LOCUS       NM_134371               4165 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 8 (Trpm8), mRNA.
ACCESSION   NM_134371
VERSION     NM_134371.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4165)
  AUTHORS   Kozyreva,T.V., Orlov,I.V., Boyarskaya,A.R. and Voronova,I.P.
  TITLE     Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of
            temperature homeostasis at water balance changes
  JOURNAL   Neurosci Lett 828, 137763 (2024)
   PUBMED   38574849
  REMARK    GeneRIF: Hypothalamic TRPM8 and TRPA1 ion channel genes in the
            regulation of temperature homeostasis at water balance changes.
REFERENCE   2  (bases 1 to 4165)
  AUTHORS   Skagen,C., Lovsletten,N.G., Asoawe,L., Al-Karbawi,Z., Rustan,A.C.,
            Thoresen,G.H. and Haugen,F.
  TITLE     Functional expression of the thermally activated transient receptor
            potential channels TRPA1 and TRPM8 in human myotubes
  JOURNAL   J Therm Biol 116, 103623 (2023)
   PUBMED   37542841
  REMARK    GeneRIF: Functional expression of the thermally activated transient
            receptor potential channels TRPA1 and TRPM8 in human myotubes.
REFERENCE   3  (bases 1 to 4165)
  AUTHORS   Chakraborty,R. and Goswami,C.
  TITLE     Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion channels
            regulate microglial activity
  JOURNAL   Biochem Biophys Res Commun 611, 132-139 (2022)
   PUBMED   35489198
  REMARK    GeneRIF: Both heat-sensitive TRPV4 and cold-sensitive TRPM8 ion
            channels regulate microglial activity.
REFERENCE   4  (bases 1 to 4165)
  AUTHORS   Huang,Y., Li,S., Jia,Z., Li,S., He,W., Zhou,C., Zhang,R., Xu,R.,
            Sun,B., Ali,D.W., Michalak,M., Chen,X.Z. and Tang,J.
  TITLE     TRIM4 interacts with TRPM8 and regulates its channel function
            through K423-mediated ubiquitination
  JOURNAL   J Cell Physiol 236 (4), 2934-2949 (2021)
   PUBMED   33037615
  REMARK    GeneRIF: TRIM4 interacts with TRPM8 and regulates its channel
            function through K423-mediated ubiquitination.
REFERENCE   5  (bases 1 to 4165)
  AUTHORS   Lai,H., Liu,C., Hou,L., Lin,W., Chen,T. and Hong,A.
  TITLE     TRPM8-regulated calcium mobilization plays a critical role in
            synergistic chemosensitization of Borneol on Doxorubicin
  JOURNAL   Theranostics 10 (22), 10154-10170 (2020)
   PUBMED   32929340
  REMARK    GeneRIF: TRPM8-regulated calcium mobilization plays a critical role
            in synergistic chemosensitization of Borneol on Doxorubicin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4165)
  AUTHORS   Hu,H.Z., Gu,Q., Wang,C., Colton,C.K., Tang,J., Kinoshita-Kawada,M.,
            Lee,L.Y., Wood,J.D. and Zhu,M.X.
  TITLE     2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2,
            and TRPV3
  JOURNAL   J Biol Chem 279 (34), 35741-35748 (2004)
   PUBMED   15194687
REFERENCE   7  (bases 1 to 4165)
  AUTHORS   Nealen,M.L., Gold,M.S., Thut,P.D. and Caterina,M.J.
  TITLE     TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal
            neurons from rat
  JOURNAL   J Neurophysiol 90 (1), 515-520 (2003)
   PUBMED   12634279
  REMARK    GeneRIF: TRPM8 is preferentially expressed within a subset of
            rapidly responsive, low-threshold (approximately 30 degrees C),
            cold-sensitive neurons in trigeminal ganglia.
REFERENCE   8  (bases 1 to 4165)
  AUTHORS   Story,G.M., Peier,A.M., Reeve,A.J., Eid,S.R., Mosbacher,J.,
            Hricik,T.R., Earley,T.J., Hergarden,A.C., Andersson,D.A.,
            Hwang,S.W., McIntyre,P., Jegla,T., Bevan,S. and Patapoutian,A.
