prostate cancer cells
  JOURNAL   Biochem Biophys Res Commun 312 (3), 578-584 (2003)
   PUBMED   14680804
REFERENCE   7  (residues 1 to 1281)
  AUTHORS   Kaiser,F.J., Moroy,T., Chang,G.T., Horsthemke,B. and Ludecke,H.J.
  TITLE     The RING finger protein RNF4, a co-regulator of transcription,
            interacts with the TRPS1 transcription factor
  JOURNAL   J Biol Chem 278 (40), 38780-38785 (2003)
   PUBMED   12885770
REFERENCE   8  (residues 1 to 1281)
  AUTHORS   Perdomo,J. and Crossley,M.
  TITLE     The Ikaros family protein Eos associates with C-terminal-binding
            protein corepressors
  JOURNAL   Eur J Biochem 269 (23), 5885-5892 (2002)
   PUBMED   12444977
REFERENCE   9  (residues 1 to 1281)
  AUTHORS   Momeni,P., Glockner,G., Schmidt,O., von Holtum,D., Albrecht,B.,
            Gillessen-Kaesbach,G., Hennekam,R., Meinecke,P., Zabel,B.,
            Rosenthal,A., Horsthemke,B. and Ludecke,H.J.
  TITLE     Mutations in a new gene, encoding a zinc-finger protein, cause
            tricho-rhino-phalangeal syndrome type I
  JOURNAL   Nat Genet 24 (1), 71-74 (2000)
   PUBMED   10615131
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Sep 10, 2008 this sequence version replaced
            XP_235264.4, XP_001064835.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132264, SAMD00132266
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     Protein         1..1281
                     /product="zinc finger transcription factor Trps1"
                     /note="trichorhinophalangeal syndrome I homolog"
                     /calculated_mol_wt=140885
     Region          895..951
                     /region_name="ZnF_GATA"
                     /note="Zinc finger DNA binding domain; binds specifically
                     to DNA consensus sequence [AT]GATA[AG] promoter elements;
                     a subset of family members may also bind protein;
                     zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C;
                     cd00202"
                     /db_xref="CDD:238123"
     Site            order(896,899,917,920)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:238123"
     Site            order(905..906,908,917..927,948,950..951)
                     /site_type="DNA binding"
                     /note="DNA-binding region [nucleotide binding]"
                     /db_xref="CDD:238123"
     CDS             1..1281
                     /gene="Trps1"
                     /coded_by="NM_001134837.1:193..4038"
                     /db_xref="GeneID:299897"
                     /db_xref="RGD:1311883"
ORIGIN      
        1 mvrkknpplr nvasegegqt leptateska sgknkefsad qmsentdqsd vaelntkeeh
       61 sthgqepsss skkdlqisgl sekagfnyes pskggnlasf phdevtdrnm lafsspaagg
      121 vceplkspqr aeaddpqdma ctpsgdslet kedhkmspka teetgpvqsg qancqglspv
      181 svasknpqvp sdggvrlskp ksdllvsdnp dpaplspelq dfkcnicgyg yygndptdli
      241 khfrkyhlgl hnrtrqdael dskilalhnm vqfshskdfq kvnrsvlsgv lqdisssrpa
      301 llngtydvqv tsggtfigig rktpdcqgnt kyfrckfcnf tymgnsstel eqhflqthpn
      361 kikvslpsse gvkaseknsn ksipalrasd sgdvgkwqdk mtvkagddtp vgysvpikpl
      421 dssrqngtea tsyywckfcs fscesssslk llehygkqhg avqsgglnpe lndklprgsv
      481 inqndlaksv egepltkpek glsgakkkdf pskgaednmv tsyncqfcdf ryskshgpdv
      541 ivvgpllrhy qqlhnihkct ikhcpfcprg lcspekhlge itypfacrks ncshcallll
      601 hlspgvagss rvkhqchqcs fstpdvdvll fhyetmhesq asdvkqevnh llgsegqqaa
      661 rdskehsctk cdfitqveee isrhyrrahs cykcrqcsft agdtqslleh fntvhcqeqe
      721 vatangeedg haiptikeep kidlkvysll npdskmgetv pesivkrekl ddkeglkdki
      781 wtesstddlr gvtwrgadil rgspsytqas lglltpvsss qeqtktlrds pnveaahlar
      841 pmyglavdtk gflqgapagg eksasltqqy pasgegktkd esqsllrrrr gsgvfcancl
      901 ttktslwrkn anggyvcnac glyqklhstp rplniikqnn geqiirrrtr krlnpealqa
      961 eqlnkqqrgs geeqvngspl errsedhlse shqreiplps lskyeaqgsl tkshsaqqpv
     1021 lvsqtldihk rmqplhiqik spqestgdpg nsssvsdgkg ssergspiek ymrpakhpny
     1081 sppgspieky qyplfgvpfv hndfqseadw lrfwskykls vpgnphylsh vpglpnpcqn
     1141 yvpyptfnlp phfsavgsdn dipldlaikh srpgptanga akekskapsn vknegplnvv
     1201 ktekvdrstq delstkcvhc givfldevmy alhmschgds gpfqcsicqh lctdkydftt
     1261 hiqrglhrnn aqaekngkpk e
//
