LOCUS       XM_039101381            7307 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus transient receptor potential cation
            channel, subfamily M, member 6 (Trpm6), transcript variant X1,
            mRNA.
ACCESSION   XM_039101381
VERSION     XM_039101381.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051336.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039101381.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..7307
                     /gene="Trpm6"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 6; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 mRNA, 4 ESTs, 25
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 18 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:293874"
                     /db_xref="RGD:1309942"
     CDS             852..6926
                     /gene="Trpm6"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 6 isoform X1"
                     /protein_id="XP_038957309.1"
                     /db_xref="GeneID:293874"
                     /db_xref="RGD:1309942"
                     /translation="MQVKKSWIERVFYKRECNKFIPSSKDPHRCTPGCQICQNLVRCY
                     CGRLIQEHQGLDRAWSLSATEGNGNEQWSVEKHTVKSPTDTFGTINFQDGEHIYHSKY
                     IRTSWDTKSDHLLHLMLKEWNMELPKLVISVHGGLQNFKMPSKLKETFSQGLVKAAET
                     TGAWIITEGINSGVSKHVGDALKAHSSMSLRKIWTVGIPPWGVIENQRELVGKDVVCM
                     YQTLSNPLSKLTTLNCMHSHFILCDDGTVGKYGNEEKLRRNLEKHLSMQKIHTCSRQG
                     VPVVGLVVEGGPNVILWVWETVRNKEPVVVCEGTGRAADLLAFTYKHSEDGGILRPQV
                     KEEILCLIQNMFNFSLRQSKHLFQILMECMVHKDSITIFDADSEEHQDLDLAILKALL
                     KGTSLSISEQLNLAMAWDRMDIAKKHILIYGQHWKPGALEQAMRDALVMDRVDFVKLL
                     IENGVNLHRFLTISRLEDLYNTKQGPTNKFLRHLVQDVKQHTLLSSYRITLIDIGLVI
                     EYLIGGAYRSSYTRKSFRVLYNDLYRKHKGMTSFAQGLSQHPLHQRHSLGNRKESSES
                     TLHSQFFRTAQPYKSKDKPEDSHKPKKKSKERHSLSEDPGSAGFIYPYNDLLVWAVLM
                     KRQKMAMFFWQHGEEATVKAVIASILYRAMAREAKESNMVDDTSEELKKYSEQFGQLA
                     LDVLEKAFKQNEPMAMKLLTYELKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWM
                     GRLKMRKNSWLKIIISILLPPMILTLEFKSKAEMSHVPQSQDFQFTWNYSDQGLSNTK
                     EAKDYDLERGPDEKLDEALHLDLRNVPQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFL
                     MLFTYTVLVEMQPQPSVQEWLVIIYIFTNAIEKVREICISEPSKFTQKVKMWLSEYWN
                     LMETVAIGLFAVGFGLRWGHPPLHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTM
                     IAKMAANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWRLARDIVFEPYWMMYGEVYA
                     SEIDVCSNETSCPPGSFLTPFLQAVYLFVQYIIMVNLLIACFNNIYLDIKSISNKLWK
                     YNRYRYIMTYHQKPWLPPPFILISHLCLLLRGLCCRPAPQDQEEGDMGLKLYLTKDDL
                     KKLHDFEEQCVEKYFHEKTEGLNCSCEEQIRATSERVSEMFFQLKEMNEKVSFIKDSL
                     LSLDSQVGHLQDLSALTVDTLKVLSAVDTLQEDEILLANRKHSTCRKRPHSWTNVICA
                     KVLTDMESCGKQKFQYYSMPPSLLRSLARSQLPPGVQRGALVEVTHNTREASHVREDQ
                     KEREVEQRTIASGVSHVRQAHSKYGQFLLVPPSEKQVSLSLENPPHLFRASGETGTDD
                     VALQHRHPSDVTIHLPGQTPAVSHQALGAEHKDQHEAVIQMSGKPDKAEQDSLKFSGT
                     PAPMAVTSLPSRAISMQDEGGYVNWAFSESDEAGVFSFKKKWKTCLASTCDSGSKPGG
                     DCSLQAAGRSGLDNSRLAQSCEWPAGPWTQARRSFWINPLCRDKPLLKSHSFRFHKEE