  TITLE     ANKTM1, a TRP-like channel expressed in nociceptive neurons, is
            activated by cold temperatures
  JOURNAL   Cell 112 (6), 819-829 (2003)
   PUBMED   12654248
REFERENCE   9  (bases 1 to 4165)
  AUTHORS   Peier,A.M., Moqrich,A., Hergarden,A.C., Reeve,A.J., Andersson,D.A.,
            Story,G.M., Earley,T.J., Dragoni,I., McIntyre,P., Bevan,S. and
            Patapoutian,A.
  TITLE     A TRP channel that senses cold stimuli and menthol
  JOURNAL   Cell 108 (5), 705-715 (2002)
   PUBMED   11893340
REFERENCE   10 (bases 1 to 4165)
  AUTHORS   McKemy,D.D., Neuhausser,W.M. and Julius,D.
  TITLE     Identification of a cold receptor reveals a general role for TRP
            channels in thermosensation
  JOURNAL   Nature 416 (6876), 52-58 (2002)
   PUBMED   11882888
  REMARK    GeneRIF: CMR1 is a member of the TRP family of excitatory ion
            channels and is proposed to function as a transducer of cold
            stimuli in the somatosensory system
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_134371.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY072788.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                JAXUCZ010000009.1  96351683-96351715
            34-155              JAXUCZ010000009.1  96364479-96364600
            156-229             JAXUCZ010000009.1  96368424-96368497
            230-386             JAXUCZ010000009.1  96372666-96372822
            387-564             JAXUCZ010000009.1  96373628-96373805
            565-737             JAXUCZ010000009.1  96375632-96375804
            738-912             JAXUCZ010000009.1  96378783-96378957
            913-980             JAXUCZ010000009.1  96380090-96380157
            981-1178            JAXUCZ010000009.1  96384661-96384858
            1179-1281           JAXUCZ010000009.1  96388803-96388905
            1282-1400           JAXUCZ010000009.1  96390578-96390696
            1401-1691           JAXUCZ010000009.1  96395599-96395889
            1692-1787           JAXUCZ010000009.1  96397596-96397691
            1788-1917           JAXUCZ010000009.1  96398589-96398718
            1918-2063           JAXUCZ010000009.1  96399081-96399226
            2064-2176           JAXUCZ010000009.1  96402172-96402284
            2177-2393           JAXUCZ010000009.1  96402899-96403115
            2394-2485           JAXUCZ010000009.1  96407199-96407290
            2486-2627           JAXUCZ010000009.1  96408083-96408224
            2628-2799           JAXUCZ010000009.1  96409265-96409436
            2800-2977           JAXUCZ010000009.1  96411502-96411679
            2978-3168           JAXUCZ010000009.1  96421698-96421888
            3169-3268           JAXUCZ010000009.1  96426453-96426552
            3269-3302           JAXUCZ010000009.1  96427970-96428003
            3303-3394           JAXUCZ010000009.1  96431874-96431965
            3395-4165           JAXUCZ010000009.1  96435575-96436345
FEATURES             Location/Qualifiers
     source          1..4165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..4165
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 8"
                     /db_xref="GeneID:171384"
                     /db_xref="RGD:620762"
     exon            1..33
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..155
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..3353
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /note="cold menthol receptor 1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 8"
                     /protein_id="NP_599198.2"
                     /db_xref="GeneID:171384"
                     /db_xref="RGD:620762"
                     /translation="MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNF
                     IQANFKKRECVFFTRDSKAMESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDA
                     FGDIQFETLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPR
                     MRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWG
