LOCUS       NM_001191896            3942 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 5 (Trpm5), mRNA.
ACCESSION   NM_001191896 XM_017589502 XM_344979
VERSION     NM_001191896.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3942)
  AUTHORS   Yamaguchi,S., Tanimoto,A., Iwasa,S. and Otsuguro,K.
  TITLE     TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca2+
            Sensitivity but Not Significance of PI(4,5)P2
  JOURNAL   Int J Mol Sci 20 (8), 2012 (2019)
   PUBMED   31022885
  REMARK    GeneRIF: The Ca(2+)-binding sites of TRPM4 and TRPM5 were shown to
            be formed by the same amino acid residues by functional analyses,
            but the impact of PI(4,5)P2 on the regulation of TRPM5 seemed to be
            smaller than that on the regulation of TRPM4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3942)
  AUTHORS   Qian,J., Mummalaneni,S., Grider,J.R., Damaj,M.I. and Lyall,V.
  TITLE     Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5
            positive taste receptor cells (TRCs)
  JOURNAL   PLoS One 13 (1), e0190465 (2018)
   PUBMED   29293602
  REMARK    GeneRIF: conclude that nAChR subunits are expressed in
            Trpm5-positive TRCs and their expression levels are differentially
            altered by chronic oral exposure to nicotine and ethanol
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3942)
  AUTHORS   Feng,R., Qian,C., Liu,Q., Jin,Y., Liu,L., Li,S., Liao,Y., Zhou,H.,
            Liu,W., Rayner,C.K. and Ma,J.
  TITLE     Expression of sweet taste receptor and gut hormone secretion in
            modelled type 2 diabetes
  JOURNAL   Gen Comp Endocrinol 252, 142-149 (2017)
   PUBMED   28782537
  REMARK    GeneRIF: Sweet taste molecules of T1R2, T1R3, alpha-gustducin and
            TRPM5 in ileum were dramatically higher than those in duodenum
            (P<0.01 for each).
REFERENCE   4  (bases 1 to 3942)
  AUTHORS   Krishnan,K., Ma,Z., Bjorklund,A. and Islam,M.S.
  TITLE     Role of transient receptor potential melastatin-like subtype 5
            channel in insulin secretion from rat beta-cells
  JOURNAL   Pancreas 43 (4), 597-604 (2014)
   PUBMED   24632551
  REMARK    GeneRIF: In rat pancreatic islets, TRPM5 is involved in mediating
            insulin secretion by glucose and l-arginine and in potentiating the
            glucose-induced insulin secretion by glucagon-like peptide 1.
REFERENCE   5  (bases 1 to 3942)
  AUTHORS   Ren,Z., Rhyu,M.R., Phan,T.H., Mummalaneni,S., Murthy,K.S.,
            Grider,J.R., DeSimone,J.A. and Lyall,V.
  TITLE     TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda
            tympani taste nerve response
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 305 (1), G106-G117 (2013)
   PUBMED   23639808
  REMARK    GeneRIF: The results suggest that pharmacological or genetic
            alteration of TRPM5 activity modulates the benzamil-insensitive
            NaCl chorda tympani response and its modulation by TRPV1 agonists.
REFERENCE   6  (bases 1 to 3942)
  AUTHORS   Teruyama,R., Sakuraba,M., Kurotaki,H. and Armstrong,W.E.
  TITLE     Transient receptor potential channel m4 and m5 in magnocellular
            cells in rat supraoptic and paraventricular nuclei
  JOURNAL   J Neuroendocrinol 23 (12), 1204-1213 (2011)
   PUBMED   21848647
  REMARK    GeneRIF: These channels may play an important role in determining
            the distinct firing properties of vasopressin neurones in the
            supraoptic nucleus.
REFERENCE   7  (bases 1 to 3942)
  AUTHORS   Liu,D. and Liman,E.R.