                     KLRKTWKNNSHSKASETGSTWLKAKLLTKNRSLSKKRRKAQGLQVPVITVNACYQSDQ
                     LTSESGETNTTEDYSKNWLSVSNFSQIGLEPYIYQKMKMKEIERHTTQASYHLRQMQE
                     DPDKNPSWNSRSASVSRSFLTRSPNEVDKISASLKSPPEPHRHYSAIERNNLMRLSQT
                     IPFTPIQLFTGEEVTIYKLEETSPLTLDKSMSSWSQHGRAAIIQVLSQEEMDGGLRKA
                     MRVISTWSEDDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKL
                     IYTFNQVKPQTIPYTPRFLEVSLVYCHSANQWLTIEKYMTGEFRKYNNNNGDEIAPTN
                     TLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEDKQSRGMVFGPANLGE
                     DAIRSFIAKHRCNSCCGKLRLPDLKRNDYSHARAHCNLELAKTTEPAEEHPERDRNRS
                     PLEDHTRL"
ORIGIN      
        1 tttgtatgat acttcataaa taaagcacgt taactctctt ttcacagtgt aatctctgtg
       61 aggaaggagg gttttcttta ttactctctc tgtatagatg agtaaactga ggcccagaag
      121 agtttcttgt catgctcagc aattcgtggg cgtttcagaa acacggagaa cacaaaccga
      181 gtgtctcttc ccctaaagtt ctgacccagg aatctgagat ttgtctgatg gcagtgacca
      241 tcccatctga tcatcagtct gacttctttg gagtcctgtt tttcctacac aggagttaac
      301 agagccccaa aggcattgtg aaaactccac agggctgtaa aaggcagtgt ccacgtgaag
      361 gtggagccca gattttctgt ctccacagtc aaaagctcag actgtgtttt agttgctggc
      421 ctggaaaatc taggatgaaa gccggacctg ctgctgagtg ctctcctatg cacacaggtc
      481 aagcccaggg ccccaggtgg ctgtgggtgg agccaggcgc acgcgtatct aactgcgatc
      541 tggaataggt aggatttgcg aaatgctagc tttcaagtcc tctagtctcc acccgaacat
      601 gattatcgta gctgaagttt tggcaaccgc gtggaccctc ccgaagggca ggacccgcag
      661 tctttcttcc gggagttggg accgtgccgg agctgggtca gggccgagcg gaaactgaac
      721 ccagggtctg ggcagcaggg cgcgggtgtg agtcctggtc tccggagtcc aagtcctgga
      781 ggaatccagt cctgggaggt gtccgggtcc gggaggaatc cgctgtcgct tcggctcctg
      841 tggtggtgag aatgcaggtc aagaaatcct ggattgaaag agtattctac aagagagaat
      901 gtaacaaatt catacccagc tccaaggacc ctcacagatg cactccaggc tgccaaatct
      961 gccagaattt agtcaggtgt tactgtgggc ggctgattca agagcaccag gggctagatc
     1021 gtgcctggag cctctcagcc actgagggca atggaaacga gcagtggtct gtcgagaagc
     1081 acacggtgaa aagccctaca gataccttcg gcaccattaa cttccaagat ggcgaacata
     1141 tctaccactc caagtacatt agaacttctt gggataccaa atcagatcat ctgttgcact
     1201 taatgttgaa agagtggaat atggagctgc cgaagcttgt gatctctgtt catgggggtc
     1261 ttcagaactt caagatgccc tccaagctca aagagacctt cagccagggg ctggtcaaag
     1321 ctgcagagac cacaggagca tggataatta ctgaaggcat aaactcagga gtgtccaagc
     1381 atgttgggga tgccctaaaa gcccattcct ctatgtcttt gaggaaaatc tggacagttg
     1441 gaatccctcc ttggggtgtc attgagaacc agagagagct ggttggaaaa gatgtggtgt
     1501 gtatgtacca gaccctgagt aacccactga gcaagctcac cacactcaac tgtatgcact
     1561 ctcacttcat cctgtgtgat gatgggactg tgggcaagta tggaaatgaa gagaagctca
     1621 ggcggaacct ggagaagcat ctctcgatgc agaagataca cacctgctca aggcaaggtg
     1681 tgcctgtggt gggactggtg gtggaaggag gccccaatgt catcctctgg gtatgggaga
     1741 ctgtcaggaa caaggagcct gtggtggtgt gcgaggggac cggcagagct gctgacctcc
     1801 tggccttcac ctacaaacat tcggaggatg gagggattct acgccctcag gtgaaagaag
     1861 agatcttgtg tttgattcag aacatgttca actttagcct gagacagtct aagcaccttt
     1921 tccaaattct aatggagtgc atggttcaca aggattctat taccatattt gatgctgatt
     1981 ctgaggagca ccaggacctt gatttggcaa tcctcaaggc tttgctgaag ggtacaagct
     2041 tatccatatc agaacagtta aatctggcaa tggcttggga tagaatggac attgccaaaa