                     MVSNRDTLIRNCDDEGHFSAQYIMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAK
                     LRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQ
                     IADVIASLVEVEDVLTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESPHLLT
                     VIKMEEAGDEVVSSAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTND
                     RRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRN
                     LQIAKNSYNDALLTFVWKLVANFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFI
                     WAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETR
                     AVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQW
                     YGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKHKKLLWYYVAFFTSPFVVFSW
                     NVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLW
                     NVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPK
                     IIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQ
                     VPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPRFPEWITIPLVCIYMLSTNILLV
                     NLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCFK
                     CCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINTKANDNAEEMRHRFRQLDTK
                     LNDLKGLLKEIANKIK"
     exon            156..229
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..386
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..564
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..737
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..912
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..980
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1178
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1281
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1400
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1691
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1787
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1917
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2063
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2176
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2393
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2485
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2627
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2799
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2977
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3168
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3268
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3302
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3394
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..4165
                     /gene="Trpm8"
                     /gene_synonym="CMR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagaagctc ttggctgttt gagcagctcc acggcaagat gtccttcgag ggagccaggc
       61 tcagcatgag gagccgcaga aatggaactc tgggcagcac ccggaccctg tactccagcg
      121 tgtctcggag cacagacgtg tcctacagtg aaagtgattt ggtgaatttt attcaggcaa
      181 attttaaaaa acgagaatgc gtcttcttta ccagagactc caaggccatg gagagcatat
      241 gcaagtgtgg ttatgcccag agccagcata tcgaaggcac ccagatcaac caaaatgaga
      301 agtggaacta caaaaaacac accaaggagt ttccaacaga cgcctttggg gacattcagt
      361 ttgagactct ggggaagaaa ggcaagtact tacgcttatc ctgtgacacg gactctgaaa
      421 ccctctacga actgctgacc cagcactggc acctcaaaac acccaacctg gtcatctcag
      481 tgacgggtgg agccaaaaac tttgctttga agccacgcat gcgcaaaatc ttcagtcggc
      541 tgatctacat cgctcagtct aaaggggcat ggattcttac cggaggcact cattacgggc
      601 tgatgaagta cataggtgag gtggtgagag ataacaccat cagcaggaac tcggaagaga
      661 acatcgtggc catcggcata gcggcctggg gcatggtctc caacagggac accctcatca
      721 ggaattgtga tgatgaggga catttttcag ctcaatatat catggatgac ttcatgagag
      781 atcctctcta catcctggac aacaatcata cccacctgct gcttgtggac aacggttgtc
      841 atggacaccc cacggtggaa gccaaacttc ggaatcagct ggagaagtac atctctgagc
      901 gcaccagtca agattccaac tatggtggta agatccccat cgtgtgtttt gcccagggag