  TITLE     Intracellular Ca2+ and the phospholipid PIP2 regulate the taste
            transduction ion channel TRPM5
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15160-15165 (2003)
   PUBMED   14657398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 14, 2022 this sequence version replaced
            XM_017589502.2, NM_001191896.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LC469323.1, SRR26643288.5314.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000001.1  207707000-207707088 c
            90-164              JAXUCZ010000001.1  207702790-207702864 c
            165-291             JAXUCZ010000001.1  207702448-207702574 c
            292-472             JAXUCZ010000001.1  207701866-207702046 c
            473-639             JAXUCZ010000001.1  207700677-207700843 c
            640-826             JAXUCZ010000001.1  207699846-207700032 c
            827-891             JAXUCZ010000001.1  207698273-207698337 c
            892-1083            JAXUCZ010000001.1  207697938-207698129 c
            1084-1186           JAXUCZ010000001.1  207697551-207697653 c
            1187-1305           JAXUCZ010000001.1  207696235-207696353 c
            1306-1644           JAXUCZ010000001.1  207695532-207695870 c
            1645-1785           JAXUCZ010000001.1  207695326-207695466 c
            1786-1909           JAXUCZ010000001.1  207695077-207695200 c
            1910-2055           JAXUCZ010000001.1  207694587-207694732 c
            2056-2168           JAXUCZ010000001.1  207693803-207693915 c
            2169-2261           JAXUCZ010000001.1  207693554-207693646 c
            2262-2520           JAXUCZ010000001.1  207692960-207693218 c
            2521-2639           JAXUCZ010000001.1  207692231-207692349 c
            2640-2772           JAXUCZ010000001.1  207691914-207692046 c
            2773-2947           JAXUCZ010000001.1  207691085-207691259 c
            2948-3101           JAXUCZ010000001.1  207688589-207688742 c
            3102-3283           JAXUCZ010000001.1  207687506-207687687 c
            3284-3416           JAXUCZ010000001.1  207687081-207687213 c
            3417-3489           JAXUCZ010000001.1  207686268-207686340 c
            3490-3556           JAXUCZ010000001.1  207685842-207685908 c
            3557-3942           JAXUCZ010000001.1  207685157-207685542 c
FEATURES             Location/Qualifiers
     source          1..3942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..3942
                     /gene="Trpm5"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 5"
                     /db_xref="GeneID:365391"
                     /db_xref="RGD:1310620"
     exon            1..89
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            90..164
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..3645
                     /gene="Trpm5"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 5"
                     /protein_id="NP_001178825.2"
                     /db_xref="GeneID:365391"
                     /db_xref="RGD:1310620"
                     /translation="MPGVRKVTMPMAQSSCPGSPPDTGDGWEPVLCKGEVNFGGSGKK
                     RSKFVKVPSNVAPSMLFELLLTEWHLPAPNLVVSLVGEERLFAMKSWLRDVLRKGLVK
                     AAQSTGAWILTSALHVGLARHVGQAVRDHSLASTSTKVRVVAIGMASLDRILHRQLLD
                     GVQEDTPIHYPADEGSTQGPLCPLDSNLSHFILVEPGTLGSGNDGLAELQLSLEKHIS
                     QQRTGYGGTSSIQIPVLCLLVNGDPSTLERMSRAVEQAAPWLILAGSGGIADVLAALV
                     GQPHLLVPQVTEKQFREKFPSECFSWEAIVHWTELLQNIAAHPHLLTVYDFEQEGSED
                     LDTVILKALVKACKSHSRDAQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEV
                     MTDALVSNKPDFVRLFVDSGADMAEFLTYGRLQQLYHSVSPKSLLFELLERKHEEGRL
                     TLAGLGAQQTRELPVGLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPAG
                     QKWLPDLSRKSEDPWRDLFLWAVLQNRYEMATYFWAMGREGVAAALAACKIIKEMSHL
                     EKEAEVARTMREAKYEQLALDLFSECYSNSEDRAFALLVRRNHSWSRTTCLHLATEAD
                     AKAFFAHDGVQAFLTKIWWGDMATGTPILRLLGAFTCPALIYTNLISFSEDAPQRMDL
                     EDLQEPDSLDMEKSFLCSHGGQLEKLTEAPRAPGDLGPQAAFLLTRWRKFWGAPVTVF
                     LGNVVMYFAFLFLFSYVLLVDFRPPPQGPSGSEVTLYFWVFTLVLEEIRQGFFTNEDT
                     RLVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGRTVLAIDFMVFTLRLIH
                     IFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRV
                     LYRPYLQIFGQIPLDEIDEARVNCSLHPLLLDSSASCPNLYANWLVILLLVTFLLVTN
                     VLLMNLLIAMFSYTFQVVQGNADMFWKFQRYHLIVEYHGRPALAPPFILLSHLSLVLK
                     QVFRKEAQHKQQHLERDLPDPVDQKIITWETVQKENFLSTMEKRRRDSEEEVLRKTAH
                     RVDLIAKYIGGLREQEKRIKCLESQANYCMLLLSSMTDTLAPGGTYSSSQNCGRRSQP
                     ASARDREYLEAGLPHSDT"
     exon            165..291
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            292..472
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            473..639
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            640..826
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            827..891
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1083
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1186
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1305
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1644
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1785
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1909
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2055
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2168
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2261
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2520
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2639
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2772
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2947
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3101
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3283
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3416
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3489
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3556
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3942
                     /gene="Trpm5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaagggagg aacacagcct gaagtaggtg agtggctccc acattcagta ccagcagcta
       61 catgccagga gtctggaagg aacagacagg tttccaggag accctctgca aaagcctctg
      121 gagagctgtg tcgagggtgt tggaatccag atgcccggag ttcgaaaagt cacaatgccg
      181 atggcccaga gctcttgtcc tggaagcccc ccagatactg gggatggatg ggagccagtc
      241 ctatgcaagg gagaggtcaa cttcggaggg tctgggaaaa agcgaagcaa gtttgtgaag
      301 gtgccaagca atgtggcccc ctccatgctc tttgaactcc tgctcaccga gtggcacctg
      361 ccagccccca acctggtggt gtccctggtg ggcgaggaac ggctttttgc tatgaagtcc
      421 tggcttcggg atgtcttgcg caaggggctg gtgaaagcag ctcagagcac aggtgcctgg
      481 atcctgacca gtgccctcca tgtgggcctg gcacgccatg ttggacaggc tgtacgtgat
      541 cactctctgg ctagcacgtc caccaaggtc cgtgtggtgg ccatcggaat ggcctctctg
      601 gaccgaatcc ttcaccgcca acttctagat ggtgtccagg aggatactcc catccactac
      661 ccagcagatg agggcagcac tcagggaccc ctctgccctc tggacagcaa tctctcccac
      721 ttcatcctcg tggagccagg cacccttggg agtgggaacg acggactggc agagctgcag
      781 ctgagcctgg agaagcacat ctctcagcag aggacaggtt atgggggtac cagcagcatc
      841 cagatacctg tcctttgctt gctagtcaat ggtgacccca gcaccctaga gaggatgtcc
      901 agggcagtgg agcaggctgc cccatggctg atcctggcag gttctggggg cattgctgat
      961 gtactcgctg ccctggtggg ccagcctcat ctcctggtgc cccaggtgac cgagaagcag