     2101 aacatatcct aatttacgga caacattgga agcctggtgc tctggaacaa gcaatgcgag
     2161 atgccttagt gatggatcga gtggacttcg tgaagctctt gatagagaat ggggtgaacc
     2221 tacaccgctt cctcaccatc tcccggctgg aagatctcta taacacaaaa caaggaccaa
     2281 cgaataagtt tttgcgtcat cttgtccaag atgtaaagca gcataccctt ctctcgagct
     2341 acagaataac actcatcgac attgggctgg taatagagta cctcattggt ggagcgtatc
     2401 gaagcagcta cactaggaaa agtttcagag ttctctacaa cgacctctac agaaaacaca
     2461 agggtatgac tagctttgct cagggtcttt cccagcaccc tcttcatcag agacattcat
     2521 taggaaatag aaaggagtct tcggaaagca cactgcactc ccagttcttc aggacggccc
     2581 agccctacaa atccaaggac aagcctgaag actctcataa accaaagaag aagtccaagg
     2641 aaagacacag cctgtcagag gaccccgggt ctgctggctt tatctaccca tacaatgacc
     2701 tgctggtgtg ggcggtgctc atgaagagac agaagatggc catgttcttc tggcagcatg
     2761 gagaggaggc cacagtcaag gcggtcattg ctagcatcct ctacagagcc atggcccggg
     2821 aagctaagga gagcaacatg gtagatgata cttcagaaga gttgaagaag tactcagagc
     2881 agtttggcca gctcgccctg gatgtattag agaaagcctt caagcagaac gagccgatgg
     2941 ccatgaagct gttgacctat gaactcaaga actggagcaa ttctacctgc ttgaaactgg
     3001 cagtgtctgg aggcctgcgc ccttttgtgt cacattcttg tacccaaatg ctgctgacag
     3061 acatgtggat ggggcgtttg aaaatgagga aaaactcctg gctgaagata atcatcagca
     3121 tcctcttacc acccatgatt ttgacgttgg aatttaaaag caaagcggag atgtcacatg
     3181 tcccacagtc ccaggatttc cagtttacat ggaattacag tgaccagggt ctgagtaaca
     3241 ccaaagaagc gaaagactac gatttggaaa gaggccctga tgagaaactg gatgaagctc
     3301 tgcatttaga cttaagaaat gtgccccaga gccttccctg gaccagaaga gtctacgagt
     3361 tctacagtgc tccgtttgtc aagttctggt tctacacgat ggcttatttg gcattcctca
     3421 tgctgttcac ttacacagtg ttggtggaga tgcagcccca acccagcgtg caagagtggc
     3481 ttgtcatcat ctacatcttc accaatgcta ttgagaaggt cagggagatc tgcatttcag
     3541 aaccaagcaa gtttactcag aaggtgaaga tgtggctcag tgagtactgg aacctgatgg
     3601 aaactgtggc tattggcctg tttgccgttg gctttggcct acggtgggga catccacctt
     3661 tgcatactgc agggagactc atctactgca tagacatcat attttggttt tctcggctcc
     3721 tggatttctt tgctgtgaat caacatgcag gtccatatgt gaccatgatt gcaaaaatgg
     3781 cagcaaacat gttctacatt gtgatcatca tggccattgt tctgctgagc tttggcgtgg
     3841 cacgcaaagc catcctgtca ccaaaggagc ctccttcatg gcgcctggct cgtgatattg
     3901 tattcgagcc atattggatg atgtatggag aagtctatgc ttcagagata gatgtttgtt
     3961 caaatgagac atcttgccct ccgggttctt tcctgactcc attcctgcaa gccgtctacc
     4021 tctttgtgca atatatcatc atggtgaact tgctgattgc ctgtttcaac aacatttact
     4081 tagacataaa atccatctca aacaagctct ggaaatacaa ccgctatcgc tacatcatga
     4141 cctaccacca gaagccctgg ctgcccccac ccttcatcct gataagtcac ctgtgcctgc
     4201 tcctccgagg actgtgctgt cgcccagcgc cacaggacca ggaagagggt gacatggggc
     4261 taaaactcta cctcactaag gatgacttga aaaagcttca tgattttgaa gagcagtgtg
     4321 tggaaaaata tttccatgag aagacggaag gtctgaattg tagttgtgag gaacagatcc
     4381 gagcgacatc cgaaagggta tcagagatgt tcttccaact gaaagaaatg aatgaaaaag
     4441 tgtcttttat aaaggactct ctactatccc tggacagcca ggtgggacac ctacaggatc
     4501 tctctgcctt gaccgttgac accttgaagg tcctttctgc tgttgacacc ttgcaagaag
     4561 acgagattct gctggccaac agaaaacatt ctacttgcag aaaacgtccc cacagctgga
     4621 ccaatgtcat ctgtgcaaag gttctgactg acatggagag ctgtgggaag cagaaatttc