      961 gtggaagaga aactttgaaa gccatcaaca cctctgtcaa aagtaagatc ccctgtgtgg
     1021 tggtggaagg ctcggggcag attgccgatg tgattgccag cctggtggag gtagaggatg
     1081 ttttaacctc ttccatggtc aaagagaagc tggtacggtt tttaccccgc actgtgtccc
     1141 ggctgcctga agaggagatt gagagctgga tcaaatggct caaagaaatt cttgagagcc
     1201 cccacctcct cacggtcatc aagatggagg aggctggaga cgaggtcgtg agcagcgcca
     1261 tttcctacgc gctgtacaaa gccttcagca ctaatgaaca agacaaggac aactggaacg
     1321 gacagctgaa gcttctgctg gagtggaacc aactggacct tgccagtgat gagatcttca
     1381 ccaatgaccg ccgctgggag tctgccgacc ttcaggaagt catgttcacg gccctcataa
     1441 aggacaggcc caagtttgtc cgcctcttcc tggagaatgg cctcaacctg cagaagttcc
     1501 tcaccaatga agtcctcacg gagctcttct ccacccactt cagcacccta gtgtaccgga
     1561 acctgcagat cgccaagaac tcctacaacg atgcactcct tacctttgtc tggaagttgg
     1621 tggcaaactt ccgtagaagc ttctggaaag aggacagaag cagcagggag gacttggatg
     1681 tggaactcca tgatgcatct ctcaccaccc ggcaccccct gcaggctctt ttcatctggg
     1741 ccattcttca gaacaagaag gaactctcca aggtcatctg ggagcagacc aaaggctgta
     1801 ctctggccgc cttgggggcc agcaaacttc tgaagaccct ggccaaagtt aagaatgata
     1861 tcaacgcagc tggggaatct gaggaactgg ctaatgagta tgagacccga gcagtggagt
     1921 tgttcactga gtgttacagc agtgatgagg acttggcaga acagctactg gtctactctt
     1981 gtgaagcctg gggtgggagc aactgtctgg agctggcggt ggaggctacg gaccagcatt
     2041 tcattgctca gcctggggtc cagaatttcc tttctaagca atggtatgga gagatttccc
     2101 gagacacgaa gaactggaag attatcctgt gtctgttcat catccccctg gtgggctgtg
     2161 gcctcgtatc gtttaggaag aagcccattg acaagcacaa gaagctgctc tggtactacg
     2221 tggccttctt cacttcgccc ttcgtggtct tctcctggaa cgtggtcttc tacatcgcct
     2281 tcctcctgct gtttgcgtat gtgctgctca tggacttcca ctcggtgcca cacacccccg
     2341 agctgatcct ctatgccctg gtcttcgtcc tcttctgtga tgaagtgagg cagtggtaca
     2401 tgaacggagt gaattatttc accgacctat ggaacgttat ggacacactg ggacttttct
     2461 acttcatagc gggtattgta ttccggcttc actcttcaaa taaaagctct ttgtactccg
     2521 ggcgagtcat tttctgtctg gattacatta tattcactct aaggctcatc cacattttca
     2581 ccgtgagcag gaacctggga cccaagatta taatgctgca gcggatgctc atcgacgttt
     2641 tcttcttctt gtttctcttt gctgtgtgga tggtggcctt cggcgtagcc agacagggga
     2701 tccttaggca aaatgaacag cgctggaggt ggatcttccg ctctgtcatc tatgagccct
     2761 acctggccat gtttggccag gtgcccagtg atgtggacag taccacatat gacttctccc
     2821 actgcacctt ctcgggaaat gagtccaagc cactgtgcgt ggagctagat gaatacaatc
     2881 tgccccgctt ccctgagtgg atcaccatcc cactagtgtg catctacatg ctctccacca
     2941 acatccttct ggtcaatctc ctggtcgcca tgtttggcta cacggtgggc attgtgcagg
     3001 agaacaacga tcaggtctgg aagttccagc ggtacttcct ggtgcaggag tactgcaacc
     3061 gcctcaacat ccccttcccc ttcgtcgtct tcgcttactt ctacatggtg gtcaagaagt
     3121 gtttcaaatg ctgctgtaaa gagaagaaca cggagtcttc tgcctgctgt ttcagaaatg
     3181 aggacaacga gactttggcg tgggagggcg tcatgaagga gaattacctt gtcaagatca
     3241 acacgaaggc caacgacaac gcagaggaga tgaggcatcg gttcagacaa ctggacacaa
     3301 agcttaatga tctcaaaggt cttctgaaag agattgctaa taaaatcaaa taaggcaggc
     3361 gactgctcat ggagagaagt caaattgcaa taagatcaaa tcaaacacct ggatttggag
     3421 gctcgtggga ctctgataaa caatactgct attgacttct aaaggagaca tttccaggtc
     3481 cctgggcaca aagtggatga gtcatagtca ccctcaaggg cataggtcag ggaccaaagt
     3541 gtacagagaa ctgtgcacaa gaagaggagt gcaaaggttc ctccatgaag gtgcctgtgc
     3601 tgtctgcatc tcggagcctt gaactgatgc tgaaggttta agtgatgaca cacctttccc
     3661 accctcgtct catgcacctc ccatgactgt gaccctggcc ctgattttac acctacactg
     3721 ctattgtgtt tatttcctac tgtccccttt ctgcattgta tgatgaattc atcgacatag
     3781 tgtcagagtc ctacaccacc ccaaagaaaa gtcaggccgg atgctaaaat accctggggc
     3841 aacctctcct ttctcacatg tcaaacgtgg gaggtgtggg gggggcacac ggaggcagtg
     3901 acttctttct ctggggctct ccaggactcc tgctgaagga acccttgaga gccgtacctt
     3961 gctccttttg attttgggag tgtgcctctc ctccattctc tcattatttc cccattgaga
     4021 atagcaaatg gatctcacag gaggttagag gagcacaaaa atgtatggaa acggcctccc
     4081 actcacagcc cttgctcaca cttccgtgtg tttgctcaat cccagccttt tctatgcatg
     4141 ctacacttca cttttaaaaa aaaaa
//