     1021 ttcagagaga aattcccaag cgagtgtttc tcttgggaag ccattgtaca ctggacagag
     1081 ctgctacaga acattgctgc acacccccac ctgctcacag tgtacgactt tgagcaggag
     1141 ggttccgagg acctggacac cgtcatcctc aaggcacttg tgaaagcctg caagagtcac
     1201 agccgagacg cacaagacta cctagatgag ctcaagttag cagtggcctg ggatcgcgtg
     1261 gacattgcca agagtgaaat cttcaatggg gacgtggagt ggaagtcctg tgacttggaa
     1321 gaggtgatga cagatgccct agtgagcaac aagcctgact tcgtgcgcct ctttgtggac
     1381 agtggtgctg acatggccga gttcttgacc tatgggcggc tgcagcagct ttaccactct
     1441 gtgtccccca agagcctcct ctttgaactg ctggagcgta agcatgagga gggtcggctg
     1501 acactggctg gcctgggtgc ccagcagacc cgggagctgc ccgttggtct gcctgccttt
     1561 tcactccatg aggtctcccg agttctcaaa gatttcctgc atgacgcctg ccgtggcttc
     1621 taccaggatg ggcgcaggat ggaggagaga gggccaccca agcggcctgc aggccagaaa
     1681 tggctgccgg acctcagtcg gaagagtgaa gacccatgga gggacctgtt cctttgggct
     1741 gtgctgcaga accgttatga gatggccaca tacttctggg ccatgggccg ggagggtgtg
     1801 gctgctgctc tggcggcctg caagatcatc aaggaaatgt cccacctgga gaaagaggca
     1861 gaggtggccc gcactatgcg tgaggccaag tatgagcagc tggccctcga tcttttctca
     1921 gagtgctaca gcaacagtga ggaccgtgcc tttgccctgt tggtgcgcag gaaccacagc
     1981 tggagcagga ccacctgcct gcacctggcc actgaggccg atgccaaggc cttctttgcc
     2041 catgatggtg tgcaagcatt cctgacgaag atctggtggg gagacatggc cacaggcaca
     2101 cccatcttac gacttctggg tgccttcacc tgcccagccc tcatctacac aaatctcatc
     2161 tccttcagtg aggatgcccc gcagaggatg gacctggaag atctgcagga gccagacagt
     2221 ttggatatgg aaaagagctt cctgtgcagc catggtggcc aattggagaa gttaacagag
     2281 gcgccaaggg ctcctggcga tctaggccca caagctgcct tcctgctcac acggtggagg
     2341 aagttctggg gcgctcctgt gactgtgttc ttggggaatg tggtcatgta ctttgcattc
     2401 ctcttcctat tctcctacgt cctgctggtg gatttcaggc caccacccca ggggccatct
     2461 gggtcggaag ttaccctgta tttctgggtc ttcacactgg tgctggagga aatccgacag
     2521 ggattcttca caaacgagga cacccgtctg gtgaagaagt tcactctgta cgtagaagac
     2581 aactggaaca aatgtgacat ggtggccatc ttcctgttca ttgttggtgt cacctgtaga
     2641 atggtgccct ccgtgtttga ggctggccgg actgttctgg ccattgactt catggtgttc
     2701 acacttcggc tcatccacat ctttgctatt cacaagcagc tgggtcctaa gatcatcatt
     2761 gtagagcgga tgatgaaaga tgtcttcttc ttcctcttct tcctgagcgt gtggctcgtg
     2821 gcctatggcg tgaccactca ggccctgctg cacccccacg atggccgtct ggagtggatt
     2881 ttccgccgtg tgctctacag gccttacctg cagatctttg ggcaaatccc tctggatgaa
     2941 attgatgagg cccgtgtgaa ctgctctctt cacccgttgc tgctggacag ctcagcttcc
     3001 tgccctaatc tctatgccaa ctggctggtc attctcctgc tggttacctt cctcctcgtc
     3061 actaatgtgc tacttatgaa ccttctgatc gccatgttca gctacacatt ccaggtggtg
     3121 cagggcaatg cagacatgtt ctggaagttt caacgctacc acctcatcgt tgaataccac
     3181 ggaaggccgg ctctggcccc gcccttcatc ctgctcagcc acctgagcct ggtgctcaag
     3241 caggtcttca ggaaggaagc ccagcacaaa cagcaacacc tggagagaga cttgcctgac
     3301 cccgtggacc agaagatcat tacctgggaa acagttcaaa aggagaactt cctgagtacc
     3361 atggagaaac ggaggaggga cagtgaggag gaggtgctga ggaaaacggc acacagagtg
     3421 gacttgattg ccaaatacat cgggggtctg agagagcaag aaaagaggat caagtgtctg
     3481 gagtcacagg ccaactactg tatgctcctc ttgtcctcca tgactgacac actggctcct
     3541 ggaggcacct actcaagttc tcaaaactgt ggtcgcagga gtcagccagc ctctgctaga
     3601 gacagggagt acctagaggc tggcttgcca cactcagaca cctgaaatgg agaaaccact
     3661 tgccctagag ctccagacct ggccagattg aggttttggg tcacatcaac cttcccctgc
     3721 cccagcagcc ccgagacctt gccgcagacc atgtcttgga cacctcttcc tatgaaaatg
     3781 agactcatgt ctttggcatc tatctgggag ccccaggcgt cctctccagc aggggaagtt
     3841 ttctcatgtc ctacctaaaa ctttcaccag ctaagactgg acagctggaa ctggccaagt
     3901 cccacatggg ataccatctg cctggatggg gctacttacg tc
//