     4681 agtactatag catgccccct tctttgctga ggagccttgc tagaagccag cttcccccag
     4741 gagtgcaaag gggtgccctt gtagaggtta cacacaatac gagagaggcc tcacatgtaa
     4801 gagaagacca gaaggaacga gaagtggaac agagaacaat cgcttctggg gtttcccatg
     4861 tcagacaagc acactctaag tatggtcagt ttctcctggt cccaccttct gaaaagcaag
     4921 tttctttgtc tctggaaaac cccccacatc ttttcagagc ctctggggag acaggtacag
     4981 atgatgtggc attgcaacat agacacccaa gtgacgtcac catccacttg cctgggcaaa
     5041 ctcctgctgt ctcccaccag gcattgggag cagaacacaa agatcaacat gaggcagtta
     5101 tacagatgtc aggcaaacct gacaaggcag aacaagactc actcaaattc agtggcacac
     5161 ctgctcccat ggcagtgact tctcttcctt caagagccat cagcatgcaa gatgaaggtg
     5221 gatatgtgaa ctgggcattt tcagaaagtg atgaagcagg tgtgtttagt tttaaaaaga
     5281 agtggaaaac ttgcttggct tccacttgcg acagtggctc caaaccaggt ggagactgct
     5341 ccctccaggc tgcaggcagg tccgggctgg ataactcaag actggcccag agttgtgagt
     5401 ggccagcagg accgtggacc caggcaagaa gatccttttg gatcaatcct ctctgcagag
     5461 ataaacctct ccttaagagt catagtttta gattccacaa ggaggagaaa ctgaggaaga
     5521 cctggaagaa caacagccat tcaaaagcct cagagactgg gtcaacatgg ctcaaagcaa
     5581 agctgctaac caagaatagg agtctgtcaa agaaaaggag gaaggcccag ggactccagg
     5641 tgccggtgat aacagtcaat gcctgctatc aaagtgacca attgacttca gagtccggag
     5701 aaacaaacac cactgaagac tacagcaaga actggctttc cgtgtccaac ttcagccaga
     5761 taggtttaga accttatata taccagaaaa tgaaaatgaa ggaaatcgaa cgacatacta
     5821 ctcaagccag ttaccaccta aggcagatgc aagaggaccc ggataaaaac ccctcatgga
     5881 attccaggag cgccagcgtc agcaggagtt ttctaacaag aagcccaaat gaagttgaca
     5941 agatctcagc ctctttaaaa agccctccag agcctcaccg ccattattca gccattgaaa
     6001 ggaataattt aatgagactg tctcagacca taccgtttac accaatccag ctgttcacag
     6061 gagaggaagt gaccatctac aagcttgaag agacttcccc tctgaccctt gataagagca
     6121 tgtcctcttg gtcccagcat ggtagagctg ccataatcca ggtgctgtca caagaggaga
     6181 tggatggggg cctccgcaaa gccatgcgcg ttatcagcac ctggtctgag gatgacgttc
     6241 tcaagcccgg gcaggttttc attgtgaagt cttttctccc cgaggtcgtg cagacatggt
     6301 ataaaatctt ccaggagagc actgtgcttc acctttgcct tagggaaatt caacagcaaa
     6361 gagctgccca aaaactcatc tataccttca accaagtaaa accacaaacc attccctata
     6421 caccaagatt tcttgaggtt tccttggtct actgccattc agctaaccaa tggttaacca
     6481 ttgagaagta catgacaggg gagttccgga aatacaataa caacaatggc gatgaaattg
     6541 cccccaccaa caccctggaa gaactgatgt tggctttctc tcactggacc tatgagtata
     6601 cccggggaga gctgctggtt ttagatttgc aaggtgttgg agaaaatttg acagatccat
     6661 ctgttataaa accggaagat aaacaatcaa gagggatggt gtttggaccg gccaatttag
     6721 gggaagatgc aattagaagc ttcattgcaa aacatcgctg caactcctgc tgtgggaagc
     6781 tcaggctgcc ggatttaaaa aggaatgact actcccatgc aagggcacat tgcaacttgg
     6841 aacttgcaaa aaccactgaa ccagctgagg aacatccaga aagagacaga aatagaagtc
     6901 ccctggaaga tcacacacgc ctttaaaaag gaagatgaag gaagatgatg gtcccttagc
     6961 tccttctgcc atgatttctg tggtaataga catagactga cacgatcctg actatgccag
     7021 aatctctgtc acgatgactt tacagtgtgg acctccctgg aggtaccctc tgagcctcat
     7081 ctctcactgc ccggcagagg gcaccgtgtc taatggaggg accctcctgg atactgactt
     7141 ctgagaagaa tgtgtggcat acactctcct ctcccggttc tgcatgaaga tactagatga
     7201 gtccgttggg aagactttcc tttatacctc attgcgtcag ctgcccactt ggagtagaat
     7261 gctgtgtact aaagaaccag ggaataaatt aatttatttt ctcactg
//
